STK3 (serine/threonine kinase 3) - Rat Genome Database

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Gene: STK3 (serine/threonine kinase 3) Homo sapiens
Analyze
Symbol: STK3
Name: serine/threonine kinase 3
RGD ID: 732933
HGNC Page HGNC
Description: Exhibits several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Involved in several processes, including hippo signaling; positive regulation of DNA-binding transcription factor activity; and protein stabilization. Localizes to cytoplasm; nucleus; and protein-containing complex.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ90748; hippo (Drosophila) homolog; hippo homolog; KB-1458E12.1; KRS1; mammalian STE20-like protein kinase 2; MST-2; MST2; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; serine/threonine-protein kinase Krs-1; STE20-like kinase MST2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl898,371,228 - 98,942,827 (-)EnsemblGRCh38hg38GRCh38
GRCh38898,433,048 - 98,944,329 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37899,466,861 - 99,954,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36899,536,037 - 99,907,085 (-)NCBINCBI36hg18NCBI36
Build 34899,536,042 - 99,907,085NCBI
Celera895,652,680 - 96,023,711 (-)NCBI
Cytogenetic Map8q22.2NCBI
HuRef894,670,086 - 95,157,575 (-)NCBIHuRef
CHM1_1899,507,181 - 99,995,466 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7566098   PMID:7665586   PMID:8274451   PMID:8566796   PMID:8816756   PMID:8816758   PMID:10840030   PMID:11278283   PMID:11964314   PMID:12477932   PMID:12554736   PMID:14729613  
PMID:15075335   PMID:15109305   PMID:15489334   PMID:15618521   PMID:15688006   PMID:16510573   PMID:16930133   PMID:17081983   PMID:17379520   PMID:17538946   PMID:17598981   PMID:17889669  
PMID:18082144   PMID:18328708   PMID:18347058   PMID:18362890   PMID:18640976   PMID:19327996   PMID:19484742   PMID:19525978   PMID:19797269   PMID:19822666   PMID:19919647   PMID:19962312  
PMID:19962960   PMID:20086174   PMID:20090955   PMID:20145135   PMID:20212043   PMID:20231902   PMID:20360068   PMID:20412773   PMID:20562859   PMID:20920251   PMID:20949042   PMID:21076410  
PMID:21104395   PMID:21145499   PMID:21199877   PMID:21873635   PMID:21900206   PMID:21944251   PMID:21988832   PMID:22078877   PMID:22102242   PMID:22195963   PMID:22292086   PMID:22590567  
PMID:22948661   PMID:23386615   PMID:23455922   PMID:23459937   PMID:23972470   PMID:24180524   PMID:24255178   PMID:24366813   PMID:24881775   PMID:24929361   PMID:24981860   PMID:24992339  
PMID:25035424   PMID:25241761   PMID:25332235   PMID:25367221   PMID:25416956   PMID:25693804   PMID:25814670   PMID:25900982   PMID:26186194   PMID:26344197   PMID:26496610   PMID:26638075  
PMID:26673895   PMID:26898830   PMID:26908611   PMID:26972000   PMID:27173435   PMID:27238285   PMID:27432908   PMID:27566175   PMID:28087714   PMID:28099921   PMID:28103766   PMID:28152516  
PMID:28205554   PMID:28373297   PMID:28373298   PMID:28380382   PMID:28514442   PMID:28677804   PMID:29063833   PMID:29229926   PMID:29270239   PMID:29346117   PMID:29507755   PMID:29519817  
PMID:29540532   PMID:29789391   PMID:29983373   PMID:30765703   PMID:30867124   PMID:30903103   PMID:31006538   PMID:31080060   PMID:31091453   PMID:31212215   PMID:31586073   PMID:32088727  
PMID:32296183   PMID:32814053   PMID:32994222   PMID:33001583   PMID:33007383   PMID:33060197   PMID:33758424  


Genomics

Comparative Map Data
STK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl898,371,228 - 98,942,827 (-)EnsemblGRCh38hg38GRCh38
GRCh38898,433,048 - 98,944,329 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37899,466,861 - 99,954,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36899,536,037 - 99,907,085 (-)NCBINCBI36hg18NCBI36
Build 34899,536,042 - 99,907,085NCBI
Celera895,652,680 - 96,023,711 (-)NCBI
Cytogenetic Map8q22.2NCBI
HuRef894,670,086 - 95,157,575 (-)NCBIHuRef
CHM1_1899,507,181 - 99,995,466 (-)NCBICHM1_1
Stk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391534,875,645 - 35,155,990 (-)NCBIGRCm39mm39
GRCm39 Ensembl1534,875,642 - 35,179,067 (-)Ensembl
GRCm381534,875,499 - 35,155,882 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1534,875,496 - 35,178,921 (-)EnsemblGRCm38mm10GRCm38
MGSCv371534,805,254 - 35,085,561 (-)NCBIGRCm37mm9NCBIm37
MGSCv361534,821,196 - 35,100,274 (-)NCBImm8
Celera1535,503,253 - 35,772,245 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Stk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2766,053,209 - 66,323,292 (-)NCBI
Rnor_6.0 Ensembl773,618,644 - 73,883,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0773,617,926 - 73,883,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0773,793,705 - 74,055,204 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4770,308,195 - 70,597,445 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1770,447,334 - 70,618,175 (-)NCBI
Celera763,152,608 - 63,416,831 (-)NCBICelera
Cytogenetic Map7q22NCBI
Stk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541714,095,694 - 14,381,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541714,098,851 - 14,381,553 (-)NCBIChiLan1.0ChiLan1.0
STK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1897,278,139 - 97,592,727 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl897,355,173 - 97,708,437 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0895,098,185 - 95,465,324 (-)NCBIMhudiblu_PPA_v0panPan3
STK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.113647,363 - 920,887 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl13648,216 - 920,847 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha13640,435 - 1,015,875 (-)NCBI
ROS_Cfam_1.013796,957 - 1,172,656 (-)NCBI
UMICH_Zoey_3.113639,257 - 1,015,142 (-)NCBI
UNSW_CanFamBas_1.013747,613 - 1,123,107 (-)NCBI
UU_Cfam_GSD_1.013753,947 - 1,129,925 (-)NCBI
Stk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530336,733,336 - 37,010,196 (+)NCBI
SpeTri2.0NW_00493647044,159,449 - 44,436,295 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl437,945,597 - 38,306,775 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1438,011,802 - 38,306,777 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2441,016,047 - 41,330,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1893,374,528 - 93,698,143 (-)NCBI
ChlSab1.1 Ensembl893,374,517 - 93,697,758 (-)Ensembl
Vero_WHO_p1.0NW_02366603947,027,424 - 47,360,853 (+)NCBI
Stk3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247635,568,079 - 5,886,722 (-)NCBI

Position Markers
D8S2107  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,487,309 - 99,487,476UniSTSGRCh37
Build 36899,556,485 - 99,556,652RGDNCBI36
Celera895,673,127 - 95,673,294RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,690,539 - 94,690,706UniSTS
D8S1924  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,466,936 - 99,467,081UniSTSGRCh37
Build 36899,536,112 - 99,536,257RGDNCBI36
Celera895,652,755 - 95,652,900RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,670,163 - 94,670,308UniSTS
TNG Radiation Hybrid Map847343.0UniSTS
Whitehead-YAC Contig Map8 UniSTS
GeneMap99-G3 RH Map83799.0UniSTS
RH38901  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,645,818 - 99,645,942UniSTSGRCh37
Build 36899,714,994 - 99,715,118RGDNCBI36
Celera895,831,621 - 95,831,745RGD
Cytogenetic Map21q21.1UniSTS
Cytogenetic Map8q22.2UniSTS
HuRef894,848,935 - 94,849,059UniSTS
RH64860  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,467,200 - 99,467,340UniSTSGRCh37
Build 36899,536,376 - 99,536,516RGDNCBI36
Celera895,653,019 - 95,653,159RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,670,427 - 94,670,567UniSTS
RH103761  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,476,914 - 99,477,100UniSTSGRCh37
Build 36899,546,090 - 99,546,276RGDNCBI36
Celera895,662,732 - 95,662,918RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,680,141 - 94,680,327UniSTS
GeneMap99-GB4 RH Map8441.04UniSTS
G49552  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,821,980 - 99,822,169UniSTSGRCh37
Build 36899,891,156 - 99,891,345RGDNCBI36
Celera896,007,780 - 96,007,969RGD
Cytogenetic Map8q22.2UniSTS
HuRef895,025,001 - 95,025,190UniSTS
TNG Radiation Hybrid Map847493.0UniSTS
G17283  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,689,869 - 99,690,006UniSTSGRCh37
Build 36899,759,045 - 99,759,182RGDNCBI36
Celera895,875,670 - 95,875,807RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,892,984 - 94,893,121UniSTS
WI-20184  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,466,865 - 99,467,131UniSTSGRCh37
Build 36899,536,041 - 99,536,307RGDNCBI36
Celera895,652,684 - 95,652,950RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,670,092 - 94,670,358UniSTS
GeneMap99-GB4 RH Map8442.04UniSTS
Whitehead-RH Map8582.8UniSTS
NCBI RH Map81123.7UniSTS
WI-18654  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,547,739 - 99,547,888UniSTSGRCh37
Build 36899,616,915 - 99,617,064RGDNCBI36
Celera895,733,551 - 95,733,700RGD
Cytogenetic Map8q22.2UniSTS
HuRef894,750,939 - 94,751,088UniSTS
GeneMap99-GB4 RH Map8442.14UniSTS
Whitehead-RH Map8582.8UniSTS
NCBI RH Map81124.8UniSTS
SHGC-32998  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37899,831,550 - 99,831,685UniSTSGRCh37
Build 36899,900,726 - 99,900,861RGDNCBI36
Celera896,017,352 - 96,017,487RGD
Cytogenetic Map8q22.2UniSTS
HuRef895,034,558 - 95,034,693UniSTS
Stanford-G3 RH Map83643.0UniSTS
GeneMap99-GB4 RH Map8442.34UniSTS
Whitehead-RH Map8582.8UniSTS
NCBI RH Map81119.2UniSTS
GeneMap99-G3 RH Map83733.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR141hsa-miR-141-3pTarbaseexternal_infoReporter GeneNEGATIVE
MIR133Bhsa-miR-133bOncomiRDBexternal_infoNANA22179829

Predicted Target Of
Summary Value
Count of predictions:2779
Count of miRNA genes:1109
Interacting mature miRNAs:1350
Transcripts:ENST00000419617, ENST00000424861, ENST00000517832, ENST00000518165, ENST00000518582, ENST00000518627, ENST00000519420, ENST00000520053, ENST00000520440, ENST00000520653, ENST00000521649, ENST00000521768, ENST00000522924, ENST00000523159, ENST00000523567, ENST00000523601, ENST00000523960
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 609 1006 215 30 82 24 1731 296 545 82 996 536 18 677 1167 3
Low 1826 1903 1509 594 1766 440 2625 1897 3085 335 462 1075 153 527 1621 2 2
Below cutoff 3 81 1 102 1 3 93 2 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001256312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001745584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001745585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001745586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA370619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR627416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U26424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z25422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000419617   ⟹   ENSP00000390500
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,454,633 - 98,825,688 (-)Ensembl
RefSeq Acc Id: ENST00000424861   ⟹   ENSP00000428167
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,595,330 - 98,825,666 (-)Ensembl
RefSeq Acc Id: ENST00000517832
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,401,403 - 98,526,926 (-)Ensembl
RefSeq Acc Id: ENST00000518165   ⟹   ENSP00000428014
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,548,091 - 98,825,671 (-)Ensembl
RefSeq Acc Id: ENST00000518582
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,547,960 - 98,651,724 (-)Ensembl
RefSeq Acc Id: ENST00000518627
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,553,330 - 98,601,661 (-)Ensembl
RefSeq Acc Id: ENST00000518704
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,371,355 - 98,388,247 (-)Ensembl
RefSeq Acc Id: ENST00000519420   ⟹   ENSP00000428295
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,883,754 - 98,942,827 (-)Ensembl
RefSeq Acc Id: ENST00000520053
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,579,759 - 98,596,392 (-)Ensembl
RefSeq Acc Id: ENST00000520440
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,526,415 - 98,548,162 (-)Ensembl
RefSeq Acc Id: ENST00000520653
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,594,973 - 98,602,276 (-)Ensembl
RefSeq Acc Id: ENST00000521649   ⟹   ENSP00000429369
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,579,696 - 98,825,646 (-)Ensembl
RefSeq Acc Id: ENST00000521768
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,594,877 - 98,602,182 (-)Ensembl
RefSeq Acc Id: ENST00000522924
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,579,670 - 98,595,250 (-)Ensembl
RefSeq Acc Id: ENST00000523159
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,547,966 - 98,602,255 (-)Ensembl
RefSeq Acc Id: ENST00000523567
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,875,257 - 98,883,795 (-)Ensembl
RefSeq Acc Id: ENST00000523601   ⟹   ENSP00000429744
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,454,695 - 98,942,571 (-)Ensembl
RefSeq Acc Id: ENST00000523960
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,878,898 - 98,942,645 (-)Ensembl
RefSeq Acc Id: ENST00000617590   ⟹   ENSP00000482260
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,454,631 - 98,825,671 (-)Ensembl
RefSeq Acc Id: ENST00000649151
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl898,371,228 - 98,441,007 (-)Ensembl
RefSeq Acc Id: NM_001256312   ⟹   NP_001243241
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,633 - 98,942,610 (-)NCBI
HuRef894,670,086 - 95,157,575 (-)NCBI
CHM1_1899,507,181 - 99,995,466 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001256313   ⟹   NP_001243242
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,633 - 98,825,688 (-)NCBI
GRCh37899,466,859 - 99,954,799 (-)NCBI
HuRef894,670,086 - 95,157,575 (-)NCBI
CHM1_1899,507,181 - 99,878,793 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006281   ⟹   NP_006272
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,633 - 98,825,688 (-)NCBI
GRCh37899,466,859 - 99,954,799 (-)NCBI
Build 36899,536,037 - 99,907,085 (-)NCBI Archive
HuRef894,670,086 - 95,157,575 (-)NCBI
CHM1_1899,507,181 - 99,878,803 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517248   ⟹   XP_011515550
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,633 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517251   ⟹   XP_011515553
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,433,048 - 98,825,688 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517252   ⟹   XP_011515554
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,810 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517255   ⟹   XP_011515557
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,433,048 - 98,601,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517257   ⟹   XP_011515559
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,637,725 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517258   ⟹   XP_011515560
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,433,048 - 98,602,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013756   ⟹   XP_016869245
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,434,151 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013757   ⟹   XP_016869246
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,457,275 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013758   ⟹   XP_016869247
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,633 - 98,825,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013759   ⟹   XP_016869248
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,433,048 - 98,825,713 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013760   ⟹   XP_016869249
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,433,048 - 98,825,666 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013761   ⟹   XP_016869250
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,784 - 98,825,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013762   ⟹   XP_016869251
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,668,406 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013764   ⟹   XP_016869253
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,433,048 - 98,664,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447238   ⟹   XP_024303006
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,433,048 - 98,825,713 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447239   ⟹   XP_024303007
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,784 - 98,601,023 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001745584
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,454,633 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001745585
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,721,074 - 98,944,329 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001745586
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,721,074 - 98,944,329 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001243241 (Get FASTA)   NCBI Sequence Viewer  
  NP_001243242 (Get FASTA)   NCBI Sequence Viewer  
  NP_006272 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515550 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515553 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515554 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515557 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515559 (Get FASTA)   NCBI Sequence Viewer  
  XP_011515560 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869245 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869246 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869247 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869248 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869249 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869250 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869251 (Get FASTA)   NCBI Sequence Viewer  
  XP_016869253 (Get FASTA)   NCBI Sequence Viewer  
  XP_024303006 (Get FASTA)   NCBI Sequence Viewer  
  XP_024303007 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB17261 (Get FASTA)   NCBI Sequence Viewer  
  AAC50386 (Get FASTA)   NCBI Sequence Viewer  
  AAH10640 (Get FASTA)   NCBI Sequence Viewer  
  ADO22281 (Get FASTA)   NCBI Sequence Viewer  
  BAC11487 (Get FASTA)   NCBI Sequence Viewer  
  BAF84526 (Get FASTA)   NCBI Sequence Viewer  
  BAG54769 (Get FASTA)   NCBI Sequence Viewer  
  CAA80909 (Get FASTA)   NCBI Sequence Viewer  
  EAW91781 (Get FASTA)   NCBI Sequence Viewer  
  Q13188 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_006272   ⟸   NM_006281
- Peptide Label: isoform 1
- UniProtKB: Q13188 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243241   ⟸   NM_001256312
- Peptide Label: isoform 2
- UniProtKB: Q13188 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243242   ⟸   NM_001256313
- Peptide Label: isoform 3
- UniProtKB: A0A087WZ06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011515553   ⟸   XM_011517251
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011515560   ⟸   XM_011517258
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_011515557   ⟸   XM_011517255
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_011515554   ⟸   XM_011517252
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011515550   ⟸   XM_011517248
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011515559   ⟸   XM_011517257
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_016869248   ⟸   XM_017013759
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016869249   ⟸   XM_017013760
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016869253   ⟸   XM_017013764
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_016869245   ⟸   XM_017013756
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016869250   ⟸   XM_017013761
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_016869247   ⟸   XM_017013758
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016869246   ⟸   XM_017013757
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016869251   ⟸   XM_017013762
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_024303006   ⟸   XM_024447238
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_024303007   ⟸   XM_024447239
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: ENSP00000428167   ⟸   ENST00000424861
RefSeq Acc Id: ENSP00000428014   ⟸   ENST00000518165
RefSeq Acc Id: ENSP00000428295   ⟸   ENST00000519420
RefSeq Acc Id: ENSP00000429369   ⟸   ENST00000521649
RefSeq Acc Id: ENSP00000390500   ⟸   ENST00000419617
RefSeq Acc Id: ENSP00000429744   ⟸   ENST00000523601
RefSeq Acc Id: ENSP00000482260   ⟸   ENST00000617590
Protein Domains
Protein kinase   SARAH

Promoters
RGD ID:7213871
Promoter ID:EPDNEW_H12680
Type:initiation region
Name:STK3_1
Description:serine/threonine kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12683  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38898,825,671 - 98,825,731EPDNEW
RGD ID:6806637
Promoter ID:HG_KWN:61784
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000339879,   NM_006281,   UC010MBM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36899,906,726 - 99,907,602 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.2(chr8:98920719-99451919)x1 copy number loss See cases [RCV000052788] Chr8:98920719..99451919 [GRCh38]
Chr8:99932947..100464147 [GRCh37]
Chr8:100002123..100533323 [NCBI36]
Chr8:8q22.2
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NM_006281.3(STK3):c.1254C>T (p.Phe418=) single nucleotide variant Malignant melanoma [RCV000068451] Chr8:98526805 [GRCh38]
Chr8:99539033 [GRCh37]
Chr8:99608209 [NCBI36]
Chr8:8q22.2
not provided
NM_001256312.1(STK3):c.110+43662C>A single nucleotide variant Lung cancer [RCV000107924] Chr8:98839985 [GRCh38]
Chr8:99852213 [GRCh37]
Chr8:8q22.2
uncertain significance
NM_001256312.1(STK3):c.-206-3308C>T single nucleotide variant Lung cancer [RCV000107925] Chr8:98893210 [GRCh38]
Chr8:99905438 [GRCh37]
Chr8:8q22.2
uncertain significance
NM_001256312.1(STK3):c.-206-7491A>T single nucleotide variant Lung cancer [RCV000107926] Chr8:98897393 [GRCh38]
Chr8:99909621 [GRCh37]
Chr8:8q22.2
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q22.2(chr8:99545491-99606060)x1 copy number loss See cases [RCV000446142] Chr8:99545491..99606060 [GRCh37]
Chr8:8q22.2
likely benign
GRCh37/hg19 8q22.2(chr8:99735761-99772486)x1 copy number loss See cases [RCV000446146] Chr8:99735761..99772486 [GRCh37]
Chr8:8q22.2
uncertain significance
GRCh37/hg19 8q22.2(chr8:99545492-99607093)x1 copy number loss See cases [RCV000446427] Chr8:99545492..99607093 [GRCh37]
Chr8:8q22.2
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.2(chr8:99816841-100523891)x1 copy number loss See cases [RCV000445667] Chr8:99816841..100523891 [GRCh37]
Chr8:8q22.2
uncertain significance
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.2(chr8:99681689-100173606)x3 copy number gain not provided [RCV000849134] Chr8:99681689..100173606 [GRCh37]
Chr8:8q22.2
uncertain significance
GRCh37/hg19 8q22.2(chr8:99501354-100350153)x3 copy number gain not provided [RCV000849911] Chr8:99501354..100350153 [GRCh37]
Chr8:8q22.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11406 AgrOrtholog
COSMIC STK3 COSMIC
Ensembl Genes ENSG00000104375 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000390500 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428014 UniProtKB/TrEMBL
  ENSP00000428167 UniProtKB/TrEMBL
  ENSP00000429369 UniProtKB/TrEMBL
  ENSP00000429744 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000482260 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000419617 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000424861 UniProtKB/TrEMBL
  ENST00000518165 UniProtKB/TrEMBL
  ENST00000521649 UniProtKB/TrEMBL
  ENST00000523601 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000617590 ENTREZGENE, UniProtKB/TrEMBL
GTEx ENSG00000104375 GTEx
HGNC ID HGNC:11406 ENTREZGENE
Human Proteome Map STK3 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mst1_SARAH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 6788 ENTREZGENE
OMIM 605030 OMIM
Pfam Mst1_SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36213 PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WZ06 ENTREZGENE, UniProtKB/TrEMBL
  A0A384MR07_HUMAN UniProtKB/TrEMBL
  E5RFQ9_HUMAN UniProtKB/TrEMBL
  E5RIM6_HUMAN UniProtKB/TrEMBL
  Q13188 ENTREZGENE
  Q8NBU1_HUMAN UniProtKB/TrEMBL
  STK3_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8K722 UniProtKB/Swiss-Prot
  B3KYA7 UniProtKB/Swiss-Prot
  Q15445 UniProtKB/Swiss-Prot
  Q15801 UniProtKB/Swiss-Prot
  Q96FM6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-01-24 STK3  serine/threonine kinase 3  STK3  serine/threonine kinase 3  Symbol and/or name change 5135510 APPROVED
2011-07-27 STK3  serine/threonine kinase 3  STK3  serine/threonine kinase 3 (STE20 homolog, yeast)  Symbol and/or name change 5135510 APPROVED