Gene: Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) Mus musculus
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Symbol:
Ndufaf3
Name:
NADH:ubiquinone oxidoreductase complex assembly factor 3
Description:
INVOLVED IN mitochondrial respiratory chain complex I assembly (ortholog); ASSOCIATED WITH mitochondrial complex I deficiency (ortholog); Mitochondrial Complex I Deficiency, Nuclear Type 1 (ortholog); Mitochondrial Complex I Deficiency, Nuclear Type 18 (ortholog); FOUND IN mitochondrial inner membrane (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dibutyl phthalate; ethanol
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
4733401H18Rik; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; nuclear protein E3-3; protein 2P1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor 3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
ndufaf3 (NADH:ubiquinone oxidoreductase complex assembly factor)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
nuaf-3
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
CG5569
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
Gm13338
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,565,587 - 108,567,436 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,468,196 - 108,469,673 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,423,968 - 108,425,445 (-) NCBI mm8 Celera 9 108,177,106 - 108,178,583 (-) NCBI Celera Cytogenetic Map 9 F2 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - OMIM
Mitochondrial Complex I Deficiency, Nuclear Type 18 ISO RGD:1601767 7240710 OMIM
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NDUFAF3 promoter] CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:708545 6480464 Tetrachlorodibenzodioxin results in decreased expression of NDUFAF3 mRNA CTD PMID:21215274 aflatoxin B1 increases expression ISO RGD:1601767 6480464 Aflatoxin B1 results in increased expression of NDUFAF3 mRNA CTD PMID:27153756 ammonium chloride affects expression ISO RGD:708545 6480464 Ammonium Chloride affects the expression of NDUFAF3 mRNA CTD PMID:16483693 bexarotene increases expression ISO RGD:708545 6480464 bexarotene results in increased expression of NDUFAF3 mRNA CTD PMID:16648578 bisphenol A affects expression ISO RGD:708545 6480464 bisphenol A affects the expression of NDUFAF3 mRNA CTD PMID:25181051 cobalt dichloride decreases expression ISO RGD:1601767 6480464 cobaltous chloride results in decreased expression of NDUFAF3 mRNA CTD PMID:19320972 , PMID:19376846 copper(II) sulfate decreases expression ISO RGD:1601767 6480464 Copper Sulfate results in decreased expression of NDUFAF3 mRNA CTD PMID:19549813 cyclosporin A increases expression ISO RGD:1601767 6480464 Cyclosporine results in increased expression of NDUFAF3 mRNA CTD PMID:27989131 diazinon increases methylation ISO RGD:1601767 6480464 Diazinon results in increased methylation of NDUFAF3 gene CTD PMID:22964155 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of NDUFAF3 mRNA CTD PMID:21266533 doxorubicin increases expression ISO RGD:1601767 6480464 Doxorubicin results in increased expression of NDUFAF3 mRNA CTD PMID:29803840 ethanol affects expression EXP 6480464 Ethanol affects the expression of NDUFAF3 mRNA CTD PMID:30319688 ethyl methanesulfonate decreases expression ISO RGD:1601767 6480464 Ethyl Methanesulfonate results in decreased expression of NDUFAF3 mRNA CTD PMID:23649840 finasteride increases expression ISO RGD:708545 6480464 Finasteride results in increased expression of NDUFAF3 mRNA CTD PMID:24136188 flutamide increases expression ISO RGD:708545 6480464 Flutamide results in increased expression of NDUFAF3 mRNA CTD PMID:24136188 lipopolysaccharide multiple interactions ISO RGD:1601767 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of NDUFAF3 mRNA CTD PMID:31059760 methapyrilene decreases expression ISO RGD:708545 6480464 Methapyrilene results in decreased expression of NDUFAF3 mRNA CTD PMID:30467583 methyl methanesulfonate decreases expression ISO RGD:1601767 6480464 Methyl Methanesulfonate results in decreased expression of NDUFAF3 mRNA CTD PMID:23649840 nefazodone increases expression ISO RGD:708545 6480464 nefazodone results in increased expression of NDUFAF3 mRNA CTD PMID:24136188 paracetamol decreases expression ISO RGD:1601767 6480464 Acetaminophen results in decreased expression of NDUFAF3 mRNA CTD PMID:31059760 paracetamol multiple interactions ISO RGD:1601767 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of NDUFAF3 mRNA CTD PMID:31059760 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of NDUFAF3 protein CTD PMID:25505154 rotenone increases expression ISO RGD:708545 6480464 Rotenone results in increased expression of NDUFAF3 mRNA CTD PMID:19013527 sodium dichromate decreases expression ISO RGD:1601767 6480464 sodium bichromate results in decreased expression of NDUFAF3 mRNA CTD PMID:17685462 T-2 Toxin increases expression ISO RGD:708545 6480464 T-2 Toxin results in increased expression of NDUFAF3 mRNA CTD PMID:29870751 tetrachloroethene decreases expression EXP 6480464 Tetrachloroethylene results in decreased expression of NDUFAF3 mRNA CTD PMID:28973375 tris(2-butoxyethyl) phosphate affects expression ISO RGD:1601767 6480464 tris(2-butoxyethyl) phosphate affects the expression of NDUFAF3 mRNA CTD PMID:29024780 valproic acid increases expression ISO RGD:1601767 6480464 Valproic Acid results in increased expression of NDUFAF3 mRNA CTD PMID:23179753 , PMID:27188386
Gene Ontology Annotations
13207569 Tcq13_m total cholesterol QTL 13 (mouse) 9 59990000 109260000 Mouse 4141833 W10q13_m weight 10 weeks QTL 13 (mouse) Not determined 63332429 120362868 Mouse 4141545 Tailaq2_m tail length adjusted QTL 2 (mouse) Not determined 63332429 120362868 Mouse 1357635 Splq4_m spleen weight QTL 4 (mouse) Not determined 9 63332429 120362868 Mouse 1302065 El1_m epilepsy 1 (mouse) Not determined 9 75775364 114474379 Mouse 10054492 El7_m epilepsy 7 (mouse) Not determined 9 75775364 114474379 Mouse 1301407 Rapop2_m radiation-induced apoptosis 2 (mouse) Not determined 9 76535936 110536130 Mouse 1301192 Skts6_m skin tumor susceptibility 6 (mouse) Not determined 9 78640645 112640755 Mouse 10401247 Bglu14_m blood glucose level 14 (mouse) Not determined 9 79397810 113397888 Mouse 1301732 Char1_m P. chabaudi malaria resistance QTL 1 (mouse) Not determined 9 81798268 115798392 Mouse 1300884 Sluc11_m susceptibility to lung cancer 11 (mouse) Not determined 9 82910333 116910428 Mouse 1357461 Idd2_m insulin dependent diabetes susceptibility 2 (mouse) Not determined 9 82910333 116910428 Mouse 10766454 Char10_m P. chabaudi malaria resistance QTL 10 (mouse) 9 82910333 116910428 Mouse 1301487 Nociq1_m nociceptive sensitivity inflammatory QTL 1 (mouse) Not determined 9 84528818 118528921 Mouse 10412180 Msam3_m muscle, skeletal, activity measure 3 (mouse) Not determined 9 85897510 108641186 Mouse 1300549 Bbaa17_m B. burgdorferi-associated arthritis 17 (mouse) Not determined 9 86230401 120230530 Mouse 1302103 Dob2_m dietary obesity 2 (mouse) Not determined 9 86239845 120289624 Mouse 11251716 Siim2_m stress induced immobility 2 (mouse) 9 86748483 120748483 Mouse 12880422 V25Dq6_m vitamin D inactive form serum level QTL 6 (mouse) 9 87800000 121800000 Mouse 10412242 Alpq8_m alcohol preference QTL 8 (mouse) Not determined 9 89284925 123284925 Mouse 1301649 Psl1_m promotion susceptibility QTL 1 (mouse) Not determined 9 89412277 123412396 Mouse 1357657 Pymr_m Plasmodium yoelli malaria resistance (mouse) Not determined 9 89977005 118938021 Mouse 12910770 Splic1_m spleen iron content 1 (mouse) 9 91413879 124595110 Mouse 12910772 Lvic6_m liver iron content 6 (mouse) 9 91413879 124595110 Mouse 12910773 Splic3_m spleen iron content 3 (mouse) 9 91413879 124595110 Mouse 1558767 Skmw11_m skeletal muscle weight 11 (mouse) Not determined 9 91641084 124595110 Mouse 13463474 Hbbcq5_m hemoglobin concentration QTL 5 (mouse) 9 91641084 124595110 Mouse 13463475 Hctq7_m hematocrit QTL 7 (mouse) 9 91641084 124595110 Mouse 13463477 Rbc9_m red blood cell count 9 (mouse) 9 91641084 124595110 Mouse 13463478 Mchq18_m mean corpuscular hemoglobin QTL 18 (mouse) 9 91641084 124595110 Mouse 13463480 Mchcq2_m mean corpuscular hemoglobin concentration QTL 2 (mouse) 9 91641084 124595110 Mouse 12904937 Edlmmq9_m extensor digitorum longus muscle mass QTL 9 (mouse) 9 91683173 124595110 Mouse 12904947 Tammq7_m tibialis anterior muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 12904961 Gmmq7_m gastrocnemius muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 1302001 Bdln5_m body length 5 (mouse) Not determined 9 93762590 124595110 Mouse 1301484 Bwq6_m body weight (mouse) Not determined 9 93762590 124595110 Mouse 14746992 Manh67_m mandible shape 67 (mouse) 9 94036768 124595110 Mouse 11081166 Psl5_m promotion susceptibility QTL 5 (mouse) 9 94981301 112872929 Mouse 11537364 Cnes5_m C. neoformans susceptibility locus 5 (mouse) 9 96917590 124595110 Mouse 1301297 Lcho1_m liver cholesterol 1 (mouse) Not determined 9 101060861 124595110 Mouse 1357627 Tgq2_m triglyceride QTL 2 (mouse) Not determined 9 102000187 124595110 Mouse 1357648 Obq18_m obesity QTL 18 (mouse) Not determined 9 102000187 124595110 Mouse 1301789 Pbwg4_m postnatal body weight growth 4 (mouse) Not determined 9 103289445 124595110 Mouse 10412290 Pvacm1l_m plasma vascular cell adhesion molecule 1 levels (mouse) Not determined 9 103289445 124595110 Mouse 12879896 Berr3_m berghei resistance locus 3 (mouse) 9 103289445 124595110 Mouse
Predicted Target Of
Count of predictions: 152 Count of miRNA genes: 139 Interacting mature miRNAs: 152 Transcripts: ENSMUST00000074208 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
