Top1 (topoisomerase (DNA) I) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Top1 (topoisomerase (DNA) I) Mus musculus
Analyze
Symbol: Top1
Name: topoisomerase (DNA) I
RGD ID: 733199
MGI Page MGI
Description: Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within DNA replication; DNA topological change; and embryonic cleavage. Located in cytoplasm; male germ cell nucleus; and perikaryon. Is expressed in brain; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA topoisomerase I).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI467334; D130064I21Rik; DNA topoisomerase 1; DNA topoisomerase I; Top; Top-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Top1-ps2  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392160,487,901 - 160,564,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2160,487,808 - 160,564,684 (+)EnsemblGRCm39 Ensembl
GRCm382160,645,897 - 160,722,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2160,645,888 - 160,722,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv372160,471,633 - 160,548,500 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362160,337,671 - 160,414,152 (+)NCBIMGSCv36mm8
Celera2166,577,915 - 166,654,823 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
actinomycin D  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracenes  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
betulinic acid  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Boswellic acid  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camptothecin  (ISO)
captafol  (EXP)
chloroacetaldehyde  (ISO)
choline  (EXP)
cidofovir anhydrous  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
dibenzo[a,l]pyrene  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
graphene oxide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (EXP)
ifosfamide  (ISO)
indirubin  (ISO)
inulin  (EXP)
irinotecan  (ISO)
L-methionine  (EXP)
lapatinib  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
menadione  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
miconazole  (EXP)
moxifloxacin  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nevadensin  (ISO)
Nitidine  (ISO)
oleanolic acid  (ISO)
oxaliplatin  (ISO)
p-anisidine  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
palbociclib  (ISO)
palmatine  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pirinixic acid  (EXP)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrahydropalmatine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1372074   PMID:7752808   PMID:7806233   PMID:7842491   PMID:8012118   PMID:8096488   PMID:8111124   PMID:8193161   PMID:8943335   PMID:9094096   PMID:9144489   PMID:9291580  
PMID:10334875   PMID:10349636   PMID:10922068   PMID:11016921   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11255022   PMID:11322760   PMID:11756244   PMID:12477932   PMID:12520002  
PMID:12708316   PMID:12904583   PMID:14610273   PMID:14678976   PMID:14688260   PMID:14691545   PMID:15741177   PMID:16107646   PMID:16141072   PMID:16141073   PMID:16261531   PMID:17015433  
PMID:17967808   PMID:18515798   PMID:18799693   PMID:18982460   PMID:19138663   PMID:19380834   PMID:19521500   PMID:20018730   PMID:21677750   PMID:21873635   PMID:22080610   PMID:22158865  
PMID:22308494   PMID:22911747   PMID:22922362   PMID:24457600   PMID:24793032   PMID:24798329   PMID:24952961   PMID:25404338   PMID:25869824   PMID:26167872   PMID:26305952   PMID:26336360  
PMID:26584622   PMID:26919559   PMID:27231886   PMID:28007908   PMID:28135252   PMID:28199696   PMID:30196744   PMID:30550785   PMID:31040226   PMID:32098917   PMID:32325033   PMID:32327659  
PMID:33524014   PMID:34321999   PMID:34644582   PMID:35140396   PMID:37086201   PMID:37094168   PMID:37142655   PMID:37442135   PMID:37833256  


Genomics

Comparative Map Data
Top1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392160,487,901 - 160,564,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2160,487,808 - 160,564,684 (+)EnsemblGRCm39 Ensembl
GRCm382160,645,897 - 160,722,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2160,645,888 - 160,722,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv372160,471,633 - 160,548,500 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362160,337,671 - 160,414,152 (+)NCBIMGSCv36mm8
Celera2166,577,915 - 166,654,823 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.96NCBI
TOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382041,028,822 - 41,124,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2041,028,822 - 41,124,487 (+)EnsemblGRCh38hg38GRCh38
GRCh372039,657,462 - 39,753,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362039,090,876 - 39,186,541 (+)NCBINCBI36Build 36hg18NCBI36
Build 342039,090,875 - 39,186,541NCBI
Celera2036,368,028 - 36,463,696 (+)NCBICelera
Cytogenetic Map20q12NCBI
HuRef2036,395,468 - 36,491,177 (+)NCBIHuRef
CHM1_12039,561,887 - 39,657,539 (+)NCBICHM1_1
T2T-CHM13v2.02042,760,511 - 42,856,164 (+)NCBIT2T-CHM13v2.0
Top1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83169,713,195 - 169,796,330 (+)NCBIGRCr8
mRatBN7.23149,293,469 - 149,376,618 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3149,293,403 - 149,376,623 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3153,107,309 - 153,188,513 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03161,606,688 - 161,687,898 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03159,345,818 - 159,427,549 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03156,635,688 - 156,717,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3156,642,464 - 156,717,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03162,865,335 - 162,947,076 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43151,428,931 - 151,512,884 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13151,334,966 - 151,418,920 (+)NCBI
Celera3147,968,261 - 148,049,789 (+)NCBICelera
Cytogenetic Map3q42NCBI
Top1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544515,834,017 - 15,922,785 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544515,834,017 - 15,922,785 (-)NCBIChiLan1.0ChiLan1.0
TOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,769,898 - 46,866,351 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12046,762,969 - 46,859,450 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02037,368,606 - 37,464,649 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12038,468,197 - 38,563,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2038,468,452 - 38,562,652 (+)Ensemblpanpan1.1panPan2
TOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12429,075,267 - 29,166,733 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2429,075,492 - 29,165,864 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2428,720,984 - 28,812,380 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02429,781,234 - 29,872,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2429,781,498 - 29,872,296 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12429,049,969 - 29,141,401 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02429,153,861 - 29,245,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02429,650,217 - 29,741,420 (+)NCBIUU_Cfam_GSD_1.0
Top1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640178,026,161 - 178,108,033 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936561641,423 - 723,518 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936561641,451 - 723,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1743,710,290 - 43,799,700 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11743,710,270 - 43,799,700 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21749,135,554 - 49,193,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1222,655,085 - 22,751,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl222,651,995 - 22,751,102 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605071,467,009 - 71,562,443 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249191,668,440 - 1,756,629 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249191,668,712 - 1,756,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Top1
3062 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1096
Count of miRNA genes:587
Interacting mature miRNAs:710
Transcripts:ENSMUST00000109468, ENSMUST00000129289, ENSMUST00000133262, ENSMUST00000150039, ENSMUST00000164510, ENSMUST00000164694
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse

Markers in Region
BB194945  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382160,648,912 - 160,648,996UniSTSGRCm38
MGSCv372160,474,648 - 160,474,732UniSTSGRCm37
Celera2166,580,930 - 166,581,014UniSTS
Cytogenetic Map2H2-3UniSTS
Whitehead/MRC_RH21837.69UniSTS
AI467334  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382160,649,874 - 160,650,000UniSTSGRCm38
MGSCv372160,475,610 - 160,475,736UniSTSGRCm37
Celera2166,581,892 - 166,582,018UniSTS
Cytogenetic Map2H2-3UniSTS
Whitehead/MRC_RH21841.02UniSTS
D2Mit143  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382160,671,690 - 160,671,788UniSTSGRCm38
MGSCv372160,497,426 - 160,497,524UniSTSGRCm37
Celera2166,603,727 - 166,603,831UniSTS
Cytogenetic Map2H2-3UniSTS
cM Map291.9UniSTS
Whitehead Genetic278.7UniSTS
Whitehead_YAC2 UniSTS
UniSTS:234589  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382160,649,779 - 160,649,998UniSTSGRCm38
MGSCv372160,475,515 - 160,475,734UniSTSGRCm37
Celera2166,581,797 - 166,582,016UniSTS
Cytogenetic Map2H2-3UniSTS
BE115617  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382160,645,980 - 160,646,143UniSTSGRCm38
MGSCv372160,471,716 - 160,471,879UniSTSGRCm37
Celera2166,577,998 - 166,578,161UniSTS
Cytogenetic Map2H2-3UniSTS
D2Ertd122e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382160,666,817 - 160,667,052UniSTSGRCm38
MGSCv372160,492,553 - 160,492,788UniSTSGRCm37
Celera2166,598,837 - 166,599,072UniSTS
Cytogenetic Map2H2-3UniSTS
cM Map293.0UniSTS
UniSTS:225214  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382160,690,329 - 160,690,515UniSTSGRCm38
MGSCv372160,516,065 - 160,516,251UniSTSGRCm37
Celera2166,622,389 - 166,622,575UniSTS
Cytogenetic Map2H2-3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001413148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001413149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001413150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ279850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF733054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF734074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN717304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO425650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV645012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000109468   ⟹   ENSMUSP00000105094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2160,487,808 - 160,564,684 (+)Ensembl
GRCm38.p6 Ensembl2160,645,888 - 160,722,764 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129289
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2160,512,053 - 160,526,871 (+)Ensembl
GRCm38.p6 Ensembl2160,670,133 - 160,684,951 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133262
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2160,487,900 - 160,492,027 (+)Ensembl
GRCm38.p6 Ensembl2160,645,980 - 160,650,107 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150039
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2160,559,389 - 160,563,304 (+)Ensembl
GRCm38.p6 Ensembl2160,717,469 - 160,721,384 (+)Ensembl
Ensembl Acc Id: ENSMUST00000164510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2160,544,063 - 160,545,599 (+)Ensembl
GRCm38.p6 Ensembl2160,702,143 - 160,703,679 (+)Ensembl
Ensembl Acc Id: ENSMUST00000164694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2160,527,589 - 160,535,636 (+)Ensembl
GRCm38.p6 Ensembl2160,685,669 - 160,693,716 (+)Ensembl
RefSeq Acc Id: NM_001413148   ⟹   NP_001400077
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392160,487,901 - 160,564,684 (+)NCBI
RefSeq Acc Id: NM_001413149   ⟹   NP_001400078
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392160,487,901 - 160,564,684 (+)NCBI
RefSeq Acc Id: NM_001413150   ⟹   NP_001400079
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392160,487,901 - 160,564,684 (+)NCBI
RefSeq Acc Id: NM_009408   ⟹   NP_033434
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392160,487,901 - 160,564,684 (+)NCBI
GRCm382160,645,897 - 160,722,764 (+)ENTREZGENE
MGSCv372160,471,633 - 160,548,500 (+)RGD
Celera2166,577,915 - 166,654,823 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033434   ⟸   NM_009408
- Peptide Label: isoform 1
- UniProtKB: A2A4B7 (UniProtKB/Swiss-Prot),   Q04750 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000105094   ⟸   ENSMUST00000109468
RefSeq Acc Id: NP_001400078   ⟸   NM_001413149
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001400077   ⟸   NM_001413148
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001400079   ⟸   NM_001413150
- Peptide Label: isoform 4
Protein Domains
DNA topoisomerase I DNA binding eukaryotic-type   DNA topoisomerase I eukaryotic-type   Topo IB-type catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04750-F1-model_v2 AlphaFold Q04750 1-767 view protein structure

Promoters
RGD ID:6832963
Promoter ID:MM_KWN:32777
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000002309,   UC008NQX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362160,471,321 - 160,471,842 (+)MPROMDB
RGD ID:6879524
Promoter ID:EPDNEW_M3213
Type:initiation region
Name:Top1_1
Description:Mus musculus topoisomerase I , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382160,645,981 - 160,646,041EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98788 AgrOrtholog
Ensembl Genes ENSMUSG00000016934
  ENSMUSG00000070544 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000109468 ENTREZGENE
  ENSMUST00000109468.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.132.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.170.11.10 UniProtKB/Swiss-Prot
InterPro DNA_brk_join_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom2 UniProtKB/Swiss-Prot
  TopoI UniProtKB/Swiss-Prot
  TopoI_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_cat_a-hlx-sub_euk UniProtKB/Swiss-Prot
  TopoI_cat_a/b-sub_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_cat_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_DNA-bd_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_DNA-bd_euk_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topoisomer_I_DNA-bd UniProtKB/Swiss-Prot
  Topoisomerase_IB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21969 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98788 ENTREZGENE
NCBI Gene 21969 ENTREZGENE
PANTHER DNA TOPOISOMERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA TOPOISOMERASE I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Topo_C_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topoisom_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topoisom_I_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TOP1 RGD
PhenoGen Top1 PhenoGen
PRINTS EUTPISMRASEI UniProtKB/Swiss-Prot
PROSITE TOPO_IB_2 UniProtKB/Swiss-Prot
  TOPOISOMERASE_I_EUK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TOPEUc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Eukaryotic DNA topoisomerase I, dispensable insert domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56349 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A4B7 ENTREZGENE
  Q04750 ENTREZGENE
  Q3TPX7_MOUSE UniProtKB/TrEMBL
  Q3TSR2_MOUSE UniProtKB/TrEMBL
  Q3TUS4_MOUSE UniProtKB/TrEMBL
  Q3ULF5_MOUSE UniProtKB/TrEMBL
  Q569Q5_MOUSE UniProtKB/TrEMBL
  TOP1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2A4B7 UniProtKB/Swiss-Prot