Sv2a (synaptic vesicle glycoprotein 2 a) - Rat Genome Database

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Gene: Sv2a (synaptic vesicle glycoprotein 2 a) Mus musculus
Analyze
Symbol: Sv2a
Name: synaptic vesicle glycoprotein 2 a
RGD ID: 733212
MGI Page MGI
Description: Enables protein kinase binding activity. Involved in synaptic vesicle priming. Acts upstream of or within cellular calcium ion homeostasis. Located in several cellular components, including neuromuscular junction; presynaptic active zone; and synaptic vesicle. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AI746429; calcium regulator SV2A; mKIAA0736; synaptic vesicle glycoprotein 2A; synaptic vesicle protein 2; synaptic vesicle protein 2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,088,543 - 96,102,499 (+)NCBIGRCm39mm39
GRCm39 Ensembl396,088,467 - 96,102,837 (+)Ensembl
GRCm38396,181,227 - 96,195,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,181,151 - 96,195,521 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,985,150 - 95,999,106 (+)NCBIGRCm37mm9NCBIm37
MGSCv36396,266,632 - 96,280,588 (+)NCBImm8
Celera397,620,657 - 97,631,186 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8653788   PMID:8738414   PMID:8889548   PMID:9136771   PMID:9364238   PMID:9882498   PMID:10349636   PMID:10398046   PMID:10611374   PMID:10624962   PMID:10712642   PMID:10922068  
PMID:11018052   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11312299   PMID:11389829   PMID:11483953   PMID:11668586   PMID:12074840   PMID:12172780   PMID:12441053   PMID:12477932  
PMID:12687700   PMID:12693553   PMID:14681479   PMID:14755516   PMID:15345243   PMID:15466855   PMID:15489334   PMID:15713258   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16436618  
PMID:16512683   PMID:16543415   PMID:16602821   PMID:16614351   PMID:17038521   PMID:17114649   PMID:17119023   PMID:17715346   PMID:18692481   PMID:18799693   PMID:18815274   PMID:19041904  
PMID:19144828   PMID:19176798   PMID:19723784   PMID:20410110   PMID:20498043   PMID:20702688   PMID:20843861   PMID:21124874   PMID:21228161   PMID:21307259   PMID:21664258   PMID:21677750  
PMID:21873635   PMID:22266237   PMID:22627288   PMID:22661231   PMID:22847229   PMID:22908222   PMID:23227180   PMID:23637329   PMID:23894296   PMID:23937191   PMID:24035762   PMID:24764192  
PMID:25176044   PMID:25673844   PMID:26015569   PMID:26044557   PMID:26156989   PMID:26287463   PMID:27103069   PMID:27325702   PMID:27476503   PMID:27713690   PMID:28167615   PMID:28386022  
PMID:28413018   PMID:28647557   PMID:30113308   PMID:30562941   PMID:31875546   PMID:32341095   PMID:32553155  


Genomics

Comparative Map Data
Sv2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,088,543 - 96,102,499 (+)NCBIGRCm39mm39
GRCm39 Ensembl396,088,467 - 96,102,837 (+)Ensembl
GRCm38396,181,227 - 96,195,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,181,151 - 96,195,521 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,985,150 - 95,999,106 (+)NCBIGRCm37mm9NCBIm37
MGSCv36396,266,632 - 96,280,588 (+)NCBImm8
Celera397,620,657 - 97,631,186 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
SV2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1149,903,318 - 149,917,844 (-)EnsemblGRCh38hg38GRCh38
GRCh381149,903,318 - 149,917,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371149,874,870 - 149,889,396 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,141,859 - 148,156,054 (-)NCBINCBI36hg18NCBI36
Celera1122,990,840 - 123,005,404 (-)NCBI
Cytogenetic Map1q21.2NCBI
HuRef1121,255,354 - 121,269,918 (-)NCBIHuRef
CHM1_11151,271,444 - 151,286,008 (-)NCBICHM1_1
Sv2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,741,455 - 183,757,290 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl2198,321,142 - 198,336,913 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02198,321,100 - 198,336,889 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,808,165 - 217,823,872 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,989,187 - 191,000,859 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12190,948,188 - 190,963,566 (+)NCBI
Celera2176,272,713 - 176,284,621 (+)NCBICelera
Cytogenetic Map2q34NCBI
Sv2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413834,743 - 851,023 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955413834,743 - 849,176 (+)NCBIChiLan1.0ChiLan1.0
SV2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11128,904,140 - 128,918,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1128,904,151 - 128,918,829 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01125,247,429 - 125,262,041 (-)NCBIMhudiblu_PPA_v0panPan3
SV2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,185,715 - 59,195,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,187,244 - 59,195,888 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,633,794 - 58,647,878 (-)NCBI
ROS_Cfam_1.01760,182,727 - 60,196,808 (-)NCBI
UMICH_Zoey_3.11759,032,197 - 59,046,284 (-)NCBI
UNSW_CanFamBas_1.01759,115,941 - 59,130,018 (-)NCBI
UU_Cfam_GSD_1.01759,843,004 - 59,857,105 (-)NCBI
Sv2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,213,447 - 21,227,353 (-)NCBI
SpeTri2.0NW_004936580243,829 - 257,708 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SV2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,138,342 - 99,153,149 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,138,319 - 99,153,153 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,567,034 - 108,581,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SV2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603813,389,665 - 13,404,056 (+)NCBI
Sv2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477217,684,061 - 17,698,728 (-)NCBI

Position Markers
AI746429  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38396,194,936 - 96,195,041UniSTSGRCm38
MGSCv37395,998,859 - 95,998,964UniSTSGRCm37
Celera397,630,939 - 97,631,044UniSTS
Cytogenetic Map3F2UniSTS
Whitehead/MRC_RH31090.4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390469620124469756Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390470701124470701Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390603910100556821Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391092789125101432Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:785
Count of miRNA genes:502
Interacting mature miRNAs:574
Transcripts:ENSMUST00000035371, ENSMUST00000133665
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035371   ⟹   ENSMUSP00000037576
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl396,181,151 - 96,195,521 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133665
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl396,186,671 - 96,188,429 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196912
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl396,192,546 - 96,195,518 (+)Ensembl
RefSeq Acc Id: NM_022030   ⟹   NP_071313
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,088,543 - 96,102,499 (+)NCBI
GRCm38396,181,227 - 96,195,183 (+)ENTREZGENE
MGSCv37395,985,150 - 95,999,106 (+)RGD
Celera397,620,657 - 97,631,186 (+)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071313   ⟸   NM_022030
- UniProtKB: Q9JIS5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000037576   ⟸   ENSMUST00000035371

Promoters
RGD ID:6834514
Promoter ID:MM_KWN:35355
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell
Transcripts:OTTMUST00000052009
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,984,191 - 95,985,227 (+)MPROMDB
RGD ID:6847764
Promoter ID:MM_ACW:32592
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:SV2A.BSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,988,926 - 95,989,426 (+)MPROMDB
RGD ID:6834515
Promoter ID:MM_KWN:35356
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000052010
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,990,826 - 95,991,326 (+)MPROMDB
RGD ID:6847765
Promoter ID:MM_ACW:32594
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:SV2A.ESEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,997,876 - 95,998,827 (+)MPROMDB
RGD ID:6881642
Promoter ID:EPDNEW_M4272
Type:initiation region
Name:Sv2a_1
Description:Mus musculus synaptic vesicle glycoprotein 2 a , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38396,181,194 - 96,181,254EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927139 AgrOrtholog
Ensembl Genes ENSMUSG00000038486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000037576 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035371 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro 5peptide_repeat UniProtKB/Swiss-Prot
  MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
  SV2 UniProtKB/Swiss-Prot
KEGG Report mmu:64051 UniProtKB/Swiss-Prot
MGD MGI:1927139 ENTREZGENE
NCBI Gene 64051 ENTREZGENE
Pfam MFS_1 UniProtKB/Swiss-Prot
  Pentapeptide_4 UniProtKB/Swiss-Prot
  Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Sv2a PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGRFAMs synapt_SV2 UniProtKB/Swiss-Prot
UniProt Q9JIS5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q80TT0 UniProtKB/Swiss-Prot
  Q8R0R5 UniProtKB/Swiss-Prot