Insl3 (insulin-like 3) - Rat Genome Database
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Gene: Insl3 (insulin-like 3) Mus musculus
Analyze
Symbol: Insl3
Name: insulin-like 3
RGD ID: 732313
MGI Page MGI
Description: Predicted to have G protein-coupled receptor binding activity and protease binding activity. Involved in in utero embryonic development; male gonad development; and regulation of male gonad development. Predicted to localize to extracellular space and perinuclear region of cytoplasm. Is expressed in cornea; ovary; testis; and trunk. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human INSL3 (insulin like 3); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ley I-L; ley-I-L; leydig insulin-like peptide; R; relaxin like factor; relaxin-like factor; Rlf; Rlnl
RGD Orthologs
Human
Rat
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,141,896 - 72,143,221 (+)NCBIGRCm39mm39
GRCm38871,689,252 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,689,214 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,213,151 - 74,214,474 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,618,241 - 74,619,564 (+)NCBImm8
Celera874,203,798 - 74,205,121 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8770925   PMID:8889548   PMID:9110312   PMID:9403069   PMID:9428631   PMID:10319319   PMID:10349636   PMID:10391220   PMID:10486311   PMID:10650968   PMID:10715534   PMID:11042159  
PMID:11076861   PMID:11170269   PMID:11180952   PMID:11217851   PMID:11342953   PMID:11818498   PMID:11861512   PMID:12466851   PMID:12477932   PMID:12933905   PMID:12943998   PMID:14628051  
PMID:14666470   PMID:15256493   PMID:15956690   PMID:16141072   PMID:16141073   PMID:16223865   PMID:16237153   PMID:16949566   PMID:17393433   PMID:18303090   PMID:18499751   PMID:18534133  
PMID:18981061   PMID:19100252   PMID:19268447   PMID:19420383   PMID:19428929   PMID:19520787   PMID:19696014   PMID:19950223   PMID:20400152   PMID:21147849   PMID:21487003   PMID:21613322  
PMID:21677750   PMID:21779533   PMID:21873635   PMID:21900680   PMID:23077169   PMID:23087174   PMID:23100620   PMID:23136395   PMID:23300479   PMID:23840809   PMID:24640567   PMID:24780841  
PMID:24956260   PMID:25289806   PMID:25344072   PMID:25668066   PMID:25725066   PMID:25933105   PMID:26108792   PMID:26823808   PMID:29324782   PMID:29438518   PMID:30067986   PMID:30178547  
PMID:30518625   PMID:31748609   PMID:32301970   PMID:32497091  


Genomics

Comparative Map Data
Insl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,141,896 - 72,143,221 (+)NCBIGRCm39mm39
GRCm38871,689,252 - 71,690,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,689,214 - 71,690,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,213,151 - 74,214,474 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,618,241 - 74,619,564 (+)NCBImm8
Celera874,203,798 - 74,205,121 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
INSL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,816,512 - 17,821,574 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,816,512 - 17,821,519 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,927,322 - 17,932,383 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,788,322 - 17,793,320 (-)NCBINCBI36hg18NCBI36
Build 341917,788,321 - 17,793,320NCBI
Celera1917,829,042 - 17,834,041 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,492,756 - 17,497,784 (-)NCBIHuRef
CHM1_11917,926,865 - 17,931,926 (-)NCBICHM1_1
Insl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,120,753 - 20,122,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,121,352 - 20,122,696 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,981,216 - 19,983,156 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,890,131 - 18,891,475 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,890,128 - 18,891,473 (+)NCBI
Celera1618,601,812 - 18,603,156 (+)NCBICelera
Cytogenetic Map16p14NCBI
Insl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,413,764 - 3,415,691 (+)NCBIChiLan1.0ChiLan1.0
INSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,050,526 - 45,072,805 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,071,128 - 45,072,446 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
INSL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,929,581 - 59,931,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,929,591 - 59,931,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,499,023 - 59,500,652 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q12-q13NCBI
INSL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,291,220 - 16,296,705 (-)NCBI
Insl3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,368,660 - 1,369,740 (-)NCBI

Position Markers
Jak3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,688,153 - 71,688,278UniSTSGRCm38
MGSCv37874,212,052 - 74,212,177UniSTSGRCm37
Celera874,202,699 - 74,202,824UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map833.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:162
Interacting mature miRNAs:170
Transcripts:ENSMUST00000034261
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034261   ⟹   ENSMUSP00000034261
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,689,214 - 71,690,575 (+)Ensembl
RefSeq Acc Id: NM_013564   ⟹   NP_038592
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,141,896 - 72,143,221 (+)NCBI
GRCm38871,689,252 - 71,690,577 (+)ENTREZGENE
MGSCv37874,213,151 - 74,214,474 (+)RGD
Celera874,203,798 - 74,205,123 (+)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038592   ⟸   NM_013564
- Peptide Label: precursor
- UniProtKB: Q5RL10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034261   ⟸   ENSMUST00000034261
Protein Domains
IlGF

Promoters
RGD ID:8667433
Promoter ID:EPDNEW_M11747
Type:multiple initiation site
Name:Insl3_1
Description:Mus musculus insulin-like 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,689,252 - 71,689,312EPDNEW
RGD ID:6843326
Promoter ID:MM_KWN:54816
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000049959
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,212,221 - 74,213,222 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108427 AgrOrtholog
Ensembl Genes ENSMUSG00000053778
  ENSMUSG00000079019 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034261 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034261 ENTREZGENE, UniProtKB/TrEMBL
InterPro INSL3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSL3/INSL4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16336 UniProtKB/TrEMBL
MGD MGI:108427 ENTREZGENE
NCBI Gene 16336 ENTREZGENE
PANTHER PTHR10423 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10423:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Insulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Insl3 PhenoGen
PRINTS INSULINFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IlGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.476857 ENTREZGENE
UniProt INSL3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5RL10 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97744 UniProtKB/Swiss-Prot