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Gene: TGM1 (transglutaminase 1) Homo sapiens
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Symbol: TGM1
Name: transglutaminase 1
Description: Exhibits protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including keratinocyte differentiation; peptide cross-linking; and positive regulation of keratinocyte proliferation. Localizes to the intrinsic component of membrane. Implicated in autosomal recessive congenital ichthyosis 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARCI1; epidermal TGase; ICR2; K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase; KTG; LI; LI1; protein-glutamine gamma-glutamyltransferase K; TG(K); TGASE; TGase K; TGase-1; TGK; transglutaminase 1 isoform; transglutaminase K; transglutaminase, keratinocyte; transglutaminase-1
Orthologs:
Mus musculus (house mouse) : Tgm1 (transglutaminase 1, K polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgm1 (transglutaminase 1)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : TGM1 (transglutaminase 1)
Canis lupus familiaris (dog) : TGM1 (transglutaminase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgm1 (transglutaminase 1)
Sus scrofa (pig) : TGM1 (transglutaminase 1)
Chlorocebus sabaeus (green monkey) : TGM1 (transglutaminase 1)
Heterocephalus glaber (naked mole-rat) : Tgm1 (transglutaminase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1424,249,114 - 24,264,432 (-)Ensembl
GRCh381424,249,114 - 24,263,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371424,718,159 - 24,733,115 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,788,160 - 23,802,256 (-)NCBINCBI36hg18NCBI36
Build 341423,788,161 - 23,802,212NCBI
Celera144,582,959 - 4,597,032 (-)NCBI
Cytogenetic Map14q12NCBI
HuRef144,833,089 - 4,847,573 (-)NCBIHuRef
CHM1_11424,716,943 - 24,731,017 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TGM1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731987
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.