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Gene: LNPEP (leucyl and cystinyl aminopeptidase) Homo sapiens
Symbol: LNPEP
Name: leucyl and cystinyl aminopeptidase
Description: Exhibits aminopeptidase activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; peptide catabolic process; and proteolysis. Localizes to the integral component of plasma membrane. Biomarker of breast cancer; leiomyoma; polyhydramnios; renal cell carcinoma; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aminopeptidase vp165; angiotensin IV receptor; AT (4) receptor; CAP; cystinyl aminopeptidase; insulin-regulated aminopeptidase; insulin-regulated membrane aminopeptidase; insulin-responsive aminopeptidase; IRAP; leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; otase; oxytocinase; P-LAP; placental leucine aminopeptidase; PLAP; vasopressinase
Mus musculus (house mouse) : Lnpep (leucyl/cystinyl aminopeptidase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lnpep (leucyl and cystinyl aminopeptidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lnpep (leucyl and cystinyl aminopeptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : LNPEP (leucyl and cystinyl aminopeptidase)
Canis lupus familiaris (dog) : LNPEP (leucyl and cystinyl aminopeptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lnpep (leucyl and cystinyl aminopeptidase)
Sus scrofa (pig) : LNPEP (leucyl and cystinyl aminopeptidase)
Chlorocebus sabaeus (green monkey) : LNPEP (leucyl and cystinyl aminopeptidase)
Heterocephalus glaber (naked mole-rat) : Lnpep (leucyl and cystinyl aminopeptidase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl596,935,394 - 97,037,513 (+)Ensembl
GRCh38596,934,859 - 97,037,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37596,271,346 - 96,365,115 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36596,297,102 - 96,390,871 (+)NCBINCBI36hg18NCBI36
Build 34596,297,554 - 96,390,496NCBI
Celera592,155,866 - 92,249,526 (+)NCBI
Cytogenetic Map5q15NCBI
HuRef591,461,444 - 91,554,831 (+)NCBIHuRef
CHM1_1595,704,043 - 95,797,761 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LNPEP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732137
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.