Tnfsf4 (tumor necrosis factor (ligand) superfamily, member 4) - Rat Genome Database

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Gene: Tnfsf4 (tumor necrosis factor (ligand) superfamily, member 4) Mus musculus
Symbol: Tnfsf4
Name: tumor necrosis factor (ligand) superfamily, member 4
RGD ID: 733125
Description: Enables tumor necrosis factor receptor binding activity. Involved in several processes, including T cell activation; regulation of gene expression; and regulation of lymphocyte activation. Acts upstream of or within cholesterol metabolic process; inflammatory response; and negative regulation of cytokine production. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in sensory organ and skeleton. Used to study primary pulmonary hypertension and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human TNFSF4 (TNF superfamily member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ath; Ath-; Ath-1; Ath1; atherosclerosis 1; CD134; CD134L; gp3; gp34; OX-40L; OX4; OX40 ligand; Ox40l; tax-transcriptionally activated glycoprotein 1 ligand; Tnlg2b; tumor necrosis factor ligand 2b; tumor necrosis factor ligand superfamily member 4; Txgp; TXGP1; Txgp1l
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391161,223,009 - 161,245,777 (+)NCBIGRCm39mm39
GRCm39 Ensembl1161,222,980 - 161,245,981 (+)Ensembl
GRCm381161,395,438 - 161,418,206 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,395,409 - 161,418,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv371163,325,569 - 163,348,337 (+)NCBIGRCm37mm9NCBIm37
MGSCv361163,232,135 - 163,254,883 (+)NCBImm8
Celera1163,843,815 - 163,866,564 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R)-mevalonic acid  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
calcipotriol  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
genistein  (ISO)
graphite  (ISO)
hydrogen peroxide  (ISO)
isoflurane  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
p-menthan-3-ol  (ISO)
paraquat  (EXP)
pentobarbital  (ISO)
permethrin  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sulfur dioxide  (EXP)
tacrine  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
trichloroethene  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (IMP)
blood vessel development  (NAS)
CD4-positive, alpha-beta T cell costimulation  (IDA)
cellular response to lipopolysaccharide  (ISO,NAS)
cellular response to nitrogen dioxide  (IMP)
cellular response to prostaglandin E stimulus  (ISO)
cholesterol metabolic process  (IMP)
cytokine production  (ISO)
defense response to nematode  (IMP)
immune response  (IEA)
inflammatory response  (IBA,IPI)
innate immune response  (NAS)
memory T cell activation  (IMP)
negative regulation of activation-induced cell death of T cells  (IC)
negative regulation of cytokine production  (IPI)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of extrinsic apoptotic signaling pathway  (IC)
negative regulation of interleukin-17 production  (ISO)
negative regulation of regulatory T cell differentiation  (IMP)
negative regulation of T cell apoptotic process  (IC)
negative regulation of T-helper 1 cell differentiation  (IDA)
negative regulation of type II interferon production  (IDA)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of alpha-beta T cell proliferation  (IMP)
positive regulation of B cell activation  (IDA)
positive regulation of CD4-positive, alpha-beta T cell costimulation  (IDA)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (IDA)
positive regulation of chemokine production  (IMP)
positive regulation of cytokine production  (IBA)
positive regulation of immune effector process  (TAS)
positive regulation of immunoglobulin mediated immune response  (IMP)
positive regulation of immunoglobulin production  (IDA)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-10 production  (IMP)
positive regulation of interleukin-12 production  (IMP)
positive regulation of interleukin-13 production  (IDA)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-4 production  (IDA,IMP,ISO)
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes  (IMP)
positive regulation of interleukin-6 production  (IMP,ISO)
positive regulation of memory T cell activation  (IMP)
positive regulation of memory T cell differentiation  (IDA)
positive regulation of T cell costimulation  (IDA)
positive regulation of T cell cytokine production  (IDA)
positive regulation of T cell migration  (NAS)
positive regulation of T cell proliferation  (IBA)
positive regulation of T-helper 2 cell activation  (IMP)
positive regulation of T-helper 2 cell differentiation  (IDA)
positive regulation of type 2 immune response  (IDA,IMP)
positive regulation of type II interferon production  (IMP,ISO)
regulation of adaptive immune response  (IDA)
regulation of inflammatory response  (IDA)
response to nitrogen dioxide  (IDA)
response to virus  (IDA)
T cell proliferation  (ISO)
T-helper 2 cell activation  (IMP)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Wang X, etal., Nat Genet. 2005 Apr;37(4):365-72. Epub 2005 Mar 6.
7. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
Additional References at PubMed
PMID:1352323   PMID:1856605   PMID:2499515   PMID:3128974   PMID:3450276   PMID:3473481   PMID:7749983   PMID:7889405   PMID:8040344   PMID:8076595   PMID:8422330   PMID:8765008  
PMID:9077551   PMID:9488716   PMID:9670042   PMID:10626891   PMID:10626892   PMID:10637280   PMID:11239407   PMID:11489951   PMID:11509650   PMID:11567634   PMID:12058253   PMID:12355440  
PMID:12370402   PMID:12420131   PMID:12466851   PMID:12496423   PMID:12521997   PMID:12555678   PMID:12668647   PMID:12672051   PMID:12794142   PMID:12938213   PMID:14608036   PMID:14635034  
PMID:14662903   PMID:14701919   PMID:14730361   PMID:14872007   PMID:15004159   PMID:15368274   PMID:15489519   PMID:15921521   PMID:16034107   PMID:16081804   PMID:16439706   PMID:16455980  
PMID:16670306   PMID:16905106   PMID:16920944   PMID:17068285   PMID:17182586   PMID:17575071   PMID:17641228   PMID:17785785   PMID:17975668   PMID:18060034   PMID:18259609   PMID:18354165  
PMID:18485335   PMID:18713990   PMID:18799150   PMID:18941188   PMID:18993084   PMID:19032782   PMID:19050285   PMID:19643985   PMID:19663699   PMID:19786544   PMID:20400709   PMID:20584752  
PMID:20639485   PMID:20659336   PMID:20844189   PMID:21267068   PMID:21345313   PMID:21820713   PMID:21873635   PMID:21924079   PMID:22171643   PMID:22564682   PMID:22966002   PMID:23593329  
PMID:23630352   PMID:24045961   PMID:24068673   PMID:24254032   PMID:24462862   PMID:24469824   PMID:24781052   PMID:25002484   PMID:25613092   PMID:25839234   PMID:26100084   PMID:26564814  
PMID:26646413   PMID:26976612   PMID:27066504   PMID:27298374   PMID:27708417   PMID:28045060   PMID:28696253   PMID:28747670   PMID:28818832   PMID:29344664   PMID:30297856   PMID:30552020  
PMID:30760919   PMID:31470268   PMID:31704879   PMID:32353897   PMID:32647184   PMID:33757384   PMID:34084166   PMID:34093535  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391161,223,009 - 161,245,777 (+)NCBIGRCm39mm39
GRCm39 Ensembl1161,222,980 - 161,245,981 (+)Ensembl
GRCm381161,395,438 - 161,418,206 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,395,409 - 161,418,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv371163,325,569 - 163,348,337 (+)NCBIGRCm37mm9NCBIm37
MGSCv361163,232,135 - 163,254,883 (+)NCBImm8
Celera1163,843,815 - 163,866,564 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381173,172,870 - 173,450,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1173,183,731 - 173,207,331 (-)EnsemblGRCh38hg38GRCh38
GRCh371173,152,870 - 173,176,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,419,493 - 171,443,094 (-)NCBINCBI36hg18NCBI36
Build 341169,884,527 - 169,908,128NCBI
Celera1146,262,332 - 146,285,933 (-)NCBI
Cytogenetic Map1q25.1NCBI
HuRef1144,377,608 - 144,401,209 (-)NCBIHuRef
CHM1_11174,575,344 - 174,598,945 (-)NCBICHM1_1
T2T-CHM13v2.01172,541,831 - 172,565,431 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21373,723,329 - 73,746,809 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1373,723,329 - 73,746,788 (+)Ensembl
Rnor_6.01379,269,973 - 79,293,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,269,973 - 79,293,778 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01384,166,838 - 84,190,566 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,026,337 - 77,050,223 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11377,040,524 - 77,064,407 (+)NCBI
Celera1373,499,753 - 73,523,609 (+)NCBICelera
Cytogenetic Map13q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540613,477,077 - 13,493,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,477,077 - 13,493,309 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11152,391,450 - 152,699,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1152,391,450 - 152,415,845 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01148,684,689 - 148,989,775 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1725,883,297 - 25,909,608 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl725,883,251 - 25,906,892 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,415,436 - 25,441,738 (+)NCBI
ROS_Cfam_1.0725,634,585 - 25,660,879 (+)NCBI
ROS_Cfam_1.0 Ensembl725,634,528 - 25,660,603 (+)Ensembl
UMICH_Zoey_3.1725,553,133 - 25,579,437 (+)NCBI
UNSW_CanFamBas_1.0725,626,526 - 25,652,838 (+)NCBI
UU_Cfam_GSD_1.0725,780,205 - 25,806,523 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934496,542,360 - 96,562,833 (+)NCBI
SpeTri2.0NW_00493648114,391,359 - 14,409,514 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl9115,550,569 - 115,659,263 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,535,185 - 115,857,457 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,042,208 - 127,049,271 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12555,714,291 - 55,998,009 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2555,974,691 - 55,997,374 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605557,291,046 - 57,591,856 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247718,580,489 - 8,599,735 (+)NCBIHetGla_female_1.0hetGla2

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301818Ap1q_malcohol preference 1 QTL (mouse)Not determined1146908199167586222Mouse
1357567Nidd3k_mNidd3 on KK-A<y> (mouse)Not determined7147125258169038913Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
4141075Bmd1a_mbone mineral density 1a (mouse)Not determined1155837814162145325Mouse
13452393Ity3b_mimmunity to S. typhimurium 3b (mouse)1156497439172097436Mouse
13452394Leusq1_mleucocytosis susceptibility QTL 1 (mouse)1156602037168186402Mouse
1301232Hcs7_mhepatocarcinogenesis susceptibility 7 (mouse)Not determined1156602037168186402Mouse
13452397Leusq4_mleucocytosis susceptibility QTL 4 (mouse)1156602037170803640Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
10449381Actre11_mactivity response to ethanol 11 (mouse)1160284665161840065Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:665
Count of miRNA genes:379
Interacting mature miRNAs:433
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000028024   ⟹   ENSMUSP00000028024
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1161,222,980 - 161,245,981 (+)Ensembl
GRCm38.p6 Ensembl1161,395,409 - 161,418,410 (+)Ensembl
RefSeq Acc Id: NM_009452   ⟹   NP_033478
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391161,223,009 - 161,245,777 (+)NCBI
GRCm381161,395,438 - 161,418,206 (+)ENTREZGENE
MGSCv371163,325,569 - 163,348,337 (+)RGD
Celera1163,843,815 - 163,866,564 (+)RGD
Protein Sequences
Protein RefSeqs NP_033478 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA21871 (Get FASTA)   NCBI Sequence Viewer  
  ACI22376 (Get FASTA)   NCBI Sequence Viewer  
  CTQ86162 (Get FASTA)   NCBI Sequence Viewer  
  EDL39314 (Get FASTA)   NCBI Sequence Viewer  
  P43488 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_033478   ⟸   NM_009452
- UniProtKB: P43488 (UniProtKB/Swiss-Prot),   B6DXE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028024   ⟸   ENSMUST00000028024
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43488-F1-model_v2 AlphaFold P43488 1-198 view protein structure

RGD ID:6875444
Promoter ID:EPDNEW_M1173
Type:multiple initiation site
Description:Mus musculus tumor necrosis factor superfamily, member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381161,395,437 - 161,395,497EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104511 AgrOrtholog
Ensembl Genes ENSMUSG00000026700 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000028024 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028024 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFSF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22164 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR17534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnfsf4 PhenoGen
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P43488 ENTREZGENE, UniProtKB/Swiss-Prot