Uncx (UNC homeobox) - Rat Genome Database

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Gene: Uncx (UNC homeobox) Mus musculus
Analyze
Symbol: Uncx
Name: UNC homeobox
RGD ID: 733184
MGI Page MGI
Description: Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including animal organ development; common myeloid progenitor cell proliferation; and pattern specification process. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; paraxial mesenchyme; sensory organ; and skeleton. Orthologous to human UNCX (UNC homeobox); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Chx4; homeobox protein unc-4 homolog; homeobox protein Uncx4.1; Unc4.1 homeobox; Uncx4.; Uncx4.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,529,620 - 139,533,934 (+)NCBIGRCm39mm39
GRCm39 Ensembl5139,529,249 - 139,533,934 (+)Ensembl
GRCm385139,543,865 - 139,548,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,543,494 - 139,548,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv375140,019,852 - 140,024,133 (+)NCBIGRCm37mm9NCBIm37
MGSCv365139,797,551 - 139,801,821 (+)NCBImm8
Celera5136,597,528 - 136,635,493 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References

Additional References at PubMed
PMID:8761990   PMID:8855241   PMID:9286595   PMID:9690472   PMID:9690473   PMID:10196361   PMID:10330372   PMID:10341080   PMID:10349636   PMID:10545229   PMID:10556064   PMID:10557208  
PMID:10804168   PMID:10804169   PMID:10879540   PMID:10906448   PMID:10932180   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11262239   PMID:11562355   PMID:11641270   PMID:11747084  
PMID:11783997   PMID:11923214   PMID:11934853   PMID:11973278   PMID:11978781   PMID:12001066   PMID:12086465   PMID:12421720   PMID:12441295   PMID:12477932   PMID:12591245   PMID:12620991  
PMID:12636920   PMID:12670869   PMID:12697902   PMID:12783854   PMID:12839624   PMID:12900443   PMID:14672936   PMID:14681479   PMID:14745966   PMID:14960495   PMID:15107403   PMID:15155583  
PMID:15162501   PMID:15170214   PMID:15469977   PMID:15511637   PMID:15545629   PMID:15618518   PMID:15652703   PMID:15677726   PMID:15731404   PMID:15822856   PMID:15857913   PMID:15866159  
PMID:16000382   PMID:16127714   PMID:16141072   PMID:16141073   PMID:16319111   PMID:16387292   PMID:16412699   PMID:16461927   PMID:16467359   PMID:16489341   PMID:16511601   PMID:16516838  
PMID:16602821   PMID:16728472   PMID:16782087   PMID:16919269   PMID:16943278   PMID:16958122   PMID:16996494   PMID:17095659   PMID:17223098   PMID:17306789   PMID:17359303   PMID:17360776  
PMID:17473173   PMID:17477400   PMID:17490632   PMID:17531978   PMID:17572911   PMID:17584735   PMID:17664336   PMID:17681139   PMID:17849441   PMID:17937396   PMID:18045842   PMID:18061569  
PMID:18157121   PMID:18171685   PMID:18191120   PMID:18234727   PMID:18257070   PMID:18287559   PMID:18445292   PMID:18486455   PMID:18708576   PMID:18773491   PMID:18794329   PMID:18799476  
PMID:18981480   PMID:19056682   PMID:19161597   PMID:19268448   PMID:19403658   PMID:19463158   PMID:19464179   PMID:19520072   PMID:19590010   PMID:19660449   PMID:19701191   PMID:19795512  
PMID:19853565   PMID:19906845   PMID:19956724   PMID:20236942   PMID:20335362   PMID:20346937   PMID:20562861   PMID:20630950   PMID:20692344   PMID:21098559   PMID:21111815   PMID:21203428  
PMID:21224256   PMID:21256124   PMID:21267068   PMID:21300886   PMID:21303853   PMID:21331042   PMID:21350016   PMID:21360789   PMID:21368122   PMID:21440680   PMID:21632822   PMID:21750544  
PMID:21795391   PMID:21799763   PMID:21873635   PMID:21930923   PMID:21998026   PMID:22069191   PMID:22326607   PMID:22432025   PMID:22675207   PMID:22689267   PMID:22954964   PMID:23217170  
PMID:23219549   PMID:23501471   PMID:23555292   PMID:23671110   PMID:23685333   PMID:23727513   PMID:23763947   PMID:24167636   PMID:24284205   PMID:24318811   PMID:24449764   PMID:24475213  
PMID:24514266   PMID:24560643   PMID:24633704   PMID:24946904   PMID:24952961   PMID:25031030   PMID:25152336   PMID:25248974   PMID:25392491   PMID:25641698   PMID:25652362   PMID:25652402  
PMID:25809880   PMID:25813538   PMID:25856312   PMID:26114479   PMID:26237517   PMID:26243870   PMID:26283362   PMID:26496195   PMID:26534985   PMID:26666435   PMID:26718008   PMID:26728556  
PMID:26801181   PMID:26811377   PMID:27026076   PMID:27144312   PMID:27187787   PMID:27329940   PMID:27381226   PMID:27411055   PMID:27453501   PMID:27506116   PMID:27747430   PMID:27870829  
PMID:27894818   PMID:28710810   PMID:28893950   PMID:28959017   PMID:29141987   PMID:29555813   PMID:29898387   PMID:30254164   PMID:30289388   PMID:31590629   PMID:32324134   PMID:32421711  
PMID:32597756   PMID:32692983   PMID:32907848   PMID:33051257   PMID:34032268  


Genomics

Comparative Map Data
Uncx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,529,620 - 139,533,934 (+)NCBIGRCm39mm39
GRCm39 Ensembl5139,529,249 - 139,533,934 (+)Ensembl
GRCm385139,543,865 - 139,548,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,543,494 - 139,548,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv375140,019,852 - 140,024,133 (+)NCBIGRCm37mm9NCBIm37
MGSCv365139,797,551 - 139,801,821 (+)NCBImm8
Celera5136,597,528 - 136,635,493 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.75NCBI
UNCX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl71,232,872 - 1,237,326 (+)EnsemblGRCh38hg38GRCh38
GRCh3871,232,872 - 1,237,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3771,272,508 - 1,276,962 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,239,180 - 1,243,139 (+)NCBINCBI36hg18NCBI36
Celera71,234,813 - 1,238,773 (+)NCBI
Cytogenetic Map7p22.3NCBI
HuRef71,189,971 - 1,193,933 (+)NCBIHuRef
CHM1_171,272,238 - 1,276,197 (+)NCBICHM1_1
CRA_TCAGchr7v271,325,450 - 1,343,496 (+)NCBI
Uncx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,092,779 - 15,097,300 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1215,092,784 - 15,097,300 (-)Ensembl
Rnor_6.01217,182,158 - 17,186,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,182,163 - 17,186,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,169,967 - 19,174,488 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,576,541 - 15,581,062 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11215,606,472 - 15,610,990 (-)NCBI
Celera1216,848,463 - 16,852,881 (-)NCBICelera
Cytogenetic Map12q11NCBI
Uncx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554608,941,629 - 8,945,761 (+)NCBIChiLan1.0ChiLan1.0
UNCX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v071,479,804 - 1,485,041 (+)NCBIMhudiblu_PPA_v0panPan3
UNCX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,652,600 - 15,657,016 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,653,576 - 15,657,927 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,126,224 - 17,130,466 (-)NCBI
ROS_Cfam_1.0615,784,556 - 15,788,864 (-)NCBI
UMICH_Zoey_3.1615,587,278 - 15,591,644 (-)NCBI
UNSW_CanFamBas_1.0615,513,954 - 15,518,308 (-)NCBI
UU_Cfam_GSD_1.0615,801,188 - 15,805,422 (-)NCBI
UNCX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3804,177 - 809,770 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13804,188 - 808,574 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23913,067 - 917,837 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UNCX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,365,400 - 20,367,458 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660901,339,476 - 1,344,292 (+)NCBIVero_WHO_p1.0
Uncx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474026,793,627 - 26,797,753 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Uncx4.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385139,547,961 - 139,548,108UniSTSGRCm38
MGSCv375140,023,915 - 140,024,062UniSTSGRCm37
Cytogenetic Map5G2UniSTS
cM Map582.0UniSTS
Uncx  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
cM Map582.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125101165141714711Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109362284143362395Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107829235141829348Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119806972141714711Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109090176143090317Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107829235141829348Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109090176143090317Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107829235141829348Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:993
Count of miRNA genes:473
Interacting mature miRNAs:557
Transcripts:ENSMUST00000031523, ENSMUST00000172997, ENSMUST00000174792
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000172997   ⟹   ENSMUSP00000134067
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,529,249 - 139,533,934 (+)Ensembl
GRCm38.p6 Ensembl5139,543,494 - 139,548,179 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174792   ⟹   ENSMUSP00000139081
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5139,529,653 - 139,531,023 (+)Ensembl
GRCm38.p6 Ensembl5139,543,898 - 139,545,268 (+)Ensembl
RefSeq Acc Id: NM_013702   ⟹   NP_038730
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,529,653 - 139,533,934 (+)NCBI
GRCm385139,543,898 - 139,548,179 (+)ENTREZGENE
MGSCv375140,019,852 - 140,024,133 (+)RGD
Celera5136,597,528 - 136,635,493 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030254366   ⟹   XP_030110226
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,529,653 - 139,533,934 (+)NCBI
GRCm385139,543,898 - 139,548,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254367   ⟹   XP_030110227
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395139,529,620 - 139,533,934 (+)NCBI
GRCm385139,543,865 - 139,548,179 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038730   ⟸   NM_013702
- UniProtKB: O08934 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030110227   ⟸   XM_030254367
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030110226   ⟸   XM_030254366
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000134067   ⟸   ENSMUST00000172997
RefSeq Acc Id: ENSMUSP00000139081   ⟸   ENSMUST00000174792
Protein Domains
Homeobox

Promoters
RGD ID:6888568
Promoter ID:EPDNEW_M7735
Type:initiation region
Name:Uncx_1
Description:Mus musculus UNC homeobox , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385139,543,898 - 139,543,958EPDNEW
RGD ID:6838620
Promoter ID:MM_KWN:44623
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_013702,   UC009AGU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365140,019,606 - 140,020,106 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108013 AgrOrtholog
Ensembl Genes ENSMUSG00000029546 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000134067 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139081 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000172997 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000174792 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22255 UniProtKB/Swiss-Prot
MGD MGI:108013 ENTREZGENE
NCBI Gene 22255 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uncx PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O08934 ENTREZGENE, UniProtKB/Swiss-Prot
  V9GXC0_MOUSE UniProtKB/TrEMBL
UniProt Secondary P70457 UniProtKB/Swiss-Prot
  Q78DU3 UniProtKB/Swiss-Prot