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Gene: GNA12 (G protein subunit alpha 12) Homo sapiens
Symbol: GNA12
Name: G protein subunit alpha 12
Description: Predicted to have D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Localizes to focal adhesion; PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 17beta-estradiol; 2-methylcholine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: g alpha-12; G-protein subunit alpha-12; gep; guanine nucleotide binding protein (G protein) alpha 12; guanine nucleotide binding protein, alpha 12; guanine nucleotide-binding protein subunit alpha-12; MGC104623; MGC99644; NNX3; RMP; WUGSC:H_GS165O14.2
Mus musculus (house mouse) : Gna12 (guanine nucleotide binding protein, alpha 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gna12 (G protein subunit alpha 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gna12 (G protein subunit alpha 12)
Pan paniscus (bonobo/pygmy chimpanzee) : GNA12 (G protein subunit alpha 12)
Canis lupus familiaris (dog) : GNA12 (G protein subunit alpha 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gna12 (G protein subunit alpha 12)
Sus scrofa (pig) : GNA12 (G protein subunit alpha 12)
Chlorocebus sabaeus (African green monkey) : GNA12 (G protein subunit alpha 12)
Heterocephalus glaber (naked mole-rat) : Gna12 (G protein subunit alpha 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl72,728,105 - 2,844,308 (-)EnsemblGRCh38hg38GRCh38
GRCh3872,728,105 - 2,844,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3772,767,739 - 2,883,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3672,734,265 - 2,850,485 (-)NCBINCBI36hg18NCBI36
Build 3472,540,980 - 2,657,200NCBI
Celera72,736,337 - 2,852,578 (-)NCBI
Cytogenetic Map7p22.3-p22.2NCBI
HuRef72,686,290 - 2,802,582 (-)NCBIHuRef
CHM1_172,767,404 - 2,883,659 (-)NCBICHM1_1
CRA_TCAGchr7v272,815,641 - 2,931,835 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GNA12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732491
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.