Brs3 (bombesin-like receptor 3) - Rat Genome Database

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Gene: Brs3 (bombesin-like receptor 3) Mus musculus
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Symbol: Brs3
Name: bombesin-like receptor 3
RGD ID: 733513
MGI Page MGI
Description: Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in neuronal cell body. Predicted to be active in plasma membrane. Is expressed in lung; lung epithelium; lung mesenchyme; pons; and pons mantle layer. Orthologous to human BRS3 (bombesin receptor subtype 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bombesin receptor subtype-3; BRS; BRS-3; MGC129146; MGC129147
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,088,434 - 56,094,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,088,434 - 56,094,118 (+)EnsemblGRCm39 Ensembl
GRCm38X57,043,074 - 57,048,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,043,074 - 57,048,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,296,251 - 54,301,935 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,389,858 - 53,395,542 (+)NCBIMGSCv36mm8
CeleraX43,522,304 - 43,527,988 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX30.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). Liu J, etal., Biochemistry 2002 Jul 16;41(28):8954-60.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Ohki-Hamazaki H, etal., Nature 1997 Nov 13;390(6656):165-9.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9262170   PMID:9573346   PMID:9920658   PMID:10349636   PMID:10405115   PMID:10713297   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11803457   PMID:12477932   PMID:12959933  
PMID:14988239   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16603607   PMID:18039774   PMID:18719666   PMID:20096642   PMID:20467915   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:21878513   PMID:22304924   PMID:22911445   PMID:24326363   PMID:24452453   PMID:26562312   PMID:26801314   PMID:29107299   PMID:30349101   PMID:32229422   PMID:34038711  
PMID:34326065   PMID:34478905   PMID:36317965  


Genomics

Comparative Map Data
Brs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,088,434 - 56,094,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,088,434 - 56,094,118 (+)EnsemblGRCm39 Ensembl
GRCm38X57,043,074 - 57,048,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,043,074 - 57,048,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,296,251 - 54,301,935 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,389,858 - 53,395,542 (+)NCBIMGSCv36mm8
CeleraX43,522,304 - 43,527,988 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX30.78NCBI
BRS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,487,947 - 136,493,780 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX136,487,947 - 136,493,780 (+)EnsemblGRCh38hg38GRCh38
GRCh37X135,570,106 - 135,575,939 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,397,791 - 135,402,264 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X135,295,644 - 135,300,118NCBI
CeleraX135,933,763 - 135,938,238 (+)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX124,840,740 - 124,845,212 (+)NCBIHuRef
CHM1_1X135,481,778 - 135,486,251 (+)NCBICHM1_1
T2T-CHM13v2.0X134,796,688 - 134,802,523 (+)NCBIT2T-CHM13v2.0
Brs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X139,944,080 - 139,969,637 (+)NCBIGRCr8
mRatBN7.2X134,906,817 - 134,932,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,906,784 - 134,930,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX137,123,452 - 137,127,830 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X140,678,073 - 140,682,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X138,247,469 - 138,251,847 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X159,484,953 - 159,510,944 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,505,344 - 159,511,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,114,756 - 154,140,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,688,650 - 141,693,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X141,762,082 - 141,766,461 (+)NCBI
CeleraX142,968,657 - 142,973,035 (+)NCBICelera
Cytogenetic MapXq36NCBI
Brs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,627,569 - 8,631,810 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,627,569 - 8,631,810 (-)NCBIChiLan1.0ChiLan1.0
BRS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X135,906,752 - 135,912,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X135,910,464 - 135,916,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,617,592 - 125,623,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X135,883,613 - 135,888,069 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX135,883,613 - 135,888,069 (+)Ensemblpanpan1.1panPan2
BRS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X106,838,893 - 106,844,877 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX106,838,890 - 106,843,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,659,589 - 92,664,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X108,818,684 - 108,823,165 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX108,818,528 - 108,824,578 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X105,959,634 - 105,964,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X108,151,435 - 108,155,900 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,791,869 - 107,796,352 (+)NCBIUU_Cfam_GSD_1.0
Brs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,825,895 - 104,831,805 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651310,784,181 - 10,788,680 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651310,784,181 - 10,788,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,615,564 - 111,620,124 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,615,695 - 111,620,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,473,443 - 127,479,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,488,422 - 111,496,637 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,489,165 - 111,493,375 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606549,172,883 - 49,177,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,652,776 - 10,658,498 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480810,652,817 - 10,658,434 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brs3
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:421
Count of miRNA genes:285
Interacting mature miRNAs:343
Transcripts:ENSMUST00000033464
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
1301351Obq6_mobesity QTL 6 (mouse)Not determinedX5077237570434751Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
4142286Pubt1_mpubertal timing 1 (mouse)Not determined5241220061880496Mouse
4141126Lvic5_mliver iron content 5 (mouse)Not determined5241220063027567Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse

Markers in Region
Brs3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X57,046,969 - 57,047,252UniSTSGRCm38
MGSCv37X54,300,146 - 54,300,429UniSTSGRCm37
CeleraX43,526,199 - 43,526,482UniSTS
Cytogenetic MapXA7.1-A7.2UniSTS
cM MapX UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000033464   ⟹   ENSMUSP00000033464
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX56,088,434 - 56,094,118 (+)Ensembl
GRCm38.p6 EnsemblX57,043,074 - 57,048,758 (+)Ensembl
RefSeq Acc Id: NM_009766   ⟹   NP_033896
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X56,088,434 - 56,094,118 (+)NCBI
GRCm38X57,043,074 - 57,048,758 (+)ENTREZGENE
MGSCv37X54,296,251 - 54,301,935 (+)RGD
CeleraX43,522,304 - 43,527,988 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033896   ⟸   NM_009766
- UniProtKB: O88790 (UniProtKB/Swiss-Prot),   Q544G9 (UniProtKB/Swiss-Prot),   O54798 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033464   ⟸   ENSMUST00000033464

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54798-F1-model_v2 AlphaFold O54798 1-399 view protein structure

Promoters
RGD ID:6845535
Promoter ID:MM_KWN:60409
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_009766
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X54,296,261 - 54,296,761 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1100501 AgrOrtholog
Ensembl Genes ENSMUSG00000031130 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033464 ENTREZGENE
  ENSMUST00000033464.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Bombesin_rcpt_3 UniProtKB/Swiss-Prot
  Bombsn_rcpt-like UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:12209 UniProtKB/Swiss-Prot
MGD MGI:1100501 ENTREZGENE
NCBI Gene 12209 ENTREZGENE
PANTHER BOMBESIN RECEPTOR SUBTYPE-3 UniProtKB/Swiss-Prot
  LEUCOKININ RECEPTOR-RELATED UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB BRS3 RGD
PhenoGen Brs3 PhenoGen
PRINTS BOMBESIN3R UniProtKB/Swiss-Prot
  BOMBESINR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt BRS3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  O88790 ENTREZGENE
  Q544G9 ENTREZGENE
UniProt Secondary O88790 UniProtKB/Swiss-Prot
  Q544G9 UniProtKB/Swiss-Prot