Prl3b1 (prolactin family 3, subfamily b, member 1)

Gene: Prl3b1 (prolactin family 3, subfamily b, member 1) Mus musculus

Analyze

No known orthologs.

Symbol:

Prl3b1

Name:

prolactin family 3, subfamily b, member 1

RGD ID:

732812

MGI Page

MGI

Description:

Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in several structures, including brain; extraembryonic component; and genitourinary system.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

chorionic somatomammotropin hormone 2; Csh; Csh2; Ghd8; growth hormone d8; m; mP; mPL-II; mplII; P; PL; Pl-2; PL-II; Pl2; placental lactogen 2; placental lactogen II; prolactin-3B1; prolactin-like

RGD Orthologs

Alliance Genes

More Info

homologs ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	27,426,413 - 27,433,666 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	27,425,830 - 27,433,666 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	27,242,430 - 27,249,683 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	27,241,847 - 27,249,683 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	27,334,299 - 27,341,609 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	27,249,895 - 27,257,205 (+)	NCBI		MGSCv36	mm8
Celera	13	27,469,604 - 27,476,914 (+)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	12.35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (EXP)

1,2-dimethylhydrazine (EXP)

4,4'-sulfonyldiphenol (EXP)

bisphenol A (EXP)

bisphenol F (EXP)

calcium silicate (EXP)

chlorpyrifos (EXP)

crocidolite asbestos (EXP)

dextran sulfate (EXP)

folic acid (EXP)

titanium dioxide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

female pregnancy (IBA)

mammary gland development (IBA)

positive regulation of cell population proliferation (IBA)

positive regulation of lactation (IBA)

positive regulation of receptor signaling pathway via JAK-STAT (IBA)

response to nutrient levels (IBA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IDA,ISO)

Molecular Function

hormone activity (IBA)

prolactin receptor binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	The mouse prolactin gene family locus.	Wiemers DO, etal., Endocrinology 2003 Jan;144(1):313-25.

Additional References at PubMed

PMID:1570305	PMID:2009333	PMID:2612380	PMID:2836164	PMID:3464966	PMID:3859868	PMID:7720652	PMID:7964326	PMID:8060345	PMID:8543912	PMID:8951051	PMID:9356169
PMID:9500551	PMID:9671946	PMID:9716552	PMID:10349636	PMID:10607900	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11456449	PMID:11466198	PMID:11832378	PMID:12477932
PMID:14500757	PMID:15695374	PMID:15963972	PMID:16141072	PMID:16141073	PMID:16579983	PMID:16957025	PMID:17062983	PMID:17177860	PMID:17289015	PMID:17476555	PMID:17576768
PMID:18287559	PMID:18340042	PMID:18662396	PMID:18776147	PMID:18836439	PMID:19307312	PMID:19884348	PMID:20459838	PMID:21084569	PMID:21238448	PMID:21558372	PMID:21677750
PMID:21729874	PMID:21873635	PMID:22193412	PMID:22225908	PMID:22378764	PMID:22967998	PMID:22987638	PMID:23911935	PMID:24391757	PMID:24855001	PMID:24866916	PMID:25446274
PMID:25758223	PMID:25774501	PMID:26476147	PMID:26697363	PMID:26811378	PMID:26862561	PMID:27306493	PMID:27542691	PMID:28708136	PMID:30096149	PMID:30158284	PMID:32244352
PMID:32798765	PMID:32959379	PMID:33884443	PMID:34767447	PMID:34850819	PMID:35377412	PMID:36843585	PMID:38374152

Genomics

Variants

Variants in Prl3b1
351 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	100
Count of miRNA genes:	99
Interacting mature miRNAs:	99
Transcripts:	ENSMUST00000035273
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301255	Cd4ts6_m	CD4 T cell subset 6 (mouse)			Not determined		13	168545	34168684	Mouse
10449140	Eosn2_m	eosinophil differential 2 (mouse)					13	221311	34221311	Mouse
15039338	Nmrs34_m	NAFLD-associated magnetic resonance shift 34 (mouse)					13	221311	34221311	Mouse
1301455	Bmd3_m	bone mineral density 3 (mouse)			Not determined		13	3477612	37477820	Mouse
10045624	Heal24_m	wound healing/regeneration (mouse)			Not determined		13	3477612	37477820	Mouse
10045625	Heal23_m	wound healing/regeneration 23 (mouse)			Not determined		13	3477612	37477820	Mouse
1301367	Twq1_m	testis weight QTL 1 (mouse)			Not determined		13	3615512	37615672	Mouse
1301733	Heal3_m	wound healing/regeneration 3 (mouse)			Not determined		13	3680200	37680343	Mouse
26884393	Humsd7_m	humerus midshaft diameter 7, 16 week (mouse)					13	3950000	76048119	Mouse
1558898	Hpi1_m	hapatic PMN infiltration 1 (mouse)			Not determined		13	4414025	53101640	Mouse
10402494	Igmsc1_m	immunoglobulin M secreting cells 1 (mouse)			Not determined		13	17168545	44918560	Mouse
1301984	Pbd2_m	peak bone density 2 (mouse)			Not determined		13	17189508	38947406	Mouse
1301880	Hypt_m	hypertension (mouse)			Not determined		13	18156792	52156924	Mouse
13463469	Gssq1_m	glomerulosclerosis severity QTL 1 (mouse)					13	19060908	53061050	Mouse
12880423	V25Dq7_m	vitamin D inactive form serum level QTL 7 (mouse)					13	19583983	53583983	Mouse
1301015	Sysbp2_m	systolic blood pressure 2 (mouse)			Not determined		13	20477612	59821605	Mouse
4142147	Mvwf4_m	modifier of von Willebrand factor 4 (mouse)			Not determined			20477612	112898424	Mouse
1357591	Tesq1_m	testis weight QTL 1 (mouse)			Not determined		13	20615512	55720517	Mouse
4142009	Pregq3_m	pregnancy QTL 3 (mouse)			Not determined		13	20615512	72385189	Mouse
10045618	Heal17_m	wound healing/regeneration 17 (mouse)			Not determined		13	20746939	54747056	Mouse
4142489	Ath25_m	atherosclerosis 25 (mouse)			Not determined			25836529	59836529	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_008865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH003190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK005542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK005543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK131667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK167483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL589679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LM644175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M14647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000035273 ⟹ ENSMUSP00000047680

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	27,426,413 - 27,433,666 (+)	Ensembl
GRCm38.p6 Ensembl	13	27,242,430 - 27,249,683 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000225089 ⟹ ENSMUSP00000153139

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	27,425,830 - 27,431,928 (+)	Ensembl
GRCm38.p6 Ensembl	13	27,241,847 - 27,247,945 (+)	Ensembl

RefSeq Acc Id:

NM_008865 ⟹ NP_032891

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	27,426,413 - 27,433,666 (+)	NCBI
GRCm38	13	27,242,430 - 27,249,683 (+)	NCBI
MGSCv37	13	27,334,299 - 27,341,609 (+)	RGD
Celera	13	27,469,604 - 27,476,914 (+)	RGD
cM Map	13		ENTREZGENE

Sequence:

show sequence

AGCACTCGGGGAACAGCAGCCTTCTGGTGTTGTCAGCACTTCAAGAGAACTCCTCAGAGATGAA
GCTGTCTTTGAGTCAACCATGCTCCTTCTCTGGGGCACTCCTGTTGCTGGCAGTGTCAAACCTA
CTTGTCTGGGAGAAGGTGACTTCCTTACCAAATTATCGATTACCCACTGAAAGCCTATACCAAC
GTGTGATTGTGGTGTCACACAACGCCCATGATCTTGCTTCAAAAGCCTTCATGGAATTTGAAAT
GAAGTTTGGTAGGACAGCTTGGACCTATGGCCTGATGTTAAGCCCCTGCCACACTGCTGCAATC
CTTACTCCAGAAAACAGCGAGCAAGTCCACCAGACAACATCGGAAGACCTTCTGAAAGTGTCCA
TCACTATTTTACAAGCCTGGGAAGAGCCTCTGAAACACATGGTGGCAGCAGTGGCTGCTCTTCC
ACATGTACCTGATACTCTGCTGTCAAGAACAAAGGAGTTGGAGGAAAGAATTCAAGGGCTTCTG
GAAGGACTGAAGATCATATTCAATAGGGTTTACCCAGGAGCTGTTGCAAGTGACTATACTTTCT
GGTCTGCATGGTCAGATTTGCAGTCATCTGATGAATCCACTAAGAACAGTGCTCTTAGAACCTT
ATGGCGGTGCGTGCGCAGGGATACACATAAAGTTGACAATTACCTCAAGGTCCTGAAGTGTCGT
GATGTTCATAACAACAACTGCTGAACATCTATCCCTCTTCTCTGTCTCTTAGAAGGTCCCTCGT
GATCTAGACCTTCAAAGCACCAATGAATTTCCCCTTCTTTGGTGCCTTTCTAGATTGAGTTGTC
ATCTTACCCCCAAATAAACTGATTCTTTGCAAATGCTAAATTGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_032891	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA39947	(Get FASTA)	NCBI Sequence Viewer
	AAA75165	(Get FASTA)	NCBI Sequence Viewer
	AAH99386	(Get FASTA)	NCBI Sequence Viewer
	BAB24111	(Get FASTA)	NCBI Sequence Viewer
	BAB24112	(Get FASTA)	NCBI Sequence Viewer
	BAE20754	(Get FASTA)	NCBI Sequence Viewer
	BAE39564	(Get FASTA)	NCBI Sequence Viewer
	CDW51422	(Get FASTA)	NCBI Sequence Viewer
	EDL32445	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000047680
	ENSMUSP00000047680.3
	ENSMUSP00000153139.2
GenBank Protein	P09586	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_032891 ⟸ NM_008865
- Peptide Label:	precursor
- UniProtKB:	P09586 (UniProtKB/Swiss-Prot), Q5SZY3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKLSLSQPCSFSGALLLLAVSNLLVWEKVTSLPNYRLPTESLYQRVIVVSHNAHDLASKAFMEF EMKFGRTAWTYGLMLSPCHTAAILTPENSEQVHQTTSEDLLKVSITILQAWEEPLKHMVAAVAA LPHVPDTLLSRTKELEERIQGLLEGLKIIFNRVYPGAVASDYTFWSAWSDLQSSDESTKNSALR TLWRCVRRDTHKVDNYLKVLKCRDVHNNNC hide sequence

RefSeq Acc Id:

ENSMUSP00000153139 ⟸ ENSMUST00000225089

RefSeq Acc Id:

ENSMUSP00000047680 ⟸ ENSMUST00000035273

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P09586-F1-model_v2	AlphaFold	P09586	1-222	view protein structure

Promoters

RGD ID:

8679930

Promoter ID:

EPDNEW_M17996

Type:

multiple initiation site

Name:

Prl3b1_1

Description:

Mus musculus prolactin family 3, subfamily b, member 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	13	27,242,430 - 27,242,490	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:97607	AgrOrtholog
Ensembl Genes	ENSMUSG00000038891	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000035273	ENTREZGENE
	ENSMUST00000035273.4	UniProtKB/Swiss-Prot
	ENSMUST00000225089.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	4_helix_cytokine-like_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Somatotropin/Prolactin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Somatotropin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:18776	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:97607	ENTREZGENE
NCBI Gene	18776	ENTREZGENE
PANTHER	PROLACTIN-3B1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11417	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Hormone_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Prl3b1	PhenoGen
PRINTS	SOMATOTROPIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SOMATOTROPIN_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOMATOTROPIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47266	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A286YCU9_MOUSE	UniProtKB/TrEMBL
	P09586	ENTREZGENE, UniProtKB/Swiss-Prot
	Q5SZY3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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