Mogs (mannosyl-oligosaccharide glucosidase) - Rat Genome Database
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Gene: Mogs (mannosyl-oligosaccharide glucosidase) Mus musculus
Analyze
Symbol: Mogs
Name: mannosyl-oligosaccharide glucosidase
RGD ID: 732424
MGI Page MGI
Description: Predicted to have mannosyl-oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to localize to endoplasmic reticulum and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1810017N02Rik; AI181835; Gcs; Gcs1; glucosidase 1; glucosidase I; glycoprotein-processing glucosidase I
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,092,477 - 83,095,883 (+)NCBIGRCm39mm39
GRCm38683,115,506 - 83,118,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,115,496 - 83,118,898 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,065,500 - 83,068,892 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,081,164 - 83,084,556 (+)NCBImm8
Celera685,098,207 - 85,101,599 (+)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:10406845   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:21873635   PMID:24194600   PMID:24457600   PMID:26167872   PMID:27626380   PMID:28378742   PMID:29465311   PMID:29530978   PMID:30196744   PMID:31609468  


Genomics

Comparative Map Data
Mogs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,092,477 - 83,095,883 (+)NCBIGRCm39mm39
GRCm38683,115,506 - 83,118,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,115,496 - 83,118,898 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,065,500 - 83,068,892 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,081,164 - 83,084,556 (+)NCBImm8
Celera685,098,207 - 85,101,599 (+)NCBICelera
Cytogenetic Map6C3NCBI
MOGS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl274,461,057 - 74,465,410 (-)EnsemblGRCh38hg38GRCh38
GRCh38274,461,057 - 74,465,382 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37274,688,184 - 74,692,509 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37274,688,184 - 74,692,537 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,541,692 - 74,546,045 (-)NCBINCBI36hg18NCBI36
Build 34274,599,850 - 74,604,161NCBI
Celera274,519,373 - 74,523,726 (-)NCBI
Cytogenetic Map2p13.1NCBI
HuRef274,424,479 - 74,428,832 (-)NCBIHuRef
CHM1_1274,617,601 - 74,621,954 (-)NCBICHM1_1
Mogs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,621,623 - 115,625,026 (+)NCBI
Rnor_6.0 Ensembl4113,948,514 - 113,951,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04113,948,328 - 113,951,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04178,633,399 - 178,636,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,327,609 - 117,331,012 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14117,572,089 - 117,575,493 (+)NCBI
Celera4104,615,822 - 104,619,225 (+)NCBICelera
Cytogenetic Map4q34NCBI
Mogs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,290,849 - 11,324,464 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,317,605 - 11,321,192 (+)NCBIChiLan1.0ChiLan1.0
MOGS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A76,033,692 - 76,038,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,033,692 - 76,038,561 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A74,527,710 - 74,532,319 (-)NCBIMhudiblu_PPA_v0panPan3
MOGS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1748,667,224 - 48,670,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11748,666,220 - 48,670,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mogs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936556684,203 - 688,037 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOGS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,578,218 - 68,581,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,578,207 - 68,581,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,840,317 - 71,844,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MOGS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,812,318 - 32,816,358 (+)NCBI
ChlSab1.1 Ensembl1432,812,065 - 32,820,175 (+)Ensembl
Mogs
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474929,041,631 - 29,045,407 (+)NCBI

Position Markers
RH135911  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,117,778 - 83,118,129UniSTSGRCm38
MGSCv37683,067,772 - 83,068,123UniSTSGRCm37
Celera685,100,479 - 85,100,830UniSTS
Cytogenetic Map6D1UniSTS
Mogs  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
cM Map635.94UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:419
Count of miRNA genes:316
Interacting mature miRNAs:339
Transcripts:ENSMUST00000032114, ENSMUST00000145403
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC104324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF001797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY625811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032114   ⟹   ENSMUSP00000032114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,115,496 - 83,118,898 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145403
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,116,516 - 83,117,351 (+)Ensembl
RefSeq Acc Id: NM_020619   ⟹   NP_065644
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,092,487 - 83,095,883 (+)NCBI
GRCm38683,115,506 - 83,118,902 (+)NCBI
MGSCv37683,065,500 - 83,068,892 (+)RGD
Celera685,098,207 - 85,101,599 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506424   ⟹   XP_006506487
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,092,477 - 83,095,883 (+)NCBI
GRCm38683,115,637 - 83,118,902 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_065644   ⟸   NM_020619
- UniProtKB: Q80UM7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506487   ⟸   XM_006506424
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000032114   ⟸   ENSMUST00000032114
Protein Domains
Glyco_hydro_63   Glyco_hydro_63N

Promoters
RGD ID:6839352
Promoter ID:MM_KWN:46575
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000059442
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,065,146 - 83,065,646 (+)MPROMDB
RGD ID:6839353
Promoter ID:MM_KWN:46576
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000059443
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,065,926 - 83,066,722 (+)MPROMDB
RGD ID:6890132
Promoter ID:EPDNEW_M8517
Type:initiation region
Name:Mogs_1
Description:Mus musculus mannosyl-oligosaccharide glucosidase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,115,545 - 83,115,605EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929872 AgrOrtholog
Ensembl Genes ENSMUSG00000030036 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000032114 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032114 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.98.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-hairpin_glycosidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6hp_glycosidase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_63_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_63N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_63N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_63 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:57377 UniProtKB/Swiss-Prot
MGD MGI:1929872 ENTREZGENE
NCBI Gene 57377 ENTREZGENE
PANTHER PTHR10412 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_63 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_63N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mogs PhenoGen
Superfamily-SCOP SSF48208 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MOGS_MOUSE UniProtKB/Swiss-Prot
  Q3U026_MOUSE UniProtKB/TrEMBL
  Q3U8P9_MOUSE UniProtKB/TrEMBL
  Q3U950_MOUSE UniProtKB/TrEMBL
  Q3UME9_MOUSE UniProtKB/TrEMBL
  Q80UM7 ENTREZGENE
UniProt Secondary Q9Z2W5 UniProtKB/Swiss-Prot