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Gene: PLCB2 (phospholipase C beta 2) Homo sapiens
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Symbol: PLCB2
Name: phospholipase C beta 2
Description: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; FLJ38135; phosphoinositide phospholipase C-beta-2; phospholipase C, beta 2; phospholipase C-beta-2; PLC-beta-2
Orthologs:
Mus musculus (house mouse) : Plcb2 (phospholipase C, beta 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plcb2 (phospholipase C, beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcb2 (phospholipase C beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCB2 (phospholipase C beta 2)
Canis lupus familiaris (dog) : PLCB2 (phospholipase C beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcb2 (phospholipase C beta 2)
Sus scrofa (pig) : PLCB2 (phospholipase C beta 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,285,496 - 40,307,973 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371540,576,461 - 40,600,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,367,390 - 38,387,466 (-)NCBINCBI36hg18NCBI36
Build 341538,367,401 - 38,387,330NCBI
Celera1517,346,090 - 17,366,157 (-)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1517,423,058 - 17,443,532 (-)NCBIHuRef
CHM1_11540,700,041 - 40,720,115 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on PLCB2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732409
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.