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Gene: Jup (junction plakoglobin) Mus musculus
Symbol: Jup
Name: junction plakoglobin
Description: Exhibits alpha-catenin binding activity. Involved in cell-cell adhesion; desmosome assembly; and skin development. Localizes to several cellular components, including Z disc; catenin complex; and intermediate filament. Predicted to colocalize with actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study arrhythmogenic right ventricular dysplasia 12 and epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AL022715; AW545708; Ctnng; D930025P04Rik; desmoplakin III; desmoplakin-3; gamma-catenin; PG; plakoglobin
Homo sapiens (human) : JUP (junction plakoglobin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Jup (junction plakoglobin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jup (junction plakoglobin)
Pan paniscus (bonobo/pygmy chimpanzee) : JUP (junction plakoglobin)
Canis lupus familiaris (dog) : JUP (junction plakoglobin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jup (junction plakoglobin)
Sus scrofa (pig) : JUP (junction plakoglobin)
Chlorocebus sabaeus (African green monkey) : JUP (junction plakoglobin)
Heterocephalus glaber (naked mole-rat) : Jup (junction plakoglobin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl11100,368,958 - 100,397,763 (-)EnsemblGRCm38mm10GRCm38
GRCm3811100,368,856 - 100,397,839 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711100,231,933 - 100,259,053 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,186,709 - 100,213,829 (-)NCBImm8
Celera11110,988,014 - 111,016,158 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Jup
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732397
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.