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Gene: Lrpap1 (low density lipoprotein receptor-related protein associated protein 1) Mus musculus
Symbol: Lrpap1
Name: low density lipoprotein receptor-related protein associated protein 1
Description: Exhibits low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Predicted to localize to several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; egg cylinder; foregut; genitourinary system; and lung. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1); PARTICIPATES IN Hedgehog signaling pathway; Reelin signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA617339; AI790446; alpha-2-macroglobulin receptor-associated protein; alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-MRAP); Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44); alpha-2-MRAP; AU042172; C77774; HBP-44; HBP44; heparin-binding protein 44; low density lipoprotein receptor related protein, associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; RAP
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl535,091,501 - 35,105,766 (-)EnsemblGRCm38mm10GRCm38
GRCm38535,091,490 - 35,105,699 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37535,434,155 - 35,448,346 (-)NCBIGRCm37mm9NCBIm37
MGSCv36535,408,367 - 35,422,558 (-)NCBImm8
Celera532,566,121 - 32,580,312 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map518.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lrpap1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732762
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.