Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PICALM (phosphatidylinositol binding clathrin assembly protein) Homo sapiens
Analyze
Symbol: PICALM
Name: phosphatidylinositol binding clathrin assembly protein
Description: Exhibits several functions, including clathrin heavy chain binding activity; low-density lipoprotein particle receptor binding activity; and tau protein binding activity. Involved in several processes, including negative regulation of cellular protein localization; receptor-mediated endocytosis; and regulation of amyloid precursor protein catabolic process. Localizes to several cellular components, including the clathrin-coated pit; cytoplasmic vesicle; and neurofibrillary tangle. Colocalizes with the AP-2 adaptor complex. Implicated in acute myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CALM; clathrin assembly lymphoid myeloid leukemia protein; clathrin assembly lymphoid-myeloid leukemia; CLTH; LAP; phosphatidylinositol-binding clathrin assembly protein
Orthologs:
Mus musculus (house mouse) : Picalm (phosphatidylinositol binding clathrin assembly protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Picalm (phosphatidylinositol binding clathrin assembly protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Picalm (phosphatidylinositol binding clathrin assembly protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PICALM (phosphatidylinositol binding clathrin assembly protein)
Canis lupus familiaris (dog) : PICALM (phosphatidylinositol binding clathrin assembly protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Picalm (phosphatidylinositol binding clathrin assembly protein)
Sus scrofa (pig) : PICALM (phosphatidylinositol binding clathrin assembly protein)
Chlorocebus sabaeus (African green monkey) : PICALM (phosphatidylinositol binding clathrin assembly protein)
Heterocephalus glaber (naked mole-rat) : Picalm (phosphatidylinositol binding clathrin assembly protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1185,957,175 - 86,069,882 (-)Ensembl
GRCh381185,957,175 - 86,069,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371185,668,214 - 85,780,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,346,133 - 85,457,756 (-)NCBINCBI36hg18NCBI36
Build 341185,346,133 - 85,457,756NCBI
Celera1182,977,768 - 83,089,435 (-)NCBI
Cytogenetic Map11q14.2NCBI
HuRef1181,965,384 - 82,078,030 (-)NCBIHuRef
CHM1_11185,553,010 - 85,665,742 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
  
More on PICALM
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732553
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.