Fcnb (ficolin B) - Rat Genome Database

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Gene: Fcnb (ficolin B) Mus musculus
Analyze
Symbol: Fcnb
Name: ficolin B
RGD ID: 732192
MGI Page MGI
Description: Exhibits sialic acid binding activity. Predicted to be involved in several processes, including activation of immune response; positive regulation of interleukin-8 production; and protein localization to cell surface. Predicted to localize to collagen-containing extracellular matrix; extracellular space; and extrinsic component of external side of plasma membrane. Is expressed in bone marrow; embryo; liver; and spleen. Orthologous to several human genes including FCN1 (ficolin 1); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; folic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: collagen/fibrinogen domain-containing protein 2; Fcn2; ficolin-2; ficolin-B; ficolin-beta; L-ficolin; MGC130137; MGC130138
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,966,491 - 27,974,921 (-)NCBIGRCm39mm39
GRCm39 Ensembl227,966,390 - 27,974,897 (-)Ensembl
GRCm38228,076,479 - 28,084,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,076,378 - 28,084,885 (-)EnsemblGRCm38mm10GRCm38
MGSCv37227,931,999 - 27,940,398 (-)NCBIGRCm37mm9NCBIm37
MGSCv36227,898,488 - 27,906,887 (-)NCBImm8
Celera227,779,281 - 27,787,680 (-)NCBICelera
Cytogenetic Map2A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:9611252   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15475251   PMID:15489334   PMID:15950722   PMID:16141072   PMID:16141073   PMID:16328467   PMID:16602821  
PMID:21267068   PMID:21873635   PMID:22459270   PMID:22523468   PMID:23150716   PMID:23911405   PMID:24040095   PMID:24952961   PMID:27467404   PMID:28739878   PMID:30818229  


Genomics

Comparative Map Data
Fcnb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,966,491 - 27,974,921 (-)NCBIGRCm39mm39
GRCm39 Ensembl227,966,390 - 27,974,897 (-)Ensembl
GRCm38228,076,479 - 28,084,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,076,378 - 28,084,885 (-)EnsemblGRCm38mm10GRCm38
MGSCv37227,931,999 - 27,940,398 (-)NCBIGRCm37mm9NCBIm37
MGSCv36227,898,488 - 27,906,887 (-)NCBImm8
Celera227,779,281 - 27,787,680 (-)NCBICelera
Cytogenetic Map2A3NCBI
FCN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9134,903,232 - 134,917,912 (-)EnsemblGRCh38hg38GRCh38
GRCh389134,903,232 - 134,917,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379137,795,078 - 137,809,758 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369136,941,253 - 136,949,630 (-)NCBINCBI36hg18NCBI36
Build 349135,027,380 - 135,035,754NCBI
Celera9108,315,253 - 108,323,628 (-)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9107,265,062 - 107,273,437 (-)NCBIHuRef
CHM1_19137,950,267 - 137,958,642 (-)NCBICHM1_1
Fcnb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2311,393,771 - 11,402,198 (-)NCBI
Rnor_6.0 Ensembl36,617,751 - 6,626,284 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.036,617,816 - 6,626,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0311,974,691 - 11,983,068 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,010,989 - 7,019,366 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.137,011,288 - 7,019,666 (-)NCBI
Celera36,185,644 - 6,194,021 (-)NCBICelera
Cytogenetic Map3p12NCBI
Fcn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555133,687,232 - 3,698,673 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555133,690,550 - 3,697,785 (-)NCBIChiLan1.0ChiLan1.0
FCN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19135,040,722 - 135,049,105 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9135,040,310 - 135,049,111 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09106,039,315 - 106,047,648 (-)NCBIMhudiblu_PPA_v0panPan3
FCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,868,942 - 50,876,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,868,973 - 50,875,792 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha950,152,289 - 50,159,350 (+)NCBI
ROS_Cfam_1.0951,746,147 - 51,753,208 (+)NCBI
UMICH_Zoey_3.1950,506,401 - 50,513,474 (+)NCBI
UNSW_CanFamBas_1.0950,850,289 - 50,857,359 (+)NCBI
UU_Cfam_GSD_1.0950,927,946 - 50,935,059 (+)NCBI
FCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1274,103,877 - 274,111,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11274,106,276 - 274,111,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21308,195,158 - 308,203,079 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FCN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1123,227,790 - 3,236,161 (+)NCBI
Vero_WHO_p1.0NW_0236660581,894,000 - 1,902,427 (-)NCBI
Fcn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247602,743,996 - 2,751,116 (-)NCBI

Position Markers
Fcnb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map2 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323390328289138Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2778910341789249Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2834628442346384Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2841803942418228Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2949443443494563Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2949443443494563Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212472666726109Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21432455548324701Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2123971355239859Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22123971355239859Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22379913357799257Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22470000055000000Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22478910333633160Mouse
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22478910333633160Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22541803957081799Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22713263056506216Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:558
Count of miRNA genes:378
Interacting mature miRNAs:422
Transcripts:ENSMUST00000028179, ENSMUST00000117486, ENSMUST00000135472
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028179   ⟹   ENSMUSP00000028179
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl228,076,378 - 28,084,885 (-)Ensembl
RefSeq Acc Id: ENSMUST00000117486   ⟹   ENSMUSP00000112625
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl228,078,099 - 28,084,885 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135472   ⟹   ENSMUSP00000119098
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl228,079,739 - 28,084,885 (-)Ensembl
RefSeq Acc Id: NM_010190   ⟹   NP_034320
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39227,966,491 - 27,974,890 (-)NCBI
GRCm38228,076,479 - 28,084,878 (-)NCBI
MGSCv37227,931,999 - 27,940,398 (-)RGD
Celera227,779,281 - 27,787,680 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497676   ⟹   XP_006497739
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39227,966,841 - 27,974,921 (-)NCBI
GRCm38228,076,829 - 28,084,910 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034320   ⟸   NM_010190
- Peptide Label: precursor
- UniProtKB: O70497 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006497739   ⟸   XM_006497676
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000028179   ⟸   ENSMUST00000028179
RefSeq Acc Id: ENSMUSP00000119098   ⟸   ENSMUST00000135472
RefSeq Acc Id: ENSMUSP00000112625   ⟸   ENSMUST00000117486
Promoters
RGD ID:6876776
Promoter ID:EPDNEW_M1839
Type:single initiation site
Name:Fcnb_1
Description:Mus musculus ficolin B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38228,084,885 - 28,084,945EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341158 AgrOrtholog
Ensembl Genes ENSMUSG00000026835 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000028179 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112625 UniProtKB/TrEMBL
  ENSMUSP00000119098 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028179 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000117486 UniProtKB/TrEMBL
  ENSMUST00000135472 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.530.10 UniProtKB/Swiss-Prot
InterPro Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_2 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/Swiss-Prot
KEGG Report mmu:14134 UniProtKB/Swiss-Prot
MGD MGI:1341158 ENTREZGENE
NCBI Gene 14134 ENTREZGENE
Pfam Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fcnb PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2FDG6_MOUSE UniProtKB/TrEMBL
  FCN2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U9R5_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3KNL6 UniProtKB/Swiss-Prot