Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) - Rat Genome Database
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Gene: Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) Mus musculus
Analyze
Symbol: Ndufaf3
Name: NADH:ubiquinone oxidoreductase complex assembly factor 3
RGD ID: 732122
MGI Page MGI
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Localizes to mitochondrion. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4733401H18Rik; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; nuclear protein E3-3; protein 2P1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm13338  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,442,786 - 108,444,635 (-)NCBIGRCm39mm39
GRCm389108,565,587 - 108,567,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,565,537 - 108,567,434 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,468,196 - 108,469,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,423,968 - 108,425,445 (-)NCBImm8
Celera9108,177,106 - 108,178,583 (-)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12653254   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17971504  
PMID:18614015   PMID:21267068   PMID:21873635   PMID:32325033  


Genomics

Comparative Map Data
Ndufaf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,442,786 - 108,444,635 (-)NCBIGRCm39mm39
GRCm389108,565,587 - 108,567,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,565,537 - 108,567,434 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,468,196 - 108,469,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv369108,423,968 - 108,425,445 (-)NCBImm8
Celera9108,177,106 - 108,178,583 (-)NCBICelera
Cytogenetic Map9F2NCBI
NDUFAF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,020,459 - 49,023,495 (+)EnsemblGRCh38hg38GRCh38
GRCh38349,020,452 - 49,023,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,057,908 - 49,060,928 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,032,912 - 49,035,932 (+)NCBINCBI36hg18NCBI36
Celera349,014,631 - 49,017,650 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,115,773 - 49,118,793 (+)NCBIHuRef
CHM1_1349,010,469 - 49,013,489 (+)NCBICHM1_1
Ndufaf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,351,628 - 117,353,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,351,629 - 117,353,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,696,131 - 116,698,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,611,624 - 113,613,668 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,631,358 - 113,632,446 (-)NCBI
Celera8108,557,136 - 108,558,968 (-)NCBICelera
Cytogenetic Map8q32NCBI
Ndufaf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,045,852 - 1,046,594 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,045,854 - 1,046,738 (+)NCBIChiLan1.0ChiLan1.0
NDUFAF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,026,822 - 50,029,260 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,026,989 - 50,029,260 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0348,945,667 - 48,947,933 (+)NCBIMhudiblu_PPA_v0panPan3
NDUFAF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2040,141,552 - 40,172,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12040,141,550 - 40,143,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ndufaf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936529746,620 - 748,145 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFAF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,656,946 - 31,659,221 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,656,941 - 31,658,087 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,899,945 - 34,901,091 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFAF3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,421,359 - 10,423,626 (+)NCBI
ChlSab1.1 Ensembl2210,421,996 - 10,423,510 (+)Ensembl
Ndufaf3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,069,083 - 3,070,675 (+)NCBI

Position Markers
AV253134  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389108,568,986 - 108,569,125UniSTSGRCm38
MGSCv379108,471,317 - 108,471,456UniSTSGRCm37
Celera9108,180,227 - 108,180,366UniSTS
Cytogenetic Map9F2UniSTS
Whitehead/MRC_RH91110.14UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:139
Interacting mature miRNAs:152
Transcripts:ENSMUST00000074208
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000074208   ⟹   ENSMUSP00000073832
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,565,537 - 108,567,434 (-)Ensembl
RefSeq Acc Id: ENSMUST00000193242
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,565,877 - 108,566,910 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194381   ⟹   ENSMUSP00000141291
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,565,861 - 108,566,717 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194666
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,566,177 - 108,566,930 (-)Ensembl
RefSeq Acc Id: NM_023247   ⟹   NP_075736
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,442,786 - 108,444,635 (-)NCBI
GRCm389108,565,587 - 108,567,436 (-)NCBI
MGSCv379108,468,196 - 108,469,673 (-)RGD
Celera9108,177,106 - 108,178,583 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075736   ⟸   NM_023247
- UniProtKB: Q9JKL4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000073832   ⟸   ENSMUST00000074208
RefSeq Acc Id: ENSMUSP00000141291   ⟸   ENSMUST00000194381

Promoters
RGD ID:6844871
Promoter ID:MM_KWN:58809
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   Brain,   Kidney,   MEF_B6,   Spleen
Transcripts:ENSMUST00000074208
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,468,831 - 108,469,847 (-)MPROMDB
RGD ID:8670912
Promoter ID:EPDNEW_M13487
Type:initiation region
Name:Ndufaf3_1
Description:Mus musculus NADH dehydrogenase 1 alpha subcomplex, assemblyfactor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13488  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,566,943 - 108,567,003EPDNEW
RGD ID:8670914
Promoter ID:EPDNEW_M13488
Type:initiation region
Name:Ndufaf3_2
Description:Mus musculus NADH dehydrogenase 1 alpha subcomplex, assemblyfactor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13487  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,567,381 - 108,567,441EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913956 AgrOrtholog
Ensembl Genes ENSMUSG00000070283 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000073832 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141291 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000074208 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000194381 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MTH938-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDUF3 UniProtKB/Swiss-Prot
  NDUFAF3/AAMDC UniProtKB/Swiss-Prot
KEGG Report mmu:66706 UniProtKB/Swiss-Prot
MGD MGI:1913956 ENTREZGENE
NCBI Gene 66706 ENTREZGENE
PANTHER PTHR21192 UniProtKB/Swiss-Prot
Pfam DUF498 UniProtKB/Swiss-Prot
PhenoGen Ndufaf3 PhenoGen
Superfamily-SCOP SSF64076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.29471 ENTREZGENE
UniProt A0A0A6YVW1_MOUSE UniProtKB/TrEMBL
  NDUF3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8K1A3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-22 Ndufaf3  NADH:ubiquinone oxidoreductase complex assembly factor 3    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3  Symbol and/or name change 5135510 APPROVED