KCNMA1 (potassium calcium-activated channel subfamily M alpha 1)

Advanced Search (OLGA)

Gene: KCNMA1 (potassium calcium-activated channel subfamily M alpha 1) Homo sapiens

Analyze

Symbol:

KCNMA1

Name:

potassium calcium-activated channel subfamily M alpha 1

Description:

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

bA205K10.1; big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha subunit; BKTM; CADEDS; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; DKFZp686K1437; Drosophila slowpoke-like; hSlo; k(VCA)alpha; KCa1.1; maxi K channel; maxi-K channel HSLO; MaxiK; MGC71881; mSLO1; OTTHUMP00000019904; OTTHUMP00000019905; OTTHUMP00000019906; OTTHUMP00000019907; OTTHUMP00000019908; OTTHUMP00000019909; OTTHUMP00000019910; OTTHUMP00000019911; OTTHUMP00000019912; OTTHUMP00000019913; OTTHUMP00000019914; PNKD3; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; SAKCA; SLO; slo homolog; SLO-ALPHA; SLO1; slowpoke homolog; stretch-activated Kca channel

Orthologs:

Mus musculus (house mouse) : Kcnma1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) MGI Alliance
Rattus norvegicus (Norway rat) : Kcnma1 (potassium calcium-activated channel subfamily M alpha 1) Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kcnma1 (potassium calcium-activated channel subfamily M alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KCNMA1 (potassium calcium-activated channel subfamily M alpha 1)
Canis lupus familiaris (dog) : KCNMA1 (potassium calcium-activated channel subfamily M alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kcnma1 (potassium calcium-activated channel subfamily M alpha 1)

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	76,869,601 - 77,637,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	10	78,629,359 - 79,397,577 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	78,299,366 - 79,067,583 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	78,314,640 - 79,067,583	NCBI
Celera	10	71,914,113 - 72,684,182 (-)	NCBI
Cytogenetic Map	10	q22.3	NCBI
HuRef	10	72,624,294 - 73,391,824 (-)	NCBI		HuRef
CHM1_1	10	78,911,952 - 79,680,009 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

Gene Ontology Annotations

Phenotype Annotations

References - curated

References - uncurated

RGD Disease Portals

Genomics

Comparative Map Data

Position Markers

miRNA Target Status

Sequence

Nucleotide Sequences

Protein Sequences

Promoters

Clinical Variants

Additional Information

External Database Links

Nomenclature History

More on KCNMA1
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	731981
Created:	2004-01-12
Species:	Homo sapiens
Last Modified:	2018-04-10
Status:	ACTIVE

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

RGD Manual Annotations

Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - OMIM