Gene: Chst3 (carbohydrate sulfotransferase 3) Mus musculus
Analyze
Symbol:
Chst3
Name:
carbohydrate sulfotransferase 3
Description:
ENCODES a protein that exhibits chondroitin 6-sulfotransferase activity; proteoglycan sulfotransferase activity; INVOLVED IN chondroitin sulfate biosynthetic process; T cell homeostasis; positive regulation of cellular component movement (ortholog); PARTICIPATES IN chondroitin sulfate biosynthetic pathway; ASSOCIATED WITH abnormal bone marrow morphology; abnormal ovarian follicle morphology; decreased aggression towards mice; ASSOCIATED WITH bone development disease (ortholog); Larsen syndrome (ortholog); Larsen-like syndrome B3GAT3 type (ortholog); FOUND IN Golgi apparatus (inferred); Golgi membrane (inferred); integral component of membrane (inferred); INTERACTS WITH 4,4'-diaminodiphenylmethane; benzo[a]pyrene; benzo[b]fluoranthene
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
C6ST; C6ST-1; carbohydrate (chondroitin 6/keratan) sulfotransferase 3; chondroitin 6-O-sulfotransferase 1; chondroitin 6-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0; GST-0
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CHST3 (carbohydrate sulfotransferase 3) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Chst3 (carbohydrate sulfotransferase 3) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Chst3 (carbohydrate sulfotransferase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CHST3 (carbohydrate sulfotransferase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CHST3 (carbohydrate sulfotransferase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Chst3 (carbohydrate sulfotransferase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CHST3 (carbohydrate sulfotransferase 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Chst3 (carbohydrate sulfotransferase 3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
CHST3 (carbohydrate sulfotransferase 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
chst3a (carbohydrate (chondroitin 6) sulfotransferase 3a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Danio rerio (zebrafish):
chst3b (carbohydrate (chondroitin 6) sulfotransferase 3b)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, ZFIN)
Drosophila melanogaster (fruit fly):
CG31637
Alliance
DIOPT (Ensembl Compara, InParanoid, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
CG9550
Alliance
DIOPT (Ensembl Compara, InParanoid, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 10 60,181,527 - 60,222,114 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 10 59,644,275 - 59,682,008 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 10 59,576,891 - 59,584,064 (-) NCBI mm8 Celera 10 61,277,814 - 61,316,112 (-) NCBI Celera Cytogenetic Map 10 B4 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
bone development disease ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Skeletal dysplasia ClinVar bone development disease ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Skeletal dysplasia ClinVar PMID:28492532 Larsen syndrome ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Larsen syndrome ClinVar Larsen syndrome ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Larsen syndrome ClinVar PMID:28492532 osteochondrodysplasia ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia ClinVar PMID:28492532 osteochondrodysplasia ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia ClinVar spondyloepiphyseal dysplasia congenita ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia congenita ClinVar spondyloepiphyseal dysplasia congenita ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia congenita ClinVar PMID:28492532 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia with congenital joint dislocations ClinVar PMID:25741868 , PMID:27753269 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia with congenital joint dislocations ClinVar PMID:20830804 more ... spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia with congenital joint dislocations ClinVar PMID:25741868 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia with congenital joint dislocations ClinVar PMID:28492532 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by term: Spondyloepiphyseal dysplasia with congenital joint dislocations ClinVar spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:23918704 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:18513679 more ... spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:18698629 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:19320654 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:15098240 , PMID:15215498 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:18513679 , PMID:20830804 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:15368507 more ... spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:18513679 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:20830804 spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 8554872 ClinVar Annotator: match by OMIM:143095 ClinVar PMID:112567 , PMID:18513679
Imported Annotations - CTD
Larsen-like syndrome B3GAT3 type ISO RGD:1352183 11554173 CTD Direct Evidence: marker/mechanism CTD osteochondrodysplasia ISO RGD:1352183 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30200136 Imported Annotations - MGI
schizophrenia IEA 13592920 OMIM:181500 MouseDO Imported Annotations - OMIM
spondyloepiphyseal dysplasia with congenital joint dislocations ISO RGD:1352183 7240710 OMIM
(RS)-amphetamine decreases expression ISO RGD:620355 6480464 Amphetamine results in decreased expression of CHST3 mRNA CTD PMID:30779732 2-methylcholine affects expression ISO RGD:1352183 6480464 beta-methylcholine affects the expression of CHST3 mRNA CTD PMID:21179406 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of CHST3 mRNA CTD PMID:18648102 aflatoxin B1 increases expression ISO RGD:1352183 6480464 Aflatoxin B1 results in increased expression of CHST3 mRNA CTD PMID:22100608 ammonium chloride affects expression ISO RGD:620355 6480464 Ammonium Chloride affects the expression of CHST3 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:1352183 6480464 Antirheumatic Agents results in increased expression of CHST3 mRNA CTD PMID:24449571 atrazine increases expression ISO RGD:1352183 6480464 Atrazine results in increased expression of CHST3 mRNA CTD PMID:22378314 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CHST3 mRNA CTD PMID:22228805 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CHST3 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1352183 6480464 7 more ... CTD PMID:19150397 benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of CHST3 mRNA CTD PMID:26377693 bisphenol A decreases expression ISO RGD:620355 6480464 bisphenol A results in decreased expression of CHST3 mRNA CTD PMID:25181051 calcitriol increases expression ISO RGD:1352183 6480464 Calcitriol results in increased expression of CHST3 mRNA CTD PMID:16002434 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of CHST3 mRNA, Nanotubes, Carbon results in decreased expression of CHST3 mRNA CTD PMID:25554681 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CHST3 gene CTD PMID:20938992 chromium atom increases expression ISO RGD:1352183 6480464 Chromium results in increased expression of CHST3 mRNA CTD PMID:17547211 chromium(3+) increases expression ISO RGD:1352183 6480464 Chromium results in increased expression of CHST3 mRNA CTD PMID:17547211 cisplatin increases expression ISO RGD:1352183 6480464 Cisplatin results in increased expression of CHST3 mRNA CTD PMID:27392435 clobetasol decreases expression EXP 6480464 Clobetasol results in decreased expression of CHST3 mRNA CTD PMID:27462272 clothianidin increases expression ISO RGD:1352183 6480464 clothianidin results in increased expression of CHST3 mRNA CTD PMID:29044138 cyclosporin A increases expression ISO RGD:1352183 6480464 Cyclosporine results in increased expression of CHST3 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:1352183 6480464 Cyclosporine results in decreased expression of CHST3 mRNA CTD PMID:27989131 dicrotophos increases expression ISO RGD:1352183 6480464 dicrotophos results in increased expression of CHST3 mRNA CTD PMID:28302478 doxorubicin decreases expression ISO RGD:1352183 6480464 Doxorubicin results in decreased expression of CHST3 mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:1352183 6480464 Selenium results in increased expression of CHST3 mRNA CTD PMID:19244175 ethyl methanesulfonate increases expression ISO RGD:1352183 6480464 Ethyl Methanesulfonate results in increased expression of CHST3 mRNA CTD PMID:23649840 fenamidone increases expression EXP 6480464 fenamidone results in increased expression of CHST3 mRNA CTD PMID:27029645 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CHST3 gene CTD PMID:20938992 formaldehyde increases expression ISO RGD:1352183 6480464 Formaldehyde results in increased expression of CHST3 mRNA CTD PMID:23649840 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CHST3 gene CTD PMID:20938992 lead(0) affects expression ISO RGD:1352183 6480464 Lead affects the expression of CHST3 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1352183 6480464 Lead affects the expression of CHST3 mRNA CTD PMID:28903495 leflunomide increases expression ISO RGD:1352183 6480464 leflunomide results in increased expression of CHST3 mRNA CTD PMID:28988120 methyl methanesulfonate increases expression ISO RGD:1352183 6480464 Methyl Methanesulfonate results in increased expression of CHST3 mRNA CTD PMID:23649840 N-methyl-4-phenylpyridinium increases expression ISO RGD:1352183 6480464 1-Methyl-4-phenylpyridinium results in increased expression of CHST3 mRNA CTD PMID:24810058 paracetamol increases expression ISO RGD:1352183 6480464 Acetaminophen results in increased expression of CHST3 mRNA CTD PMID:29067470 phenol increases expression ISO RGD:1352183 6480464 Phenol results in increased expression of CHST3 mRNA CTD PMID:17547211 potassium chromate decreases expression ISO RGD:1352183 6480464 potassium chromate(VI) results in decreased expression of CHST3 mRNA CTD PMID:22714537 potassium dichromate increases expression ISO RGD:1352183 6480464 Potassium Dichromate results in increased expression of CHST3 mRNA CTD PMID:17547211 quercetin increases expression ISO RGD:1352183 6480464 Quercetin results in increased expression of CHST3 mRNA CTD PMID:21632981 selenium atom increases expression ISO RGD:1352183 6480464 Selenium results in increased expression of CHST3 mRNA CTD PMID:19244175 tetraphene increases expression EXP 6480464 benz(a)anthracene results in increased expression of CHST3 mRNA CTD PMID:26377693 trichostatin A increases expression ISO RGD:1352183 6480464 trichostatin A results in increased expression of CHST3 mRNA CTD PMID:24935251 triclosan decreases expression ISO RGD:1352183 6480464 Triclosan results in decreased expression of CHST3 mRNA CTD PMID:30510588 urethane increases expression ISO RGD:1352183 6480464 Urethane results in increased expression of CHST3 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1352183 6480464 Valproic Acid affects the expression of CHST3 mRNA CTD PMID:25979313 valproic acid increases methylation ISO RGD:1352183 6480464 Valproic Acid results in increased methylation of CHST3 gene CTD PMID:29154799 vitamin E increases expression ISO RGD:1352183 6480464 Vitamin E results in increased expression of CHST3 mRNA CTD PMID:19244175
Biological Process carbohydrate metabolic process IEA InterPro:IPR016469 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 carbohydrate metabolic process IEA UniProtKB-KW:KW-0119 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 chondroitin sulfate biosynthetic process IDA 2290270 (MGI:MGI:1206144, PMID:9597547) MGI MGI:MGI:1206144 , PMID:9597547 chondroitin sulfate biosynthetic process IBA MGI:MGI:1858224 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 chondroitin sulfate biosynthetic process ISO UniProtKB:Q7LGC8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chondroitin sulfate biosynthetic process IMP MGI:MGI:2176247 2290270 (MGI:MGI:2156294, PMID:11696535) MGI MGI:MGI:2156294 , PMID:11696535 N-acetylglucosamine metabolic process IBA MGI:MGI:1931825 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 positive regulation of cellular component movement ISO RGD:620355 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 sulfur compound metabolic process ISO UniProtKB:Q7LGC8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 sulfur compound metabolic process IBA MGI:MGI:1931825 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 T cell homeostasis IMP MGI:MGI:2176247 2290270 (MGI:MGI:2156294, PMID:11696535) MGI MGI:MGI:2156294 , PMID:11696535 Cellular Component Golgi apparatus IEA UniProtKB-KW:KW-0333 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Golgi membrane IEA InterPro:IPR016469 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 trans-Golgi network IBA PANTHER:PTN000842282 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function chondroitin 6-sulfotransferase activity IDA 2290270 (MGI:MGI:1206144, PMID:9597547) MGI MGI:MGI:1206144 , PMID:9597547 chondroitin 6-sulfotransferase activity IBA MGI:MGI:1858224 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 chondroitin 6-sulfotransferase activity ISO UniProtKB:Q7LGC8 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 N-acetylglucosamine 6-O-sulfotransferase activity IBA MGI:MGI:1931825 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 proteoglycan sulfotransferase activity IMP MGI:MGI:2176247 2290270 (MGI:MGI:2156294, PMID:11696535) MGI MGI:MGI:2156294 , PMID:11696535 proteoglycan sulfotransferase activity ISO RGD:620355 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 sulfotransferase activity IEA InterPro:IPR000863 , InterPro:IPR016469 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194
Imported Annotations - KEGG (archival)
chondroitin sulfate biosynthetic pathway IEA 6907045 KEGG mmu:00532
Gene-Chemical Interaction Annotations
