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Gene: Crx (cone-rod homeobox) Mus musculus
Symbol: Crx
Name: cone-rod homeobox
Description: Exhibits several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and nuclear hormone receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II and retina development in camera-type eye. Localizes to nucleus and transcription regulator complex. Is expressed in several structures, including eye; face; and nervous system. Used to study Leber congenital amaurosis 7. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox); PARTICIPATES IN retinitis pigmentosa pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cone-rod homeobox containing; cone-rod homeobox protein; Crx1
Homo sapiens (human) : CRX (cone-rod homeobox)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Crx (cone-rod homeobox)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crx (cone-rod homeobox)
Pan paniscus (bonobo/pygmy chimpanzee) : CRX (cone-rod homeobox)
Canis lupus familiaris (dog) : CRX (cone-rod homeobox)
Sus scrofa (pig) : CRX (cone-rod homeobox)
Chlorocebus sabaeus (African green monkey) : CRX (cone-rod homeobox)
Heterocephalus glaber (naked mole-rat) : Crx (cone-rod homeobox)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl715,865,947 - 15,879,968 (-)EnsemblGRCm38mm10GRCm38
GRCm38715,865,947 - 15,879,955 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37716,451,296 - 16,465,304 (-)NCBIGRCm37mm9NCBIm37
MGSCv36715,024,471 - 15,038,416 (-)NCBImm8
Celera713,064,380 - 13,078,683 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Crx
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733183
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.