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Gene: AACS (acetoacetyl-CoA synthetase) Homo sapiens
Symbol: AACS
Name: acetoacetyl-CoA synthetase
RGD ID: 732340
Description: Predicted to have acetoacetate-CoA ligase activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to localize to cytosol; PARTICIPATES IN butanoate metabolic pathway; ketone bodies metabolic pathway; INTERACTS WITH antirheumatic drug; carbamazepine; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetoacetate-CoA ligase; ACSF1; acyl-CoA synthetase family member 1; FLJ12389; FLJ41251; homolog of C. elegans supressor of ras 5 (sur-5); protein sur-5 homolog; SUR-5
Mus musculus (house mouse) : Aacs (acetoacetyl-CoA synthetase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aacs (acetoacetyl-CoA synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aacs (acetoacetyl-CoA synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : AACS (acetoacetyl-CoA synthetase)
Canis lupus familiaris (dog) : AACS (acetoacetyl-CoA synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aacs (acetoacetyl-CoA synthetase)
Sus scrofa (pig) : AACS (acetoacetyl-CoA synthetase)
Chlorocebus sabaeus (African green monkey) : AACS (acetoacetyl-CoA synthetase)
Heterocephalus glaber (naked mole-rat) : Aacs (acetoacetyl-CoA synthetase)
more info ...
Related Pseudogenes: AACSP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl12125,065,434 - 125,143,333 (+)EnsemblGRCh38hg38GRCh38
GRCh3812125,065,435 - 125,143,327 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712125,549,925 - 125,627,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612124,115,878 - 124,193,824 (+)NCBINCBI36hg18NCBI36
Build 3412124,074,886 - 124,152,745NCBI
Celera12125,154,148 - 125,231,815 (+)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12122,513,724 - 122,591,469 (+)NCBIHuRef
CHM1_112125,371,178 - 125,449,300 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on AACS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732340
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.