Dctpp1 (dCTP pyrophosphatase 1) - Rat Genome Database

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Gene: Dctpp1 (dCTP pyrophosphatase 1) Mus musculus
Analyze
Symbol: Dctpp1
Name: dCTP pyrophosphatase 1
RGD ID: 733252
MGI Page MGI
Description: Enables several functions, including identical protein binding activity; magnesium ion binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in nucleoside triphosphate catabolic process. Located in cytosol. Is expressed in several structures, including brain ventricular layer; gut; jaw; lung; and vertebral axis musculature. Orthologous to human DCTPP1 (dCTP pyrophosphatase 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2410015N17Rik; AI854235; dCTPase 1; deoxycytidine-triphosphatase 1; RS21-; RS21-C6; XTP3-transactivated gene A protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm7653  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,856,131 - 126,859,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,856,131 - 126,859,881 (-)EnsemblGRCm39 Ensembl
GRCm387127,256,959 - 127,260,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,256,959 - 127,260,709 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,400,473 - 134,404,181 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,048,107 - 127,051,815 (-)NCBIMGSCv36mm8
Celera7127,105,674 - 127,109,383 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
caffeine  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (EXP,ISO)
Cinobufagin  (ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
furan  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
trimellitic anhydride  (EXP)
tungsten  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA,ISO,TAS)
mitochondrion  (IDA,ISO)
nucleoplasm  (ISO)
nucleus  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12904583   PMID:14610273   PMID:15840001   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:17320107   PMID:19220460   PMID:21267068   PMID:21677750   PMID:21873635   PMID:28378742  


Genomics

Comparative Map Data
Dctpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,856,131 - 126,859,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,856,131 - 126,859,881 (-)EnsemblGRCm39 Ensembl
GRCm387127,256,959 - 127,260,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,256,959 - 127,260,709 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,400,473 - 134,404,181 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,048,107 - 127,051,815 (-)NCBIMGSCv36mm8
Celera7127,105,674 - 127,109,383 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.42NCBI
DCTPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,423,615 - 30,430,030 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,423,615 - 30,430,030 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,434,936 - 30,441,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,342,520 - 30,348,874 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,857,548 - 29,863,885 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,997,232 - 28,003,588 (-)NCBIHuRef
CHM1_11631,751,466 - 31,757,820 (-)NCBICHM1_1
T2T-CHM13v2.01630,809,819 - 30,816,234 (-)NCBIT2T-CHM13v2.0
Dctpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,307,933 - 191,311,326 (-)NCBIGRCr8
mRatBN7.21181,877,440 - 181,880,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,877,437 - 181,880,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,228,131 - 190,231,512 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,414,218 - 197,417,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,082,593 - 190,085,974 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,703,459 - 198,706,852 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,703,461 - 198,706,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,696,305 - 205,699,698 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,519,955 - 186,523,348 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,669,837 - 186,673,229 (-)NCBI
Celera1179,528,917 - 179,532,300 (-)NCBICelera
Cytogenetic Map1q37NCBI
Dctpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,357,204 - 7,360,034 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,357,204 - 7,360,034 (-)NCBIChiLan1.0ChiLan1.0
DCTPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21833,629,486 - 33,636,121 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11638,430,932 - 38,438,331 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01624,538,023 - 24,545,426 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11630,794,268 - 30,802,207 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,794,268 - 30,802,179 (-)Ensemblpanpan1.1panPan2
DCTPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,679,681 - 17,683,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,679,722 - 17,683,570 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,253,648 - 19,257,592 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,810,663 - 17,814,594 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,810,709 - 17,814,520 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,610,846 - 17,614,777 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,526,330 - 17,530,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,841,310 - 17,845,272 (+)NCBIUU_Cfam_GSD_1.0
Dctpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,782,876 - 124,786,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,879,241 - 12,884,287 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,880,745 - 12,884,240 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCTPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,886,890 - 17,900,557 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,896,426 - 17,900,562 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,312,086 - 18,316,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCTPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,096,489 - 27,102,778 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,096,212 - 27,102,835 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,416,903 - 2,423,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:132
Interacting mature miRNAs:136
Transcripts:ENSMUST00000035276
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
38501066Tip2_mtuberculosis immunophenotype 2, spleen CFU (mouse)7124299223126899172Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse

Markers in Region
AI854235  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38962,790,349 - 62,790,458UniSTSGRCm38
GRCm387127,256,993 - 127,257,103UniSTSGRCm38
MGSCv377134,400,507 - 134,400,617UniSTSGRCm37
MGSCv37962,638,156 - 62,638,265UniSTSGRCm37
Celera960,015,614 - 60,015,723UniSTS
Celera7127,105,708 - 127,105,818UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map7F3UniSTS
Whitehead/MRC_RH71295.83UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000035276   ⟹   ENSMUSP00000047845
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7126,856,131 - 126,859,881 (-)Ensembl
GRCm38.p6 Ensembl7127,256,959 - 127,260,709 (-)Ensembl
RefSeq Acc Id: NM_023203   ⟹   NP_075692
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,856,131 - 126,859,839 (-)NCBI
GRCm387127,256,959 - 127,260,667 (-)ENTREZGENE
MGSCv377134,400,473 - 134,404,181 (-)RGD
Celera7127,105,674 - 127,109,383 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_075692   ⟸   NM_023203
- UniProtKB: Q9QY93 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000047845   ⟸   ENSMUST00000035276

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QY93-F1-model_v2 AlphaFold Q9QY93 1-170 view protein structure

Promoters
RGD ID:8665657
Promoter ID:EPDNEW_M10859
Type:initiation region
Name:Dctpp1_1
Description:Mus musculus dCTP pyrophosphatase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387127,260,633 - 127,260,693EPDNEW
RGD ID:6840924
Promoter ID:MM_KWN:52764
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000072864
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367134,403,921 - 134,404,421 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913672 AgrOrtholog
Ensembl Genes ENSMUSG00000042462 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035276 ENTREZGENE
  ENSMUST00000035276.5 UniProtKB/Swiss-Prot
Gene3D-CATH MazG-like UniProtKB/Swiss-Prot
InterPro dCTP_Pyrophosphatase UniProtKB/Swiss-Prot
  DCTPP UniProtKB/Swiss-Prot
KEGG Report mmu:66422 UniProtKB/Swiss-Prot
MGD MGI:1913672 ENTREZGENE
NCBI Gene 66422 ENTREZGENE
PANTHER DCTP PYROPHOSPHATASE 1 UniProtKB/Swiss-Prot
  DCTP PYROPHOSPHATASE 1 UniProtKB/Swiss-Prot
Pfam MazG-like UniProtKB/Swiss-Prot
PhenoGen Dctpp1 PhenoGen
Superfamily-SCOP all-alpha NTP pyrophosphatases UniProtKB/Swiss-Prot
UniProt DCTP1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE