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Gene: Eif2b1 (eukaryotic translation initiation factor 2B, subunit 1 (alpha)) Mus musculus
Symbol: Eif2b1
Name: eukaryotic translation initiation factor 2B, subunit 1 (alpha)
Description: Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; negative regulation of guanyl-nucleotide exchange factor activity; and oligodendrocyte development. Predicted to localize to eukaryotic translation initiation factor 2 complex; eukaryotic translation initiation factor 2B complex; and plasma membrane. Is expressed in several structures, including cranium; nervous system; physiological umbilical hernia; submandibular gland primordium; and thoracic intervertebral disc. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 26kDa; D5Ertd406e; eIF-2B GDP-GTP exchange factor subunit alpha; EIF2B; EIF2BA; eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa); MGC6458; translation initiation factor eIF-2B subunit alpha
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5124,570,213 - 124,579,131 (-)EnsemblGRCm38mm10GRCm38
GRCm385124,570,214 - 124,579,131 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375125,020,223 - 125,029,066 (-)NCBIGRCm37mm9NCBIm37
MGSCv365124,831,271 - 124,839,665 (-)NCBImm8
Celera5121,646,913 - 121,655,757 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map563.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Eif2b1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733322
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.