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Gene: ST14 (ST14 transmembrane serine protease matriptase) Homo sapiens
Symbol: ST14
Name: ST14 transmembrane serine protease matriptase
Description: Exhibits serine-type peptidase activity. Involved in keratinocyte differentiation and proteolysis. Predicted to localize to extracellular region. Implicated in autosomal recessive congenital ichthyosis 11. Biomarker of ductal carcinoma in situ; dysgerminoma; granulosa cell tumor; prostate carcinoma in situ; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARCI11; HAI; membrane-type serine protease 1; MT-SP1; MTSP1; prostamin; PRSS14; serine protease 14; serine protease TADG-15; SNC19; suppression of tumorigenicity 14; suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); suppressor of tumorigenicity 14 protein; TADG15; TMPRSS14; tumor associated differentially expressed gene 15 protein; tumor-associated differentially-expressed gene 15 protein
Mus musculus (house mouse) : St14 (suppression of tumorigenicity 14 (colon carcinoma))  MGI  Alliance
Rattus norvegicus (Norway rat) : St14 (ST14 transmembrane serine protease matriptase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : St14 (ST14 transmembrane serine protease matriptase)
Pan paniscus (bonobo/pygmy chimpanzee) : ST14 (ST14 transmembrane serine protease matriptase)
Canis lupus familiaris (dog) : ST14 (ST14 transmembrane serine protease matriptase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : St14 (ST14 transmembrane serine protease matriptase)
Sus scrofa (pig) : ST14 (ST14 transmembrane serine protease matriptase)
Chlorocebus sabaeus (African green monkey) : ST14 (ST14 transmembrane serine protease matriptase)
Heterocephalus glaber (naked mole-rat) : St14 (ST14 transmembrane serine protease matriptase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11130,159,782 - 130,210,362 (+)EnsemblGRCh38hg38GRCh38
GRCh3811130,159,782 - 130,210,362 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711130,029,682 - 130,080,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,534,892 - 129,585,467 (+)NCBINCBI36hg18NCBI36
Build 3411129,534,932 - 129,585,466NCBI
Celera11127,197,379 - 127,248,136 (+)NCBI
Cytogenetic Map11q24.3NCBI
HuRef11125,980,949 - 126,032,941 (+)NCBIHuRef
CHM1_111129,915,529 - 129,966,064 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ST14
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733374
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.