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Gene: Top1 (topoisomerase (DNA) I) Mus musculus
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Symbol: Top1
Name: topoisomerase (DNA) I
Description: Exhibits DNA topoisomerase type I (single strand cut, ATP-independent) activity. Involved in DNA replication; DNA topological change; and embryonic cleavage. Localizes to cytoplasm; nucleus; and perikaryon. Predicted to colocalize with nuclear chromosome. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA topoisomerase I); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI467334; D130064I21Rik; DNA topoisomerase 1; DNA topoisomerase I; Top-1
Orthologs:
Homo sapiens (human) : TOP1 (DNA topoisomerase I)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Top1 (DNA topoisomerase I)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top1 (DNA topoisomerase I)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP1 (DNA topoisomerase I)
Canis lupus familiaris (dog) : TOP1 (DNA topoisomerase I)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top1 (DNA topoisomerase I)
Sus scrofa (pig) : TOP1 (DNA topoisomerase I)
Chlorocebus sabaeus (African green monkey) : TOP1 (DNA topoisomerase I)
Heterocephalus glaber (naked mole-rat) : Top1 (DNA topoisomerase I)
more info ...
Related Pseudogenes: Top1-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl2160,645,888 - 160,722,764 (+)EnsemblGRCm38mm10GRCm38
GRCm382160,645,897 - 160,722,764 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372160,471,633 - 160,548,500 (+)NCBIGRCm37mm9NCBIm37
MGSCv362160,337,671 - 160,414,152 (+)NCBImm8
Celera2166,577,915 - 166,654,823 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Top1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733199
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.