Lhx1 (LIM homeobox protein 1) - Rat Genome Database

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Gene: Lhx1 (LIM homeobox protein 1) Mus musculus
Analyze
Symbol: Lhx1
Name: LIM homeobox protein 1
RGD ID: 732964
MGI Page MGI
Description: Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; formation of primary germ layer; and regionalization. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesoderm; genitourinary system; gut; and sensory organ. Orthologous to human LHX1 (LIM homeobox 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeobox protein Lim-1; Li; LIM homeo box protein 1; LIM/homeobox protein Lhx1; Lim1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,408,801 - 84,416,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,409,110 - 84,416,361 (-)EnsemblGRCm39 Ensembl
GRCm381184,517,975 - 84,525,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,518,284 - 84,525,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,332,881 - 84,339,036 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,335,574 - 84,341,729 (-)NCBIMGSCv36mm8
Celera1194,132,193 - 94,138,348 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IGI,IMP)
anatomical structure morphogenesis  (IMP)
anterior/posterior axis specification  (IGI)
anterior/posterior pattern specification  (IGI)
branching involved in ureteric bud morphogenesis  (IEP)
cell differentiation  (IMP)
cell-cell signaling  (IGI)
cellular response to fibroblast growth factor stimulus  (ISO)
cerebellar Purkinje cell differentiation  (IGI)
cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation  (IGI)
cerebellum development  (IGI)
cervix development  (IMP)
comma-shaped body morphogenesis  (IMP)
dorsal/ventral pattern formation  (IGI)
ectoderm formation  (IGI)
embryonic pattern specification  (IGI)
embryonic retina morphogenesis in camera-type eye  (IMP)
embryonic viscerocranium morphogenesis  (IMP)
endoderm development  (IMP)
endoderm formation  (IMP)
epithelium development  (IMP)
forebrain regionalization  (IGI)
gastrulation with mouth forming second  (IMP)
head development  (IGI)
kidney development  (IMP)
lateral motor column neuron migration  (IMP)
mesendoderm development  (IMP)
mesonephric duct development  (ISO)
mesonephric tubule development  (ISO)
mesonephros development  (IEP)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric glomerulus development  (ISO)
metanephric part of ureteric bud development  (ISO)
metanephric renal vesicle morphogenesis  (IEP)
metanephric S-shaped body morphogenesis  (IEP)
metanephros development  (IEP)
motor neuron axon guidance  (IMP)
negative regulation of DNA-templated transcription  (IMP)
nephric duct elongation  (IMP)
nephric duct morphogenesis  (IMP)
nervous system development  (IEA)
neuron differentiation  (IBA)
oviduct development  (IMP)
oviduct epithelium development  (IMP)
paramesonephric duct development  (IMP)
pattern specification process  (IGI,IMP)
positive regulation of anterior head development  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of DNA-templated transcription  (IGI,IMP)
positive regulation of embryonic development  (IMP)
positive regulation of gastrulation  (IMP)
positive regulation of nephron tubule epithelial cell differentiation  (IMP)
post-embryonic development  (IMP)
primitive streak formation  (IMP)
pronephros development  (IEP)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IMP)
regulation of transcription by RNA polymerase II  (IBA)
renal vesicle morphogenesis  (IMP)
retina development in camera-type eye  (IEP)
retina layer formation  (IEP,IMP)
S-shaped body morphogenesis  (IMP)
somite rostral/caudal axis specification  (IMP)
spinal cord association neuron differentiation  (IGI)
spinal cord development  (IEP)
telencephalon development  (IEP)
transcription by RNA polymerase II  (IDA)
ureter morphogenesis  (IGI)
ureteric bud development  (IMP)
urogenital system development  (IMP)
uterine epithelium development  (IMP)
uterus development  (IMP)
vagina development  (IMP)
ventral spinal cord development  (IEP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal anterior head development  (IAGP)
abnormal axon guidance  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal gastrulation movements  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney medulla development  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mesonephros morphology  (IAGP)
abnormal Mullerian duct morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal primitive streak elongation  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal ureter development  (IAGP)
abnormal ureter morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal Wolffian duct morphology  (IAGP)
absent cerebellar foliation  (IAGP)
absent epididymis  (IAGP)
absent forebrain  (IAGP)
absent kidney  (IAGP)
absent metanephros  (IAGP)
absent midbrain  (IAGP)
absent Mullerian ducts  (IAGP)
absent nephron  (IAGP)
absent ovary  (IAGP)
absent prechordal mesoderm  (IAGP)
absent Purkinje cell layer  (IAGP)
absent renal glomerulus  (IAGP)
absent testes  (IAGP)
absent ureter  (IAGP)
absent uterus  (IAGP)
absent vas deferens  (IAGP)
acephaly  (IAGP)
agonadal  (IAGP)
cardia bifida  (IAGP)
cellular necrosis  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased embryo size  (IAGP)
decreased nephron number  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased renal glomerulus number  (IAGP)
dilated allantois  (IAGP)
duplex kidney  (IAGP)
ectopic ureter  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic-extraembryonic boundary constriction  (IAGP)
enlarged pericardium  (IAGP)
failure of initiation of embryo turning  (IAGP)
hydronephrosis  (IAGP)
hydroureter  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
incomplete embryo turning  (IAGP)
microcephaly  (IAGP)
Mullerian duct degeneration  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
renal hypoplasia  (IAGP)
rostral-caudal axis duplication  (IAGP)
rudimentary Mullerian ducts  (IAGP)
rudimentary Wolffian ducts  (IAGP)
single kidney  (IAGP)
small allantois  (IAGP)
small cerebellum  (IAGP)
small kidney  (IAGP)
small metanephros  (IAGP)
uterus hypoplasia  (IAGP)
Wolffian duct degeneration  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Perea-Gomez A, etal., Development 1999 Oct;126(20):4499-511.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
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PMID:9315901   PMID:9431803   PMID:9434953   PMID:9449667   PMID:9449674   PMID:9468533   PMID:9520423   PMID:9689088   PMID:9790191   PMID:9811592   PMID:9858722   PMID:10328927  
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PMID:21822279   PMID:21830221   PMID:21844226   PMID:21873635   PMID:21880902   PMID:21888672   PMID:21896659   PMID:21909369   PMID:21925604   PMID:21930913   PMID:21943603   PMID:21963425  
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PMID:24550112   PMID:24560999   PMID:24594479   PMID:24598167   PMID:24715462   PMID:24767996   PMID:24917498   PMID:24924197   PMID:24952961   PMID:25035422   PMID:25108913   PMID:25139858  
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PMID:31869353   PMID:31923383   PMID:31950080   PMID:32071204   PMID:32141129   PMID:32187534   PMID:32433954   PMID:32439762   PMID:32441560   PMID:32541007   PMID:32554463   PMID:32868762  
PMID:32878923   PMID:32986815   PMID:33315499   PMID:33727334   PMID:33899734   PMID:33951437   PMID:33996801   PMID:34170322   PMID:34374463   PMID:34687812   PMID:34730112   PMID:34815802  
PMID:35008655   PMID:35084365   PMID:35341793   PMID:35395624   PMID:35440748   PMID:35815619   PMID:35942939   PMID:36205075   PMID:36395107   PMID:36476876   PMID:36527791  


Genomics

Comparative Map Data
Lhx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,408,801 - 84,416,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,409,110 - 84,416,361 (-)EnsemblGRCm39 Ensembl
GRCm381184,517,975 - 84,525,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,518,284 - 84,525,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,332,881 - 84,339,036 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,335,574 - 84,341,729 (-)NCBIMGSCv36mm8
Celera1194,132,193 - 94,138,348 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.31NCBI
LHX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381736,936,785 - 36,944,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1736,936,785 - 36,944,612 (+)EnsemblGRCh38hg38GRCh38
GRCh371735,294,772 - 35,301,912 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361732,368,612 - 32,374,607 (+)NCBINCBI36Build 36hg18NCBI36
Build 341732,368,611 - 32,374,607NCBI
Celera1732,116,628 - 32,122,623 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1731,230,715 - 31,237,858 (+)NCBIHuRef
CHM1_11735,329,038 - 35,336,178 (+)NCBICHM1_1
T2T-CHM13v2.01737,924,529 - 37,931,669 (+)NCBIT2T-CHM13v2.0
Lhx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21069,396,829 - 69,403,617 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1069,396,829 - 69,403,617 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1074,016,816 - 74,023,604 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01073,521,849 - 73,528,637 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01068,986,264 - 68,993,052 (-)NCBIRnor_WKY
Rnor_6.01071,843,991 - 71,849,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1071,843,991 - 71,849,293 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01071,752,917 - 71,758,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41072,800,497 - 72,805,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11072,814,866 - 72,820,169 (-)NCBI
Celera1068,324,814 - 68,330,116 (-)NCBICelera
Cytogenetic Map10q26NCBI
Lhx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554511,037,825 - 1,048,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554511,037,936 - 1,048,501 (-)NCBIChiLan1.0ChiLan1.0
LHX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11720,430,618 - 20,437,751 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1720,430,618 - 20,437,751 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01720,134,308 - 20,140,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LHX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1936,760,890 - 36,768,345 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl936,761,826 - 36,768,164 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha935,986,818 - 35,993,342 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0937,571,199 - 37,577,732 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl937,571,878 - 37,576,839 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1936,353,003 - 36,359,535 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0936,640,659 - 36,647,196 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0936,727,884 - 36,734,417 (+)NCBIUU_Cfam_GSD_1.0
Lhx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560235,742,907 - 35,750,671 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364901,324,370 - 1,331,505 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364901,324,378 - 1,332,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1238,450,708 - 38,456,139 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11238,450,708 - 38,457,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21240,067,286 - 40,073,812 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LHX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11630,843,062 - 30,850,182 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1630,842,652 - 30,849,465 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660771,575,851 - 1,584,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248713,954,504 - 3,963,033 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248713,954,490 - 3,961,861 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1227
Count of miRNA genes:592
Interacting mature miRNAs:773
Transcripts:ENSMUST00000018842, ENSMUST00000092827, ENSMUST00000176503, ENSMUST00000184646
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse

Markers in Region
Lhx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1148.0UniSTS
cM Map1148.0UniSTS
Z27410  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381184,519,383 - 84,519,462UniSTSGRCm38
MGSCv371184,332,885 - 84,332,964UniSTSGRCm37
Celera1194,132,197 - 94,132,276UniSTS
Cytogenetic Map11CUniSTS
cM Map1148.0UniSTS
Whitehead/MRC_RH111059.1UniSTS
Whitehead_YAC11 UniSTS
Lhx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1148.0UniSTS
Lhx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11CUniSTS
cM Map1148.0UniSTS
Z27410  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381184,519,386 - 84,519,526UniSTSGRCm38
MGSCv371184,332,888 - 84,333,028UniSTSGRCm37
Celera1194,132,200 - 94,132,340UniSTS
Cytogenetic Map11CUniSTS
Whitehead/MRC_RH111059.1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000018842   ⟹   ENSMUSP00000018842
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,409,110 - 84,416,361 (-)Ensembl
GRCm38.p6 Ensembl1184,518,284 - 84,525,535 (-)Ensembl
RefSeq Acc Id: ENSMUST00000092827   ⟹   ENSMUSP00000090503
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,412,722 - 84,413,537 (-)Ensembl
GRCm38.p6 Ensembl1184,521,896 - 84,522,711 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176503
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,410,532 - 84,412,893 (-)Ensembl
GRCm38.p6 Ensembl1184,519,706 - 84,522,067 (-)Ensembl
RefSeq Acc Id: ENSMUST00000184646   ⟹   ENSMUSP00000138899
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,410,268 - 84,413,157 (-)Ensembl
GRCm38.p6 Ensembl1184,519,442 - 84,522,331 (-)Ensembl
RefSeq Acc Id: NM_008498   ⟹   NP_032524
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391184,408,801 - 84,416,360 (-)NCBI
GRCm381184,517,975 - 84,525,534 (-)NCBI
MGSCv371184,332,881 - 84,339,036 (-)RGD
Celera1194,132,193 - 94,138,348 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032524   ⟸   NM_008498
- UniProtKB: P63006 (UniProtKB/Swiss-Prot),   Q569N5 (UniProtKB/TrEMBL),   A0A8C6GZP0 (UniProtKB/TrEMBL),   A0A6P7RU91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000138899   ⟸   ENSMUST00000184646
RefSeq Acc Id: ENSMUSP00000090503   ⟸   ENSMUST00000092827
RefSeq Acc Id: ENSMUSP00000018842   ⟸   ENSMUST00000018842
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63006-F1-model_v2 AlphaFold P63006 1-406 view protein structure

Promoters
RGD ID:6821176
Promoter ID:MM_KWN:8950
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:ENSMUST00000092827,   ENSMUST00000108082
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,336,051 - 84,336,551 (-)MPROMDB
RGD ID:6821198
Promoter ID:MM_KWN:8951
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:ENSMUST00000018842,   LINCRNA_175,   OTTMUST00000001917,   OTTMUST00000001918,   OTTMUST00000001919
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,338,754 - 84,339,254 (+)MPROMDB
RGD ID:8675956
Promoter ID:EPDNEW_M16009
Type:multiple initiation site
Name:Lhx1_1
Description:Mus musculus LIM homeobox protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381184,525,534 - 84,525,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99783 AgrOrtholog
Ensembl Genes ENSMUSG00000018698 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000018842 ENTREZGENE
  ENSMUSP00000018842.7 UniProtKB/Swiss-Prot
  ENSMUSP00000090503.5 UniProtKB/TrEMBL
  ENSMUSP00000138899.3 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018842 ENTREZGENE
  ENSMUST00000018842.14 UniProtKB/Swiss-Prot
  ENSMUST00000092827.3 UniProtKB/TrEMBL
  ENSMUST00000184646.3 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16869 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99783 ENTREZGENE
NCBI Gene 16869 ENTREZGENE
PANTHER LIM/HOMEOBOX PROTEIN LHX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM/HOMEOBOX PROTEIN LHX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lhx1 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WNK8_MOUSE UniProtKB/TrEMBL
  A0A0A0MQA9_MOUSE UniProtKB/TrEMBL
  A0A6P7RU91 ENTREZGENE
  A0A8C6GZP0 ENTREZGENE
  LHX1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3URX6_MOUSE UniProtKB/TrEMBL
  Q569N5 ENTREZGENE, UniProtKB/TrEMBL
  Q8BNR0_MOUSE UniProtKB/TrEMBL
  Q8CCU9_MOUSE UniProtKB/TrEMBL
UniProt Secondary P36199 UniProtKB/Swiss-Prot