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Gene: Top1 (topoisomerase (DNA) I) Mus musculus
Symbol: Top1
Name: topoisomerase (DNA) I
Description: Exhibits DNA topoisomerase type I (single strand cut, ATP-independent) activity. Involved in DNA replication; DNA topological change; and embryonic cleavage. Localizes to cytoplasm; nucleus; and perikaryon. Predicted to colocalize with nuclear chromosome. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA topoisomerase I); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI467334; D130064I21Rik; DNA topoisomerase 1; DNA topoisomerase I; Top-1
Homo sapiens (human) : TOP1 (DNA topoisomerase I)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Top1 (DNA topoisomerase I)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top1 (DNA topoisomerase I)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP1 (DNA topoisomerase I)
Canis lupus familiaris (dog) : TOP1 (DNA topoisomerase I)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top1 (DNA topoisomerase I)
Sus scrofa (pig) : TOP1 (DNA topoisomerase I)
Chlorocebus sabaeus (African green monkey) : TOP1 (DNA topoisomerase I)
Heterocephalus glaber (naked mole-rat) : Top1 (DNA topoisomerase I)
more info ...
Related Pseudogenes: Top1-ps2  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl2160,645,888 - 160,722,764 (+)EnsemblGRCm38mm10GRCm38
GRCm382160,645,897 - 160,722,764 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372160,471,633 - 160,548,500 (+)NCBIGRCm37mm9NCBIm37
MGSCv362160,337,671 - 160,414,152 (+)NCBImm8
Celera2166,577,915 - 166,654,823 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Top1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733199
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.