RGS2 (regulator of G protein signaling 2) - Rat Genome Database

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Gene: RGS2 (regulator of G protein signaling 2) Homo sapiens
Analyze
Symbol: RGS2
Name: regulator of G protein signaling 2
RGD ID: 732360
HGNC Page HGNC:9998
Description: Enables G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in several processes, including negative regulation of phospholipase activity; regulation of muscle system process; and regulation of signal transduction. Predicted to act upstream of or within brown fat cell differentiation. Located in cytosol; nucleus; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cell growth-inhibiting gene 31 protein; cell growth-inhibiting protein 31; G0 to G1 switch regulatory 8, 24kD; G0/G1 switch regulatory protein 8; G0S8; regulator of G-protein signaling 2; regulator of G-protein signaling 2, 24kDa; regulator of g-protein signaling protein 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381192,809,039 - 192,812,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1192,809,039 - 192,812,275 (+)EnsemblGRCh38hg38GRCh38
GRCh371192,778,169 - 192,781,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,044,794 - 191,048,026 (+)NCBINCBI36Build 36hg18NCBI36
Build 341189,509,827 - 189,513,060NCBI
Celera1165,887,766 - 165,891,002 (+)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,013,977 - 164,017,213 (+)NCBIHuRef
CHM1_11194,199,847 - 194,203,081 (+)NCBICHM1_1
T2T-CHM13v2.01192,156,109 - 192,159,345 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
acetamide  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (EXP)
antimycin A  (EXP)
antirheumatic drug  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (ISO)
camptothecin  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
CGS-21680  (ISO)
chlordecone  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
DDE  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
disodium selenite  (EXP)
disulfiram  (EXP)
diuron  (EXP,ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
enzalutamide  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
flavonoids  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glycine betaine  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ketamine  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melphalan  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
mitoxantrone  (EXP)
Muraglitazar  (ISO)
mycophenolic acid  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalenes  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
Nutlin-3  (EXP)
ochratoxin A  (EXP,ISO)
ouabain  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenylephrine  (ISO)
potassium chromate  (EXP)
profenofos  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP)
quinolinic acid  (ISO)
ranitidine  (ISO)
reserpine  (ISO)
risperidone  (ISO)
rotenone  (EXP,ISO)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sulforaphane  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
torcetrapib  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (EXP)
vitamin E  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA)
cytoplasmic side of plasma membrane  (IEA,ISS)
cytosol  (IDA,IEA,ISS)
mitochondrion  (IEA)
nucleolus  (IEA)
nucleus  (IDA,IEA)
plasma membrane  (IDA,IEA,TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
2. An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. Ceolotto G, etal., Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Vascular microarray profiling in two models of hypertension identifies Cav-1, Rgs2 and Rgs5 as antihypertensive targets. Grayson TH, etal., BMC Genomics. 2007 Nov 7;8(1):404.
5. Gene expression changes following extinction testing in a heroin behavioral incubation model. Kuntz-Melcavage KL, etal., BMC Neurosci. 2009 Aug 7;10:95. doi: 10.1186/1471-2202-10-95.
6. RGS2: a "turn-off" in hypertension. Le TH and Coffman TM, J Clin Invest. 2003 Feb;111(4):441-3.
7. Molecular mechanisms related to parturition-induced stress urinary incontinence. Lin G, etal., Eur Urol. 2009 May;55(5):1213-22. doi: 10.1016/j.eururo.2008.02.027. Epub 2008 Mar 18.
8. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
11. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Tang KM, etal., Nat Med. 2003 Dec;9(12):1506-12. doi: 10.1038/nm958. Epub 2003 Nov 9.
12. Impaired response of regulator of Gaq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats. Wu Y, etal., Hypertens Res. 2016 Apr;39(4):210-6. doi: 10.1038/hr.2015.132. Epub 2015 Nov 26.
13. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
Additional References at PubMed
PMID:1702972   PMID:7643615   PMID:8179820   PMID:8602223   PMID:8673468   PMID:9079700   PMID:9174164   PMID:9405622   PMID:9794454   PMID:10072511   PMID:10747990   PMID:10760272  
PMID:10791963   PMID:10982407   PMID:11063746   PMID:11278586   PMID:11330340   PMID:11602604   PMID:12176127   PMID:12356577   PMID:12477932   PMID:12564955   PMID:12604604   PMID:12885252  
PMID:15292363   PMID:15362969   PMID:15375002   PMID:15383626   PMID:15489334   PMID:15536149   PMID:15609325   PMID:15793568   PMID:15917235   PMID:16003176   PMID:16169070   PMID:16189514  
PMID:16432041   PMID:16449965   PMID:16627589   PMID:16685212   PMID:16691626   PMID:16710414   PMID:16736243   PMID:16895908   PMID:17143182   PMID:17220356   PMID:17244887   PMID:17294519  
PMID:17353931   PMID:17464283   PMID:17558307   PMID:17728697   PMID:17901199   PMID:18067675   PMID:18230714   PMID:18249218   PMID:18262772   PMID:18316676   PMID:18347610   PMID:18360038  
PMID:18398336   PMID:18496125   PMID:18663369   PMID:18833580   PMID:19023274   PMID:19064631   PMID:19155782   PMID:19156702   PMID:19162436   PMID:19175184   PMID:19243996   PMID:19427970  
PMID:19478087   PMID:19626040   PMID:19778949   PMID:19813112   PMID:19913121   PMID:19931593   PMID:19948975   PMID:20001967   PMID:20032508   PMID:20140863   PMID:20375904   PMID:20403096  
PMID:20453000   PMID:20468064   PMID:20627871   PMID:20628086   PMID:20628624   PMID:20633139   PMID:20662725   PMID:20847599   PMID:20981351   PMID:21041608   PMID:21291998   PMID:21438143  
PMID:21451528   PMID:21500190   PMID:21529451   PMID:21779398   PMID:21900206   PMID:21988832   PMID:22057271   PMID:22080612   PMID:22695717   PMID:22704538   PMID:23277133   PMID:23339167  
PMID:23349832   PMID:23434405   PMID:23464602   PMID:23587726   PMID:23859711   PMID:23870195   PMID:24297163   PMID:24299002   PMID:24561123   PMID:24562335   PMID:24593135   PMID:24794857  
PMID:25187114   PMID:25323766   PMID:25368964   PMID:25416956   PMID:25509855   PMID:25613138   PMID:25664600   PMID:25740197   PMID:25766235   PMID:25847876   PMID:25849301   PMID:25910212  
PMID:25970626   PMID:27549302   PMID:27558088   PMID:27701409   PMID:28102109   PMID:28514442   PMID:28784619   PMID:28974581   PMID:29593124   PMID:29925530   PMID:29944393   PMID:30021884  
PMID:30107643   PMID:30392211   PMID:30425097   PMID:30467386   PMID:31741433   PMID:32296183   PMID:32449815   PMID:32517689   PMID:32814053   PMID:33008920   PMID:33393490   PMID:33947275  
PMID:33961781   PMID:34041882   PMID:34493304   PMID:35168462   PMID:35430356   PMID:36098468   PMID:36443250   PMID:36591293   PMID:36653442  


Genomics

Comparative Map Data
RGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381192,809,039 - 192,812,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1192,809,039 - 192,812,275 (+)EnsemblGRCh38hg38GRCh38
GRCh371192,778,169 - 192,781,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,044,794 - 191,048,026 (+)NCBINCBI36Build 36hg18NCBI36
Build 341189,509,827 - 189,513,060NCBI
Celera1165,887,766 - 165,891,002 (+)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,013,977 - 164,017,213 (+)NCBIHuRef
CHM1_11194,199,847 - 194,203,081 (+)NCBICHM1_1
T2T-CHM13v2.01192,156,109 - 192,159,345 (+)NCBIT2T-CHM13v2.0
Rgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,875,076 - 143,879,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,875,076 - 143,879,899 (-)EnsemblGRCm39 Ensembl
GRCm381143,999,338 - 144,004,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,999,338 - 144,004,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv371145,846,468 - 145,851,279 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361145,762,215 - 145,766,367 (-)NCBIMGSCv36mm8
Celera1146,559,706 - 146,564,519 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.56NCBI
Rgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,350,063 - 58,352,666 (-)NCBIGRCr8
mRatBN7.21355,799,749 - 55,802,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,798,829 - 55,802,385 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,360,545 - 58,363,155 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,628,437 - 59,631,073 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,918,817 - 56,921,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,846,458 - 60,849,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,846,308 - 60,849,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,831,386 - 65,833,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,891,849 - 57,894,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,905,025 - 57,908,545 (-)NCBI
Celera1355,875,644 - 55,878,228 (-)NCBICelera
Cytogenetic Map13q21NCBI
Rgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,261,757 - 30,266,005 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540630,261,757 - 30,265,389 (+)NCBIChiLan1.0ChiLan1.0
RGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2156,975,986 - 56,983,152 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1156,639,690 - 56,643,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,273,112 - 168,276,348 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,566,701 - 172,569,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,566,701 - 172,569,955 (+)Ensemblpanpan1.1panPan2
RGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1386,200,237 - 6,203,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,200,657 - 6,203,494 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,297,498 - 6,300,827 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,217,614 - 6,220,944 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,217,616 - 6,220,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,216,415 - 6,219,748 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,582,061 - 6,585,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,817,823 - 6,821,151 (-)NCBIUU_Cfam_GSD_1.0
Rgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934481,075,734 - 81,079,076 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366381,065,832 - 1,069,247 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366381,065,866 - 1,068,649 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl10936,789 - 940,098 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.110936,836 - 940,083 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,543,481 - 2,546,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10pNCBI
RGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,620,047 - 36,623,367 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,619,140 - 36,623,308 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605537,569,789 - 37,573,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814753,164 - 758,192 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624814754,743 - 758,148 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RGS2
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q31.2(chr1:192567876-193180049)x1 copy number loss See cases [RCV000053950] Chr1:192567876..193180049 [GRCh38]
Chr1:192537006..193149179 [GRCh37]
Chr1:190803629..191415802 [NCBI36]
Chr1:1q31.2
pathogenic
GRCh38/hg38 1q25.2-32.1(chr1:179032905-199724897)x1 copy number loss See cases [RCV000053948] Chr1:179032905..199724897 [GRCh38]
Chr1:179002040..199694025 [GRCh37]
Chr1:177268663..197960648 [NCBI36]
Chr1:1q25.2-32.1
pathogenic
GRCh38/hg38 1q25.2-31.3(chr1:176595962-196301688)x1 copy number loss See cases [RCV000134144] Chr1:176595962..196301688 [GRCh38]
Chr1:176565098..196270818 [GRCh37]
Chr1:174831721..194537441 [NCBI36]
Chr1:1q25.2-31.3
pathogenic
GRCh38/hg38 1q31.1-32.1(chr1:189034483-199615866)x1 copy number loss See cases [RCV000135590] Chr1:189034483..199615866 [GRCh38]
Chr1:189003614..199584994 [GRCh37]
Chr1:187270237..197851617 [NCBI36]
Chr1:1q31.1-32.1
pathogenic
NM_002923.4(RGS2):c.274+1G>T single nucleotide variant not provided [RCV000412916] Chr1:192810432 [GRCh38]
Chr1:192779562 [GRCh37]
Chr1:1q31.2
likely pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737)x1 copy number loss See cases [RCV000445748] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265)x1 copy number loss See cases [RCV000448809] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758)x1 copy number loss See cases [RCV000448686] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3
pathogenic
NM_002923.4(RGS2):c.68G>A (p.Gly23Asp) single nucleotide variant not provided [RCV004691232]|not specified [RCV000455699] Chr1:192809139 [GRCh38]
Chr1:192778269 [GRCh37]
Chr1:1q31.2
uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:179011314-199022759)x1 copy number loss See cases [RCV000512128] Chr1:179011314..199022759 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_002923.4(RGS2):c.32A>G (p.His11Arg) single nucleotide variant not specified [RCV004322955] Chr1:192809103 [GRCh38]
Chr1:192778233 [GRCh37]
Chr1:1q31.2
uncertain significance
Single allele deletion Hyperparathyroidism 1 [RCV000677958] Chr1:191919194..194615758 [GRCh38]
Chr1:191888324..194584888 [GRCh37]
Chr1:1q31.2-31.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
NM_002923.4(RGS2):c.148C>A (p.Gln50Lys) single nucleotide variant not provided [RCV000883967] Chr1:192810203 [GRCh38]
Chr1:192779333 [GRCh37]
Chr1:1q31.2
likely benign
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:177551193-199599056)x1 copy number loss not provided [RCV001005157] Chr1:177551193..199599056 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737) copy number loss not specified [RCV002053780] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q31.2(chr1:192731793-193391298) copy number gain not specified [RCV002053813] Chr1:192731793..193391298 [GRCh37]
Chr1:1q31.2
uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265) copy number loss not specified [RCV002053769] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758) copy number loss not specified [RCV002053736] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3
pathogenic
NM_002923.4(RGS2):c.517G>A (p.Ala173Thr) single nucleotide variant not specified [RCV004322918] Chr1:192811477 [GRCh38]
Chr1:192780607 [GRCh37]
Chr1:1q31.2
uncertain significance
GRCh37/hg19 1q31.1-32.1(chr1:189633885-199854163)x1 copy number loss not provided [RCV002472500] Chr1:189633885..199854163 [GRCh37]
Chr1:1q31.1-32.1
likely pathogenic
NM_002923.4(RGS2):c.255C>A (p.Asp85Glu) single nucleotide variant not specified [RCV004155496] Chr1:192810412 [GRCh38]
Chr1:192779542 [GRCh37]
Chr1:1q31.2
uncertain significance
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3
pathogenic
NM_002923.4(RGS2):c.-3A>G single nucleotide variant RGS2-related disorder [RCV003936886] Chr1:192809069 [GRCh38]
Chr1:192778199 [GRCh37]
Chr1:1q31.2
benign
NM_002923.4(RGS2):c.49G>A (p.Asp17Asn) single nucleotide variant not specified [RCV004449158] Chr1:192809120 [GRCh38]
Chr1:192778250 [GRCh37]
Chr1:1q31.2
uncertain significance
NM_002923.4(RGS2):c.203C>T (p.Ala68Val) single nucleotide variant not specified [RCV004449155] Chr1:192810258 [GRCh38]
Chr1:192779388 [GRCh37]
Chr1:1q31.2
uncertain significance
NM_002923.4(RGS2):c.429A>C (p.Glu143Asp) single nucleotide variant not specified [RCV004449157] Chr1:192811135 [GRCh38]
Chr1:192780265 [GRCh37]
Chr1:1q31.2
uncertain significance
NC_000001.10:g.(?_190829412)_(216061974_?)del deletion not provided [RCV004579260] Chr1:190829412..216061974 [GRCh37]
Chr1:1q31.2-41
pathogenic
NM_002923.4(RGS2):c.419T>C (p.Ile140Thr) single nucleotide variant not specified [RCV004662954] Chr1:192811125 [GRCh38]
Chr1:192780255 [GRCh37]
Chr1:1q31.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:586
Count of miRNA genes:466
Interacting mature miRNAs:504
Transcripts:ENST00000235382, ENST00000464302, ENST00000483295, ENST00000487236
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH104484  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,780,767 - 192,780,961UniSTSGRCh37
Build 361191,047,390 - 191,047,584RGDNCBI36
Celera1165,890,362 - 165,890,556RGD
Cytogenetic Map1q31UniSTS
HuRef1164,016,573 - 164,016,767UniSTS
GeneMap99-GB4 RH Map1650.15UniSTS
G54115  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,781,078 - 192,781,254UniSTSGRCh37
Build 361191,047,701 - 191,047,877RGDNCBI36
Celera1165,890,673 - 165,890,849RGD
Cytogenetic Map1q31UniSTS
HuRef1164,016,884 - 164,017,060UniSTS
RH69011  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,781,008 - 192,781,198UniSTSGRCh37
Build 361191,047,631 - 191,047,821RGDNCBI36
Celera1165,890,603 - 165,890,793RGD
Cytogenetic Map1q31UniSTS
HuRef1164,016,814 - 164,017,004UniSTS
GeneMap99-GB4 RH Map1646.97UniSTS
NCBI RH Map11592.4UniSTS
PMC229255P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,780,144 - 192,780,719UniSTSGRCh37
Build 361191,046,767 - 191,047,342RGDNCBI36
Celera1165,889,739 - 165,890,314RGD
Cytogenetic Map1q31UniSTS
HuRef1164,015,950 - 164,016,525UniSTS
RGS2_386  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,780,573 - 192,781,450UniSTSGRCh37
Build 361191,047,196 - 191,048,073RGDNCBI36
Celera1165,890,168 - 165,891,045RGD
HuRef1164,016,379 - 164,017,256UniSTS
D1S2392  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,780,928 - 192,781,265UniSTSGRCh37
Build 361191,047,551 - 191,047,888RGDNCBI36
Celera1165,890,523 - 165,890,860RGD
Cytogenetic Map1q31UniSTS
HuRef1164,016,734 - 164,017,071UniSTS
Stanford-G3 RH Map17552.0UniSTS
GeneMap99-GB4 RH Map1650.15UniSTS
Whitehead-RH Map1805.9UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map11604.7UniSTS
GeneMap99-G3 RH Map17508.0UniSTS
SHGC-76063  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,780,958 - 192,781,084UniSTSGRCh37
Build 361191,047,581 - 191,047,707RGDNCBI36
Celera1165,890,553 - 165,890,679RGD
Cytogenetic Map1q31UniSTS
HuRef1164,016,764 - 164,016,890UniSTS
TNG Radiation Hybrid Map193410.0UniSTS
GeneMap99-GB4 RH Map1650.15UniSTS
Whitehead-RH Map1805.9UniSTS
NCBI RH Map11608.0UniSTS
GDB:683288  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371192,779,303 - 192,780,714UniSTSGRCh37
Celera1165,888,900 - 165,890,309UniSTS
Cytogenetic Map1q31UniSTS
HuRef1164,015,111 - 164,016,520UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2438 2788 2253 4974 1726 2351 6 624 1947 465 2270 7301 6468 52 3734 1 852 1744 1617 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF493926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY971351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI912389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD700013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000235382   ⟹   ENSP00000235382
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1192,809,039 - 192,812,275 (+)Ensembl
Ensembl Acc Id: ENST00000464302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1192,809,042 - 192,811,239 (+)Ensembl
Ensembl Acc Id: ENST00000483295
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1192,809,039 - 192,810,899 (+)Ensembl
Ensembl Acc Id: ENST00000487236
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1192,809,143 - 192,811,032 (+)Ensembl
RefSeq Acc Id: NM_002923   ⟹   NP_002914
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381192,809,039 - 192,812,275 (+)NCBI
GRCh371192,778,169 - 192,781,407 (+)ENTREZGENE
Build 361191,044,794 - 191,048,026 (+)NCBI Archive
HuRef1164,013,977 - 164,017,213 (+)ENTREZGENE
CHM1_11194,199,847 - 194,203,081 (+)NCBI
T2T-CHM13v2.01192,156,109 - 192,159,345 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002914   ⟸   NM_002923
- UniProtKB: Q6I9U5 (UniProtKB/Swiss-Prot),   P41220 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000235382   ⟸   ENST00000235382
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41220-F1-model_v2 AlphaFold P41220 1-211 view protein structure

Promoters
RGD ID:6786424
Promoter ID:HG_KWN:6624
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_002923,   OTTHUMT00000086397,   OTTHUMT00000086398,   OTTHUMT00000086399
Position:
Human AssemblyChrPosition (strand)Source
Build 361191,044,559 - 191,045,059 (+)MPROMDB
RGD ID:6851828
Promoter ID:EP73719
Type:single initiation site
Name:HS_RGS2
Description:Regulator of G-protein signalling 2, 24kDa.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361191,044,794 - 191,044,854EPD
RGD ID:6858428
Promoter ID:EPDNEW_H2379
Type:multiple initiation site
Name:RGS2_1
Description:regulator of G protein signaling 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381192,809,041 - 192,809,101EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9998 AgrOrtholog
COSMIC RGS2 COSMIC
Ensembl Genes ENSG00000116741 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000235382 ENTREZGENE
  ENST00000235382.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000116741 GTEx
HGNC ID HGNC:9998 ENTREZGENE
Human Proteome Map RGS2 Human Proteome Map
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS2 UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot
KEGG Report hsa:5997 UniProtKB/Swiss-Prot
NCBI Gene 5997 ENTREZGENE
OMIM 600861 OMIM
PANTHER PTHR10845:SF43 UniProtKB/Swiss-Prot
  REGULATOR OF G PROTEIN SIGNALING UniProtKB/Swiss-Prot
Pfam RGS UniProtKB/Swiss-Prot
PharmGKB PA34372 PharmGKB
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P41220 ENTREZGENE
  Q49A86_HUMAN UniProtKB/TrEMBL
  Q6I9U5 ENTREZGENE
  RGS2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q6I9U5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-18 RGS2  regulator of G protein signaling 2  RGS2  regulator of G-protein signaling 2  Symbol and/or name change 5135510 APPROVED
2014-06-24 RGS2  regulator of G-protein signaling 2  RGS2  regulator of G-protein signaling 2, 24kDa  Symbol and/or name change 5135510 APPROVED