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Gene: PLP1 (proteolipid protein 1) Homo sapiens
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Symbol: PLP1
Name: proteolipid protein 1
Description: Exhibits identical protein binding activity. Involved in substantia nigra development. Localizes to the plasma membrane. Implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GPM6C; HLD1; lipophilin; major myelin proteolipid protein; MMPL; myelin proteolipid protein; PLP; PLP/DM20; PMD; proteolipid protein; proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); SPG2
Orthologs:
Mus musculus (house mouse) : Plp1 (proteolipid protein (myelin) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plp1 (proteolipid protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plp1 (proteolipid protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLP1 (proteolipid protein 1)
Canis lupus familiaris (dog) : PLP1 (proteolipid protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plp1 (proteolipid protein 1)
Sus scrofa (pig) : PLP1 (proteolipid protein 1)
Chlorocebus sabaeus (green monkey) : PLP1 (proteolipid protein 1)
Heterocephalus glaber (naked mole-rat) : Plp1 (proteolipid protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX103,773,718 - 103,792,619 (+)Ensembl
GRCh38X103,776,506 - 103,792,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X103,031,439 - 103,047,548 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,918,410 - 102,934,204 (+)NCBINCBI36hg18NCBI36
Build 34X102,837,898 - 102,853,690NCBI
CeleraX103,470,449 - 103,486,558 (+)NCBI
Cytogenetic MapXq22.2NCBI
HuRefX92,687,547 - 92,703,609 (+)NCBIHuRef
CHM1_1X102,924,421 - 102,940,535 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PLP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732304
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.