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Gene: Prop1 (paired like homeodomain factor 1) Mus musculus
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Symbol: Prop1
Name: paired like homeodomain factor 1
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; beta-catenin binding activity; and protein C-terminus binding activity. Involved in several processes, including canonical Wnt signaling pathway; diencephalon development; and regulation of transcription by RNA polymerase II. Localizes to transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ames dwarf; df; homeobox protein prophet of Pit-1; pituitary specific homeodomain factor; pituitary-specific homeodomain factor; Prop-1; prophet of Pit-1
Orthologs:
Homo sapiens (human) : PROP1 (PROP paired-like homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prop1 (PROP paired-like homeobox 1)  Alliance
Canis lupus familiaris (dog) : PROP1 (PROP paired-like homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prop1 (PROP paired-like homeobox 1)
Sus scrofa (pig) : PROP1 (PROP paired-like homeobox 1)
Chlorocebus sabaeus (African green monkey) : PROP1 (PROP paired-like homeobox 1)
Heterocephalus glaber (naked mole-rat) : Prop1 (PROP paired-like homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1150,950,806 - 50,953,765 (-)EnsemblGRCm38mm10GRCm38
GRCm381150,950,806 - 50,953,757 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371150,764,308 - 50,767,134 (-)NCBIGRCm37mm9NCBIm37
MGSCv361150,794,229 - 50,797,055 (-)NCBImm8
MGSCv361151,370,609 - 51,374,220 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
cM Map1130.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Prop1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733046
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.