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Gene: LGI1 (leucine rich glioma inactivated 1) Homo sapiens
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Symbol: LGI1
Name: leucine rich glioma inactivated 1
Description: This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADLTE; ADPAEF; ADPEAF; EPITEMPIN; epitempin-1; EPT; ETL1; IB1099; leucine-rich glioma inactivated 1; leucine-rich glioma-inactivated protein 1; leucine-rich, glioma inactivated 1
Orthologs:
Mus musculus (house mouse) : Lgi1 (leucine-rich repeat LGI family, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lgi1 (leucine-rich, glioma inactivated 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lgi1 (leucine rich glioma inactivated 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LGI1 (leucine rich glioma inactivated 1)
Canis lupus familiaris (dog) : LGI1 (leucine rich glioma inactivated 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lgi1 (leucine rich glioma inactivated 1)
Sus scrofa (pig) : LGI1 (leucine rich glioma inactivated 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381093,757,809 - 93,798,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371095,517,566 - 95,557,916 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,507,668 - 95,547,906 (+)NCBINCBI36hg18NCBI36
Build 341095,507,667 - 95,547,906NCBI
Celera1089,258,689 - 89,298,048 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1089,145,309 - 89,184,670 (+)NCBIHuRef
CHM1_11095,800,134 - 95,839,515 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LGI1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733103
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.