Gene: NEO1 (neogenin 1) Homo sapiens
Symbol: NEO1
Name: neogenin 1
Description: This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp547A066; DKFZp547B146; HsT17534; IGDCC2; immunoglobulin superfamily DCC subclass member 2; neogenin; neogenin homolog 1; NGN; NTN1R2
Mus musculus (house mouse) : Neo1 (neogenin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Neo1 (neogenin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Neo1 (neogenin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NEO1 (neogenin 1)
Canis lupus familiaris (dog) : NEO1 (neogenin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Neo1 (neogenin 1)
Sus scrofa (pig) : NEO1 (neogenin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381573,051,715 - 73,305,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371573,344,056 - 73,597,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361571,131,928 - 71,384,599 (+)NCBINCBI36hg18NCBI36
Build 341571,131,927 - 71,382,835NCBI
Celera1550,287,439 - 50,476,112 (+)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1550,240,408 - 50,428,957 (+)NCBIHuRef
CHM1_11573,462,785 - 73,715,509 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NEO1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733424
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-04-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.