CAND2 (cullin associated and neddylation dissociated 2 (putative)) - Rat Genome Database

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Gene: CAND2 (cullin associated and neddylation dissociated 2 (putative)) Homo sapiens
Analyze
Symbol: CAND2
Name: cullin associated and neddylation dissociated 2 (putative)
RGD ID: 733192
HGNC Page HGNC
Description: Predicted to have TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of transcription, DNA-templated; and protein ubiquitination. Localizes to cytosol; INTERACTS WITH 5-aza-2'-deoxycytidine; benzo[a]pyrene; carbamazepine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cullin-associated and neddylation-dissociated 2 (putative); cullin-associated and neddylation-dissociated protein 2; cullin-associated NEDD8-dissociated protein 2; epididymis tissue protein Li 169; KIAA0667; p120 CAND2; TBP interacting protein; TBP-interacting protein 120B; TBP-interacting protein of 120 kDa B; tbp-interacting protein tip120b; TIP120B; Tp120b
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl312,796,472 - 12,871,916 (+)EnsemblGRCh38hg38GRCh38
GRCh38312,796,654 - 12,834,818 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37312,838,179 - 12,876,302 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,813,171 - 12,851,301 (+)NCBINCBI36hg18NCBI36
Celera312,776,461 - 12,814,604 (+)NCBI
Cytogenetic Map3p25.2NCBI
HuRef312,772,260 - 12,810,226 (+)NCBIHuRef
CHM1_1312,788,141 - 12,826,306 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA)
nucleus  (IBA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:9734811   PMID:10441524   PMID:11278995   PMID:12207886   PMID:12477932   PMID:12692129   PMID:16641997   PMID:19159115   PMID:20736409   PMID:21169563   PMID:21873635   PMID:22190034  
PMID:22613845   PMID:22952844   PMID:23027611   PMID:23181366   PMID:23414517   PMID:23864651   PMID:23951410   PMID:25754235   PMID:26186194   PMID:26344197   PMID:27173435   PMID:27432908  
PMID:28330616   PMID:28514442   PMID:28675297   PMID:28712289   PMID:29103612   PMID:29499133   PMID:29717274   PMID:29955894   PMID:30097533   PMID:30349055   PMID:30833792   PMID:31073040  
PMID:31091453   PMID:31950832   PMID:32296183   PMID:33957083  


Genomics

Comparative Map Data
CAND2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl312,796,472 - 12,871,916 (+)EnsemblGRCh38hg38GRCh38
GRCh38312,796,654 - 12,834,818 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37312,838,179 - 12,876,302 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,813,171 - 12,851,301 (+)NCBINCBI36hg18NCBI36
Celera312,776,461 - 12,814,604 (+)NCBI
Cytogenetic Map3p25.2NCBI
HuRef312,772,260 - 12,810,226 (+)NCBIHuRef
CHM1_1312,788,141 - 12,826,306 (+)NCBICHM1_1
Cand2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,751,518 - 115,782,516 (+)NCBIGRCm39mm39
GRCm39 Ensembl6115,751,499 - 115,782,518 (+)Ensembl
GRCm386115,774,557 - 115,805,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,774,538 - 115,805,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv376115,724,575 - 115,755,573 (+)NCBIGRCm37mm9NCBIm37
MGSCv366115,740,194 - 115,770,488 (+)NCBImm8
Celera6117,614,220 - 117,645,199 (+)NCBICelera
Cytogenetic Map6E3NCBI
Cand2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24148,835,050 - 148,864,039 (+)NCBI
Rnor_6.0 Ensembl4147,686,490 - 147,714,585 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04147,686,487 - 147,714,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04210,970,266 - 210,998,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,912,174 - 151,940,734 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14152,157,014 - 152,185,575 (+)NCBI
Celera4137,725,100 - 137,753,194 (+)NCBICelera
Cytogenetic Map4q42NCBI
Cand2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542917,891,796 - 17,913,866 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,891,306 - 17,913,961 (-)NCBIChiLan1.0ChiLan1.0
CAND2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1313,066,133 - 13,102,246 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl313,066,135 - 13,102,246 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0312,722,259 - 12,757,983 (+)NCBIMhudiblu_PPA_v0panPan3
CAND2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1205,756,576 - 5,789,892 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl205,757,566 - 5,811,408 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha205,793,865 - 5,827,176 (-)NCBI
ROS_Cfam_1.0205,786,186 - 5,819,576 (-)NCBI
UMICH_Zoey_3.1205,502,290 - 5,535,612 (-)NCBI
UNSW_CanFamBas_1.0205,855,197 - 5,888,510 (-)NCBI
UU_Cfam_GSD_1.0205,830,851 - 5,864,169 (-)NCBI
Cand2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,900,816 - 17,922,373 (+)NCBI
SpeTri2.0NW_004936602987,292 - 1,008,825 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAND2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,758,636 - 68,787,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,758,739 - 68,787,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21376,028,327 - 76,057,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAND2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,771,419 - 48,809,911 (+)NCBI
ChlSab1.1 Ensembl2248,771,987 - 48,809,093 (+)Ensembl
Vero_WHO_p1.0NW_023666041117,679,110 - 117,717,259 (-)NCBI
Cand2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624872404,263 - 429,866 (+)NCBI

Position Markers
SHGC-76713  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37312,876,159 - 12,876,285UniSTSGRCh37
Build 36312,851,159 - 12,851,285RGDNCBI36
Celera312,814,450 - 12,814,576RGD
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map3p25-p24UniSTS
HuRef312,810,072 - 12,810,198UniSTS
TNG Radiation Hybrid Map38960.0UniSTS
GeneMap99-GB4 RH Map352.59UniSTS
Whitehead-RH Map358.6UniSTS
RH93304  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37312,876,142 - 12,876,265UniSTSGRCh37
Build 36312,851,142 - 12,851,265RGDNCBI36
Celera312,814,433 - 12,814,556RGD
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map3p25-p24UniSTS
HuRef312,810,055 - 12,810,178UniSTS
GeneMap99-GB4 RH Map351.47UniSTS
SHGC-32188  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37312,876,465 - 12,876,590UniSTSGRCh37
Build 36312,851,465 - 12,851,590RGDNCBI36
Celera312,814,756 - 12,814,881RGD
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map3p25-p24UniSTS
HuRef312,810,378 - 12,810,503UniSTS
Whitehead-RH Map358.6UniSTS
GeneMap99-G3 RH Map3590.0UniSTS
D3S4338  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37312,854,650 - 12,854,866UniSTSGRCh37
Build 36312,829,650 - 12,829,866RGDNCBI36
Celera312,792,942 - 12,793,158RGD
HuRef312,788,559 - 12,788,775UniSTS
D3S4400  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37312,861,128 - 12,861,350UniSTSGRCh37
Build 36312,836,128 - 12,836,350RGDNCBI36
Celera312,799,419 - 12,799,641RGD
HuRef312,795,037 - 12,795,259UniSTS
D3S4401  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37312,866,818 - 12,867,033UniSTSGRCh37
Build 36312,841,818 - 12,842,033RGDNCBI36
Celera312,805,109 - 12,805,324RGD
HuRef312,800,731 - 12,800,946UniSTS
WI-21041  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37312,876,470 - 12,876,644UniSTSGRCh37
Build 36312,851,470 - 12,851,644RGDNCBI36
Celera312,814,761 - 12,814,935RGD
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map3p25-p24UniSTS
HuRef312,810,383 - 12,810,557UniSTS
GeneMap99-GB4 RH Map351.09UniSTS
Whitehead-RH Map355.6UniSTS
NCBI RH Map3164.5UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1584
Count of miRNA genes:681
Interacting mature miRNAs:757
Transcripts:ENST00000295989, ENST00000446928, ENST00000454887, ENST00000456430, ENST00000466558
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 740 1607 269 12 34 3 1687 1494 1147 24 721 100 13 17 1539 1
Low 1566 670 1312 475 903 321 2611 679 2571 326 701 1448 158 1 1186 1243 2 2
Below cutoff 104 709 135 131 963 133 54 19 13 57 32 54 3 1 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000295989   ⟹   ENSP00000295989
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl312,796,472 - 12,834,802 (+)Ensembl
RefSeq Acc Id: ENST00000446928   ⟹   ENSP00000390996
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl312,796,672 - 12,813,092 (+)Ensembl
RefSeq Acc Id: ENST00000454887   ⟹   ENSP00000403093
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl312,827,446 - 12,871,916 (+)Ensembl
RefSeq Acc Id: ENST00000456430   ⟹   ENSP00000387641
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl312,796,680 - 12,834,803 (+)Ensembl
RefSeq Acc Id: ENST00000466558
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl312,807,133 - 12,810,153 (+)Ensembl
RefSeq Acc Id: ENST00000626378   ⟹   ENSP00000486760
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl312,796,721 - 12,810,038 (+)Ensembl
RefSeq Acc Id: ENST00000650119   ⟹   ENSP00000497240
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl312,796,686 - 12,834,804 (+)Ensembl
RefSeq Acc Id: NM_001162499   ⟹   NP_001155971
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38312,796,680 - 12,834,803 (+)NCBI
GRCh37312,838,171 - 12,876,313 (+)RGD
Celera312,776,461 - 12,814,604 (+)RGD
HuRef312,772,260 - 12,810,226 (+)ENTREZGENE
CHM1_1312,788,141 - 12,826,306 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012298   ⟹   NP_036430
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38312,796,680 - 12,834,803 (+)NCBI
GRCh37312,838,171 - 12,876,313 (+)RGD
Build 36312,813,171 - 12,851,301 (+)NCBI Archive
Celera312,776,461 - 12,814,604 (+)RGD
HuRef312,772,260 - 12,810,226 (+)ENTREZGENE
CHM1_1312,788,141 - 12,826,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011533503   ⟹   XP_011531805
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38312,796,654 - 12,828,330 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011533504   ⟹   XP_011531806
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38312,797,206 - 12,834,818 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036430   ⟸   NM_012298
- Peptide Label: isoform 2
- UniProtKB: O75155 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001155971   ⟸   NM_001162499
- Peptide Label: isoform 1
- UniProtKB: O75155 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011531805   ⟸   XM_011533503
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011531806   ⟸   XM_011533504
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000295989   ⟸   ENST00000295989
RefSeq Acc Id: ENSP00000497240   ⟸   ENST00000650119
RefSeq Acc Id: ENSP00000403093   ⟸   ENST00000454887
RefSeq Acc Id: ENSP00000486760   ⟸   ENST00000626378
RefSeq Acc Id: ENSP00000387641   ⟸   ENST00000456430
RefSeq Acc Id: ENSP00000390996   ⟸   ENST00000446928
Protein Domains
TIP120

Promoters
RGD ID:6863622
Promoter ID:EPDNEW_H4976
Type:initiation region
Name:CAND2_1
Description:cullin associated and neddylation dissociated 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38312,796,682 - 12,796,742EPDNEW
RGD ID:6800719
Promoter ID:HG_KWN:43817
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_001162499,   OTTHUMT00000339855,   OTTHUMT00000339856,   OTTHUMT00000339858
Position:
Human AssemblyChrPosition (strand)Source
Build 36312,812,869 - 12,813,369 (+)MPROMDB
RGD ID:6812262
Promoter ID:HG_ACW:52894
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:CAND2.IAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 36312,850,566 - 12,851,066 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p25.2(chr3:12608508-12802654)x3 copy number gain See cases [RCV000051437] Chr3:12608508..12802654 [GRCh38]
Chr3:12650007..12844153 [GRCh37]
Chr3:12625007..12819153 [NCBI36]
Chr3:3p25.2
uncertain significance
GRCh38/hg38 3p26.3-22.2(chr3:52266-37148076)x3 copy number gain See cases [RCV000051097] Chr3:52266..37148076 [GRCh38]
Chr3:93949..37189567 [GRCh37]
Chr3:68949..37164571 [NCBI36]
Chr3:3p26.3-22.2
pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:52066-20280127)x3 copy number gain See cases [RCV000051690] Chr3:52066..20280127 [GRCh38]
Chr3:93749..20321619 [GRCh37]
Chr3:68749..20296623 [NCBI36]
Chr3:3p26.3-24.3
pathogenic
GRCh38/hg38 3p26.3-24.1(chr3:52266-29248782)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051718]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051718]|See cases [RCV000051718] Chr3:52266..29248782 [GRCh38]
Chr3:93949..29290273 [GRCh37]
Chr3:68949..29265277 [NCBI36]
Chr3:3p26.3-24.1
pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:63843-19510600)x3 copy number gain See cases [RCV000051719] Chr3:63843..19510600 [GRCh38]
Chr3:105526..19552092 [GRCh37]
Chr3:80526..19527096 [NCBI36]
Chr3:3p26.3-24.3
pathogenic
GRCh38/hg38 3p25.3-22.2(chr3:11463328-38919543)x3 copy number gain See cases [RCV000051720] Chr3:11463328..38919543 [GRCh38]
Chr3:11504802..38961034 [GRCh37]
Chr3:11479802..38936038 [NCBI36]
Chr3:3p25.3-22.2
pathogenic
NM_001162499.1(CAND2):c.113C>T (p.Ser38Phe) single nucleotide variant Malignant melanoma [RCV000060697] Chr3:12803532 [GRCh38]
Chr3:12845031 [GRCh37]
Chr3:12820031 [NCBI36]
Chr3:3p25.2
not provided
NM_001162499.1(CAND2):c.114C>T (p.Ser38=) single nucleotide variant Malignant melanoma [RCV000060698] Chr3:12803533 [GRCh38]
Chr3:12845032 [GRCh37]
Chr3:12820032 [NCBI36]
Chr3:3p25.2
not provided
NM_001162499.1(CAND2):c.1255G>C (p.Glu419Gln) single nucleotide variant Malignant melanoma [RCV000060700] Chr3:12815389 [GRCh38]
Chr3:12856888 [GRCh37]
Chr3:12831888 [NCBI36]
Chr3:3p25.2
not provided
NM_000994.3(RPL32):c.*1334A>G single nucleotide variant Lung cancer [RCV000092894] Chr3:12834760 [GRCh38]
Chr3:12876259 [GRCh37]
Chr3:3p25.2
uncertain significance
GRCh38/hg38 3p25.2(chr3:12487565-12997325)x3 copy number gain See cases [RCV000138028] Chr3:12487565..12997325 [GRCh38]
Chr3:12529064..13038825 [GRCh37]
Chr3:12504064..13013825 [NCBI36]
Chr3:3p25.2
uncertain significance
GRCh38/hg38 3p26.3-24.1(chr3:32241-30064208)x3 copy number gain See cases [RCV000138004] Chr3:32241..30064208 [GRCh38]
Chr3:73914..30105699 [GRCh37]
Chr3:48914..30080703 [NCBI36]
Chr3:3p26.3-24.1
pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:32241-20334387)x3 copy number gain See cases [RCV000137941] Chr3:32241..20334387 [GRCh38]
Chr3:73914..20375879 [GRCh37]
Chr3:48914..20350883 [NCBI36]
Chr3:3p26.3-24.3
pathogenic
GRCh38/hg38 3p26.3-25.1(chr3:32241-13613818)x3 copy number gain See cases [RCV000138946] Chr3:32241..13613818 [GRCh38]
Chr3:73914..13655318 [GRCh37]
Chr3:48914..13630319 [NCBI36]
Chr3:3p26.3-25.1
pathogenic
GRCh38/hg38 3p26.3-22.1(chr3:53308-41381521)x3 copy number gain See cases [RCV000141810] Chr3:53308..41381521 [GRCh38]
Chr3:94991..41423012 [GRCh37]
Chr3:69991..41398016 [NCBI36]
Chr3:3p26.3-22.1
pathogenic
GRCh38/hg38 3p26.1-25.1(chr3:7356110-14360442)x3 copy number gain See cases [RCV000143766] Chr3:7356110..14360442 [GRCh38]
Chr3:7397797..14401942 [GRCh37]
Chr3:7372797..14376946 [NCBI36]
Chr3:3p26.1-25.1
pathogenic
GRCh37/hg19 3p26.3-24.2(chr3:61891-24432821)x3 copy number gain See cases [RCV000447247] Chr3:61891..24432821 [GRCh37]
Chr3:3p26.3-24.2
pathogenic
GRCh37/hg19 3p25.2(chr3:12630746-12839915)x3 copy number gain See cases [RCV000448788] Chr3:12630746..12839915 [GRCh37]
Chr3:3p25.2
uncertain significance
GRCh37/hg19 3p26.3-22.2(chr3:61891-36710181)x3 copy number gain See cases [RCV000448528] Chr3:61891..36710181 [GRCh37]
Chr3:3p26.3-22.2
pathogenic
GRCh37/hg19 3p25.2(chr3:12630912-12839915)x3 copy number gain See cases [RCV000448432] Chr3:12630912..12839915 [GRCh37]
Chr3:3p25.2
uncertain significance
GRCh37/hg19 3p26.3-22.3(chr3:61891-33958201)x3 copy number gain See cases [RCV000510429] Chr3:61891..33958201 [GRCh37]
Chr3:3p26.3-22.3
pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-37459464)x3 copy number gain See cases [RCV000511463] Chr3:61891..37459464 [GRCh37]
Chr3:3p26.3-22.2
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p25.2(chr3:12630912-12839915)x3 copy number gain not provided [RCV000682245] Chr3:12630912..12839915 [GRCh37]
Chr3:3p25.2
uncertain significance
GRCh37/hg19 3p26.3-24.3(chr3:1897972-19519085)x3 copy number gain not provided [RCV000682215] Chr3:1897972..19519085 [GRCh37]
Chr3:3p26.3-24.3
pathogenic
Single allele duplication not provided [RCV000677929] Chr3:12586302..12970555 [GRCh37]
Chr3:3p25.2
uncertain significance
GRCh37/hg19 3p26.1-24.3(chr3:5173870-16760262)x3 copy number gain not provided [RCV000682233] Chr3:5173870..16760262 [GRCh37]
Chr3:3p26.1-24.3
pathogenic
GRCh37/hg19 3p25.2(chr3:12526440-12839915)x3 copy number gain not provided [RCV000682243] Chr3:12526440..12839915 [GRCh37]
Chr3:3p25.2
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_001162499.2(CAND2):c.1473C>T (p.Ser491=) single nucleotide variant not provided [RCV000961435] Chr3:12816405 [GRCh38]
Chr3:12857904 [GRCh37]
Chr3:3p25.2
benign
NM_001162499.2(CAND2):c.2960G>A (p.Arg987Gln) single nucleotide variant not provided [RCV000948646] Chr3:12820101 [GRCh38]
Chr3:12861600 [GRCh37]
Chr3:3p25.2
benign
NM_001162499.2(CAND2):c.3407C>T (p.Ala1136Val) single nucleotide variant not provided [RCV000970295] Chr3:12831496 [GRCh38]
Chr3:12872995 [GRCh37]
Chr3:3p25.2
benign
NM_001162499.2(CAND2):c.3082C>T (p.Arg1028Cys) single nucleotide variant not provided [RCV000964728] Chr3:12825511 [GRCh38]
Chr3:12867010 [GRCh37]
Chr3:3p25.2
benign
GRCh37/hg19 3p25.2(chr3:12630912-12839659)x3 copy number gain not provided [RCV000845868] Chr3:12630912..12839659 [GRCh37]
Chr3:3p25.2
uncertain significance
NM_001162499.2(CAND2):c.2126A>G (p.His709Arg) single nucleotide variant not provided [RCV000958905] Chr3:12817058 [GRCh38]
Chr3:12858557 [GRCh37]
Chr3:3p25.2
benign
GRCh37/hg19 3p25.2(chr3:12522670-12893013)x3 copy number gain not provided [RCV001259805] Chr3:12522670..12893013 [GRCh37]
Chr3:3p25.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30689 AgrOrtholog
COSMIC CAND2 COSMIC
Ensembl Genes ENSG00000144712 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000295989 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387641 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390996 UniProtKB/TrEMBL
  ENSP00000403093 UniProtKB/TrEMBL
  ENSP00000486760 UniProtKB/TrEMBL
  ENSP00000497240 UniProtKB/TrEMBL
Ensembl Transcript ENST00000295989 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000446928 UniProtKB/TrEMBL
  ENST00000454887 UniProtKB/TrEMBL
  ENST00000456430 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000626378 UniProtKB/TrEMBL
  ENST00000650119 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000144712 GTEx
HGNC ID HGNC:30689 ENTREZGENE
Human Proteome Map CAND2 Human Proteome Map
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAND1/CAND2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TATA-bd_TIP120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:23066 UniProtKB/Swiss-Prot
NCBI Gene 23066 ENTREZGENE
OMIM 610403 OMIM
PANTHER PTHR12696 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIP120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142672208 PharmGKB
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B3ISC4_HUMAN UniProtKB/TrEMBL
  C9JH00_HUMAN UniProtKB/TrEMBL
  CAND2_HUMAN UniProtKB/Swiss-Prot
  F8WBB8_HUMAN UniProtKB/TrEMBL
  O75155 ENTREZGENE
UniProt Secondary B9EGM9 UniProtKB/Swiss-Prot
  E9KL24 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-03 CAND2  cullin associated and neddylation dissociated 2 (putative)    cullin-associated and neddylation-dissociated 2 (putative)  Symbol and/or name change 5135510 APPROVED