TKT (transketolase) - Rat Genome Database

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Gene: TKT (transketolase) Homo sapiens
Analyze
Symbol: TKT
Name: transketolase
RGD ID: 732645
HGNC Page HGNC
Description: Enables metal ion binding activity; protein homodimerization activity; and transketolase activity. Involved in glyceraldehyde-3-phosphate biosynthetic process and pentose-phosphate shunt. Located in nuclear body.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis luminal protein 107; epididymis secretory protein Li 48; FLJ34765; HEL-S-48; HEL107; SDDHD; TK; TKT1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl353,224,712 - 53,256,052 (-)EnsemblGRCh38hg38GRCh38
GRCh38353,224,712 - 53,256,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37353,258,728 - 53,290,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,234,704 - 53,264,998 (-)NCBINCBI36hg18NCBI36
Build 34353,234,705 - 53,264,998NCBI
Celera353,225,747 - 53,257,192 (-)NCBI
Cytogenetic Map3p21.1NCBI
HuRef353,308,475 - 53,339,480 (-)NCBIHuRef
CHM1_1353,210,297 - 53,241,712 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
astaxanthin  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
benfotiamine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
butan-1-ol  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
felbamate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
gabapentin  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydroquinone  (EXP)
imidacloprid  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
lead(II) chloride  (EXP)
levofloxacin  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
mercury dibromide  (EXP)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
morphine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (ISO)
thimerosal  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trovafloxacin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1486804   PMID:2495942   PMID:8125298   PMID:8419340   PMID:8850526   PMID:8969223   PMID:9115179   PMID:9357955   PMID:9611778   PMID:11736629   PMID:11788595   PMID:12477932  
PMID:12665801   PMID:14702039   PMID:14702098   PMID:15302935   PMID:15489334   PMID:15592455   PMID:15952740   PMID:16009940   PMID:16289162   PMID:16712791   PMID:16916647   PMID:17353931  
PMID:18029348   PMID:18676363   PMID:19056867   PMID:19110265   PMID:19190083   PMID:19738201   PMID:20000738   PMID:20360068   PMID:20458337   PMID:20471030   PMID:20562859   PMID:20667822  
PMID:20826743   PMID:21044950   PMID:21076409   PMID:21081666   PMID:21145461   PMID:21150319   PMID:21319273   PMID:21555518   PMID:21873635   PMID:22268729   PMID:22645655   PMID:22939629  
PMID:22944692   PMID:23118983   PMID:23261987   PMID:23376485   PMID:23414517   PMID:23492569   PMID:23533145   PMID:23874603   PMID:24114639   PMID:24816252   PMID:24981175   PMID:24981860  
PMID:25192599   PMID:25693804   PMID:25852190   PMID:25895698   PMID:25921289   PMID:25940091   PMID:25959826   PMID:25963833   PMID:26344197   PMID:26485645   PMID:26496610   PMID:26499835  
PMID:26618866   PMID:26641092   PMID:26687479   PMID:26760575   PMID:26811478   PMID:26831064   PMID:26871637   PMID:27103086   PMID:27248496   PMID:27259054   PMID:27342126   PMID:27381654  
PMID:27512140   PMID:27751915   PMID:27760737   PMID:28302793   PMID:28330616   PMID:28378594   PMID:28514442   PMID:28515276   PMID:28533407   PMID:28581483   PMID:28675297   PMID:28685749  
PMID:28700943   PMID:29128334   PMID:29162697   PMID:29229926   PMID:29449217   PMID:29467282   PMID:29507755   PMID:29564676   PMID:30110629   PMID:30397336   PMID:30455355   PMID:30463901  
PMID:30575818   PMID:30659097   PMID:30809309   PMID:30948266   PMID:31046837   PMID:31067453   PMID:31091453   PMID:31186535   PMID:31280863   PMID:31300519   PMID:31415630   PMID:31424204  
PMID:31436131   PMID:31501420   PMID:31536960   PMID:31586073   PMID:31594818   PMID:31646581   PMID:31949131   PMID:32347575   PMID:32416067   PMID:32529326   PMID:32659474   PMID:32694731  
PMID:32807901   PMID:32814769   PMID:32828637   PMID:32941674   PMID:33022573   PMID:33024031   PMID:33567341   PMID:33916271   PMID:33961781   PMID:34079125   PMID:34161071  


Genomics

Comparative Map Data
TKT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl353,224,712 - 53,256,052 (-)EnsemblGRCh38hg38GRCh38
GRCh38353,224,712 - 53,256,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37353,258,728 - 53,290,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,234,704 - 53,264,998 (-)NCBINCBI36hg18NCBI36
Build 34353,234,705 - 53,264,998NCBI
Celera353,225,747 - 53,257,192 (-)NCBI
Cytogenetic Map3p21.1NCBI
HuRef353,308,475 - 53,339,480 (-)NCBIHuRef
CHM1_1353,210,297 - 53,241,712 (-)NCBICHM1_1
Tkt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,271,088 - 30,296,681 (+)NCBIGRCm39mm39
GRCm39 Ensembl1430,270,316 - 30,296,677 (+)Ensembl
GRCm381430,549,131 - 30,574,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,548,359 - 30,574,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,362,335 - 31,387,908 (+)NCBIGRCm37mm9NCBIm37
MGSCv361429,378,158 - 29,403,731 (+)NCBImm8
Celera1426,805,317 - 26,830,435 (+)NCBICelera
Cytogenetic Map14BNCBI
Tkt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2165,723,764 - 5,748,702 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl165,723,762 - 5,748,698 (+)Ensembl
Rnor_6.0166,609,670 - 6,634,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,609,668 - 6,634,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,543,529 - 6,568,467 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,908,759 - 5,933,695 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1165,908,756 - 5,933,689 (+)NCBI
Celera169,440,328 - 9,465,209 (-)NCBICelera
Cytogenetic Map16p16NCBI
Tkt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554303,178,830 - 3,193,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554303,178,830 - 3,193,241 (-)NCBIChiLan1.0ChiLan1.0
TKT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1354,389,549 - 54,420,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl354,389,549 - 54,420,704 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0353,168,426 - 53,199,003 (-)NCBIMhudiblu_PPA_v0panPan3
TKT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12036,690,540 - 36,705,980 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2036,681,531 - 36,742,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2036,617,359 - 36,642,352 (+)NCBI
ROS_Cfam_1.02036,959,138 - 36,984,142 (+)NCBI
UMICH_Zoey_3.12036,395,903 - 36,420,888 (+)NCBI
UNSW_CanFamBas_1.02036,757,580 - 36,782,577 (+)NCBI
UU_Cfam_GSD_1.02036,972,262 - 36,997,252 (+)NCBI
Tkt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,812,273 - 170,840,216 (-)NCBI
SpeTri2.0NW_0049364733,950,846 - 3,978,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TKT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1335,348,912 - 35,377,580 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,348,921 - 35,377,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,418,457 - 38,447,124 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TKT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,620,340 - 14,650,694 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,620,287 - 14,650,655 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041152,245,198 - 152,275,549 (+)NCBIVero_WHO_p1.0
Tkt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248223,989,292 - 4,014,150 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH79674  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,259,703 - 53,259,943UniSTSGRCh37
Build 36353,234,743 - 53,234,983RGDNCBI36
Celera353,226,727 - 53,226,967RGD
Cytogenetic Map3p14.3UniSTS
HuRef353,309,455 - 53,309,695UniSTS
GeneMap99-GB4 RH Map3164.44UniSTS
SHGC-147747  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,265,947 - 53,266,285UniSTSGRCh37
Build 36353,240,987 - 53,241,325RGDNCBI36
Celera353,232,974 - 53,233,312RGD
Cytogenetic Map3p14.3UniSTS
TNG Radiation Hybrid Map333164.0UniSTS
SHGC-57226  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,258,758 - 53,259,089UniSTSGRCh37
Build 36353,233,798 - 53,234,129RGDNCBI36
Celera353,225,782 - 53,226,113RGD
Cytogenetic Map3p14.3UniSTS
HuRef353,308,510 - 53,308,841UniSTS
TNG Radiation Hybrid Map333168.0UniSTS
MARC_13462-13463:1002299004:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37353,262,357 - 53,263,345UniSTSGRCh37
Build 36353,237,397 - 53,238,385RGDNCBI36
Celera353,229,382 - 53,230,370RGD
HuRef353,312,084 - 53,313,072UniSTS
WI-18916  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p14.3UniSTS
GeneMap99-GB4 RH Map3161.69UniSTS
Whitehead-RH Map3216.3UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5541
Count of miRNA genes:1101
Interacting mature miRNAs:1434
Transcripts:ENST00000296289, ENST00000423516, ENST00000423525, ENST00000450814, ENST00000460243, ENST00000460343, ENST00000461139, ENST00000462138, ENST00000466765, ENST00000469678, ENST00000472528, ENST00000483706, ENST00000487660, ENST00000494523
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 61 61 1 1
Medium 2437 2734 1669 567 1879 408 3870 1530 3719 416 1459 1613 175 1 1204 2301 6 2
Low 2 196 57 57 11 57 487 667 14 3 487
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_027815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001135055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001258028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_047580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011534055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC247043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE504944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ430230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA421169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB139769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB503248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC406010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU794667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ472197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U55017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000296289   ⟹   ENSP00000296289
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,225,659 - 53,256,013 (-)Ensembl
RefSeq Acc Id: ENST00000423516   ⟹   ENSP00000391481
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,225,657 - 53,256,022 (-)Ensembl
RefSeq Acc Id: ENST00000423525   ⟹   ENSP00000405455
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,224,714 - 53,256,000 (-)Ensembl
RefSeq Acc Id: ENST00000450814   ⟹   ENSP00000413503
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,225,657 - 53,256,022 (-)Ensembl
RefSeq Acc Id: ENST00000460243
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,228,681 - 53,229,437 (-)Ensembl
RefSeq Acc Id: ENST00000460343
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,225,652 - 53,235,607 (-)Ensembl
RefSeq Acc Id: ENST00000461139
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,225,657 - 53,232,299 (-)Ensembl
RefSeq Acc Id: ENST00000462138   ⟹   ENSP00000417773
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,224,712 - 53,256,022 (-)Ensembl
RefSeq Acc Id: ENST00000466765
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,232,760 - 53,235,160 (-)Ensembl
RefSeq Acc Id: ENST00000469678   ⟹   ENSP00000418340
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,225,702 - 53,255,974 (-)Ensembl
RefSeq Acc Id: ENST00000472528   ⟹   ENSP00000417312
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,231,454 - 53,255,987 (-)Ensembl
RefSeq Acc Id: ENST00000483706
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,241,895 - 53,256,052 (-)Ensembl
RefSeq Acc Id: ENST00000487660
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,234,852 - 53,242,199 (-)Ensembl
RefSeq Acc Id: ENST00000494523
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl353,231,460 - 53,235,019 (-)Ensembl
RefSeq Acc Id: NM_001064   ⟹   NP_001055
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,224,712 - 53,256,022 (-)NCBI
GRCh37353,258,723 - 53,290,130 (-)ENTREZGENE
Build 36353,234,704 - 53,264,998 (-)NCBI Archive
HuRef353,308,475 - 53,339,480 (-)ENTREZGENE
CHM1_1353,211,226 - 53,241,712 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001135055   ⟹   NP_001128527
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,224,712 - 53,256,022 (-)NCBI
GRCh37353,258,723 - 53,290,130 (-)ENTREZGENE
HuRef353,308,475 - 53,339,480 (-)ENTREZGENE
CHM1_1353,210,297 - 53,241,712 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001258028   ⟹   NP_001244957
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,224,712 - 53,256,022 (-)NCBI
GRCh37353,258,723 - 53,290,130 (-)NCBI
HuRef353,308,475 - 53,339,480 (-)NCBI
CHM1_1353,211,226 - 53,241,712 (-)NCBI
Sequence:
RefSeq Acc Id: NR_047580
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,224,712 - 53,256,022 (-)NCBI
GRCh37353,258,723 - 53,290,130 (-)NCBI
HuRef353,308,475 - 53,339,480 (-)NCBI
CHM1_1353,211,226 - 53,241,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011534054   ⟹   XP_011532356
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,224,712 - 53,256,052 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011534055   ⟹   XP_011532357
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,225,648 - 53,256,022 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001055 (Get FASTA)   NCBI Sequence Viewer  
  NP_001128527 (Get FASTA)   NCBI Sequence Viewer  
  NP_001244957 (Get FASTA)   NCBI Sequence Viewer  
  XP_011532356 (Get FASTA)   NCBI Sequence Viewer  
  XP_011532357 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA61222 (Get FASTA)   NCBI Sequence Viewer  
  AAA98961 (Get FASTA)   NCBI Sequence Viewer  
  AAH02433 (Get FASTA)   NCBI Sequence Viewer  
  AAH08615 (Get FASTA)   NCBI Sequence Viewer  
  AAH09970 (Get FASTA)   NCBI Sequence Viewer  
  AAH24026 (Get FASTA)   NCBI Sequence Viewer  
  ACJ13721 (Get FASTA)   NCBI Sequence Viewer  
  ACV87172 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33819 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33820 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33821 (Get FASTA)   NCBI Sequence Viewer  
  BAD97334 (Get FASTA)   NCBI Sequence Viewer  
  BAF82143 (Get FASTA)   NCBI Sequence Viewer  
  BAG51860 (Get FASTA)   NCBI Sequence Viewer  
  BAG52746 (Get FASTA)   NCBI Sequence Viewer  
  BAG56942 (Get FASTA)   NCBI Sequence Viewer  
  BAG62803 (Get FASTA)   NCBI Sequence Viewer  
  BAG64284 (Get FASTA)   NCBI Sequence Viewer  
  CAA47919 (Get FASTA)   NCBI Sequence Viewer  
  CAE46212 (Get FASTA)   NCBI Sequence Viewer  
  EAW65281 (Get FASTA)   NCBI Sequence Viewer  
  EAW65282 (Get FASTA)   NCBI Sequence Viewer  
  P29401 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001128527   ⟸   NM_001135055
- Peptide Label: isoform 1
- UniProtKB: P29401 (UniProtKB/Swiss-Prot),   V9HWD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001055   ⟸   NM_001064
- Peptide Label: isoform 1
- UniProtKB: P29401 (UniProtKB/Swiss-Prot),   V9HWD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001244957   ⟸   NM_001258028
- Peptide Label: isoform 2
- UniProtKB: P29401 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011532356   ⟸   XM_011534054
- Peptide Label: isoform X1
- UniProtKB: P29401 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011532357   ⟸   XM_011534055
- Peptide Label: isoform X2
- UniProtKB: A0A0B4J1R6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000405455   ⟸   ENST00000423525
RefSeq Acc Id: ENSP00000391481   ⟸   ENST00000423516
RefSeq Acc Id: ENSP00000413503   ⟸   ENST00000450814
RefSeq Acc Id: ENSP00000296289   ⟸   ENST00000296289
RefSeq Acc Id: ENSP00000418340   ⟸   ENST00000469678
RefSeq Acc Id: ENSP00000417312   ⟸   ENST00000472528
RefSeq Acc Id: ENSP00000417773   ⟸   ENST00000462138
Protein Domains
Transket_pyr   TRANSKETOLASE_1

Promoters
RGD ID:6801781
Promoter ID:HG_KWN:45285
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:UC003DGP.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,239,211 - 53,240,637 (-)MPROMDB
RGD ID:6812432
Promoter ID:HG_ACW:54059
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:TKT.JAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,251,301 - 53,251,801 (-)MPROMDB
RGD ID:6864736
Promoter ID:EPDNEW_H5533
Type:initiation region
Name:TKT_1
Description:transketolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38353,256,022 - 53,256,082EPDNEW
RGD ID:6801779
Promoter ID:HG_KWN:45286
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001064,   NM_001135055,   UC010HMU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36353,264,701 - 53,265,201 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3
pathogenic
NM_001135055.2(TKT):c.133G>A (p.Ala45Thr) single nucleotide variant not specified [RCV000255739] Chr3:53242217 [GRCh38]
Chr3:53276233 [GRCh37]
Chr3:3p21.1
uncertain significance
GRCh38/hg38 3p21.2-14.3(chr3:51394434-55064449)x1 copy number loss See cases [RCV000143631] Chr3:51394434..55064449 [GRCh38]
Chr3:51431865..55098476 [GRCh37]
Chr3:51406905..55073516 [NCBI36]
Chr3:3p21.2-14.3
likely pathogenic
NM_001064.4(TKT):c.633G>A (p.Trp211Ter) single nucleotide variant Short stature, developmental delay, and congenital heart defects [RCV000236892] Chr3:53233271 [GRCh38]
Chr3:53267287 [GRCh37]
Chr3:3p21.1
pathogenic
NM_001064.4(TKT):c.769_770insCTACCTCCTTATCTTCTG (p.Trp257delinsSerThrSerLeuSerSerGly) insertion not provided [RCV000210782] Chr3:53231529..53231530 [GRCh38]
Chr3:53265545..53265546 [GRCh37]
Chr3:3p21.1
pathogenic
NM_001064.4(TKT):c.952C>T (p.Arg318Cys) single nucleotide variant Short stature, developmental delay, and congenital heart defects [RCV000235885] Chr3:53230612 [GRCh38]
Chr3:53264628 [GRCh37]
Chr3:3p21.1
pathogenic
NM_001135055.2:c.769_770insCTACCTCCTTATCTTCTG insertion Short stature, developmental delay, and congenital heart defects [RCV000236308]|not provided [RCV000210782] Chr3:53231529..53231530 [GRCh38]
Chr3:53265545..53265546 [GRCh37]
Chr3:3p21.1
pathogenic
GRCh37/hg19 3p21.2-14.2(chr3:52086599-59689209)x1 copy number loss See cases [RCV000239886] Chr3:52086599..59689209 [GRCh37]
Chr3:3p21.2-14.2
pathogenic
NM_001064.4(TKT):c.339+3A>C single nucleotide variant not provided [RCV000514273] Chr3:53241129 [GRCh38]
Chr3:53275145 [GRCh37]
Chr3:3p21.1
benign|likely benign
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_001064.4(TKT):c.898A>C (p.Asn300His) single nucleotide variant not provided [RCV000514637] Chr3:53231401 [GRCh38]
Chr3:53265417 [GRCh37]
Chr3:3p21.1
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_001064.4(TKT):c.393C>T (p.Ala131=) single nucleotide variant not provided [RCV000958672] Chr3:53240295 [GRCh38]
Chr3:53274311 [GRCh37]
Chr3:3p21.1
benign
NM_001064.4(TKT):c.1306A>G (p.Met436Val) single nucleotide variant not provided [RCV000971697] Chr3:53229096 [GRCh38]
Chr3:53263112 [GRCh37]
Chr3:3p21.1
benign
NM_001064.4(TKT):c.1383C>G (p.Ala461=) single nucleotide variant not provided [RCV000899180] Chr3:53229019 [GRCh38]
Chr3:53263035 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.354C>T (p.Thr118=) single nucleotide variant not provided [RCV000925620] Chr3:53240334 [GRCh38]
Chr3:53274350 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.81C>T (p.Ile27=) single nucleotide variant not provided [RCV000915963] Chr3:53255862 [GRCh38]
Chr3:53289878 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.630-9T>C single nucleotide variant not provided [RCV000885054] Chr3:53233283 [GRCh38]
Chr3:53267299 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.1353C>T (p.Gly451=) single nucleotide variant not provided [RCV000925298] Chr3:53229049 [GRCh38]
Chr3:53263065 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.1272C>T (p.Asp424=) single nucleotide variant not provided [RCV000940344] Chr3:53229130 [GRCh38]
Chr3:53263146 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.848A>T (p.Lys283Met) single nucleotide variant not provided [RCV000881326] Chr3:53231451 [GRCh38]
Chr3:53265467 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.629+9G>A single nucleotide variant not provided [RCV000928576] Chr3:53234974 [GRCh38]
Chr3:53268990 [GRCh37]
Chr3:3p21.1
likely benign
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1
pathogenic
NM_001064.4(TKT):c.1790A>G (p.Lys597Arg) single nucleotide variant not provided [RCV000892819] Chr3:53225838 [GRCh38]
Chr3:53259854 [GRCh37]
Chr3:3p21.1
benign
NM_001064.4(TKT):c.1782A>G (p.Arg594=) single nucleotide variant not provided [RCV000893734] Chr3:53225846 [GRCh38]
Chr3:53259862 [GRCh37]
Chr3:3p21.1
benign
NM_001064.4(TKT):c.541A>G (p.Ile181Val) single nucleotide variant Short stature, developmental delay, and congenital heart defects [RCV001336237]|not provided [RCV000958528] Chr3:53235071 [GRCh38]
Chr3:53269087 [GRCh37]
Chr3:3p21.1
likely benign|uncertain significance
NM_014053.4(FLVCR1):c.663C>T (p.Pro221=) single nucleotide variant not provided [RCV001648206] Chr3:53235147 [GRCh38]
Chr3:53269163 [GRCh37]
Chr3:3p21.1
benign
null single nucleotide variant not provided [RCV001674754] Chr3:53235030 [GRCh38]
Chr3:53269046 [GRCh37]
Chr3:3p21.1
benign
NM_001064.4(TKT):c.1539C>G (p.His513Gln) single nucleotide variant not provided [RCV000953475] Chr3:53228090 [GRCh38]
Chr3:53262106 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.737G>A (p.Arg246Gln) single nucleotide variant not provided [RCV000954398] Chr3:53233167 [GRCh38]
Chr3:53267183 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.600C>A (p.Asp200Glu) single nucleotide variant not provided [RCV000954399] Chr3:53235012 [GRCh38]
Chr3:53269028 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.1227C>T (p.Asn409=) single nucleotide variant not provided [RCV000969013] Chr3:53229317 [GRCh38]
Chr3:53263333 [GRCh37]
Chr3:3p21.1
benign
NM_001064.4(TKT):c.129C>T (p.Ser43=) single nucleotide variant not provided [RCV000924778] Chr3:53242221 [GRCh38]
Chr3:53276237 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.1170A>G (p.Ala390=) single nucleotide variant not provided [RCV000933495] Chr3:53229374 [GRCh38]
Chr3:53263390 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.1284G>A (p.Gln428=) single nucleotide variant not provided [RCV000890441] Chr3:53229118 [GRCh38]
Chr3:53263134 [GRCh37]
Chr3:3p21.1
likely benign
NM_001064.4(TKT):c.1209C>G (p.Ala403=) single nucleotide variant not provided [RCV000889931] Chr3:53229335 [GRCh38]
Chr3:53263351 [GRCh37]
Chr3:3p21.1
benign
NM_001064.4(TKT):c.1531dup (p.Thr511fs) duplication Short stature, developmental delay, and congenital heart defects [RCV001336235] Chr3:53228097..53228098 [GRCh38]
Chr3:53262113..53262114 [GRCh37]
Chr3:3p21.1
pathogenic
NM_001064.4(TKT):c.1540G>A (p.Glu514Lys) single nucleotide variant Short stature, developmental delay, and congenital heart defects [RCV001336236] Chr3:53228089 [GRCh38]
Chr3:53262105 [GRCh37]
Chr3:3p21.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11834 AgrOrtholog
COSMIC TKT COSMIC
Ensembl Genes ENSG00000163931 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000296289 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000391481 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000405455 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000413503 UniProtKB/TrEMBL
  ENSP00000417312 UniProtKB/TrEMBL
  ENSP00000417773 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000418340 UniProtKB/TrEMBL
Ensembl Transcript ENST00000296289 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000423516 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000423525 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000450814 UniProtKB/TrEMBL
  ENST00000462138 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000469678 UniProtKB/TrEMBL
  ENST00000472528 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000163931 GTEx
HGNC ID HGNC:11834 ENTREZGENE
Human Proteome Map TKT Human Proteome Map
InterPro THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketo_C/PFOR_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7086 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7086 ENTREZGENE
OMIM 606781 OMIM
  617044 OMIM
Pfam Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36537 PharmGKB
PROSITE TRANSKETOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSKETOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0B4J1R6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2Z4T2_HUMAN UniProtKB/TrEMBL
  A0A0S2Z5C0_HUMAN UniProtKB/TrEMBL
  E9PFF2_HUMAN UniProtKB/TrEMBL
  F8W888_HUMAN UniProtKB/TrEMBL
  F8WAX4_HUMAN UniProtKB/TrEMBL
  P29401 ENTREZGENE, UniProtKB/Swiss-Prot
  V9HWD9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A024R2Z9 UniProtKB/TrEMBL
  A8K089 UniProtKB/Swiss-Prot
  B4DE31 UniProtKB/Swiss-Prot
  E7EPA7 UniProtKB/Swiss-Prot
  Q8TBA3 UniProtKB/Swiss-Prot
  Q96HH3 UniProtKB/Swiss-Prot