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Gene: TCF4 (transcription factor 4) Homo sapiens
Symbol: TCF4
Name: transcription factor 4
Description: Exhibits several functions, including DNA-binding transcription factor activity; beta-catenin binding activity; and protein C-terminus binding activity. Involved in positive regulation of transcription, DNA-templated. Localizes to beta-catenin-TCF7L2 complex and nuclear chromatin. Implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHb19; class B basic helix-loop-helix protein 19; E2-2; FECD3; immunoglobulin transcription factor 2; ITF-2; ITF2; MGC149723; MGC149724; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; SL3-3 enhancer factor 2; TCF-4; transcription factor 4, isoform B+; transcription factor 4, isoform B-; transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R
Mus musculus (house mouse) : Tcf4 (transcription factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tcf4 (transcription factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf4 (transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF4 (transcription factor 4)
Canis lupus familiaris (dog) : TCF4 (transcription factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf4 (transcription factor 4)
Sus scrofa (pig) : TCF4 (transcription factor 4)
Chlorocebus sabaeus (African green monkey) : TCF4 (transcription factor 4)
Heterocephalus glaber (naked mole-rat) : Tcf4 (transcription factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: TCF4 (Gene ID: 6925) and TCF7L2 (Gene ID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [08 Feb 2019]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1855,222,185 - 55,664,787 (-)EnsemblGRCh38hg38GRCh38
GRCh381855,222,185 - 55,635,957 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371852,889,562 - 53,303,252 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361851,040,560 - 51,406,858 (-)NCBINCBI36hg18NCBI36
Build 341851,045,966 - 51,406,441NCBI
Celera1849,606,934 - 49,973,119 (-)NCBI
Cytogenetic Map18q21.2NCBI
HuRef1849,599,225 - 50,013,477 (-)NCBIHuRef
CHM1_11852,884,825 - 53,299,013 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences