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Gene: ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3) Homo sapiens
Symbol: ITIH3
Name: inter-alpha-trypsin inhibitor heavy chain 3
Description: Predicted to have endopeptidase inhibitor activity. Predicted to be involved in platelet degranulation. Localizes to extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H3P; inter-alpha (globulin) inhibitor H3; inter-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-inhibitor heavy chain 3; inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; pre-alpha (globulin) inhibitor, H3 polypeptide; pre-alpha-inhibitor, heavy chain 3; serum-derived hyaluronan-associated protein; SHAP
Mus musculus (house mouse) : Itih3 (inter-alpha trypsin inhibitor, heavy chain 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itih3 (inter-alpha trypsin inhibitor, heavy chain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itih3 (inter-alpha-trypsin inhibitor heavy chain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3)
Canis lupus familiaris (dog) : LOC491368 (inter-alpha-trypsin inhibitor heavy chain H3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itih3 (inter-alpha-trypsin inhibitor heavy chain 3)
Sus scrofa (pig) : ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3)
Chlorocebus sabaeus (African green monkey) : ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3)
Heterocephalus glaber (naked mole-rat) : Itih3 (inter-alpha-trypsin inhibitor heavy chain 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl352,794,768 - 52,809,009 (+)EnsemblGRCh38hg38GRCh38
GRCh38352,794,768 - 52,809,009 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,828,784 - 52,843,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,803,824 - 52,818,065 (+)NCBINCBI36hg18NCBI36
Build 34352,803,853 - 52,817,854NCBI
Celera352,807,505 - 52,821,742 (+)NCBI
Cytogenetic Map3p21.1NCBI
HuRef352,890,445 - 52,904,683 (+)NCBIHuRef
CHM1_1352,780,986 - 52,795,224 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITIH3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732422
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.