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Gene: Lrpap1 (low density lipoprotein receptor-related protein associated protein 1) Mus musculus
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Symbol: Lrpap1
Name: low density lipoprotein receptor-related protein associated protein 1
Description: Exhibits low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Predicted to localize to several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; egg cylinder; foregut; genitourinary system; and lung. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1); PARTICIPATES IN Hedgehog signaling pathway; Reelin signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA617339; AI790446; alpha-2-macroglobulin receptor-associated protein; alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-MRAP); Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44); alpha-2-MRAP; AU042172; C77774; HBP-44; HBP44; heparin-binding protein 44; low density lipoprotein receptor related protein, associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; RAP
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl535,091,501 - 35,105,766 (-)EnsemblGRCm38mm10GRCm38
GRCm38535,091,490 - 35,105,699 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37535,434,155 - 35,448,346 (-)NCBIGRCm37mm9NCBIm37
MGSCv36535,408,367 - 35,422,558 (-)NCBImm8
Celera532,566,121 - 32,580,312 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map518.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lrpap1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732762
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.