Kcnmb4 (potassium large conductance calcium-activated channel, subfamily M, beta member 4) - Rat Genome Database
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Gene: Kcnmb4 (potassium large conductance calcium-activated channel, subfamily M, beta member 4) Mus musculus
Analyze
Symbol: Kcnmb4
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4
RGD ID: 732910
Description: Exhibits calcium-activated potassium channel activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Localizes to voltage-gated potassium channel complex. Is expressed in several structures, including central nervous system; hindlimb phalanx; naris; tarsus; and tooth. Orthologous to human KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4); INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1700058G18Rik; 2900045G12Rik; BK channel subunit beta-4; BKbeta4; calcium-activated potassium channel subunit beta-4; calcium-activated potassium channel, subfamily M subunit beta-4; charybdotoxin receptor subunit beta-4; k(VCA)beta-4; large conductance calcium-dependent potassium ion channel beta 4 subunit; maxi K channel subunit beta-4; MGC143660; slo-beta-4; Slowpoke beta 4
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,253,766 - 116,309,782 (-)NCBI
GRCm3810116,417,861 - 116,473,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10116,417,861 - 116,473,878 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710115,854,924 - 115,910,579 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610115,821,978 - 115,877,633 (-)NCBImm8
Celera10118,359,444 - 118,414,989 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12388098   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16261134   PMID:16985003   PMID:17135251   PMID:17945424  
PMID:17962348   PMID:18359571   PMID:18480178   PMID:18981408   PMID:19578543   PMID:20299355   PMID:21267068   PMID:21438011   PMID:21723921   PMID:21848922   PMID:21873635   PMID:22084117  
PMID:23002235   PMID:23312518   PMID:23439122   PMID:23761673   PMID:24573316   PMID:24952961   PMID:25561520   PMID:26940770   PMID:27146987   PMID:29145442   PMID:29163049   PMID:30484346  


Genomics

Comparative Map Data
Kcnmb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,253,766 - 116,309,782 (-)NCBI
GRCm3810116,417,861 - 116,473,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10116,417,861 - 116,473,878 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710115,854,924 - 115,910,579 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610115,821,978 - 115,877,633 (-)NCBImm8
Celera10118,359,444 - 118,414,989 (-)NCBICelera
Cytogenetic Map10D2NCBI
KCNMB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1270,366,290 - 70,434,292 (+)EnsemblGRCh38hg38GRCh38
GRCh381270,366,220 - 70,434,292 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371270,760,062 - 70,828,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,046,329 - 69,111,245 (+)NCBINCBI36hg18NCBI36
Build 341269,046,328 - 69,111,245NCBI
Celera1270,423,736 - 70,488,648 (+)NCBI
Cytogenetic Map12q15NCBI
HuRef1267,810,221 - 67,878,259 (+)NCBIHuRef
CHM1_11270,729,372 - 70,797,379 (+)NCBICHM1_1
Kcnmb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0759,461,808 - 59,514,759 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,461,799 - 59,514,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0759,472,024 - 59,525,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,751,633 - 55,807,075 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1755,772,362 - 55,827,805 (-)NCBI
Celera748,846,351 - 48,898,813 (-)NCBICelera
Cytogenetic Map7q22NCBI
Kcnmb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540510,559,074 - 10,615,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540510,559,074 - 10,615,744 (+)NCBIChiLan1.0ChiLan1.0
KCNMB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11270,644,953 - 70,712,211 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1270,644,953 - 70,712,211 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01267,876,582 - 67,944,318 (+)NCBIMhudiblu_PPA_v0panPan3
KCNMB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,211,372 - 12,251,739 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kcnmb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365458,052,407 - 8,115,310 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNMB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl534,562,052 - 34,634,238 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1534,561,990 - 34,634,241 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNMB4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1165,944,522 - 66,007,201 (+)Ensembl
ChlSab1.11165,944,489 - 66,008,479 (+)NCBI
Kcnmb4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475027,356,489 - 27,424,413 (-)NCBI

Position Markers
BE691650  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810116,462,866 - 116,463,001UniSTSGRCm38
MGSCv3710115,899,922 - 115,900,057UniSTSGRCm37
Celera10118,404,583 - 118,404,718UniSTS
Cytogenetic Map10D2UniSTS
Whitehead/MRC_RH101227.07UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1074151384125680038Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1074151384125680038Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082473556116473795Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082473556116473795Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082473556116473795Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082473556116473795Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082473556116473795Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082473556116473795Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082556941116557090Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83181141117181274Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084243786122205623Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84243786122205623Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84243786122205623Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84243786122205623Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84243786122205623Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084243786122205623Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084243786122205623Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085619118118661448Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086877747120877895Mouse
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1087073224121073368Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1087073224121073368Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088252393122252530Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined89000595123000595Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1090091790124091893Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090671039125739363Mouse
13208554Lgth11_mbody length 11 (mouse)1091000000121000000Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097381196130694993Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097381196130694993Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397381196130694993Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097381196130694993Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097700000130694993Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97922739130694993Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099384730130694993Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099384730130694993Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099384730130694993Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10101150611130694993Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10101150611130694993Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101661259130694993Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101661259130694993Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102671003130694993Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102900000123400000Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10103011947130694993Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10103066603130694993Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103407822130694993Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104274116130694993Mouse
14746996Manh69_mmandible shape 69 (mouse)10104927733130694993Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105205399130694993Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105205399130694993Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105205399130694993Mouse
4141269Ipng2_mimprinted postnatal growth 2 (mouse)Not determined105252393118661448Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105343808130694993Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105343808130694993Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105343808130694993Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108680038130694993Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108680038130694993Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108739225130694993Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108739225130694993Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108739225130694993Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108739225130694993Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108800000125600000Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110200000125600000Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110617486125680038Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110617486125680038Mouse
10412078Hylaq3_mHyperlocomotor activity related QTL 3 (mouse)Not determined10111732321118150744Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113700000121800000Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113700000125900000Mouse
4141242Psrs2_mpsoriasis susceptibility 2 (mouse)Not determined10114381196118661448Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114400000122900000Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114500000123800000Mouse
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114800000122900000Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116384730122343923Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:864
Count of miRNA genes:542
Interacting mature miRNAs:661
Transcripts:ENSMUST00000068233, ENSMUST00000087965, ENSMUST00000091477, ENSMUST00000164271
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000068233   ⟹   ENSMUSP00000065384
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10116,417,861 - 116,473,878 (-)Ensembl
RefSeq Acc Id: ENSMUST00000087965
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10116,462,646 - 116,473,422 (-)Ensembl
RefSeq Acc Id: ENSMUST00000091477
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10116,443,484 - 116,446,408 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164271
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10116,436,193 - 116,473,435 (-)Ensembl
RefSeq Acc Id: NM_021452   ⟹   NP_067427
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910116,253,773 - 116,309,428 (-)NCBI
GRCm3810116,417,868 - 116,473,523 (-)NCBI
MGSCv3710115,854,924 - 115,910,579 (-)RGD
Celera10118,359,444 - 118,414,989 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513911   ⟹   XP_006513974
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910116,295,867 - 116,309,782 (-)NCBI
GRCm3810116,459,962 - 116,473,543 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155902   ⟹   XP_036011795
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910116,253,766 - 116,279,815 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_067427   ⟸   NM_021452
- UniProtKB: Q9JIN6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513974   ⟸   XM_006513911
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000065384   ⟸   ENSMUST00000068233
RefSeq Acc Id: XP_036011795   ⟸   XM_036155902
- Peptide Label: isoform X2

Promoters
RGD ID:8673300
Promoter ID:EPDNEW_M14681
Type:initiation region
Name:Kcnmb4_1
Description:Mus musculus potassium large conductance calcium-activated channel,subfamily M, beta member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810116,473,429 - 116,473,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913272 AgrOrtholog
Ensembl Genes ENSMUSG00000054934 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000065384 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000068233 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro K_chnl_Ca-activ_BK_bsu UniProtKB/Swiss-Prot
KEGG Report mmu:58802 UniProtKB/Swiss-Prot
MGD MGI:1913272 ENTREZGENE
NCBI Gene 58802 ENTREZGENE
PANTHER PTHR10258 UniProtKB/Swiss-Prot
Pfam CaKB UniProtKB/Swiss-Prot
PhenoGen Kcnmb4 PhenoGen
UniGene Mm.440652 ENTREZGENE
UniProt KCMB4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q149I1 UniProtKB/Swiss-Prot