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Gene: SIX3 (SIX homeobox 3) Homo sapiens
Symbol: SIX3
Name: SIX homeobox 3
Description: Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription corepressor binding activity. Involved in eye development; forebrain dorsal/ventral pattern formation; and negative regulation of transcription, DNA-templated. Predicted to localize to nuclear chromatin and transcription factor complex. Implicated in holoprosencephaly and holoprosencephaly 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: homeobox protein SIX3; HPE2; sine oculis homeobox homolog 3; sine oculis homeobox-like protein 3; truncated SIX3
Mus musculus (house mouse) : Six3 (sine oculis-related homeobox 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Six3 (SIX homeobox 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Six3 (SIX homeobox 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SIX3 (SIX homeobox 3)
Canis lupus familiaris (dog) : SIX3 (SIX homeobox 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Six3 (SIX homeobox 3)
Sus scrofa (pig) : SIX3 (SIX homeobox 3)
Chlorocebus sabaeus (African green monkey) : SIX3 (SIX homeobox 3)
Heterocephalus glaber (naked mole-rat) : Six3 (SIX homeobox 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl244,941,702 - 44,946,071 (+)EnsemblGRCh38hg38GRCh38
GRCh38244,941,702 - 44,946,071 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37245,169,037 - 45,173,216 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36245,022,541 - 45,025,894 (+)NCBINCBI36hg18NCBI36
Build 34245,080,511 - 45,084,092NCBI
Celera245,007,709 - 45,011,888 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef244,885,400 - 44,910,885 (+)NCBIHuRef
CHM1_1245,098,943 - 45,103,122 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SIX3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733474
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.