Trpc5 (transient receptor potential cation channel, subfamily C, member 5) - Rat Genome Database

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Gene: Trpc5 (transient receptor potential cation channel, subfamily C, member 5) Mus musculus
Analyze
Symbol: Trpc5
Name: transient receptor potential cation channel, subfamily C, member 5
RGD ID: 733335
MGI Page MGI
Description: Enables inositol 1,4,5 trisphosphate binding activity. Involved in neuron apoptotic process and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Predicted to be part of calcium channel complex. Predicted to be integral component of plasma membrane. Is expressed in brain; cochlea; dorsal root ganglion; and vagus ganglion. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: capacitative calcium entry channel 2; CCE2; MGC124500; mtrp5; short transient receptor potential channel 5; TR; transient receptor protein 5; TRP-5; trp-related protein 5; TRP5; Trrp5; vtransient receptor potential cation channel, subfamily C, member 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X143,160,323 - 143,471,176 (-)NCBIGRCm39mm39
GRCm39 EnsemblX143,164,667 - 143,471,176 (-)Ensembl
GRCm38X144,377,327 - 144,688,180 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX144,381,671 - 144,688,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X140,816,214 - 141,122,723 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X139,628,039 - 139,934,548 (-)NCBImm8
CeleraX128,337,325 - 128,644,030 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX65.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9553080   PMID:9687496   PMID:9722956   PMID:10349636   PMID:10493832   PMID:10980202   PMID:11042159   PMID:11076861   PMID:11390792   PMID:12477932   PMID:12631560   PMID:14505576  
PMID:15336983   PMID:15385169   PMID:15689561   PMID:15843439   PMID:15987684   PMID:16044320   PMID:16141072   PMID:16141073   PMID:16306123   PMID:16368680   PMID:16460286   PMID:17480026  
PMID:17593972   PMID:17624425   PMID:17626205   PMID:17884814   PMID:18495872   PMID:18832422   PMID:18989690   PMID:19156209   PMID:19299701   PMID:19322198   PMID:19398778   PMID:19450521  
PMID:19521566   PMID:19815560   PMID:19834762   PMID:20390293   PMID:20978238   PMID:21267068   PMID:21430274   PMID:21677750   PMID:21873635   PMID:21968068   PMID:22025699   PMID:22051675  
PMID:22135323   PMID:22157757   PMID:22461428   PMID:22547824   PMID:22668831   PMID:23188715   PMID:23233529   PMID:23677990   PMID:24117252   PMID:24194600   PMID:24358869   PMID:24952961  
PMID:25471572   PMID:26317356   PMID:26520460   PMID:27165180   PMID:27177420   PMID:27411851   PMID:27626380   PMID:27920205   PMID:28099839   PMID:28237267   PMID:28324107   PMID:28539583  
PMID:28636132   PMID:28790178   PMID:28835433   PMID:29061651   PMID:29373286   PMID:29572499   PMID:29793963   PMID:30038709   PMID:30062674   PMID:30270038   PMID:30413532   PMID:30414390  
PMID:30452936   PMID:30692584   PMID:30786075   PMID:31285329   PMID:31355338   PMID:31536487   PMID:31844148   PMID:32033274   PMID:32110987   PMID:32350291   PMID:32414784   PMID:32729832  


Genomics

Comparative Map Data
Trpc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X143,160,323 - 143,471,176 (-)NCBIGRCm39mm39
GRCm39 EnsemblX143,164,667 - 143,471,176 (-)Ensembl
GRCm38X144,377,327 - 144,688,180 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX144,381,671 - 144,688,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X140,816,214 - 141,122,723 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X139,628,039 - 139,934,548 (-)NCBImm8
CeleraX128,337,325 - 128,644,030 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX65.49NCBI
TRPC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX111,768,011 - 112,082,776 (-)EnsemblGRCh38hg38GRCh38
GRCh38X111,768,011 - 112,082,943 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X111,011,239 - 111,326,004 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,904,198 - 111,212,660 (-)NCBINCBI36hg18NCBI36
Build 34X110,823,686 - 111,132,149NCBI
CeleraX111,497,049 - 111,805,514 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX100,639,095 - 100,946,273 (-)NCBIHuRef
CHM1_1X110,928,786 - 111,237,228 (-)NCBICHM1_1
Trpc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X107,946,163 - 108,230,978 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX107,939,131 - 108,230,991 (-)Ensembl
Rnor_6.0X115,624,670 - 115,908,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX115,627,653 - 115,908,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,079,131 - 114,359,862 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X33,989,907 - 34,126,175 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X33,897,584 - 34,179,644 (+)NCBI
CeleraX107,338,307 - 107,473,426 (-)NCBICelera
Cytogenetic MapXq34NCBI
Trpc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554903,860,909 - 4,057,275 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554903,777,756 - 4,057,275 (+)NCBIChiLan1.0ChiLan1.0
TRPC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X111,346,804 - 111,648,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX111,346,804 - 111,648,201 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X100,886,122 - 101,191,425 (-)NCBIMhudiblu_PPA_v0panPan3
TRPC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X84,835,130 - 84,989,609 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX84,801,096 - 85,116,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX70,936,399 - 71,117,033 (-)NCBI
ROS_Cfam_1.0X86,509,906 - 86,696,508 (-)NCBI
UMICH_Zoey_3.1X83,981,630 - 84,160,857 (-)NCBI
UNSW_CanFamBas_1.0X85,658,324 - 85,832,221 (-)NCBI
UU_Cfam_GSD_1.0X85,498,131 - 85,680,673 (-)NCBI
Trpc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X84,110,276 - 84,383,058 (-)NCBI
SpeTri2.0NW_0049364993,391,386 - 3,541,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX91,721,617 - 91,988,120 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X91,716,334 - 91,988,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X106,133,833 - 106,399,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X99,546,923 - 99,856,971 (-)NCBI
ChlSab1.1 EnsemblX99,550,595 - 99,736,668 (-)Ensembl
Vero_WHO_p1.0NW_02366606524,918,626 - 25,161,347 (-)NCBI
Trpc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248033,494,311 - 3,812,985 (+)NCBI

Position Markers
AF029983  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,382,160 - 144,382,241UniSTSGRCm38
MGSCv37X140,816,703 - 140,816,784UniSTSGRCm37
CeleraX128,337,814 - 128,337,895UniSTS
Cytogenetic MapXF2UniSTS
cM MapX63.0UniSTS
Whitehead/MRC_RHX1674.73UniSTS
DXMit118  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,632,777 - 144,632,910UniSTSGRCm38
MGSCv37X141,067,320 - 141,067,453UniSTSGRCm37
CeleraX128,589,021 - 128,589,154UniSTS
Cytogenetic MapXF2UniSTS
cM MapX62.1UniSTS
Whitehead GeneticX50.3UniSTS
Whitehead_YACX UniSTS
Trpc5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,418,953 - 144,419,058UniSTSGRCm38
MGSCv37X140,853,496 - 140,853,601UniSTSGRCm37
CeleraX128,374,634 - 128,374,739UniSTS
Cytogenetic MapXF2UniSTS
cM MapX63.0UniSTS
Trrp5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,381,446 - 144,382,525UniSTSGRCm38
MGSCv37X140,815,989 - 140,817,068UniSTSGRCm37
CeleraX128,337,100 - 128,338,177UniSTS
Cytogenetic MapXF2UniSTS
cM MapX63.0UniSTS
Trpc5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF2UniSTS
Trpc5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX122083468161430042Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX103012242163975945Mouse
1301276Tswt_mtestis weight (mouse)Not determinedX139475662152006342Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX134639291166515599Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX126902153160902273Mouse
13208556Lgth14_mbody length 14 (mouse)X95000000151000000Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X123000000153800000Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X55000000150000000Mouse
13208552Wght12_mweight 12 (mouse)X95000000151000000Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X130000000155000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:207
Interacting mature miRNAs:212
Transcripts:ENSMUST00000040184, ENSMUST00000148240
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000040184   ⟹   ENSMUSP00000049063
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX143,164,667 - 143,471,176 (-)Ensembl
GRCm38.p6 EnsemblX144,381,671 - 144,688,180 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148240
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX143,201,671 - 143,470,999 (-)Ensembl
GRCm38.p6 EnsemblX144,418,675 - 144,688,003 (-)Ensembl
RefSeq Acc Id: NM_009428   ⟹   NP_033454
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X143,160,323 - 143,471,176 (-)NCBI
GRCm38X144,377,327 - 144,688,180 (-)NCBI
MGSCv37X140,816,214 - 141,122,723 (-)RGD
CeleraX128,337,325 - 128,644,030 (-)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033454   ⟸   NM_009428
- UniProtKB: Q9QX29 (UniProtKB/Swiss-Prot),   Q8C8A8 (UniProtKB/TrEMBL),   Q2KHN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000049063   ⟸   ENSMUST00000040184
Protein Domains
Ion_trans   TRP_2

Promoters
RGD ID:13681574
Promoter ID:EPDNEW_M24936
Type:single initiation site
Name:Trpc5_1
Description:Mus musculus transient receptor potential cation channel, subfamilyC, member 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X144,638,956 - 144,639,016EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109524 AgrOrtholog
Ensembl Genes ENSMUSG00000041710 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000049063 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040184 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC5_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109524 ENTREZGENE
NCBI Gene 22067 ENTREZGENE
PANTHER PTHR10117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10117:SF76 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpc5 PhenoGen
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPCHANNEL5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q2KHN9 ENTREZGENE, UniProtKB/TrEMBL
  Q8C8A8 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX29 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q61059 UniProtKB/Swiss-Prot
  Q9QWT1 UniProtKB/Swiss-Prot
  Q9R0D4 UniProtKB/Swiss-Prot