Acmsd (amino carboxymuconate semialdehyde decarboxylase) - Rat Genome Database
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Gene: Acmsd (amino carboxymuconate semialdehyde decarboxylase) Mus musculus
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Symbol: Acmsd
Name: amino carboxymuconate semialdehyde decarboxylase
RGD ID: 732598
MGI Page MGI
Description: Predicted to have aminocarboxymuconate-semialdehyde decarboxylase activity and zinc ion binding activity. Predicted to be involved in several processes, including aging; carboxylic acid metabolic process; and negative regulation of quinolinate biosynthetic process. Predicted to localize to cytosol. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391127,657,150 - 127,695,301 (+)NCBIGRCm39mm39
GRCm381127,729,413 - 127,767,564 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1127,729,413 - 127,767,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv371129,625,990 - 129,664,141 (+)NCBIGRCm37mm9NCBIm37
MGSCv361129,556,959 - 129,595,110 (+)NCBImm8
Celera1130,370,820 - 130,409,013 (+)NCBICelera
Cytogenetic Map1E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16807375   PMID:21873635   PMID:22496890   PMID:30232574  
PMID:30356218  


Genomics

Comparative Map Data
Acmsd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391127,657,150 - 127,695,301 (+)NCBIGRCm39mm39
GRCm381127,729,413 - 127,767,564 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1127,729,413 - 127,767,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv371129,625,990 - 129,664,141 (+)NCBIGRCm37mm9NCBIm37
MGSCv361129,556,959 - 129,595,110 (+)NCBImm8
Celera1130,370,820 - 130,409,013 (+)NCBICelera
Cytogenetic Map1E3NCBI
ACMSD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2134,838,616 - 134,902,034 (+)EnsemblGRCh38hg38GRCh38
GRCh382134,838,319 - 134,902,906 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372135,596,186 - 135,659,604 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh372135,595,994 - 135,659,604 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362135,312,656 - 135,376,074 (+)NCBINCBI36hg18NCBI36
Build 342135,429,919 - 135,493,332NCBI
Celera2129,309,109 - 129,372,527 (+)NCBI
Cytogenetic Map2q21.3NCBI
HuRef2127,587,573 - 127,651,049 (+)NCBIHuRef
CHM1_12135,600,992 - 135,664,414 (+)NCBICHM1_1
Acmsd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21339,200,486 - 39,244,337 (+)NCBI
Rnor_6.0 Ensembl1344,424,689 - 44,468,734 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01344,424,689 - 44,468,734 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01349,510,444 - 49,553,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,547,366 - 40,573,698 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11340,561,408 - 40,587,743 (-)NCBI
Celera1339,577,658 - 39,620,559 (+)NCBICelera
Cytogenetic Map13q13NCBI
Acmsd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554402,348,396 - 2,412,706 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554402,348,434 - 2,412,706 (+)NCBIChiLan1.0ChiLan1.0
ACMSD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B138,918,281 - 138,978,407 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B138,918,281 - 138,978,407 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B24,958,661 - 25,019,901 (-)NCBIMhudiblu_PPA_v0panPan3
ACMSD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1937,659,226 - 37,725,172 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11937,658,999 - 37,725,426 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Acmsd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493646940,858,338 - 40,904,807 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACMSD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1517,106,724 - 17,163,899 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11517,121,950 - 17,164,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21519,522,142 - 19,538,454 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACMSD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11019,063,731 - 19,128,387 (+)NCBI
ChlSab1.1 Ensembl1019,064,115 - 19,129,089 (+)Ensembl
Acmsd
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473234,232,890 - 34,294,195 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174952818133363199Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)176000000128600000Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782314261147249632Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182665468135687641Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194200000148900000Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194200000172200000Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195600000162200000Mouse
1301123Cd8mts2_mCD8 memory T cell subset 2 (mouse)Not determined196690656130690827Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197126256131126460Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199579930133580115Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1103040804137040937Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1104005680191493284Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109568206143568206Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109710525143710742Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110625442144625561Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110625442144625561Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112081092168358833Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112081092175641372Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112203268146203348Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116363098150363199Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117600000180000000Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118171982152172078Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121800000139800000Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121800000153900000Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121800000154000000Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121800000165000000Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122100000165000000Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1123000000157000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:246
Interacting mature miRNAs:282
Transcripts:ENSMUST00000038006
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000038006   ⟹   ENSMUSP00000048482
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1127,729,413 - 127,767,978 (+)Ensembl
RefSeq Acc Id: ENSMUST00000186537
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1127,756,757 - 127,767,978 (+)Ensembl
RefSeq Acc Id: NM_001033041   ⟹   NP_001028213
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391127,657,150 - 127,695,301 (+)NCBI
GRCm381127,729,413 - 127,767,564 (+)ENTREZGENE
MGSCv371129,625,990 - 129,664,141 (+)RGD
Celera1130,370,820 - 130,409,013 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001028213   ⟸   NM_001033041
- UniProtKB: Q8R519 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000048482   ⟸   ENSMUST00000038006
Protein Domains
Amidohydro-rel

Promoters
RGD ID:6874780
Promoter ID:EPDNEW_M841
Type:multiple initiation site
Name:Acmsd_1
Description:Mus musculus amino carboxymuconate semialdehyde decarboxylase, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381127,729,412 - 127,729,472EPDNEW
RGD ID:6817255
Promoter ID:MM_KWN:1958
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_001033041
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361129,625,679 - 129,626,179 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2386323 AgrOrtholog
Ensembl Genes ENSMUSG00000026348 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000048482 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038006 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ACMSD UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Amidohydro-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:266645 UniProtKB/Swiss-Prot
MGD MGI:2386323 ENTREZGENE
NCBI Gene 266645 ENTREZGENE
PANTHER PTHR21240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Amidohydro_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acmsd PhenoGen
Superfamily-SCOP SSF51556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ACMSD_MOUSE UniProtKB/Swiss-Prot
  Q3TNK0_MOUSE UniProtKB/TrEMBL
  Q8R519 ENTREZGENE
UniProt Secondary B9EI97 UniProtKB/Swiss-Prot
  Q3UNW3 UniProtKB/Swiss-Prot