Gpr27 (G protein-coupled receptor 27) - Rat Genome Database
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Gene: Gpr27 (G protein-coupled receptor 27) Mus musculus
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Symbol: Gpr27
Name: G protein-coupled receptor 27
RGD ID: 733558
MGI Page MGI
Description: Predicted to have G protein-coupled receptor activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway. Localizes to plasma membrane. Orthologous to human GPR27 (G protein-coupled receptor 27); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: probable G-protein coupled receptor 27; super conserved receptor expressed in brain 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39699,669,328 - 99,672,027 (+)NCBIGRCm39mm39
GRCm38699,692,367 - 99,695,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl699,692,679 - 99,695,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv37699,642,673 - 99,643,812 (+)NCBIGRCm37mm9NCBIm37
MGSCv36699,658,142 - 99,659,281 (+)NCBImm8
Celera6101,556,763 - 101,557,942 (+)NCBICelera
Cytogenetic Map6D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:9479505   PMID:16602821   PMID:17273929   PMID:21873635   PMID:22253604   PMID:32221326  


Genomics

Comparative Map Data
Gpr27
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39699,669,328 - 99,672,027 (+)NCBIGRCm39mm39
GRCm38699,692,367 - 99,695,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl699,692,679 - 99,695,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv37699,642,673 - 99,643,812 (+)NCBIGRCm37mm9NCBIm37
MGSCv36699,658,142 - 99,659,281 (+)NCBImm8
Celera6101,556,763 - 101,557,942 (+)NCBICelera
Cytogenetic Map6D3NCBI
GPR27
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl371,753,855 - 71,756,496 (+)EnsemblGRCh38hg38GRCh38
GRCh38371,753,855 - 71,756,496 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37371,803,201 - 71,804,328 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37371,803,006 - 71,805,647 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36371,885,891 - 71,887,018 (+)NCBINCBI36hg18NCBI36
Build 34371,885,890 - 71,887,018NCBI
Celera371,733,794 - 71,734,921 (+)NCBI
Cytogenetic Map3p13NCBI
CHM1_1371,754,610 - 71,755,737 (+)NCBICHM1_1
Gpr27
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24132,328,364 - 132,329,497 (+)NCBI
Rnor_6.0 Ensembl4132,137,793 - 132,138,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04132,137,793 - 132,138,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04196,629,031 - 196,630,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44134,541,534 - 134,542,667 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14134,786,374 - 134,787,508 (+)NCBI
Celera4121,187,535 - 121,188,668 (+)NCBICelera
Cytogenetic Map4q34NCBI
Gpr27
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542116,352,643 - 16,353,094 (-)NCBIChiLan1.0ChiLan1.0
GPR27
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1373,050,542 - 73,052,347 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0371,693,611 - 71,696,247 (+)NCBIMhudiblu_PPA_v0panPan3
GPR27
(Canis lupus familiaris - dog)
No map positions available.
Gpr27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366033,241,741 - 3,289,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR27
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1353,152,062 - 53,153,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11353,152,038 - 53,154,537 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GPR27
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12232,708,228 - 32,709,820 (+)NCBI
ChlSab1.1 Ensembl2232,708,599 - 32,709,729 (+)Ensembl
Gpr27
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247736,294,850 - 6,297,249 (+)NCBI

Position Markers
UniSTS:487638  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38699,692,679 - 99,693,818UniSTSGRCm38
MGSCv37699,642,673 - 99,643,812UniSTSGRCm37
Cytogenetic Map6E1UniSTS
UniSTS:493241  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38699,692,679 - 99,693,818UniSTSGRCm38
MGSCv37699,642,673 - 99,643,812UniSTSGRCm37
Cytogenetic Map6E1UniSTS
UniSTS:494131  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38699,692,591 - 99,693,859UniSTSGRCm38
MGSCv37699,642,585 - 99,643,853UniSTSGRCm37
Cytogenetic Map6E1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:163
Interacting mature miRNAs:168
Transcripts:ENSMUST00000101122
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000101122   ⟹   ENSMUSP00000098680
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl699,692,679 - 99,695,066 (+)Ensembl
RefSeq Acc Id: NM_008158   ⟹   NP_032184
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39699,669,328 - 99,672,027 (+)NCBI
GRCm38699,692,367 - 99,695,066 (+)NCBI
MGSCv37699,642,673 - 99,643,812 (+)RGD
Celera6101,556,765 - 101,557,942 (+)ENTREZGENE
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032184 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53540 (Get FASTA)   NCBI Sequence Viewer  
  O54897 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_032184   ⟸   NM_008158
- UniProtKB: O54897 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000098680   ⟸   ENSMUST00000101122

Promoters
RGD ID:6839412
Promoter ID:MM_KWN:47045
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:NM_008158
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36699,641,881 - 99,643,657 (+)MPROMDB
RGD ID:6890542
Promoter ID:EPDNEW_M8722
Type:multiple initiation site
Name:Gpr27_1
Description:Mus musculus G protein-coupled receptor 27 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38699,692,594 - 99,692,654EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202299 AgrOrtholog
Ensembl Genes ENSMUSG00000072875 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000098680 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000101122 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:14761 UniProtKB/Swiss-Prot
MGD MGI:1202299 ENTREZGENE
NCBI Gene 14761 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gpr27 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt GPR27_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE