GNA15 (G protein subunit alpha 15)

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Gene: GNA15 (G protein subunit alpha 15) Homo sapiens

Analyze

Symbol:

GNA15

Name:

G protein subunit alpha 15

RGD ID:

732130

HGNC Page

HGNC

Description:

Exhibits G protein-coupled receptor binding activity. Involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to localize to plasma membrane; PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH (-)-demecolcine; 17beta-estradiol; 2,4-Nonadienal.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

epididymis tissue protein Li 17E; g alpha-15; g alpha-16; G-protein subunit alpha-15; G-protein subunit alpha-16; GNA16; guanine nucleotide binding protein (G protein), alpha 15 (Gq class); guanine nucleotide-binding protein subunit alpha-15; guanine nucleotide-binding protein subunit alpha-16

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	3,136,033 - 3,163,749 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	3,136,033 - 3,163,749 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	3,136,031 - 3,163,747 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	3,087,191 - 3,114,766 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	3,087,229 - 3,114,741	NCBI
Celera	19	3,072,520 - 3,100,641 (+)	NCBI
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,905,020 - 2,932,757 (+)	NCBI		HuRef
CHM1_1	19	3,135,905 - 3,163,646 (+)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,4-Nonadienal (EXP)

acetamide (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP)

aflatoxin B2 (EXP)

alpha-ionone (EXP)

ammonium chloride (ISO)

amphetamine (ISO)

antirheumatic drug (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (EXP)

bisphenol A (ISO)

butan-1-ol (EXP)

butanal (EXP)

C60 fullerene (ISO)

carvone (ISO)

citral dimethyl acetal (EXP)

citronellal (ISO)

dextran sulfate (ISO)

ethanol (ISO)

flavonoids (ISO)

formaldehyde (EXP)

furan (ISO)

geraniol (EXP)

heptan-2-one (EXP)

heptanal (ISO)

isoprenaline (ISO)

limonene (ISO)

methapyrilene (EXP)

methyl methanesulfonate (EXP)

nickel atom (EXP)

nickel sulfate (EXP)

nonanedioic acid (EXP)

nonanoic acid (EXP)

octanal (EXP,ISO)

octanoic acid (EXP)

paracetamol (EXP)

quercetin (EXP)

silicon dioxide (ISO)

Soman (ISO)

titanium dioxide (ISO)

valproic acid (EXP)

vincristine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

action potential (IBA)

activation of phospholipase C activity (TAS)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IBA)

G protein-coupled receptor signaling pathway (TAS)

phospholipase C-activating dopamine receptor signaling pathway (IBA)

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway (TAS)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

platelet activation (TAS)

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway (IPI,ISO)

Cellular Component

heterotrimeric G-protein complex (IBA,NAS)

membrane (ISO)

plasma membrane (TAS)

synapse (IEA)

Molecular Function

G protein-coupled receptor binding (IBA,IDA,ISO)

G-protein beta/gamma-subunit complex binding (IBA)

GTP binding (IEA)

GTPase activity (IBA)

metal ion binding (IEA)

type 2A serotonin receptor binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Chagas disease pathway (IEA)

eicosanoid signaling pathway (EXP)

endothelin signaling pathway (EXP)

Entamoebiasis pathway (IEA)

G protein mediated signaling pathway via Galphaq family (TAS)

sphingosine 1-phosphate signaling pathway (EXP)

References

References - curated


1.	GOA_HUMAN data from the GO Consortium
2.	Pipeline to import KEGG annotations from KEGG into RGD
3.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	RGD automated import pipeline for gene-chemical interactions
6.	Rhee SG Annu Rev Biochem. 2001;70:281-312.

Additional References at PubMed

PMID:1302014	PMID:1322796	PMID:1905813	PMID:7608160	PMID:7703490	PMID:7797501	PMID:7937899	PMID:8415674	PMID:8863838	PMID:9572309	PMID:9742207	PMID:9843397
PMID:9988720	PMID:10571060	PMID:10644723	PMID:10973974	PMID:11118617	PMID:11686331	PMID:12095632	PMID:12401211	PMID:12477932	PMID:12647293	PMID:12670499	PMID:12748287
PMID:12885252	PMID:14535952	PMID:14551213	PMID:15057824	PMID:15489334	PMID:16102047	PMID:16218966	PMID:17207965	PMID:18240029	PMID:18755267	PMID:19275934	PMID:19687291
PMID:20150327	PMID:20445134	PMID:20736409	PMID:21486497	PMID:21832049	PMID:21873635	PMID:22227248	PMID:23200847	PMID:24204697	PMID:25701539	PMID:28514442

Genomics

Comparative Map Data

GNA15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	3,136,033 - 3,163,749 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	3,136,033 - 3,163,749 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	3,136,031 - 3,163,747 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	3,087,191 - 3,114,766 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	3,087,229 - 3,114,741	NCBI
Celera	19	3,072,520 - 3,100,641 (+)	NCBI
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,905,020 - 2,932,757 (+)	NCBI		HuRef
CHM1_1	19	3,135,905 - 3,163,646 (+)	NCBI		CHM1_1

Gna15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	81,338,147 - 81,360,283 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	81,338,140 - 81,360,059 (-)	Ensembl
GRCm38	10	81,502,313 - 81,524,447 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,502,306 - 81,524,225 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	80,965,058 - 80,986,970 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	80,905,442 - 80,927,354 (-)	NCBI			mm8
Celera	10	82,525,696 - 82,547,406 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Gna15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	8,184,632 - 8,205,508 (+)	NCBI
Rnor_6.0 Ensembl	7	11,054,333 - 11,077,251 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	11,054,249 - 11,075,152 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	11,221,467 - 11,242,341 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	9,669,956 - 9,689,442 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	9,669,955 - 9,689,442 (+)	NCBI
Celera	7	6,375,600 - 6,396,028 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Gna15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,252,547 - 5,270,894 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	5,254,546 - 5,270,864 (-)	NCBI	ChiLan1.0	ChiLan1.0

GNA15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	3,116,969 - 3,146,118 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	3,116,969 - 3,146,118 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	2,163,773 - 2,191,985 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

GNA15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	56,118,067 - 56,126,502 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	56,117,398 - 56,129,251 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Gna15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936588	1,802,576 - 1,816,772 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNA15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	75,408,722 - 75,433,814 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	75,408,723 - 75,433,809 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	75,928,409 - 75,949,083 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GNA15
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	2,901,502 - 2,930,567 (+)	NCBI
ChlSab1.1 Ensembl	6	2,901,762 - 2,932,138 (+)	Ensembl

Gna15
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	6,048,697 - 6,062,851 (-)	NCBI

Position Markers

D19S247

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	3,139,982 - 3,140,202	UniSTS	GRCh37
Build 36	19	3,090,982 - 3,091,202	RGD	NCBI36
Celera	19	3,076,311 - 3,076,539	RGD
Cytogenetic Map	19	p13.3	UniSTS
HuRef	19	2,908,753 - 2,909,009	UniSTS
Marshfield Genetic Map	19	9.84	UniSTS
Marshfield Genetic Map	19	9.84	RGD

RH11456

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	3,163,410 - 3,163,613	UniSTS	GRCh37
Build 36	19	3,114,410 - 3,114,613	RGD	NCBI36
Celera	19	3,100,285 - 3,100,488	RGD
Cytogenetic Map	19	p13.3	UniSTS
HuRef	19	2,932,401 - 2,932,604	UniSTS
GeneMap99-GB4 RH Map	19	27.61	UniSTS

GNA15__7519

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	3,163,086 - 3,163,875	UniSTS	GRCh37
Build 36	19	3,114,086 - 3,114,875	RGD	NCBI36
Celera	19	3,099,961 - 3,100,750	RGD
HuRef	19	2,932,077 - 2,932,866	UniSTS

G13205

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	3,163,597 - 3,163,740	UniSTS	GRCh37
Build 36	19	3,114,597 - 3,114,740	RGD	NCBI36
Celera	19	3,100,472 - 3,100,615	RGD
Cytogenetic Map	19	p13.3	UniSTS
HuRef	19	2,932,588 - 2,932,731	UniSTS

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	908
Count of miRNA genes:	621
Interacting mature miRNAs:	688
Transcripts:	ENST00000262958, ENST00000586082, ENST00000592455
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

128

901

126

1386

1563

130

474

742

124

378

780

Low

2248

1934

1512

364

452

318

2143

1519

3324

289

913

749

826

1509

Below cutoff

152

160

127

126

613

639

259

499

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_002068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC005262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC005264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF493904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK291329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC013585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG178215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ015560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BT009850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ891367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU727637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU727645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF456471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M63904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000262958 ⟹ ENSP00000262958

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	19	3,136,033 - 3,163,749 (+)	Ensembl

RefSeq Acc Id:

ENST00000586082

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	19	3,149,840 - 3,155,826 (+)	Ensembl

RefSeq Acc Id:

ENST00000592455 ⟹ ENSP00000467256

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	19	3,136,442 - 3,151,822 (+)	Ensembl

RefSeq Acc Id:

NM_002068 ⟹ NP_002059

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	3,136,033 - 3,163,749 (+)	NCBI
GRCh37	19	3,136,191 - 3,163,766 (+)	ENTREZGENE
Build 36	19	3,087,191 - 3,114,766 (+)	NCBI Archive
HuRef	19	2,905,020 - 2,932,757 (+)	ENTREZGENE
CHM1_1	19	3,135,905 - 3,163,646 (+)	NCBI

Sequence:

show sequence

CAGAAGGAGGAAGAAGGGCCCTGCTGGTCACACAGGACCCAGTCTGCGGTGGGGGTTTTCCCGC
CACCGCCCCGCCCTCCCTGGGGCCCCCACCTCACCCTCTCCTGGCACCCTTCACCGTCAACCTG
TCGGGCCGGGTCTGAGCAGGTCTGGAGGTGGGCGGGGAGCCCTGGCCTCCCCACCTCCTCCCGT
CCCCACCCTGTTCCCAGCACTCAAGCCTTGCCACCGCCGAGCCGGGCTTCCTGGGTGTTTCAGG
CAAGGAAGTCTAGGTCCCTGGGGGGTGACCCCCAAGGAAAAGGCAGCCTCCCTGCGCACCCGGT
TGCCCGGAGCCCTCTCCAGGGCCGGCTGGGCTGGGGGTTGCCCTGGCCAGCAGGGGCCCGGGGG
CGATGCCACCCGGTGCCGACTGAGGCCACCGCACCATGGCCCGCTCGCTGACCTGGCGCTGCTG
CCCCTGGTGCCTGACGGAGGATGAGAAGGCCGCCGCCCGGGTGGACCAGGAGATCAACAGGATC
CTCTTGGAGCAGAAGAAGCAGGACCGCGGGGAGCTGAAGCTGCTGCTTTTGGGCCCAGGCGAGA
GCGGGAAGAGCACCTTCATCAAGCAGATGCGGATCATCCACGGCGCCGGCTACTCGGAGGAGGA
GCGCAAGGGCTTCCGGCCCCTGGTCTACCAGAACATCTTCGTGTCCATGCGGGCCATGATCGAG
GCCATGGAGCGGCTGCAGATTCCATTCAGCAGGCCCGAGAGCAAGCACCACGCTAGCCTGGTCA
TGAGCCAGGACCCCTATAAAGTGACCACGTTTGAGAAGCGCTACGCTGCGGCCATGCAGTGGCT
GTGGAGGGATGCCGGCATCCGGGCCTGCTATGAGCGTCGGCGGGAATTCCACCTGCTCGATTCA
GCCGTGTACTACCTGTCCCACCTGGAGCGCATCACCGAGGAGGGCTACGTCCCCACAGCTCAGG
ACGTGCTCCGCAGCCGCATGCCCACCACTGGCATCAACGAGTACTGCTTCTCCGTGCAGAAAAC
CAACCTGCGGATCGTGGACGTCGGGGGCCAGAAGTCAGAGCGTAAGAAATGGATCCATTGTTTC
GAGAACGTGATCGCCCTCATCTACCTGGCCTCACTGAGTGAATACGACCAGTGCCTGGAGGAGA
ACAACCAGGAGAACCGCATGAAGGAGAGCCTCGCATTGTTTGGGACTATCCTGGAACTACCCTG
GTTCAAAAGCACATCCGTCATCCTCTTTCTCAACAAAACCGACATCCTGGAGGAGAAAATCCCC
ACCTCCCACCTGGCTACCTATTTCCCCAGTTTCCAGGGCCCTAAGCAGGATGCTGAGGCAGCCA
AGAGGTTCATCCTGGACATGTACACGAGGATGTACACCGGGTGCGTGGACGGCCCCGAGGGCAG
CAAGAAGGGCGCACGATCCCGACGCCTCTTCAGCCACTACACATGTGCCACAGACACACAGAAC
ATCCGCAAGGTCTTCAAGGACGTGCGGGACTCGGTGCTCGCCCGCTACCTGGACGAGATCAACC
TGCTGTGACCCAGGCCCCACCTGGGGCAGGCGGCACCGGCGGGCGGGTGGGAGGTGGGAGTGGC
TGCAGGGACCCCTAGTGTCCCTGGTCTATCTCTCCAGCCTCGGCCCACACGCAAGGGAGTCGGG
GGACGGACGGCCCGCTGCTGGCCGCTCTCTTCTCTGCCTCTCACCAGGACAGCCGCCCCCCAGG
GTACTCCTGCCCTTGCTTGACTCAGTTTCCCTCCTTTGAAAGGGAAGGAGCAAAACGGCCATTT
GGGATGCCAGGGTGGATGAAAAGGTGAAGAAATCAGGGGATTGAGGACTTGGGTGGGTGGGCAT
CTCTCAGGAGCCCCATCTCCGGGCGTGTCACCTCCTGGGCAGGGTTCTGGGACCCTCTGTGGGT
GACGCACACCCTGGGATGGGGCTAGTAGAGCCTTCAGGCGCCTTCGGGCGTGGACTCTGGCGCA
CTCTAGTGGACAGGAGAAGGAACGCCTTCCAGGAACCTGTGGACTAGGGGTGCAGGGACTTCCC
TTTGCAAGGGGTAACAGACCGCTGGAAAACACTGTCACTTTCAGAGCTCGGTGGCTCACAGCGT
GTCCTGCCCCGGTTTGCGGACGAGAGAAATCGCGGCCCACAAGCATCCCCCCATCCCTTGCAGG
CTGGGGGCTGGGCATGCTGCATCTTAACCTTTTGTATTTATTCCCTCACCTTCTGCAGGGCTCC
GTGCGGGCTGAAATTAAAGATTTCTTAGAGGCTGCGTCGCCAGCGTCCTGTTTAAAAAAAAAAA
AAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_002059	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA35860	(Get FASTA)	NCBI Sequence Viewer
	AAC25612	(Get FASTA)	NCBI Sequence Viewer
	AAC25616	(Get FASTA)	NCBI Sequence Viewer
	AAH13585	(Get FASTA)	NCBI Sequence Viewer
	AAM12618	(Get FASTA)	NCBI Sequence Viewer
	AAP88852	(Get FASTA)	NCBI Sequence Viewer
	ADO22229	(Get FASTA)	NCBI Sequence Viewer
	ADU87639	(Get FASTA)	NCBI Sequence Viewer
	ADU87646	(Get FASTA)	NCBI Sequence Viewer
	BAF84018	(Get FASTA)	NCBI Sequence Viewer
	BAG62197	(Get FASTA)	NCBI Sequence Viewer
	EAW69338	(Get FASTA)	NCBI Sequence Viewer
	P30679	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_002059 ⟸ NM_002068

- UniProtKB:

P30679 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIKQMRI
IHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQDPYKVTTFE
KRYAAAMQWLWRDAGIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQDVLRSRMPTTGI
NEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLA
LFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQGPKQDAEAAKRFILDMYTRMY
TGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL

hide sequence

RefSeq Acc Id:

ENSP00000262958 ⟸ ENST00000262958

RefSeq Acc Id:

ENSP00000467256 ⟸ ENST00000592455

Protein Domains

G-alpha

Promoters

RGD ID:

6795606

Promoter ID:

HG_KWN:28505

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid, NB4

Transcripts:

NM_002068

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	19	3,086,981 - 3,087,481 (+)	MPROMDB

RGD ID:

7237993

Promoter ID:

EPDNEW_H24742

Type:

initiation region

Name:

GNA15_1

Description:

G protein subunit alpha 15

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	3,136,242 - 3,136,302	EPDNEW

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 19p13.3(chr19:1565575-4108128)x3	copy number gain	See cases [RCV000052878]	Chr19:1565575..4108128 [GRCh38] Chr19:1565574..4108126 [GRCh37] Chr19:1516574..4059126 [NCBI36] Chr19:19p13.3	pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:1972245-9648879)x3	copy number gain	See cases [RCV000052879]	Chr19:1972245..9648879 [GRCh38] Chr19:1972244..9759555 [GRCh37] Chr19:1923244..9620555 [NCBI36] Chr19:19p13.3-13.2	pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]\|See cases [RCV000052876]	Chr19:265917..8564134 [GRCh38] Chr19:265917..8629018 [GRCh37] Chr19:216917..8535018 [NCBI36] Chr19:19p13.3-13.2	pathogenic
GRCh38/hg38 19p13.3(chr19:233565-4699472)x3	copy number gain	See cases [RCV000052575]	Chr19:233565..4699472 [GRCh38] Chr19:233565..4699484 [GRCh37] Chr19:184565..4650484 [NCBI36] Chr19:19p13.3	pathogenic
GRCh38/hg38 19p13.3(chr19:3080621-3730716)x3	copy number gain	See cases [RCV000054107]	Chr19:3080621..3730716 [GRCh38] Chr19:3080619..3730714 [GRCh37] Chr19:3031619..3681714 [NCBI36] Chr19:19p13.3	uncertain significance
GRCh38/hg38 19p13.3(chr19:2926238-4051635)x1	copy number loss	See cases [RCV000053942]	Chr19:2926238..4051635 [GRCh38] Chr19:2926236..4051633 [GRCh37] Chr19:2877236..4002633 [NCBI36] Chr19:19p13.3	pathogenic
NM_002068.3(GNA15):c.517G>A (p.Glu173Lys)	single nucleotide variant	Malignant melanoma [RCV000063488]	Chr19:3151738 [GRCh38] Chr19:3151736 [GRCh37] Chr19:3102736 [NCBI36] Chr19:19p13.3	not provided
NM_002068.3(GNA15):c.1096C>T (p.Arg366Cys)	single nucleotide variant	Malignant melanoma [RCV000063489]	Chr19:3162990 [GRCh38] Chr19:3162988 [GRCh37] Chr19:3113988 [NCBI36] Chr19:19p13.3	not provided
GRCh38/hg38 19p13.3(chr19:1549144-4288720)x1	copy number loss	See cases [RCV000134795]	Chr19:1549144..4288720 [GRCh38] Chr19:1549143..4288717 [GRCh37] Chr19:1500143..4239717 [NCBI36] Chr19:19p13.3	pathogenic
GRCh38/hg38 19p13.3(chr19:3080621-4912622)x3	copy number gain	See cases [RCV000137713]	Chr19:3080621..4912622 [GRCh38] Chr19:3080619..4912634 [GRCh37] Chr19:3031619..4863634 [NCBI36] Chr19:19p13.3	likely pathogenic
GRCh38/hg38 19p13.3(chr19:3020573-3482611)x3	copy number gain	See cases [RCV000139774]	Chr19:3020573..3482611 [GRCh38] Chr19:3020571..3482609 [GRCh37] Chr19:2971571..3433609 [NCBI36] Chr19:19p13.3	uncertain significance
GRCh38/hg38 19p13.3(chr19:2884401-3451078)x3	copy number gain	See cases [RCV000143086]	Chr19:2884401..3451078 [GRCh38] Chr19:2884399..3451076 [GRCh37] Chr19:2835399..3402076 [NCBI36] Chr19:19p13.3	uncertain significance
GRCh38/hg38 19p13.3(chr19:259395-6795611)x3	copy number gain	See cases [RCV000142627]	Chr19:259395..6795611 [GRCh38] Chr19:259395..6795622 [GRCh37] Chr19:210395..6746622 [NCBI36] Chr19:19p13.3	pathogenic
GRCh37/hg19 19p13.3(chr19:259395-3152419)	copy number gain	Global developmental delay [RCV000626520]	Chr19:259395..3152419 [GRCh37] Chr19:19p13.3	likely pathogenic
GRCh37/hg19 19p13.3(chr19:2652901-4342179)x3	copy number gain	See cases [RCV000448078]	Chr19:2652901..4342179 [GRCh37] Chr19:19p13.3	uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3	copy number gain	See cases [RCV000511289]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic\|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)	copy number gain	See cases [RCV000512296]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3(chr19:260911-3200875)x3	copy number gain	not provided [RCV000684094]	Chr19:260911..3200875 [GRCh37] Chr19:19p13.3	pathogenic
GRCh37/hg19 19p13.3-13.2(chr19:3120160-9732820)x3	copy number gain	not provided [RCV000684096]	Chr19:3120160..9732820 [GRCh37] Chr19:19p13.3-13.2	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3	copy number gain	not provided [RCV000752444]	Chr19:260912..59097160 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3	copy number gain	not provided [RCV000752439]	Chr19:68029..59110290 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3(chr19:3015481-3543109)x3	copy number gain	not provided [RCV000740000]	Chr19:3015481..3543109 [GRCh37] Chr19:19p13.3	benign
Single allele	deletion	Internal malformations [RCV000787421]	Chr19:2229488..4004142 [GRCh37] Chr19:19p13.3	uncertain significance
NM_002068.4(GNA15):c.813C>T (p.Ser271=)	single nucleotide variant	not provided [RCV000970345]	Chr19:3157796 [GRCh38] Chr19:3157794 [GRCh37] Chr19:19p13.3	benign
NM_002068.4(GNA15):c.561G>A (p.Met187Ile)	single nucleotide variant	not provided [RCV000973222]	Chr19:3151782 [GRCh38] Chr19:3151780 [GRCh37] Chr19:19p13.3	benign
NM_002068.4(GNA15):c.341G>A (p.Ser114Asn)	single nucleotide variant	not provided [RCV000969111]	Chr19:3150141 [GRCh38] Chr19:3150139 [GRCh37] Chr19:19p13.3	benign
GRCh37/hg19 19p13.3(chr19:3076808-4796782)	copy number loss	not provided [RCV000767742]	Chr19:3076808..4796782 [GRCh37] Chr19:19p13.3	pathogenic
GRCh37/hg19 19p13.3(chr19:3132909-3907470)x3	copy number gain	not provided [RCV000847631]	Chr19:3132909..3907470 [GRCh37] Chr19:19p13.3	uncertain significance
NC_000019.9:g.1406030_3597207dup	duplication	Neurodevelopmental disorder [RCV000787423]	Chr19:1406030..3597207 [GRCh37] Chr19:19p13.3	uncertain significance
GRCh37/hg19 19p13.3(chr19:3134686-3501127)x3	copy number gain	not provided [RCV000847642]	Chr19:3134686..3501127 [GRCh37] Chr19:19p13.3	uncertain significance
GRCh37/hg19 19p13.3(chr19:260911-4788357)x3	copy number gain	not provided [RCV000846988]	Chr19:260911..4788357 [GRCh37] Chr19:19p13.3	pathogenic
GRCh37/hg19 19p13.3(chr19:260911-3501271)x3	copy number gain	not provided [RCV001007025]	Chr19:260911..3501271 [GRCh37] Chr19:19p13.3	pathogenic
GRCh37/hg19 19p13.3(chr19:260912-4384674)x3	copy number gain	See cases [RCV001007443]	Chr19:260912..4384674 [GRCh37] Chr19:19p13.3	pathogenic

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:4383	AgrOrtholog
COSMIC	GNA15	COSMIC
Ensembl Genes	ENSG00000060558	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSP00000262958	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSP00000467256	UniProtKB/TrEMBL
Ensembl Transcript	ENST00000262958	ENTREZGENE, UniProtKB/Swiss-Prot
	ENST00000592455	UniProtKB/TrEMBL
Gene3D-CATH	1.10.400.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000060558	GTEx
HGNC ID	HGNC:4383	ENTREZGENE
Human Proteome Map	GNA15	Human Proteome Map
InterPro	Gprotein_alpha_Q	UniProtKB/Swiss-Prot
	Gprotein_alpha_su	UniProtKB/Swiss-Prot
	GproteinA_insert	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
KEGG Report	hsa:2769	UniProtKB/Swiss-Prot
NCBI Gene	2769	ENTREZGENE
OMIM	139314	OMIM
PANTHER	PTHR10218	UniProtKB/Swiss-Prot
Pfam	G-alpha	UniProtKB/Swiss-Prot
PharmGKB	PA28768	PharmGKB
PRINTS	GPROTEINA	UniProtKB/Swiss-Prot
	GPROTEINAQ	UniProtKB/Swiss-Prot
PROSITE	G_ALPHA	UniProtKB/Swiss-Prot
SMART	G_alpha	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47895	UniProtKB/Swiss-Prot
	SSF52540	UniProtKB/Swiss-Prot
UniProt	GNA15_HUMAN	UniProtKB/Swiss-Prot
	K7EP74_HUMAN	UniProtKB/TrEMBL
	P30679	ENTREZGENE
UniProt Secondary	E9KL40	UniProtKB/Swiss-Prot
	E9KL47	UniProtKB/Swiss-Prot
	O75247	UniProtKB/Swiss-Prot
	Q53XK2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-14	GNA15	G protein subunit alpha 15		guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)