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Gene: CDC5L (cell division cycle 5 like) Homo sapiens
Symbol: CDC5L
Name: cell division cycle 5 like
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; and signal transduction involved in DNA damage checkpoint. Localizes to Prp19 complex; cytoplasm; and nucleus. Colocalizes with DNA replication factor A complex. Implicated in osteosarcoma. Biomarker of esophagus adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC5; CDC5 (cell division cycle 5, S. pombe, homolog)-like; CDC5 cell division cycle 5-like; CDC5-LIKE; Cdc5-related protein; CEF1; Cell division cycle 5, S. pombe, homolog-like; cell division cycle 5-like (s. pombe); cell division cycle 5-like protein; dJ319D22.1; dJ319D22.1 (CDC5-like protein); hCDC5; KIAA0432; PCDC5RP; pombe cdc5-related protein
Mus musculus (house mouse) : Cdc5l (cell division cycle 5-like (S. pombe))  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdc5l (cell division cycle 5-like)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdc5l (cell division cycle 5 like)
Pan paniscus (bonobo/pygmy chimpanzee) : CDC5L (cell division cycle 5 like)
Canis lupus familiaris (dog) : CDC5L (cell division cycle 5 like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdc5l (cell division cycle 5 like)
Sus scrofa (pig) : CDC5L (cell division cycle 5 like)
Chlorocebus sabaeus (African green monkey) : CDC5L (cell division cycle 5 like)
Heterocephalus glaber (naked mole-rat) : Cdc5l (cell division cycle 5 like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl644,387,706 - 44,450,425 (+)EnsemblGRCh38hg38GRCh38
GRCh38644,387,706 - 44,450,425 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37644,355,251 - 44,418,161 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,463,280 - 44,522,758 (+)NCBINCBI36hg18NCBI36
Build 34644,463,279 - 44,522,757NCBI
Celera645,908,480 - 45,967,835 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef644,077,869 - 44,140,670 (+)NCBIHuRef
CHM1_1644,358,890 - 44,421,686 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDC5L
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731949
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.