Symbol:
Pja2
Name:
praja ring finger ubiquitin ligase 2
Description:
Predicted to have protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including long-term memory; regulation of macrophage activation; and regulation of signal transduction. Predicted to localize to the cytoplasm; intermediate filament cytoskeleton; and plasma membrane. Is expressed in nervous system and testis. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4-hydroxyphenyl retinamide.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AI447901; AL022700; E3 ubiquitin-protein ligase Praja-2; E3 ubiquitin-protein ligase Praja2; MGC27629; mKIAA0438; Neurodap1; neurodegeneration associated protein 1; praja 2, RING-H2 motif containing; praja-2; praja2; protein carrying the RING-H2 sequence motif; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PJA2 (praja ring finger ubiquitin ligase 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Pja2 (praja ring finger ubiquitin ligase 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pja2 (praja ring finger ubiquitin ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PJA2 (praja ring finger ubiquitin ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PJA2 (praja ring finger ubiquitin ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pja2 (praja ring finger ubiquitin ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PJA2 (praja ring finger ubiquitin ligase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Pja2 (praja ring finger ubiquitin ligase 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
PJA2 (praja ring finger ubiquitin ligase 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
pja2 (praja ring finger ubiquitin ligase 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 17 64,281,006 - 64,331,883 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 17 64,630,355 - 64,681,223 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 17 93,072,176 - 93,123,044 (+) NCBI mm8 Celera 17 68,597,047 - 68,647,778 (-) NCBI Celera Cytogenetic Map 17 E1.1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
17alpha-ethynylestradiol decreases expression ISO RGD:620273 6480464 Ethinyl Estradiol results in decreased expression of PJA2 mRNA CTD PMID:15576828 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PJA2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PJA2 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PJA2 mRNA] CTD PMID:15034205 2-hydroxypropanoic acid increases expression ISO RGD:733552 6480464 Lactic Acid results in increased expression of PJA2 mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of PJA2 mRNA CTD PMID:26251327 4-hydroxyphenyl retinamide decreases expression EXP 6480464 Fenretinide results in decreased expression of PJA2 mRNA CTD PMID:28973697 aflatoxin B1 decreases methylation ISO RGD:733552 6480464 Aflatoxin B1 results in decreased methylation of PJA2 gene, Aflatoxin B1 results in decreased methylation of PJA2 intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:733552 6480464 aflatoxin B2 results in decreased methylation of PJA2 intron CTD PMID:30157460 aflatoxin M1 decreases expression ISO RGD:733552 6480464 Aflatoxin M1 results in decreased expression of PJA2 mRNA CTD PMID:30928695 all-trans-retinoic acid increases expression ISO RGD:733552 6480464 Tretinoin results in increased expression of PJA2 mRNA CTD PMID:23724009 ammonium chloride affects expression ISO RGD:620273 6480464 Ammonium Chloride affects the expression of PJA2 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of PJA2 mRNA CTD PMID:23650126 benzo[a]pyrene multiple interactions EXP 6480464 AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of PJA2 mRNA] CTD PMID:15034205 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PJA2 mRNA CTD PMID:15034205 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:733552 6480464 7 more ... CTD PMID:20018196 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of PJA2 mRNA CTD PMID:21318169 bis(2-ethylhexyl) phthalate increases expression ISO RGD:620273 6480464 Diethylhexyl Phthalate results in increased expression of PJA2 mRNA CTD PMID:21318169 bisphenol A affects expression ISO RGD:620273 6480464 bisphenol A affects the expression of PJA2 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:620273 6480464 bisphenol A results in increased methylation of PJA2 gene CTD PMID:28505145 chloropicrin increases expression ISO RGD:733552 6480464 chloropicrin results in increased expression of PJA2 mRNA CTD PMID:26352163 chloroprene increases expression ISO RGD:620273 6480464 Chloroprene results in increased expression of PJA2 mRNA CTD PMID:23125180 chlorpyrifos decreases expression ISO RGD:620273 6480464 Chlorpyrifos results in decreased expression of PJA2 mRNA CTD PMID:18668222 cocaine decreases expression ISO RGD:620273 6480464 Cocaine results in decreased expression of PJA2 mRNA CTD PMID:16076954 cyclosporin A increases expression ISO RGD:733552 6480464 Cyclosporine results in increased expression of PJA2 mRNA CTD PMID:20106945 , PMID:25562108 dibutyl phthalate increases expression ISO RGD:620273 6480464 Dibutyl Phthalate results in increased expression of PJA2 mRNA CTD PMID:21266533 dicrotophos decreases expression ISO RGD:733552 6480464 dicrotophos results in decreased expression of PJA2 mRNA CTD PMID:28302478 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of PJA2 mRNA CTD PMID:30319688 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of PJA2 mRNA CTD PMID:21318169 fenofibrate multiple interactions EXP 6480464 PPARA protein affects the reaction [Fenofibrate results in increased expression of PJA2 mRNA] CTD PMID:21318169 ferroheme b decreases expression EXP 6480464 Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 finasteride increases expression ISO RGD:620273 6480464 Finasteride results in increased expression of PJA2 mRNA CTD PMID:24136188 gamma-hexachlorocyclohexane increases expression ISO RGD:620273 6480464 Hexachlorocyclohexane results in increased expression of PJA2 mRNA CTD PMID:17785943 gemcitabine increases expression ISO RGD:733552 6480464 gemcitabine results in increased expression of PJA2 mRNA CTD PMID:17039268 heme b decreases expression EXP 6480464 Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 hydrogen peroxide affects expression ISO RGD:733552 6480464 Hydrogen Peroxide affects the expression of PJA2 mRNA CTD PMID:20044591 indometacin decreases expression ISO RGD:733552 6480464 Indomethacin results in decreased expression of PJA2 mRNA CTD PMID:16984733 leflunomide increases expression ISO RGD:733552 6480464 leflunomide results in increased expression of PJA2 mRNA CTD PMID:28988120 methapyrilene decreases expression ISO RGD:620273 6480464 Methapyrilene results in decreased expression of PJA2 mRNA CTD PMID:30467583 methylseleninic acid increases expression ISO RGD:733552 6480464 methylselenic acid results in increased expression of PJA2 mRNA CTD PMID:18548127 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of PJA2 mRNA CTD PMID:17562736 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of PJA2 mRNA CTD PMID:23091169 quercetin increases expression ISO RGD:620273 6480464 Quercetin results in increased expression of PJA2 mRNA CTD PMID:17103110 rac-lactic acid increases expression ISO RGD:733552 6480464 Lactic Acid results in increased expression of PJA2 mRNA CTD PMID:30851411 silver atom decreases expression EXP 6480464 Silver results in decreased expression of PJA2 mRNA CTD PMID:27131904 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of PJA2 mRNA CTD PMID:27131904 sodium arsenite decreases expression ISO RGD:733552 6480464 sodium arsenite results in decreased expression of PJA2 mRNA CTD PMID:28595984 succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PJA2 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PJA2 mRNA CTD PMID:21641980 , PMID:26378955 tunicamycin increases expression ISO RGD:733552 6480464 Tunicamycin results in increased expression of PJA2 mRNA CTD PMID:22378314 , PMID:29453283 urethane increases expression ISO RGD:733552 6480464 Urethane results in increased expression of PJA2 mRNA CTD PMID:28818685 valproic acid decreases expression ISO RGD:733552 6480464 Valproic Acid results in decreased expression of PJA2 mRNA CTD PMID:23179753 
Gene-Chemical Interaction Annotations
