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Gene: GRPR (gastrin releasing peptide receptor) Homo sapiens
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Symbol: GRPR
Name: gastrin releasing peptide receptor
Description: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BB2; BB2R; bombesin receptor 2; gastrin-releasing peptide receptor; GRP-preferring bombesin receptor; GRP-R
Orthologs:
Mus musculus (house mouse) : Grpr (gastrin releasing peptide receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grpr (gastrin releasing peptide receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grpr (gastrin releasing peptide receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : GRPR (gastrin releasing peptide receptor)
Canis lupus familiaris (dog) : GRPR (gastrin releasing peptide receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grpr (gastrin releasing peptide receptor)
Sus scrofa (pig) : GRPR (gastrin releasing peptide receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X16,123,565 - 16,153,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X16,141,424 - 16,171,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X16,051,345 - 16,081,562 (+)NCBINCBI36hg18NCBI36
Build 34X15,901,335 - 15,930,598NCBI
CeleraX20,259,707 - 20,289,922 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,896,945 - 13,927,133 (+)NCBIHuRef
CHM1_1X16,172,364 - 16,202,581 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GRPR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731959
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.