Symbol:
Acmsd
Name:
amino carboxymuconate semialdehyde decarboxylase
Description:
Predicted to have aminocarboxymuconate-semialdehyde decarboxylase activity and zinc ion binding activity. Predicted to be involved in aging; carboxylic acid metabolic process; and negative regulation of quinolinate biosynthetic process. Predicted to localize to the cytosol. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ACMSD (aminocarboxymuconate semialdehyde decarboxylase) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Acmsd (aminocarboxymuconate semialdehyde decarboxylase) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Acmsd (aminocarboxymuconate semialdehyde decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ACMSD (aminocarboxymuconate semialdehyde decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ACMSD (aminocarboxymuconate semialdehyde decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Acmsd (aminocarboxymuconate semialdehyde decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ACMSD (aminocarboxymuconate semialdehyde decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Acmsd (aminocarboxymuconate semialdehyde decarboxylase)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
ACMSD (aminocarboxymuconate semialdehyde decarboxylase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
acmsd (aminocarboxymuconate semialdehyde decarboxylase)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, ZFIN)
Caenorhabditis elegans (roundworm):
acsd-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 1 127,729,413 - 127,767,564 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 1 129,625,990 - 129,664,141 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 1 129,556,959 - 129,595,110 (+) NCBI mm8 Celera 1 130,370,820 - 130,409,013 (+) NCBI Celera Cytogenetic Map 1 E3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
(+)-schisandrin B multiple interactions ISO RGD:620868 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ACMSD mRNA] CTD PMID:31150632 1-nitropropane increases expression ISO RGD:620868 6480464 1-nitropropane results in increased expression of ACMSD mRNA CTD PMID:17070881 17beta-estradiol decreases expression ISO RGD:732597 6480464 Estradiol results in decreased expression of ACMSD mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ACMSD mRNA CTD PMID:21889950 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:620868 6480464 Tetrachlorodibenzodioxin results in decreased expression of ACMSD mRNA CTD PMID:21215274 2,4-diaminotoluene decreases expression ISO RGD:620868 6480464 2, 4-diaminotoluene results in decreased expression of ACMSD mRNA CTD PMID:17070881 2,6-diaminotoluene increases expression ISO RGD:620868 6480464 2, 6-diaminotoluene results in increased expression of ACMSD mRNA CTD PMID:17070881 2-acetamidofluorene decreases expression ISO RGD:620868 6480464 2-Acetylaminofluorene results in decreased expression of ACMSD mRNA CTD PMID:17070881 2-nitro-p-phenylenediamine decreases expression ISO RGD:620868 6480464 2-nitro-4-phenylenediamine results in decreased expression of ACMSD mRNA CTD PMID:17070881 2-nitropropane decreases expression ISO RGD:620868 6480464 2-nitropropane results in decreased expression of ACMSD mRNA CTD PMID:17070881 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases activity ISO RGD:620868 6480464 Puromycin Aminonucleoside results in decreased activity of ACMSD protein CTD PMID:16711654 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid multiple interactions ISO RGD:620868 6480464 MK-886 inhibits the reaction [pirinixic acid results in decreased expression of ACMSD mRNA] CTD PMID:18320257 4-acetylaminofluorene increases expression ISO RGD:620868 6480464 4-acetylaminofluorene results in increased expression of ACMSD mRNA CTD PMID:17070881 4-nitro-1,2-phenylenediamine decreases expression ISO RGD:620868 6480464 1, 2-diamino-4-nitrobenzene results in decreased expression of ACMSD mRNA CTD PMID:17070881 acrylamide decreases expression ISO RGD:620868 6480464 Acrylamide results in decreased expression of ACMSD mRNA CTD PMID:28959563 adenine decreases activity ISO RGD:620868 6480464 Adenine results in decreased activity of ACMSD protein CTD PMID:11758903 aflatoxin B1 affects expression ISO RGD:732597 6480464 Aflatoxin B1 affects the expression of ACMSD protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:732597 6480464 Aflatoxin B1 results in decreased methylation of ACMSD gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:732597 6480464 Aflatoxin B1 results in decreased expression of ACMSD mRNA CTD PMID:22100608 , PMID:27153756 ammonium chloride affects expression ISO RGD:620868 6480464 Ammonium Chloride affects the expression of ACMSD mRNA CTD PMID:16483693 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of ACMSD mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:620868 6480464 [Diethylhexyl Phthalate results in decreased activity of ACMSD protein] which results in increased abundance of Niacin CTD PMID:12036039 bis(2-ethylhexyl) phthalate decreases activity ISO RGD:620868 6480464 Diethylhexyl Phthalate results in decreased activity of ACMSD protein CTD PMID:12036039 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ACMSD mRNA] CTD PMID:19850644 bisphenol A decreases expression ISO RGD:620868 6480464 bisphenol A results in decreased expression of ACMSD mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of ACMSD promoter CTD PMID:27312807 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of ACMSD mRNA, Nanotubes, Carbon results in decreased expression of ACMSD mRNA CTD PMID:25620056 cefaloridine decreases expression ISO RGD:620868 6480464 Cephaloridine results in decreased expression of ACMSD mRNA CTD PMID:18500788 chlorpyrifos increases expression ISO RGD:620868 6480464 Chlorpyrifos results in increased expression of ACMSD mRNA CTD PMID:21968025 clofibric acid affects expression ISO RGD:620868 6480464 Clofibric Acid affects the expression of ACMSD mRNA CTD PMID:17602206 clofibric acid multiple interactions ISO RGD:620868 6480464 [Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of ACMSD mRNA CTD PMID:15833021 clofibric acid decreases expression ISO RGD:620868 6480464 Clofibric Acid results in decreased expression of ACMSD mRNA CTD PMID:15833021 cyclosporin A decreases expression ISO RGD:732597 6480464 Cyclosporine results in decreased expression of ACMSD mRNA CTD PMID:20106945 , PMID:27989131 diazinon increases expression ISO RGD:620868 6480464 Diazinon results in increased expression of ACMSD mRNA CTD PMID:21968025 dibutyl phthalate multiple interactions ISO RGD:620868 6480464 Dibutyl Phthalate affects the reaction [ACMSD protein affects the abundance of Niacin] CTD PMID:12036039 furan increases expression EXP 6480464 furan results in increased expression of ACMSD mRNA CTD PMID:24183702 furan increases expression ISO RGD:620868 6480464 furan results in increased expression of ACMSD mRNA CTD PMID:26194646 gentamycin decreases expression ISO RGD:620868 6480464 Gentamicins results in decreased expression of ACMSD protein CTD PMID:21081137 , PMID:22061828 hydroquinone O-beta-D-glucopyranoside decreases expression ISO RGD:732597 6480464 Arbutin results in decreased expression of ACMSD mRNA CTD PMID:17103032 kojic acid decreases expression ISO RGD:732597 6480464 kojic acid results in decreased expression of ACMSD mRNA CTD PMID:16595896 linoleic acid decreases expression ISO RGD:620868 6480464 Linoleic Acid results in decreased expression of ACMSD mRNA CTD PMID:18320257 N-nitrosodiethylamine multiple interactions ISO RGD:620868 6480464 [Clofibric Acid co-treated with Diethylnitrosamine] results in decreased expression of ACMSD mRNA CTD PMID:15833021 NAD zwitterion increases abundance ISO RGD:620868 6480464 ACMSD protein results in increased abundance of NAD CTD PMID:17896587 NAD(+) increases abundance ISO RGD:620868 6480464 ACMSD protein results in increased abundance of NAD CTD PMID:17896587 nicotinic acid affects abundance ISO RGD:620868 6480464 ACMSD protein affects the abundance of Niacin CTD PMID:12036039 nicotinic acid multiple interactions ISO RGD:620868 6480464 [Diethylhexyl Phthalate results in decreased activity of ACMSD protein] which results in increased abundance of Niacin, Dibutyl Phthalate affects the reaction [ACMSD protein affects the abundance of Niacin] CTD PMID:12036039 paracetamol decreases expression ISO RGD:732597 6480464 Acetaminophen results in decreased expression of ACMSD mRNA CTD PMID:29067470 pentanal decreases expression ISO RGD:732597 6480464 pentanal results in decreased expression of ACMSD mRNA CTD PMID:26079696 pirinixic acid multiple interactions EXP 6480464 HNF4A protein affects the reaction [pirinixic acid results in decreased expression of ACMSD mRNA] more ... CTD PMID:16807375 pirinixic acid decreases expression ISO RGD:620868 6480464 pirinixic acid results in decreased expression of ACMSD mRNA CTD PMID:17164430 , PMID:18320257 pirinixic acid multiple interactions ISO RGD:620868 6480464 MK-886 inhibits the reaction [pirinixic acid results in decreased expression of ACMSD mRNA] CTD PMID:18320257 pirinixic acid decreases activity EXP 6480464 pirinixic acid results in decreased activity of ACMSD mRNA CTD PMID:16807375 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of ACMSD mRNA CTD PMID:16807375 propanal decreases expression ISO RGD:732597 6480464 propionaldehyde results in decreased expression of ACMSD mRNA CTD PMID:26079696 pyrazine-2-carboxylic acid decreases activity ISO RGD:620868 6480464 pyrazinoic acid metabolite results in decreased activity of ACMSD protein CTD PMID:12224625 quinolinic acid affects abundance ISO RGD:620868 6480464 ACMSD protein affects the abundance of Quinolinic Acid CTD PMID:17896587 resveratrol increases expression ISO RGD:620868 6480464 resveratrol results in increased expression of ACMSD mRNA CTD PMID:25905778 rotenone affects expression ISO RGD:620868 6480464 Rotenone affects the expression of ACMSD mRNA CTD PMID:28374803 silicon dioxide decreases expression ISO RGD:732597 6480464 Silicon Dioxide analog results in decreased expression of ACMSD mRNA CTD PMID:25895662 sodium arsenite decreases expression ISO RGD:732597 6480464 sodium arsenite results in decreased expression of ACMSD mRNA CTD PMID:29301061 streptozocin increases activity ISO RGD:620868 6480464 Streptozocin results in increased activity of ACMSD protein CTD PMID:12042425 streptozocin increases expression ISO RGD:620868 6480464 Streptozocin results in increased expression of ACMSD mRNA CTD PMID:12042425 Tesaglitazar decreases expression ISO RGD:620868 6480464 tesaglitazar results in decreased expression of ACMSD mRNA CTD PMID:21515302 tetrachloromethane multiple interactions ISO RGD:620868 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ACMSD mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:620868 6480464 Carbon Tetrachloride results in decreased expression of ACMSD mRNA CTD PMID:31150632 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of ACMSD mRNA CTD PMID:28973375 valproic acid decreases expression ISO RGD:732597 6480464 Valproic Acid results in decreased expression of ACMSD mRNA CTD PMID:29154799 valproic acid decreases methylation ISO RGD:732597 6480464 Valproic Acid results in decreased methylation of ACMSD gene CTD PMID:29154799 zoledronic acid decreases expression ISO RGD:732597 6480464 zoledronic acid results in decreased expression of ACMSD mRNA CTD PMID:24714768 
Gene-Chemical Interaction Annotations
