CFL1 (cofilin 1) - Rat Genome Database

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Gene: CFL1 (cofilin 1) Homo sapiens
Analyze
Symbol: CFL1
Name: cofilin 1
RGD ID: 732970
HGNC Page HGNC:1874
Description: Enables actin filament binding activity. Involved in several processes, including actin filament depolymerization; positive regulation by host of viral process; and regulation of dendritic spine morphogenesis. Located in cytoplasm and focal adhesion. Biomarker of brain compression and gallbladder carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 18 kDa phosphoprotein; CFL; cofilin; cofilin 1 (non-muscle); cofilin, non-muscle isoform; cofilin-1; epididymis secretory protein Li 15; HEL-S-15; p18
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CFL1P1   CFL1P2   CFL1P3   CFL1P4   CFL1P5   CFL1P6   CFL1P7   CFL1P8  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,854,673 - 65,858,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1165,823,022 - 65,862,026 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,622,144 - 65,625,651 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,378,858 - 65,382,380 (-)NCBINCBI36hg18NCBI36
Build 341165,378,862 - 65,382,380NCBI
Celera1162,946,188 - 62,949,710 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,948,799 - 61,952,321 (-)NCBIHuRef
CHM1_11165,506,695 - 65,510,217 (-)NCBICHM1_1
T2T-CHM13v2.01165,849,144 - 65,852,651 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (EXP)
8-(4-chlorophenylthio)-cAMP  (ISO)
acetamide  (ISO)
aconitine  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bromobenzene  (ISO)
buspirone  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
carvedilol  (ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
CU-O LINKAGE  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dihydroartemisinin  (EXP)
dioxygen  (ISO)
disodium selenite  (EXP)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (EXP)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fasudil  (EXP,ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gentamycin  (ISO)
glucose  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (ISO)
indometacin  (EXP)
ionomycin  (EXP)
isoflurane  (ISO)
ivermectin  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (EXP)
lovastatin  (ISO)
methylmercury(1+)  (ISO)
miconazole  (ISO)
Monobutylphthalate  (ISO)
myricetin  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nimesulide  (ISO)
okadaic acid  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
potassium hydroxide  (EXP)
probucol  (ISO)
progesterone  (EXP)
quercetin  (EXP)
quinpirole  (ISO)
resveratrol  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
temozolomide  (EXP)
tetraphene  (ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
Y-27632  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (TAS)
actin filament depolymerization  (IBA,IDA,IEA,NAS)
actin filament fragmentation  (IBA)
actin filament organization  (ISO)
actin filament severing  (IBA)
cell motility  (IBA)
cell projection organization  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to ether  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to tumor necrosis factor  (ISO)
cytoskeleton organization  (IMP)
establishment of cell polarity  (ISO)
establishment of spindle localization  (ISS)
hippocampus development  (ISO)
mitotic cytokinesis  (IBA,ISO)
modification of postsynaptic actin cytoskeleton  (ISO)
negative regulation of actin filament bundle assembly  (ISO)
negative regulation of actin filament depolymerization  (ISO)
negative regulation of apoptotic process  (TAS)
negative regulation of cell adhesion  (ISO)
negative regulation of cell motility  (ISO)
negative regulation of cell size  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of lamellipodium assembly  (ISO)
negative regulation of postsynaptic density organization  (ISO)
negative regulation of unidimensional cell growth  (ISO)
neural crest cell migration  (ISO)
neural fold formation  (ISO)
positive regulation by host of viral process  (IMP)
positive regulation of actin filament depolymerization  (ISO)
positive regulation of barbed-end actin filament capping  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of embryonic development  (ISS)
positive regulation of establishment of cell polarity regulating cell shape  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of protein localization to cell leading edge  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of synaptic plasticity  (ISO)
protein import into nucleus  (ISO)
protein phosphorylation  (ISO)
regulation of cell morphogenesis  (IMP)
regulation of dendritic spine morphogenesis  (IMP)
response to activity  (ISO)
response to amino acid  (ISO)
response to organic cyclic compound  (ISO)
response to virus  (IEP)
Rho protein signal transduction  (TAS)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups. Ahmad S, etal., J Proteomics. 2015 Sep 8;127(Pt A):178-84. doi: 10.1016/j.jprot.2015.04.035. Epub 2015 May 14.
2. NMDA receptor triggered molecular cascade underlies compression-induced rapid dendritic spine plasticity in cortical neurons. Chen LJ, etal., Exp Neurol. 2015 Apr;266:86-98. doi: 10.1016/j.expneurol.2015.02.014. Epub 2015 Feb 20.
3. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
4. Restoration of erectile function by suppression of corporal apoptosis, fibrosis and corporal veno-occlusive dysfunction with rho-kinase inhibitors in a rat model of cavernous nerve injury. Cho MC, etal., J Urol. 2015 May;193(5):1716-23. doi: 10.1016/j.juro.2014.10.099. Epub 2014 Oct 27.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Decrease of Both Cofilin and LIM Kinase Phosphorylation in the Skeletal Muscles of Immobilization-induced Atrophy Rats. Kim MY, etal., J Phys Ther Sci. 2014 Mar;26(3):355-7. doi: 10.1589/jpts.26.355. Epub 2014 Mar 25.
7. The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling. Lai D, etal., J Mol Med (Berl). 2016 Aug 30.
8. Membrane ERalpha attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats. Lee TM, etal., J Mol Med (Berl). 2014 Jan;92(1):43-51. doi: 10.1007/s00109-013-1103-4. Epub 2013 Nov 29.
9. Cyclosporine A protects podocytes via stabilization of cofilin-1 expression in the unphosphorylated state. Li X, etal., Exp Biol Med (Maywood). 2014 Aug;239(8):922-936. Epub 2014 Apr 15.
10. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Li Y, etal., Sci Signal. 2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353.
11. Simvastatin Attenuates Neuropathic Pain by Inhibiting the RhoA/LIMK/Cofilin Pathway. Qiu Y, etal., Neurochem Res. 2016 Sep;41(9):2457-69. doi: 10.1007/s11064-016-1958-1. Epub 2016 May 23.
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Shaw PX, etal., Exp Eye Res. 2016 Jul 18. pii: S0014-4835(16)30181-6. doi: 10.1016/j.exer.2016.07.006.
15. Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal. Shen S, etal., J Proteome Res. 2016 May 6;15(5):1702-16. doi: 10.1021/acs.jproteome.6b00137. Epub 2016 Apr 11.
16. Involvement of Rho-Kinase/LIM Kinase/Cofilin Signaling Pathway in Corporal Fibrosis after Cavernous Nerve Injury in Male Rats. Song SH, etal., J Sex Med. 2015 Jul;12(7):1522-32. doi: 10.1111/jsm.12903. Epub 2015 Apr 28.
17. Proteomic identification of early changes in the renal cytoskeleton in obstructive uropathy. Stodkilde L, etal., Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1429-41. doi: 10.1152/ajprenal.00244.2013. Epub 2014 Apr 23.
18. Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus. Tsverava L, etal., Biomed Res Int. 2016;2016:2794096. doi: 10.1155/2016/2794096. Epub 2016 Aug 23.
19. Proteomic analysis on infantile spasm and prenatal stress. Wang J, etal., Epilepsy Res. 2014 Sep;108(7):1174-83. doi: 10.1016/j.eplepsyres.2014.06.001. Epub 2014 Jun 14.
20. Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-kappaB in renal tubular epithelial cells. Wang QZ, etal., J Transl Med. 2015 Oct 8;13:323. doi: 10.1186/s12967-015-0685-8.
21. Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes. Wasik AA, etal., Am J Pathol. 2014 Jun;184(6):1727-39. doi: 10.1016/j.ajpath.2014.03.002. Epub 2014 Apr 13.
22. CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder. Yang ZL, etal., Cancer Invest. 2013 Feb;31(2):132-9. doi: 10.3109/07357907.2012.756113. Epub 2013 Jan 15.
Additional References at PubMed
PMID:2263493   PMID:7552146   PMID:7821789   PMID:8037689   PMID:8195165   PMID:8482351   PMID:8800436   PMID:8806458   PMID:8824278   PMID:8889548   PMID:8892894   PMID:9655398  
PMID:10366597   PMID:10436159   PMID:10613909   PMID:11090694   PMID:11139403   PMID:11294912   PMID:11340065   PMID:11418599   PMID:11707283   PMID:11747431   PMID:11812157   PMID:11832213  
PMID:11925442   PMID:11950878   PMID:12049672   PMID:12207032   PMID:12323073   PMID:12359716   PMID:12361576   PMID:12477932   PMID:12665801   PMID:12684437   PMID:12791392   PMID:12837278  
PMID:12904289   PMID:12963706   PMID:14607843   PMID:14627701   PMID:14634665   PMID:14702039   PMID:14718574   PMID:14733918   PMID:15159416   PMID:15161933   PMID:15213453   PMID:15220930  
PMID:15485906   PMID:15489334   PMID:15592455   PMID:15598710   PMID:15647284   PMID:15660133   PMID:15671020   PMID:15719172   PMID:15816841   PMID:15846844   PMID:15952740   PMID:16009940  
PMID:16061204   PMID:16130169   PMID:16169070   PMID:16189514   PMID:16278681   PMID:16301112   PMID:16396496   PMID:16456544   PMID:16526095   PMID:16548883   PMID:16713569   PMID:16815975  
PMID:16916647   PMID:16964243   PMID:17081983   PMID:17088134   PMID:17110338   PMID:17196218   PMID:17352815   PMID:17353931   PMID:17500066   PMID:17572668   PMID:17583572   PMID:17620599  
PMID:17853892   PMID:18096821   PMID:18716285   PMID:18775311   PMID:18808680   PMID:18809681   PMID:18937355   PMID:18952063   PMID:18987670   PMID:19000834   PMID:19110265   PMID:19190083  
PMID:19199708   PMID:19223396   PMID:19339277   PMID:19403692   PMID:19424295   PMID:19483084   PMID:19546591   PMID:19556892   PMID:19567672   PMID:19654210   PMID:19683683   PMID:19734890  
PMID:19738201   PMID:19802004   PMID:19946888   PMID:19997845   PMID:20000738   PMID:20029029   PMID:20095995   PMID:20133759   PMID:20147394   PMID:20381070   PMID:20458337   PMID:20471030  
PMID:20472933   PMID:20473970   PMID:20558337   PMID:20564088   PMID:20646534   PMID:20676060   PMID:20713416   PMID:20729910   PMID:20819441   PMID:20838616   PMID:20842205   PMID:20873970  
PMID:21044950   PMID:21045147   PMID:21163940   PMID:21179570   PMID:21237490   PMID:21280222   PMID:21319273   PMID:21423176   PMID:21469165   PMID:21516116   PMID:21525957   PMID:21571222  
PMID:21647301   PMID:21653829   PMID:21723825   PMID:21735353   PMID:21800051   PMID:21834987   PMID:21873635   PMID:21875597   PMID:21894436   PMID:21900206   PMID:21923909   PMID:22145905  
PMID:22212282   PMID:22270398   PMID:22304920   PMID:22345165   PMID:22450169   PMID:22537596   PMID:22623428   PMID:22623727   PMID:22623803   PMID:22689060   PMID:22742733   PMID:22863883  
PMID:22939629   PMID:22952844   PMID:22990118   PMID:23064469   PMID:23082153   PMID:23093407   PMID:23184937   PMID:23227181   PMID:23294842   PMID:23338717   PMID:23362981   PMID:23376485  
PMID:23395798   PMID:23398456   PMID:23402259   PMID:23463506   PMID:23505076   PMID:23533145   PMID:23535729   PMID:23580065   PMID:23702034   PMID:23725790   PMID:23737525   PMID:23831569  
PMID:23911787   PMID:23979707   PMID:23999301   PMID:24003227   PMID:24018823   PMID:24023293   PMID:24052308   PMID:24106833   PMID:24163370   PMID:24254706   PMID:24418541   PMID:24425731  
PMID:24454796   PMID:24457600   PMID:24464040   PMID:24505128   PMID:24631019   PMID:24658140   PMID:24711643   PMID:24778234   PMID:24813767   PMID:24927181   PMID:25056928   PMID:25071155  
PMID:25096578   PMID:25100728   PMID:25179631   PMID:25192599   PMID:25315299   PMID:25324306   PMID:25416956   PMID:25450970   PMID:25468977   PMID:25529407   PMID:25556234   PMID:25568344  
PMID:25597880   PMID:25635941   PMID:25640309   PMID:25642645   PMID:25784483   PMID:25921289   PMID:25959826   PMID:25963833   PMID:25995115   PMID:25998423   PMID:26058485   PMID:26085344  
PMID:26186194   PMID:26209609   PMID:26268695   PMID:26269174   PMID:26324884   PMID:26344167   PMID:26344197   PMID:26485645   PMID:26496610   PMID:26558842   PMID:26561776   PMID:26639431  
PMID:26641092   PMID:26777405   PMID:26857814   PMID:26878213   PMID:26918678   PMID:26934847   PMID:26936386   PMID:26956845   PMID:26972000   PMID:26996939   PMID:27003257   PMID:27025967  
PMID:27035282   PMID:27052944   PMID:27153537   PMID:27158335   PMID:27402302   PMID:27432908   PMID:27462432   PMID:27503909   PMID:27591049   PMID:27609421   PMID:27626171   PMID:27684187  
PMID:27748441   PMID:27768223   PMID:28161904   PMID:28216224   PMID:28302793   PMID:28365778   PMID:28378594   PMID:28388575   PMID:28440035   PMID:28446539   PMID:28514442   PMID:28515276  
PMID:28581483   PMID:28679472   PMID:28700943   PMID:28826686   PMID:28902428   PMID:28927264   PMID:29102633   PMID:29162887   PMID:29229926   PMID:29298432   PMID:29347944   PMID:29396473  
PMID:29449217   PMID:29467282   PMID:29491746   PMID:29507755   PMID:29509190   PMID:29665387   PMID:29845934   PMID:29859926   PMID:29878125   PMID:29892012   PMID:30021884   PMID:30296500  
PMID:30425250   PMID:30455355   PMID:30463566   PMID:30463901   PMID:30575818   PMID:30662943   PMID:30890647   PMID:30948266   PMID:31046837   PMID:31048545   PMID:31059266   PMID:31091453  
PMID:31180492   PMID:31233187   PMID:31239290   PMID:31300519   PMID:31340145   PMID:31343991   PMID:31352037   PMID:31405213   PMID:31501420   PMID:31515488   PMID:31536960   PMID:31586073  
PMID:31620119   PMID:31623023   PMID:31980649   PMID:31990066   PMID:31996302   PMID:32015554   PMID:32129710   PMID:32203420   PMID:32296183   PMID:32320704   PMID:32463132   PMID:32513696  
PMID:32665550   PMID:32715819   PMID:32807901   PMID:32814053   PMID:32819564   PMID:32929329   PMID:32941674   PMID:32971115   PMID:33022573   PMID:33108559   PMID:33109570   PMID:33174611  
PMID:33194618   PMID:33226137   PMID:33306668   PMID:33336885   PMID:33545068   PMID:33567341   PMID:33644029   PMID:33649781   PMID:33658012   PMID:33729478   PMID:33784016   PMID:33916271  
PMID:33961781   PMID:34090209   PMID:34133714   PMID:34148878   PMID:34169836   PMID:34185411   PMID:34256187   PMID:34270554   PMID:34284854   PMID:34321041   PMID:34373451   PMID:34433058  
PMID:34508625   PMID:34568889   PMID:34650049   PMID:34709727   PMID:34711951   PMID:34839191   PMID:35013218   PMID:35092861   PMID:35152003   PMID:35271311   PMID:35418661  


Genomics

Comparative Map Data
CFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,854,673 - 65,858,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1165,823,022 - 65,862,026 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,622,144 - 65,625,651 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,378,858 - 65,382,380 (-)NCBINCBI36hg18NCBI36
Build 341165,378,862 - 65,382,380NCBI
Celera1162,946,188 - 62,949,710 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,948,799 - 61,952,321 (-)NCBIHuRef
CHM1_11165,506,695 - 65,510,217 (-)NCBICHM1_1
T2T-CHM13v2.01165,849,144 - 65,852,651 (-)NCBI
Cfl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,540,483 - 5,544,059 (+)NCBIGRCm39mm39
GRCm39 Ensembl195,540,483 - 5,545,229 (+)Ensembl
GRCm38195,490,455 - 5,494,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,490,455 - 5,495,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,490,455 - 5,494,031 (+)NCBIGRCm37mm9NCBIm37
MGSCv36195,490,525 - 5,495,201 (+)NCBImm8
Celera195,362,154 - 5,365,730 (+)NCBICelera
Cytogenetic Map19ANCBI
Cfl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,796,012 - 202,801,337 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1202,786,627 - 202,817,587 (+)Ensembl
Rnor_6.01220,869,805 - 220,873,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,869,805 - 220,873,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,799,126 - 227,802,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,133,876 - 208,137,408 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11208,287,328 - 208,290,861 (+)NCBI
Celera1200,333,275 - 200,336,807 (+)NCBICelera
Cytogenetic Map1q43NCBI
Cfl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,479,181 - 19,482,571 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,479,181 - 19,482,571 (+)NCBIChiLan1.0ChiLan1.0
CFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11164,544,275 - 64,548,372 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,544,275 - 64,550,806 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01161,215,092 - 61,218,628 (-)NCBIMhudiblu_PPA_v0panPan3
CFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,404,649 - 51,408,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,401,659 - 51,408,212 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,013,157 - 50,016,753 (+)NCBI
ROS_Cfam_1.01852,442,507 - 52,446,103 (+)NCBI
ROS_Cfam_1.0 Ensembl1852,439,523 - 52,446,096 (+)Ensembl
UMICH_Zoey_3.11851,542,563 - 51,546,159 (+)NCBI
UNSW_CanFamBas_1.01851,116,937 - 51,120,532 (+)NCBI
UU_Cfam_GSD_1.01851,906,246 - 51,909,842 (+)NCBI
Cfl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,236,442 - 7,239,965 (+)NCBI
SpeTri2.0NW_0049365993,678,724 - 3,682,314 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,469,254 - 6,475,035 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,471,558 - 6,475,019 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,575,587 - 5,579,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,408,560 - 8,410,564 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038105,687,711 - 105,692,145 (+)NCBIVero_WHO_p1.0
Cfl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,574,966 - 20,579,796 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476720,574,884 - 20,578,413 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH48139  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,624,101 - 65,624,245UniSTSGRCh37
Build 361165,380,677 - 65,380,821RGDNCBI36
Celera1162,948,007 - 62,948,151RGD
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q13.1UniSTS
HuRef1161,950,618 - 61,950,762UniSTS
GeneMap99-GB4 RH Map11251.18UniSTS
RH79826  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q13UniSTS
MARC_23793-23794:1027526010:3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,622,879 - 65,623,673UniSTSGRCh37
Celera1162,946,785 - 62,947,579UniSTS
HuRef1161,949,396 - 61,950,190UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4705
Count of miRNA genes:883
Interacting mature miRNAs:1062
Transcripts:ENST00000308162, ENST00000524553, ENST00000525451, ENST00000525710, ENST00000526975, ENST00000527344, ENST00000527752, ENST00000530157, ENST00000530413, ENST00000530945, ENST00000531407, ENST00000531413, ENST00000532134, ENST00000534769, ENST00000534784
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 13 1 1 16 1 5 1 6 3 57 13 3
Medium 2429 2968 1722 621 1932 463 4350 2189 3702 414 1391 1595 168 1204 2788 4
Low 3 3 1 1 4 16 1 2 1
Below cutoff 2 3 1 1 1 6 1 7 2 3 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK097690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB850882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU794603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM370399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U21909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000308162   ⟹   ENSP00000309629
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,854,673 - 65,858,180 (-)Ensembl
RefSeq Acc Id: ENST00000524553   ⟹   ENSP00000432226
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,054 - 65,856,964 (-)Ensembl
RefSeq Acc Id: ENST00000525451   ⟹   ENSP00000432660
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,854,675 - 65,859,415 (-)Ensembl
RefSeq Acc Id: ENST00000525710
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,826,322 - 65,831,770 (-)Ensembl
RefSeq Acc Id: ENST00000526975   ⟹   ENSP00000432153
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,974 - 65,859,282 (-)Ensembl
RefSeq Acc Id: ENST00000527344   ⟹   ENSP00000432155
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,854,975 - 65,857,033 (-)Ensembl
RefSeq Acc Id: ENST00000527752
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,823,022 - 65,858,157 (-)Ensembl
RefSeq Acc Id: ENST00000530157
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,823,022 - 65,824,103 (-)Ensembl
RefSeq Acc Id: ENST00000530413   ⟹   ENSP00000436899
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,418 - 65,856,473 (-)Ensembl
RefSeq Acc Id: ENST00000530945
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,854,832 - 65,858,194 (-)Ensembl
RefSeq Acc Id: ENST00000531407   ⟹   ENSP00000433910
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,009 - 65,857,868 (-)Ensembl
RefSeq Acc Id: ENST00000531413   ⟹   ENSP00000433131
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,257 - 65,859,289 (-)Ensembl
RefSeq Acc Id: ENST00000532134   ⟹   ENSP00000436431
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,358 - 65,862,026 (-)Ensembl
RefSeq Acc Id: ENST00000534769   ⟹   ENSP00000431696
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,241 - 65,861,421 (-)Ensembl
RefSeq Acc Id: ENST00000534784   ⟹   ENSP00000433308
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,855,957 - 65,857,543 (-)Ensembl
RefSeq Acc Id: NM_005507   ⟹   NP_005498
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,854,673 - 65,858,180 (-)NCBI
GRCh371165,622,282 - 65,625,804 (-)ENTREZGENE
Build 361165,378,858 - 65,382,380 (-)NCBI Archive
HuRef1161,948,799 - 61,952,321 (-)ENTREZGENE
CHM1_11165,506,695 - 65,510,217 (-)NCBI
T2T-CHM13v2.01165,849,144 - 65,852,651 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005498   ⟸   NM_005507
- UniProtKB: P23528 (UniProtKB/Swiss-Prot),   V9HWI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000309629   ⟸   ENST00000308162
RefSeq Acc Id: ENSP00000436899   ⟸   ENST00000530413
RefSeq Acc Id: ENSP00000433910   ⟸   ENST00000531407
RefSeq Acc Id: ENSP00000433131   ⟸   ENST00000531413
RefSeq Acc Id: ENSP00000436431   ⟸   ENST00000532134
RefSeq Acc Id: ENSP00000433308   ⟸   ENST00000534784
RefSeq Acc Id: ENSP00000431696   ⟸   ENST00000534769
RefSeq Acc Id: ENSP00000432226   ⟸   ENST00000524553
RefSeq Acc Id: ENSP00000432660   ⟸   ENST00000525451
RefSeq Acc Id: ENSP00000432153   ⟸   ENST00000526975
RefSeq Acc Id: ENSP00000432155   ⟸   ENST00000527344
Protein Domains
ADF-H

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23528-F1-model_v2 AlphaFold P23528 1-166 view protein structure

Promoters
RGD ID:6788616
Promoter ID:HG_KWN:13363
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:UC001OFS.1,   UC001OFU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,382,151 - 65,383,272 (-)MPROMDB
RGD ID:6851438
Promoter ID:EP73520
Type:multiple initiation site
Name:HS_CFL1
Description:Cofilin 1 (non-muscle).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,382,227 - 65,382,287EPD
RGD ID:6788617
Promoter ID:HG_KWN:13364
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:UC001OFT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,383,381 - 65,384,442 (-)MPROMDB
RGD ID:7221067
Promoter ID:EPDNEW_H16279
Type:initiation region
Name:CFL1_1
Description:cofilin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,858,180 - 65,858,240EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_005507.2(CFL1):c.296T>G (p.Leu99Arg) single nucleotide variant Malignant melanoma [RCV000069611] Chr11:65855950 [GRCh38]
Chr11:65623421 [GRCh37]
Chr11:65379997 [NCBI36]
Chr11:11q13.1
not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh38/hg38 11q13.1-13.2(chr11:65741431-67705669)x1 copy number loss See cases [RCV000142881] Chr11:65741431..67705669 [GRCh38]
Chr11:65508902..67473140 [GRCh37]
Chr11:65265478..67229716 [NCBI36]
Chr11:11q13.1-13.2
pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:65138976-67574402) copy number gain not provided [RCV000767601] Chr11:65138976..67574402 [GRCh37]
Chr11:11q13.1-13.2
pathogenic
GRCh37/hg19 11q13.1(chr11:65529506-65649002)x3 copy number gain not provided [RCV000846037] Chr11:65529506..65649002 [GRCh37]
Chr11:11q13.1
uncertain significance
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance
NM_005507.3(CFL1):c.198C>T (p.Asp66=) single nucleotide variant not provided [RCV001713245] Chr11:65856048 [GRCh38]
Chr11:65623519 [GRCh37]
Chr11:11q13.1
benign
GRCh37/hg19 11q13.1-13.2(chr11:64935724-66405514) copy number loss not specified [RCV002052930] Chr11:64935724..66405514 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance
NC_000011.9:g.(?_64522783)_(66283694_?)del deletion Bardet-Biedl syndrome [RCV002014493]|Glycogen storage disease, type V [RCV002004587] Chr11:64522783..66283694 [GRCh37]
Chr11:11q13.1-13.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1874 AgrOrtholog
COSMIC CFL1 COSMIC
Ensembl Genes ENSG00000172757 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000309629 ENTREZGENE
  ENSP00000309629.5 UniProtKB/Swiss-Prot
  ENSP00000431696.1 UniProtKB/TrEMBL
  ENSP00000432153.1 UniProtKB/TrEMBL
  ENSP00000432155.1 UniProtKB/TrEMBL
  ENSP00000432226.1 UniProtKB/TrEMBL
  ENSP00000432660.1 UniProtKB/Swiss-Prot
  ENSP00000433131.1 UniProtKB/TrEMBL
  ENSP00000433308.1 UniProtKB/TrEMBL
  ENSP00000433910.1 UniProtKB/TrEMBL
  ENSP00000436431.1 UniProtKB/TrEMBL
  ENSP00000436899.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000308162 ENTREZGENE
  ENST00000308162.10 UniProtKB/Swiss-Prot
  ENST00000524553.5 UniProtKB/TrEMBL
  ENST00000525451.6 UniProtKB/Swiss-Prot
  ENST00000526975.1 UniProtKB/TrEMBL
  ENST00000527344.5 UniProtKB/TrEMBL
  ENST00000530413.1 UniProtKB/TrEMBL
  ENST00000531407.5 UniProtKB/TrEMBL
  ENST00000531413.5 UniProtKB/TrEMBL
  ENST00000532134.5 UniProtKB/TrEMBL
  ENST00000534769.5 UniProtKB/TrEMBL
  ENST00000534784.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000172757 GTEx
HGNC ID HGNC:1874 ENTREZGENE
Human Proteome Map CFL1 Human Proteome Map
InterPro ADF-H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADF/Cofilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cofilin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1072 ENTREZGENE
OMIM 601442 OMIM
PANTHER PTHR11913 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11913:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cofilin_ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26423 PharmGKB
PRINTS COFILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADF_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt COF1_HUMAN UniProtKB/Swiss-Prot
  E9PK25_HUMAN UniProtKB/TrEMBL
  E9PLJ3_HUMAN UniProtKB/TrEMBL
  E9PP50_HUMAN UniProtKB/TrEMBL
  E9PQB7_HUMAN UniProtKB/TrEMBL
  E9PS23_HUMAN UniProtKB/TrEMBL
  G3V1A4_HUMAN UniProtKB/TrEMBL
  P23528 ENTREZGENE
  V9HWI5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B3KUQ1 UniProtKB/Swiss-Prot
  Q53Y87 UniProtKB/Swiss-Prot
  Q9UCA2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 CFL1  cofilin 1    cofilin 1 (non-muscle)  Symbol and/or name change 5135510 APPROVED