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Gene: ERAP1 (endoplasmic reticulum aminopeptidase 1) Homo sapiens
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Symbol: ERAP1
Name: endoplasmic reticulum aminopeptidase 1
Description: Exhibits aminopeptidase activity; interleukin-6 receptor binding activity; and metalloexopeptidase activity. Involved in membrane protein ectodomain proteolysis. Localizes to the extracellular region. Implicated in cervix carcinoma. Biomarker of endometrial carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A-LAP; adipocyte-derived leucine aminopeptidase; ALAP; aminopeptidase PILS; aminopeptidase regulator of TNFR1 shedding; APPILS; ARTS-1; ARTS1; CTD-2260A17.2; endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform; endoplasmic reticulum aminopeptidase associated with antigen processing; ERAAP; ERAAP1; KIAA0525; leucyl-specific aminopeptidase pils; PILS-AP; PILSAP; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Orthologs:
Mus musculus (house mouse) : Erap1 (endoplasmic reticulum aminopeptidase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Erap1 (endoplasmic reticulum aminopeptidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erap1 (endoplasmic reticulum aminopeptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ERAP1 (endoplasmic reticulum aminopeptidase 1)
Canis lupus familiaris (dog) : ERAP1 (endoplasmic reticulum aminopeptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erap1 (endoplasmic reticulum aminopeptidase 1)
Sus scrofa (pig) : ERAP1 (endoplasmic reticulum aminopeptidase 1)
Chlorocebus sabaeus (African green monkey) : ERAP1 (endoplasmic reticulum aminopeptidase 1)
Heterocephalus glaber (naked mole-rat) : Erap1 (endoplasmic reticulum aminopeptidase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl596,760,810 - 96,808,100 (-)Ensembl
GRCh38596,760,273 - 96,935,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37596,096,514 - 96,149,848 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36596,122,270 - 96,169,648 (-)NCBINCBI36hg18NCBI36
Build 34596,122,276 - 96,169,398NCBI
Celera591,980,937 - 92,028,293 (-)NCBI
Cytogenetic Map5q15NCBI
HuRef591,286,769 - 91,340,086 (-)NCBIHuRef
CHM1_1595,529,237 - 95,582,553 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ERAP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732566
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.