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Gene: LGI1 (leucine rich glioma inactivated 1) Homo sapiens
Symbol: LGI1
Name: leucine rich glioma inactivated 1
Description: This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADLTE; ADPAEF; ADPEAF; EPITEMPIN; epitempin-1; EPT; ETL1; IB1099; leucine-rich glioma inactivated 1; leucine-rich glioma-inactivated protein 1; leucine-rich, glioma inactivated 1
Mus musculus (house mouse) : Lgi1 (leucine-rich repeat LGI family, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lgi1 (leucine-rich, glioma inactivated 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lgi1 (leucine rich glioma inactivated 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LGI1 (leucine rich glioma inactivated 1)
Canis lupus familiaris (dog) : LGI1 (leucine rich glioma inactivated 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lgi1 (leucine rich glioma inactivated 1)
Sus scrofa (pig) : LGI1 (leucine rich glioma inactivated 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381093,757,809 - 93,798,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371095,517,566 - 95,557,916 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,507,668 - 95,547,906 (+)NCBINCBI36hg18NCBI36
Build 341095,507,667 - 95,547,906NCBI
Celera1089,258,689 - 89,298,048 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1089,145,309 - 89,184,670 (+)NCBIHuRef
CHM1_11095,800,134 - 95,839,515 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LGI1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733103
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.