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Gene: Jup (junction plakoglobin) Mus musculus
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Symbol: Jup
Name: junction plakoglobin
Description: Exhibits alpha-catenin binding activity. Involved in cell-cell adhesion; desmosome assembly; and skin development. Localizes to several cellular components, including Z disc; catenin complex; and intermediate filament. Predicted to colocalize with actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study arrhythmogenic right ventricular dysplasia 12 and epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AL022715; AW545708; Ctnng; D930025P04Rik; desmoplakin III; desmoplakin-3; gamma-catenin; PG; plakoglobin
Orthologs:
Homo sapiens (human) : JUP (junction plakoglobin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Jup (junction plakoglobin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jup (junction plakoglobin)
Pan paniscus (bonobo/pygmy chimpanzee) : JUP (junction plakoglobin)
Canis lupus familiaris (dog) : JUP (junction plakoglobin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jup (junction plakoglobin)
Sus scrofa (pig) : JUP (junction plakoglobin)
Chlorocebus sabaeus (African green monkey) : JUP (junction plakoglobin)
Heterocephalus glaber (naked mole-rat) : Jup (junction plakoglobin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl11100,368,958 - 100,397,763 (-)EnsemblGRCm38mm10GRCm38
GRCm3811100,368,856 - 100,397,839 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711100,231,933 - 100,259,053 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,186,709 - 100,213,829 (-)NCBImm8
Celera11110,988,014 - 111,016,158 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Jup
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732397
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.