P2ry6 (pyrimidinergic receptor P2Y, G-protein coupled, 6) - Rat Genome Database
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Gene: P2ry6 (pyrimidinergic receptor P2Y, G-protein coupled, 6) Mus musculus
Analyze
Symbol: P2ry6
Name: pyrimidinergic receptor P2Y, G-protein coupled, 6
RGD ID: 732055
MGI Page MGI
Description: Exhibits G protein-coupled UDP receptor activity. Involved in cellular response to organic cyclic compound; cellular response to prostaglandin E stimulus; and transepithelial chloride transport. Predicted to localize to apical plasma membrane and basolateral plasma membrane. Is expressed in dermomyotome and musculature. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010204J23Rik; P2Y; P2Y purinoceptor 6; P2Y6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,586,837 - 100,628,528 (-)NCBIGRCm39mm39
GRCm387100,937,630 - 100,975,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,937,630 - 100,974,649 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,086,148 - 108,112,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv367100,811,721 - 100,838,449 (-)NCBImm8
Celera7101,288,708 - 101,316,203 (-)NCBICelera
Cytogenetic Map7E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11259526   PMID:12477932   PMID:15489334   PMID:15670583   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17410128   PMID:18250478  
PMID:18523137   PMID:19124756   PMID:19426712   PMID:20050854   PMID:20630102   PMID:21173118   PMID:21237152   PMID:21267068   PMID:21308776   PMID:21413988   PMID:21444765   PMID:21724990  
PMID:21828185   PMID:22102722   PMID:23362118   PMID:23479225   PMID:24278446   PMID:25104800   PMID:25261483   PMID:25360548   PMID:25549240   PMID:25575683   PMID:26099306   PMID:26359991  
PMID:26560804   PMID:26787451   PMID:26827897   PMID:27231349   PMID:27255725   PMID:27590515   PMID:28199831   PMID:28396595   PMID:28539604   PMID:28815725   PMID:29454075   PMID:31271845  
PMID:31638598   PMID:32554432   PMID:32811872  


Genomics

Comparative Map Data
P2ry6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,586,837 - 100,628,528 (-)NCBIGRCm39mm39
GRCm387100,937,630 - 100,975,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,937,630 - 100,974,649 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,086,148 - 108,112,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv367100,811,721 - 100,838,449 (-)NCBImm8
Celera7101,288,708 - 101,316,203 (-)NCBICelera
Cytogenetic Map7E2NCBI
P2RY6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1173,264,505 - 73,298,625 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1173,264,505 - 73,298,617 (+)EnsemblGRCh38hg38GRCh38
GRCh381173,264,503 - 73,298,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,975,550 - 73,009,670 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,653,218 - 72,687,312 (+)NCBINCBI36hg18NCBI36
Build 341172,658,586 - 72,686,497NCBI
Celera1170,280,653 - 70,314,752 (+)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBIHuRef
CHM1_11172,859,110 - 72,893,227 (+)NCBICHM1_1
P2ry6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,972,439 - 166,008,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,169,438 - 172,204,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,381,127 - 158,406,783 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,460,144 - 158,485,800 (-)NCBI
Celera1153,376,657 - 153,401,528 (-)NCBICelera
Cytogenetic Map1q32NCBI
P2ry6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,177,406 - 18,215,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,177,406 - 18,215,428 (-)NCBIChiLan1.0ChiLan1.0
P2RY6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11171,562,990 - 71,595,540 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,594,250 - 71,595,236 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,341,722 - 68,375,923 (+)NCBIMhudiblu_PPA_v0panPan3
P2RY6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2124,929,771 - 24,930,757 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12124,929,502 - 24,966,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
P2ry6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364982,468,020 - 2,501,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,726,631 - 7,759,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,708,452 - 7,759,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,538,019 - 8,554,097 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl164,541,221 - 64,542,207 (+)Ensembl
ChlSab1.1164,508,959 - 64,543,302 (+)NCBI
P2ry6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248173,648,829 - 3,672,051 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)762200000103100000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767640886101641032Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767640886101641032Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767640886101641032Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768716387102716494Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80902474114902584Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780902474114902584Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785716387112934612Mouse
1301647Elpt_melevated leptin (mouse)Not determined786850979120851122Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787394725121394859Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787394725121394859Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787394725121394859Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787493929119886157Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)788200000108500000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:191
Interacting mature miRNAs:216
Transcripts:ENSMUST00000060174
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000060174   ⟹   ENSMUSP00000055697
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7100,937,630 - 100,964,391 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208653
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7100,963,736 - 100,964,366 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209196
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7100,939,478 - 100,974,649 (-)Ensembl
RefSeq Acc Id: NM_183168   ⟹   NP_898991
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397100,586,841 - 100,613,573 (-)NCBI
GRCm387100,937,634 - 100,964,366 (-)NCBI
MGSCv377108,086,148 - 108,112,880 (-)RGD
Celera7101,288,708 - 101,316,203 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006507640   ⟹   XP_006507703
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397100,586,837 - 100,623,913 (-)NCBI
GRCm387100,937,630 - 100,974,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241739   ⟹   XP_011240041
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397100,586,837 - 100,624,742 (-)NCBI
GRCm387100,937,630 - 100,975,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152995   ⟹   XP_036008888
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397100,586,837 - 100,628,528 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_898991   ⟸   NM_183168
- UniProtKB: Q9ERK9 (UniProtKB/Swiss-Prot),   Q3UQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006507703   ⟸   XM_006507640
- Peptide Label: isoform X1
- UniProtKB: Q9ERK9 (UniProtKB/Swiss-Prot),   Q3UQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240041   ⟸   XM_011241739
- Peptide Label: isoform X1
- UniProtKB: Q9ERK9 (UniProtKB/Swiss-Prot),   Q3UQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000055697   ⟸   ENSMUST00000060174
RefSeq Acc Id: XP_036008888   ⟸   XM_036152995
- Peptide Label: isoform X1

Promoters
RGD ID:8664947
Promoter ID:EPDNEW_M10505
Type:multiple initiation site
Name:P2ry6_2
Description:Mus musculus pyrimidinergic receptor P2Y, G-protein coupled,6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10506  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387100,940,183 - 100,940,243EPDNEW
RGD ID:8664949
Promoter ID:EPDNEW_M10506
Type:initiation region
Name:P2ry6_1
Description:Mus musculus pyrimidinergic receptor P2Y, G-protein coupled,6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10505  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387100,964,324 - 100,964,384EPDNEW
RGD ID:6841696
Promoter ID:MM_KWN:51749
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:ENSMUST00000060174,   UC009INX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367108,112,781 - 108,113,697 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2673874 AgrOrtholog
Ensembl Genes ENSMUSG00000048779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000055697 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060174 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y6_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:233571 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2673874 ENTREZGENE
NCBI Gene 233571 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2ry6 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y6PRNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.235193 ENTREZGENE
UniProt P2RY6_MOUSE UniProtKB/Swiss-Prot
  Q3UQ86 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERK9 ENTREZGENE