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Gene: Prop1 (paired like homeodomain factor 1) Mus musculus
Symbol: Prop1
Name: paired like homeodomain factor 1
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; beta-catenin binding activity; and protein C-terminus binding activity. Involved in several processes, including canonical Wnt signaling pathway; diencephalon development; and regulation of transcription by RNA polymerase II. Localizes to transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ames dwarf; df; homeobox protein prophet of Pit-1; pituitary specific homeodomain factor; pituitary-specific homeodomain factor; Prop-1; prophet of Pit-1
Homo sapiens (human) : PROP1 (PROP paired-like homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prop1 (PROP paired-like homeobox 1)  Alliance
Canis lupus familiaris (dog) : PROP1 (PROP paired-like homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prop1 (PROP paired-like homeobox 1)
Sus scrofa (pig) : PROP1 (PROP paired-like homeobox 1)
Chlorocebus sabaeus (African green monkey) : PROP1 (PROP paired-like homeobox 1)
Heterocephalus glaber (naked mole-rat) : Prop1 (PROP paired-like homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1150,950,806 - 50,953,765 (-)EnsemblGRCm38mm10GRCm38
GRCm381150,950,806 - 50,953,757 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371150,764,308 - 50,767,134 (-)NCBIGRCm37mm9NCBIm37
MGSCv361150,794,229 - 50,797,055 (-)NCBImm8
MGSCv361151,370,609 - 51,374,220 (-)NCBImm8
Cytogenetic Map11B1.3NCBI
cM Map1130.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prop1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733046
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.