Chst3 (carbohydrate sulfotransferase 3) - Rat Genome Database
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Gene: Chst3 (carbohydrate sulfotransferase 3) Mus musculus
Analyze
Symbol: Chst3
Name: carbohydrate sulfotransferase 3
RGD ID: 732189
MGI Page MGI
Description: Is expressed in several structures, including brain; genitourinary system; gut; immune system; and respiratory system. Used to study schizophrenia. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3); PARTICIPATES IN chondroitin sulfate biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C6S; C6ST; C6ST-; C6ST-1; carbohydrate (chondroitin 6/keratan) sulfotransferase 3; chondroitin 6-O-sulfotransferase 1; chondroitin 6-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0; GST-; GST-0
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,017,349 - 60,057,936 (-)NCBIGRCm39mm39
GRCm39 Ensembl1060,017,354 - 60,055,082 (-)Ensembl
GRCm381060,181,527 - 60,222,114 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,181,532 - 60,219,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv371059,644,275 - 59,682,008 (-)NCBIGRCm37mm9NCBIm37
MGSCv361059,576,891 - 59,584,064 (-)NCBImm8
Celera1061,277,814 - 61,316,112 (-)NCBICelera
Cytogenetic Map10B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11181564   PMID:11217851   PMID:11696535   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15747579   PMID:16141072  
PMID:16141073   PMID:18079434   PMID:18799693   PMID:19156209   PMID:19915053   PMID:21747937   PMID:21873635   PMID:22246436   PMID:23118208   PMID:23880769   PMID:26231575   PMID:26646821  
PMID:30228991   PMID:32201365  


Genomics

Comparative Map Data
Chst3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,017,349 - 60,057,936 (-)NCBIGRCm39mm39
GRCm39 Ensembl1060,017,354 - 60,055,082 (-)Ensembl
GRCm381060,181,527 - 60,222,114 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,181,532 - 60,219,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv371059,644,275 - 59,682,008 (-)NCBIGRCm37mm9NCBIm37
MGSCv361059,576,891 - 59,584,064 (-)NCBImm8
Celera1061,277,814 - 61,316,112 (-)NCBICelera
Cytogenetic Map10B4NCBI
CHST3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1071,964,395 - 72,013,558 (+)EnsemblGRCh38hg38GRCh38
GRCh381071,964,395 - 72,013,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371073,724,153 - 73,773,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,394,126 - 73,443,318 (+)NCBINCBI36hg18NCBI36
Build 341073,394,125 - 73,443,318NCBI
Celera1067,007,692 - 67,056,893 (+)NCBI
Cytogenetic Map10q22.1NCBI
HuRef1067,718,863 - 67,768,083 (+)NCBIHuRef
CHM1_11074,006,249 - 74,055,464 (+)NCBICHM1_1
Chst3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22028,114,387 - 28,152,046 (-)NCBI
Rnor_6.0 Ensembl2029,731,816 - 29,738,506 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02029,731,828 - 29,768,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02031,532,769 - 31,569,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42027,480,448 - 27,482,990 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12027,494,247 - 27,496,790 (-)NCBI
Celera2029,558,419 - 29,560,961 (-)NCBICelera
Cytogenetic Map20q11NCBI
Chst3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543719,563,088 - 19,569,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543719,563,645 - 19,605,747 (-)NCBIChiLan1.0ChiLan1.0
CHST3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11070,951,211 - 71,000,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,951,190 - 70,994,936 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01068,427,305 - 68,476,512 (+)NCBIMhudiblu_PPA_v0panPan3
CHST3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl422,691,336 - 22,694,254 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1422,668,430 - 22,699,157 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Chst3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365216,864,456 - 6,900,122 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHST3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,850,931 - 74,891,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11474,850,931 - 74,891,527 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,739,187 - 80,779,620 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHST3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,292,705 - 59,295,821 (-)NCBI
ChlSab1.1 Ensembl959,293,158 - 59,300,866 (-)Ensembl
Chst3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247545,800,240 - 5,832,290 (+)NCBI

Position Markers
Chst3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381060,186,450 - 60,186,540UniSTSGRCm38
MGSCv371059,649,198 - 59,649,288UniSTSGRCm37
Celera1061,282,737 - 61,282,827UniSTS
Cytogenetic Map10B4UniSTS
cM Map10 UniSTS
Chst3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B4UniSTS
Chst3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381060,185,593 - 60,186,097UniSTSGRCm38
MGSCv371059,648,341 - 59,648,845UniSTSGRCm37
Celera1061,281,880 - 61,282,384UniSTS
Cytogenetic Map10B4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102984430763844387Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103109840365098534Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103170104065701188Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4140150475401504Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104570000069300000Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104640000069400000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104809840370276821Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
12904011Cfq11_mconditioned fear QTL 11 (mouse)105660406061105062Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3378
Count of miRNA genes:749
Interacting mature miRNAs:1012
Transcripts:ENSMUST00000068690, ENSMUST00000135158, ENSMUST00000167915
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000068690   ⟹   ENSMUSP00000065010
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1060,181,534 - 60,188,707 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135158   ⟹   ENSMUSP00000126281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1060,181,532 - 60,219,260 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167915   ⟹   ENSMUSP00000131532
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1060,185,605 - 60,194,239 (-)Ensembl
RefSeq Acc Id: NM_016803   ⟹   NP_058083
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,017,349 - 60,055,082 (-)NCBI
GRCm381060,181,527 - 60,219,260 (-)NCBI
MGSCv371059,644,275 - 59,682,008 (-)RGD
Celera1061,277,814 - 61,316,112 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011243510   ⟹   XP_011241812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,017,356 - 60,051,917 (-)NCBI
GRCm381060,181,534 - 60,216,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243512   ⟹   XP_011241814
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,017,356 - 60,057,936 (-)NCBI
GRCm381060,181,534 - 60,222,114 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243513   ⟹   XP_011241815
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,017,356 - 60,043,483 (-)NCBI
GRCm381060,181,534 - 60,200,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017314030   ⟹   XP_017169519
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391060,017,356 - 60,057,936 (-)NCBI
GRCm381060,181,534 - 60,222,114 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058083   ⟸   NM_016803
- UniProtKB: O88199 (UniProtKB/Swiss-Prot),   G5E8X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241814   ⟸   XM_011243512
- Peptide Label: isoform X1
- UniProtKB: G5E8X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241812   ⟸   XM_011243510
- Peptide Label: isoform X1
- UniProtKB: G5E8X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241815   ⟸   XM_011243513
- Peptide Label: isoform X1
- UniProtKB: G5E8X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169519   ⟸   XM_017314030
- Peptide Label: isoform X1
- UniProtKB: G5E8X5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000065010   ⟸   ENSMUST00000068690
RefSeq Acc Id: ENSMUSP00000126281   ⟸   ENSMUST00000135158
RefSeq Acc Id: ENSMUSP00000131532   ⟸   ENSMUST00000167915

Promoters
RGD ID:8672058
Promoter ID:EPDNEW_M14060
Type:single initiation site
Name:Chst3_2
Description:Mus musculus carbohydrate (chondroitin 6/keratan) sulfotransferase3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14061  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381060,189,713 - 60,189,773EPDNEW
RGD ID:8672060
Promoter ID:EPDNEW_M14061
Type:initiation region
Name:Chst3_1
Description:Mus musculus carbohydrate (chondroitin 6/keratan) sulfotransferase3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14060  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381060,219,288 - 60,219,348EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858224 AgrOrtholog
Ensembl Genes ENSMUSG00000057337 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000065010 UniProtKB/Swiss-Prot
  ENSMUSP00000126281 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000131532 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000068690 UniProtKB/Swiss-Prot
  ENSMUST00000135158 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000167915 UniProtKB/Swiss-Prot
InterPro Carbohydrate_sulfotransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53374 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1858224 ENTREZGENE
NCBI Gene 53374 ENTREZGENE
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chst3 PhenoGen
PIRSF Carbohydrate_sulfotransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CHST3_MOUSE UniProtKB/Swiss-Prot
  G5E8X5 ENTREZGENE, UniProtKB/TrEMBL
  O88199 ENTREZGENE
UniProt Secondary Q794I5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-09 Chst3  carbohydrate sulfotransferase 3    carbohydrate (chondroitin 6/keratan) sulfotransferase 3  Symbol and/or name change 5135510 APPROVED