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Gene: PICALM (phosphatidylinositol binding clathrin assembly protein) Homo sapiens
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Symbol: PICALM
Name: phosphatidylinositol binding clathrin assembly protein
Description: Exhibits several functions, including clathrin heavy chain binding activity; low-density lipoprotein particle receptor binding activity; and tau protein binding activity. Involved in several processes, including negative regulation of cellular protein localization; receptor-mediated endocytosis; and regulation of amyloid precursor protein catabolic process. Localizes to several cellular components, including the clathrin-coated pit; cytoplasmic vesicle; and neurofibrillary tangle. Colocalizes with the AP-2 adaptor complex. Implicated in acute myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CALM; clathrin assembly lymphoid myeloid leukemia protein; clathrin assembly lymphoid-myeloid leukemia; CLTH; LAP; phosphatidylinositol-binding clathrin assembly protein
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1185,957,175 - 86,069,882 (-)Ensembl
GRCh381185,957,175 - 86,069,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371185,668,214 - 85,780,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,346,133 - 85,457,756 (-)NCBINCBI36hg18NCBI36
Build 341185,346,133 - 85,457,756NCBI
Celera1182,977,768 - 83,089,435 (-)NCBI
Cytogenetic Map11q14.2NCBI
HuRef1181,965,384 - 82,078,030 (-)NCBIHuRef
CHM1_11185,553,010 - 85,665,742 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PICALM
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732553
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.