Prop1 (paired like homeodomain factor 1)

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Gene: Prop1 (paired like homeodomain factor 1) Mus musculus

Analyze

Symbol:

Prop1

Name:

paired like homeodomain factor 1

RGD ID:

733046

MGI Page

MGI

Description:

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including diencephalon development; dorsal/ventral pattern formation; and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; embryo; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ames dwarf; df; homeobox protein prophet of Pit-1; pituitary specific homeodomain factor; pituitary-specific homeodomain factor; Pr; Prop-1; prophet of Pit-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PROP1 (PROP paired-like homeobox 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Prop1 (PROP paired-like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PROP1 (PROP paired-like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PROP1 (PROP paired-like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prop1 (PROP paired-like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PROP1 (PROP paired-like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PROP1 (PROP paired-like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prop1 (PROP paired-like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Prop1 (PROP paired-like homeobox 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PROP1 (PROP paired-like homeobox 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prop1 (PROP paired-like homeobox 1)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	CG32532	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	unc-42	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	prop1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	50,841,633 - 50,844,584 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	50,841,633 - 50,844,592 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	50,950,806 - 50,953,757 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	50,950,806 - 50,953,765 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	50,764,308 - 50,767,134 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	50,794,229 - 50,797,055 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	51,370,609 - 51,374,220 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	30.95	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

Combined Pituitary Hormone Deficiency 2 (ISO)

disorder of sexual development (ISO)

dyskeratosis congenita (ISO)

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

genetic disease (ISO)

hypogonadism (ISO)

hypopituitarism (IAGP,ISO)

panhypopituitarism (ISO)

Sotos syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

ammonium chloride (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (EXP)

chlorpyrifos (EXP)

copper(II) sulfate (ISO)

CU-O LINKAGE (ISO)

diquat (EXP)

dobutamine (EXP)

hydrogen peroxide (EXP)

paraquat (EXP)

pirinixic acid (EXP)

resveratrol (ISO)

sodium fluoride (EXP)

titanium dioxide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenohypophysis development (IMP)

animal organ morphogenesis (IMP)

apoptotic process (IMP)

blood vessel development (IMP)

cell migration (IGI)

dorsal/ventral pattern formation (IMP)

gland development (IMP)

hypophysis morphogenesis (IMP)

hypothalamus cell differentiation (IMP)

negative regulation of apoptotic process (IMP)

negative regulation of transcription by RNA polymerase II (IDA)

pituitary gland development (IMP)

positive regulation of transcription by RNA polymerase II (IDA,IGI)

regulation of transcription by RNA polymerase II (IBA)

somatotropin secreting cell differentiation (IMP)

Cellular Component

nucleus (IEA)

transcription regulator complex (IBA,IDA)

Molecular Function

beta-catenin binding (IPI)

chromatin binding (IDA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IDA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IDA)

protein binding (IPI)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA)

sequence-specific double-stranded DNA binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal adenohypophysis development (IAGP)

abnormal enzyme/coenzyme activity (IAGP)

abnormal granulosa cell morphology (IAGP)

abnormal neurohypophysis morphology (IAGP)

abnormal ovarian follicle morphology (IAGP)

abnormal pituitary gland development (IAGP)

abnormal pituitary gland morphology (IAGP)

abnormal pulmonary alveolus morphology (IAGP)

abnormal Rathke's pouch apoptosis (IAGP)

abnormal Rathke's pouch development (IAGP)

abnormal respiratory system physiology (IAGP)

abnormal surfactant secretion (IAGP)

absent adenohypophysis (IAGP)

absent corpus luteum (IAGP)

absent gonadotrophs (IAGP)

absent somatotrophs (IAGP)

absent tertiary ovarian follicles (IAGP)

adenohypophysis hypoplasia (IAGP)

atelectasis (IAGP)

cyanosis (IAGP)

decreased body size (IAGP)

decreased circulating follicle stimulating hormone level (IAGP)

decreased circulating growth hormone level (IAGP)

decreased circulating prolactin level (IAGP)

decreased circulating thyroid-stimulating hormone level (IAGP)

decreased follicle stimulating hormone level (IAGP)

decreased growth hormone level (IAGP)

decreased luteinizing hormone level (IAGP)

decreased pituitary hormone level (IAGP)

decreased primary ovarian follicle number (IAGP)

decreased secondary ovarian follicle number (IAGP)

decreased tertiary ovarian follicle number (IAGP)

decreased thyroid-stimulating hormone level (IAGP)

decreased thyrotroph cell number (IAGP)

female infertility (IAGP)

hypopituitarism (IAGP)

increased circulating corticosterone level (IAGP)

increased primordial ovarian follicle number (IAGP)

lethargy (IAGP)

male infertility (IAGP)

neonatal lethality, incomplete penetrance (IAGP)

pituitary gland hypoplasia (IAGP)

postnatal lethality, incomplete penetrance (IAGP)

premature death (IAGP)

proportional dwarf (IAGP)

respiratory distress (IAGP)

small adenohypophysis (IAGP)

small gonad (IAGP)

small ovary (IAGP)

small Rathke's pouch (IAGP)

small thyroid gland (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C).	Fluck C, etal., J Clin Endocrinol Metab. 1998 Oct;83(10):3727-34.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	MGD IEA	MGD IEA
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	An uncommon phenotype with familial central hypogonadism caused by a novel PROP1 gene mutant truncated in the transactivation domain.	Reynaud R, etal., J Clin Endocrinol Metab. 2005 Aug;90(8):4880-7. Epub 2005 Jun 7.
6.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Mutations in PROP1 cause familial combined pituitary hormone deficiency.	Wu W, etal., Nat Genet 1998 Feb;18(2):147-9.

Additional References at PubMed

PMID:590190	PMID:1505020	PMID:1889803	PMID:1977085	PMID:2379827	PMID:2986015	PMID:5674697	PMID:6194978	PMID:6393185	PMID:7069343	PMID:7075549	PMID:7285859
PMID:7308142	PMID:7390396	PMID:7543042	PMID:7568282	PMID:7694848	PMID:7740179	PMID:7867569	PMID:7909141	PMID:7910409	PMID:7956352	PMID:8095101	PMID:8104778
PMID:8447198	PMID:8452930	PMID:8504754	PMID:8504771	PMID:8565826	PMID:8612966	PMID:8722619	PMID:8864123	PMID:8900272	PMID:8930937	PMID:8934515	PMID:8961267
PMID:9067987	PMID:9067988	PMID:9259189	PMID:9437225	PMID:10049363	PMID:10451227	PMID:10497963	PMID:10499586	PMID:10510245	PMID:10549299	PMID:10588713	PMID:10626543
PMID:10687855	PMID:10767579	PMID:10773688	PMID:10984300	PMID:11064154	PMID:11152636	PMID:11161784	PMID:11162909	PMID:11213270	PMID:11312155	PMID:11371507	PMID:11374913
PMID:11383886	PMID:11420609	PMID:11447259	PMID:11719795	PMID:11731482	PMID:11807026	PMID:11927387	PMID:12094019	PMID:12183375	PMID:12199149	PMID:12663691	PMID:12742526
PMID:12875745	PMID:12907761	PMID:12954487	PMID:12960004	PMID:14173795	PMID:14698815	PMID:14698816	PMID:14732396	PMID:14984790	PMID:15037319	PMID:15063102	PMID:15326565
PMID:15345726	PMID:15459176	PMID:15564324	PMID:15591534	PMID:15618518	PMID:15661635	PMID:15664625	PMID:15664729	PMID:15664737	PMID:15701676	PMID:15790531	PMID:15925325
PMID:15935586	PMID:16141072	PMID:16384867	PMID:16519922	PMID:16556738	PMID:16678101	PMID:16840539	PMID:17015435	PMID:17032749	PMID:17321774	PMID:17392792	PMID:17557180
PMID:17611063	PMID:17899304	PMID:17919533	PMID:17964285	PMID:18272476	PMID:18582556	PMID:18757483	PMID:18775421	PMID:18996108	PMID:19007875	PMID:19093031	PMID:19121383
PMID:19139274	PMID:19428459	PMID:19912936	PMID:20022531	PMID:20059953	PMID:20181723	PMID:20720157	PMID:20804841	PMID:20827400	PMID:20934421	PMID:21267068	PMID:21636786
PMID:21828248	PMID:21873635	PMID:22143287	PMID:22145038	PMID:22218782	PMID:22897932	PMID:22945632	PMID:23832075	PMID:24155868	PMID:24227653	PMID:24673559	PMID:24690289
PMID:24789008	PMID:24952961	PMID:25040290	PMID:25063774	PMID:25234161	PMID:25976461	PMID:26219867	PMID:26640231	PMID:26651607	PMID:26764381	PMID:26812162	PMID:26900752
PMID:26990883	PMID:27226307	PMID:27226320	PMID:27351100	PMID:27564454	PMID:27663076	PMID:27740871	PMID:27771355	PMID:27810956	PMID:28591635	PMID:28596381	PMID:28675141
PMID:29259130	PMID:29796621	PMID:30085028	PMID:30332646	PMID:30427307	PMID:30462643	PMID:30778664	PMID:31913463	PMID:31987917	PMID:32453714	PMID:33385482	PMID:33795686
PMID:35652338	PMID:35704312	PMID:35951005	PMID:36683433	PMID:37441495	PMID:39001875

Genomics

Comparative Map Data

Prop1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	50,841,633 - 50,844,584 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	50,841,633 - 50,844,592 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	50,950,806 - 50,953,757 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	50,950,806 - 50,953,765 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	50,764,308 - 50,767,134 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	50,794,229 - 50,797,055 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	51,370,609 - 51,374,220 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	30.95	NCBI

PROP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	177,992,235 - 177,996,242 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	177,992,235 - 177,996,242 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	177,419,236 - 177,423,243 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	177,351,842 - 177,355,849 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	177,351,841 - 177,355,849	NCBI
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	172,154,313 - 172,158,320 (-)	NCBI		HuRef
CHM1_1	5	176,851,155 - 176,855,162 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	178,543,102 - 178,547,110 (-)	NCBI		T2T-CHM13v2.0

Prop1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,772,968 - 35,775,443 (-)	NCBI		GRCr8
mRatBN7.2	10	35,271,959 - 35,274,434 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,271,973 - 35,274,434 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	39,966,675 - 39,969,150 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	39,456,986 - 39,459,461 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	34,960,358 - 34,962,833 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	36,449,920 - 36,452,381 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	36,449,920 - 36,452,378 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,222,697 - 36,225,156 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	36,527,112 - 36,529,573 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	36,528,162 - 36,530,622 (-)	NCBI
Celera	10	34,630,514 - 34,632,778 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

PROP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	172,868,712 - 172,875,052 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	171,008,253 - 171,014,594 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	173,086,726 - 173,090,461 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PROP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	2,739,958 - 2,742,576 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	2,739,958 - 2,743,533 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	2,883,875 - 2,886,493 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	2,716,274 - 2,718,892 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	2,715,535 - 2,719,844 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	2,687,403 - 2,690,021 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	2,765,895 - 2,768,512 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	3,006,789 - 3,009,407 (+)	NCBI		UU_Cfam_GSD_1.0

Prop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	120,644,095 - 120,647,296 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936739	1,854,072 - 1,856,657 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936739	1,854,072 - 1,856,657 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PROP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	79,627,603 - 79,631,270 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	79,627,466 - 79,631,270 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	81,214,581 - 81,218,380 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PROP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	79,704,746 - 79,710,013 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	79,705,287 - 79,708,566 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	10,948,977 - 10,953,352 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prop1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	41,850,474 - 41,856,459 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	41,852,638 - 41,856,493 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Prop1
117 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	534
Count of miRNA genes:	367
Interacting mature miRNAs:	423
Transcripts:	ENSMUST00000051159, ENSMUST00000159179, ENSMUST00000162420
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357844	Si5lq5_m	serum IGFBP-5 level QTL 5 (mouse)			Not determined		11	28165873	62165976	Mouse
4141367	Inf1_m	acute ozone induced inflammation (mouse)			Not determined			44630038	113058009	Mouse
1357720	Kidpq1_m	kidney weight percentage QTL 1 (mouse)			Not determined		11	12268637	68500330	Mouse
1300765	Bbaa4_m	B.burgdorferi-associated arthritis 4 (mouse)			Not determined		11	46185167	80185262	Mouse
1357851	Scfq3_m	subcutaneous fat pad weight QTL 3 (mouse)			Not determined		11	12268637	68500330	Mouse
1301788	Lbw8_m	lupus NZB x NZW 8 (mouse)			Not determined		11	36503287	70509492	Mouse
27226762	Feml21_m	femur length 21, 16 week (mouse)					11	11750000	65990826	Mouse
1302021	Nidd1n_m	non-insulin-dependent diabetes mellitus 1 in NSY (mouse)			Not determined		11	45165873	79978324	Mouse
1301896	Tria1_m	T-cell receptor induced activation 1 (mouse)			Not determined		11	36613565	70613855	Mouse
4141470	Egq4_m	early growth QTL 4 (mouse)			Not determined			12268637	68500330	Mouse
1301426	Desp2_m	despair 2 (mouse)			Not determined		11	28708581	62708700	Mouse
4142109	W10q2_m	weight 10 weeks QTL 2 (mouse)			Not determined			12268637	68500330	Mouse
4141853	Skmw17_m	skeletal muscle weight 17 (mouse)			Not determined		11	37080941	71081064	Mouse
1357878	Mastr_m	modifier of astrocytoma (mouse)			Not determined		11	45708581	89818733	Mouse
13208559	Wght10_m	weight 10 (mouse)					11	3950000	88890826	Mouse
13208558	Lgth12_m	body length 12 (mouse)					11	3950000	94890826	Mouse
26884401	Huml4_m	humerus length 4, 10 week (mouse)					11	11550000	68490826	Mouse
10053687	Eae6_m	susceptibility to experimental allergic encephalomyelitis 6 (mouse)			Not determined		11	17781966	68500330	Mouse
13208569	Bmiq10_m	body mass index QTL 10 (mouse)					11	35890827	84890826	Mouse
27226798	Scvln18_m	sacral vertebrae length 2, 16 week (mouse)					11	3250000	60690826	Mouse
4141582	Lgaq1_m	late growth adjusted QTL 1 (mouse)			Not determined			12268637	68500330	Mouse
4141966	Tailq1_m	tail length QTL 1 (mouse)			Not determined			12268637	68500330	Mouse
10053675	Eae44b_m	experimental allergic encephalomyelitis susceptibility 44b (mouse)			Not determined		11	39950728	54094448	Mouse
4142475	Ity2a_m	immunity to S. typhimurium 2a (mouse)			Not determined		11	37768580	60402716	Mouse
11532699	Sluc36b_m	susceptibility to lung cancer 36b (mouse)					11	42256617	76256730	Mouse
11532698	Sluc36a_m	susceptibility to lung cancer 36a (mouse)					11	42256617	76256730	Mouse
1558945	Orgwq8_m	organ weight QTL 8 (mouse)			Not determined		11	17056175	67078411	Mouse
4142216	Lgq1_m	late growth QTL 1 (mouse)			Not determined			12268637	68500330	Mouse
1300905	Scc6_m	colon tumor susceptibility 6 (mouse)			Not determined		11	6880277	89019734	Mouse
14746971	Manh70_m	mandible shape 70 (mouse)					11	19905890	53905890	Mouse
13524848	Ppiq7_m	prepulse inhibition QTL 7 (mouse)					11	28569147	62569147	Mouse
1357782	Char8_m	P. chabaudi malaria resistance QTL 8 (mouse)			Not determined		11	35578616	69684987	Mouse
39128214	Lwq20_m	liver weight QTL 20 (mouse)					11	12268637	118022724	Mouse
11059563	Lmr31_m	leishmaniasis resistance 31 (mouse)					11	32100577	66100694	Mouse
1301328	Mol4_m	modifier of LPS-response 4 (mouse)			Not determined		11	36282577	83481356	Mouse
26884446	Sklq10_m	skull length QTL 10, 10 week (mouse)					11	3250000	62890826	Mouse
10412246	Dfs2_m	dental fluorosis suseptibility 2 (mouse)			Not determined		11	21807364	95881231	Mouse
1559002	Lmrq4_m	Leishmania major resistance QTL 4 (mouse)			Not determined		11	12268637	69684947	Mouse
1301830	Ssta4_m	susceptibility to Salmonella typhimurium antigens 4 (mouse)			Not determined		11	50078191	84078411	Mouse
1300938	Bulb3_m	bulb size 3 (mouse)			Not determined		11	18578616	52578716	Mouse
4142308	W6q3_m	weight 6 weeks QTL 3 (mouse)			Not determined		11	12268637	68500330	Mouse
1357640	Orq2_m	ovulation rate QTL 2 (mouse)			Not determined		11	12268637	68500330	Mouse
10766457	Nwa3_m	New Zealand White autoimmunity 3 (mouse)					11	38016115	72016209	Mouse
4142300	Ctrq3_m	C. trachomatis resistance QTL 3 (mouse)			Not determined		11	44630038	76854757	Mouse
1357437	Epfq4_m	epididymal fat pad weight QTL 4 (mouse)			Not determined		11	12268637	68500330	Mouse
4141398	Tgq22_m	triglyceride QTL 22 (mouse)			Not determined			21163406	55163406	Mouse
27226738	Metcl11_m	metatarsal-calcaneal length 11, 10 week (mouse)					11	8850000	61390826	Mouse
11522752	Cocia18_m	cocaine-induced activity, QTL 18 (mouse)					11	31008209	65008209	Mouse
12801459	Leuf1_m	leukocyte filtration 1 (mouse)					11	18578616	52578716	Mouse
1300579	Thypr1_m	thymocyte proliferative response 1 (mouse)			Not determined		11	19282577	53282715	Mouse
12801457	Intmrm2_m	intima/media ratio modifier 2 (mouse)					11	18578616	52578716	Mouse
12801460	Intim2_m	intima modifier 2 (mouse)					11	18578616	52578716	Mouse
1301988	Bmd11_m	bone mineral density 11 (mouse)			Not determined		11	46319407	80319522	Mouse
4141127	W3q4_m	weight 3 weeks QTL 4 (mouse)			Not determined			12268637	68500330	Mouse
4141894	Nidd6k_m	Nidd6 on KK-A (mouse)			Not determined			19124204	96897826	Mouse
1300713	Vmbic10_m	ventral midbrain iron content 10 (mouse)			Not determined		11	42772626	54081064	Mouse
26884453	Sklq16_m	skull length QTL 16, 16 week (mouse)					11	3250000	72690826	Mouse
10044006	Hbnr13_m	Heligmosomoides bakeri nematode resistance 13 (mouse)			Not determined		11	25772626	59772741	Mouse

Markers in Region

Prop1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	11	50,950,985 - 50,952,211	UniSTS	GRCm38
MGSCv37	11	50,764,487 - 50,765,713	UniSTS	GRCm37
Cytogenetic Map	11	B1.3	UniSTS
cM Map	11	25.0	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_008936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF536759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL627215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ165772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U77946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000051159 ⟹ ENSMUSP00000057231

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	11	50,841,633 - 50,844,592 (-)	Ensembl
GRCm38.p6 Ensembl	11	50,950,806 - 50,953,765 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000159179

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	11	50,842,019 - 50,843,281 (-)	Ensembl
GRCm38.p6 Ensembl	11	50,951,192 - 50,952,454 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000162420 ⟹ ENSMUSP00000125413

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	11	50,843,041 - 50,844,578 (-)	Ensembl
GRCm38.p6 Ensembl	11	50,952,214 - 50,953,751 (-)	Ensembl

RefSeq Acc Id:

NM_008936 ⟹ NP_032962

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	11	50,841,633 - 50,844,584 (-)	NCBI
GRCm38	11	50,950,806 - 50,953,757 (-)	NCBI
MGSCv37	11	50,764,308 - 50,767,134 (-)	RGD
cM Map	11		ENTREZGENE

Sequence:

show sequence

GTAAATAGAGAAAACAGAGCAGCATCGGGAAGTAGAGGCAGAGAGAAAACTGGGCAAAGCCAAG
AGAGAGAGAGAATGAGATGTCAATTCAGAGGAAGGATGCAGGGTTAGGAAAAGGGGAAACTGTG
AGAAAACAGGTATCTAGCTATATCTAGCTATACTACACACACACACACACACACACACACACAC
ACACACAGAGCAAGGGACAGACTCAGAAAAAGGTAGAAGGTAGAAACAGGGAGAAGAGAGAACA
GAAGACAAGACAAGATAGACAGAAGCAGAGAAAGACTTCGGGGAGTCACAGACTAGAGGACAGC
AGGCTAGACCATCTTTGGTTTGGGTGGCTAGCCATGGAAGCTCAAAGAAGGAGCCATCAGGAAA
AGCAAACGAAGGGTCATGCCTGTGGCCGATCCCTGCCTGAGCCACGAGTGGCCTCTGGGACTCT
GATCTCCACGGTAGACAGGAGCTCTGAGGCTTATAGGAGGCTCTCTGGTACAGAGCTGGGGAGA
CCTAAGCTTTGCCCACAGAGAGGCCGTCCCCACTCCCGGCGCCGCCACCGCACCACCTTCAACC
CAGCACAGCTGGAACAGCTGGAGTCAGCCTTTGGGAGGAACCAGTATCCTGACATCTGGGCTCG
AGAGGGGCTTGCCCAAGACACTGGCCTCAGTGAAGCCAGAATCCAGGTCTGGTTCCAGAACCGC
AGGGCTAAGCAACGGAAGCAAGAGCGGTCACTTCTCCAGCCGATAGCCCATCTATCTACGGCCA
CCTTCTCTGGCTTCTTGCCAGAATCCTCTGCCTATCCCTACACCTATGGGACACCACCTCCACC
AGCGCCCTGCTTCCCTCATCCCTACAGCCACTCTCTCCCCTCCCAGCCCTCTACGGCTGCCTCA
CTCGCTCTTCCTCCCCAGCCTGAGGACTGGTACCCCACCTTGCACCCAGCCCCCACTGGTCATC
TGCCCTGTCCCCCACCCCCACCCATGTTTCCCCTCAGCCTTGAGACGCCAAAGTCCTGGAACTA
AGTGGTGATAAGGCACCCTCTCTCCATAACCCTCTTGAAACACGAGAAAATTGGGGGCTCTCTT
TTCCTCCTAAGGGTGAACCTAGAAACGGGGGTGGGGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_032962	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB38884	(Get FASTA)	NCBI Sequence Viewer
	AAN17800	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000057231
	ENSMUSP00000057231.2
	ENSMUSP00000125413.2
GenBank Protein	P97458	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_032962 ⟸ NM_008936

- UniProtKB:

Q5NCG9 (UniProtKB/Swiss-Prot), P97458 (UniProtKB/Swiss-Prot), Q8CJ18 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAQRRSHQEKQTKGHACGRSLPEPRVASGTLISTVDRSSEAYRRLSGTELGRPKLCPQRGRPH
SRRRHRTTFNPAQLEQLESAFGRNQYPDIWAREGLAQDTGLSEARIQVWFQNRRAKQRKQERSL
LQPIAHLSTATFSGFLPESSAYPYTYGTPPPPAPCFPHPYSHSLPSQPSTAASLALPPQPEDWY
PTLHPAPTGHLPCPPPPPMFPLSLETPKSWN

hide sequence

Ensembl Acc Id:

ENSMUSP00000057231 ⟸ ENSMUST00000051159

Ensembl Acc Id:

ENSMUSP00000125413 ⟸ ENSMUST00000162420

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97458-F1-model_v2	AlphaFold	P97458	1-223	view protein structure

Promoters

RGD ID:

8674532

Promoter ID:

EPDNEW_M15297

Type:

multiple initiation site

Name:

Prop1_1

Description:

Mus musculus paired like homeodomain factor 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	11	50,953,616 - 50,953,676	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:109330	AgrOrtholog
Ensembl Genes	ENSMUSG00000044542	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000051159	ENTREZGENE
	ENSMUST00000051159.3	UniProtKB/Swiss-Prot
	ENSMUST00000162420.2	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:19127	UniProtKB/Swiss-Prot
MGD	MGI:109330	ENTREZGENE
NCBI Gene	19127	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN PROPHET OF PIT-1	UniProtKB/Swiss-Prot
	HOMEOBOX PROTEIN PROPHET OF PIT-1	UniProtKB/TrEMBL
	HOMEOBOX PROTEIN PROPHET OF PIT-1	UniProtKB/TrEMBL
	PTHR47409	UniProtKB/Swiss-Prot
Pfam	Homeodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Prop1	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain-like	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	E0CZF7_MOUSE	UniProtKB/TrEMBL
	P97458	ENTREZGENE, UniProtKB/Swiss-Prot
	Q5NCG9	ENTREZGENE
	Q8CJ18	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	Q5NCG9	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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