Cavin3 (caveolae associated 3) - Rat Genome Database

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Gene: Cavin3 (caveolae associated 3) Mus musculus
Analyze
Symbol: Cavin3
Name: caveolae associated 3
RGD ID: 731913
MGI Page MGI
Description: Exhibits protein kinase C binding activity. Involved in several processes, including circadian regulation of gene expression; negative regulation of fermentation; and regulation of intracellular signal transduction. Localizes to caveola and cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and quadriceps femoris muscle. Orthologous to human CAVIN3 (caveolae associated protein 3); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3110015B12Rik; 6330514M23Rik; caveolae-associated protein 3; cavin 3; cavin-3; MGC6598; Prkc; Prkcdbp; protein kinase C delta-binding protein; serum deprivation response factor-related gene product that binds to C-kinase; SRBC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,129,823 - 105,131,404 (-)NCBIGRCm39mm39
GRCm39 Ensembl7105,129,290 - 105,131,507 (-)Ensembl
GRCm387105,480,616 - 105,482,197 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,480,083 - 105,482,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv377112,629,130 - 112,630,711 (-)NCBIGRCm37mm9NCBIm37
MGSCv367105,354,437 - 105,356,018 (-)NCBImm8
Celera7105,752,686 - 105,754,267 (-)NCBICelera
Cytogenetic Map7E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fonofos  (ISO)
fructose  (ISO)
genistein  (EXP,ISO)
indole-3-methanol  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
Soman  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
terbufos  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (IBA,IDA,ISO)
cytoplasm  (IBA,IDA)
membrane  (IEA)
protein-containing complex  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:9857183   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635  
PMID:23079727   PMID:23652019   PMID:24013648   PMID:24069528   PMID:24194600   PMID:24714042   PMID:25036884   PMID:25588833   PMID:25921334   PMID:26839965   PMID:27626380   PMID:28285351  
PMID:32679831  


Genomics

Comparative Map Data
Cavin3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,129,823 - 105,131,404 (-)NCBIGRCm39mm39
GRCm39 Ensembl7105,129,290 - 105,131,507 (-)Ensembl
GRCm387105,480,616 - 105,482,197 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,480,083 - 105,482,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv377112,629,130 - 112,630,711 (-)NCBIGRCm37mm9NCBIm37
MGSCv367105,354,437 - 105,356,018 (-)NCBImm8
Celera7105,752,686 - 105,754,267 (-)NCBICelera
Cytogenetic Map7E3NCBI
CAVIN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl116,318,946 - 6,320,532 (-)EnsemblGRCh38hg38GRCh38
GRCh38116,318,946 - 6,320,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,340,176 - 6,341,731 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,296,752 - 6,298,316 (-)NCBINCBI36hg18NCBI36
Build 34116,296,753 - 6,298,316NCBI
Celera116,459,218 - 6,460,782 (-)NCBI
Cytogenetic Map11p15.4NCBI
HuRef116,000,077 - 6,001,641 (-)NCBIHuRef
CHM1_1116,339,390 - 6,340,954 (-)NCBICHM1_1
Cavin3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21159,826,549 - 159,828,138 (-)NCBI
Rnor_6.0 Ensembl1170,317,113 - 170,318,935 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01170,317,099 - 170,318,688 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01177,323,467 - 177,325,056 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,212,922 - 163,214,511 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11163,308,398 - 163,309,988 (-)NCBI
Celera1157,761,026 - 157,762,615 (-)NCBICelera
Cytogenetic Map1q32NCBI
Cavin3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,050,109 - 22,054,374 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,052,885 - 22,054,672 (-)NCBIChiLan1.0ChiLan1.0
CAVIN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,133,656 - 6,135,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,133,656 - 6,135,485 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0116,451,364 - 6,453,206 (-)NCBIMhudiblu_PPA_v0panPan3
CAVIN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,661,235 - 29,663,393 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,661,980 - 29,716,313 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,363,357 - 29,365,498 (-)NCBI
ROS_Cfam_1.02130,487,609 - 30,489,721 (-)NCBI
UMICH_Zoey_3.12129,808,695 - 29,810,832 (-)NCBI
UNSW_CanFamBas_1.02129,974,518 - 29,976,636 (-)NCBI
UU_Cfam_GSD_1.02130,169,413 - 30,171,524 (-)NCBI
Cavin3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,286,605 - 56,288,167 (+)NCBI
SpeTri2.0NW_004936842387,320 - 388,877 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAVIN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,378,207 - 3,379,848 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,378,144 - 3,379,851 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,991,701 - 3,993,411 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAVIN3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,504,726 - 58,507,200 (+)NCBI
ChlSab1.1 Ensembl158,504,782 - 58,507,438 (+)Ensembl
Vero_WHO_p1.0NW_023666038156,332,864 - 156,334,561 (+)NCBI
Cavin3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248177,836,671 - 7,838,590 (-)NCBI

Position Markers
AI481194  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387105,481,006 - 105,481,105UniSTSGRCm38
MGSCv377112,629,520 - 112,629,619UniSTSGRCm37
Celera7105,753,076 - 105,753,175UniSTS
Cytogenetic Map7F1UniSTS
Whitehead/MRC_RH71063.18UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80902474114902584Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780902474114902584Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785716387112934612Mouse
1301647Elpt_melevated leptin (mouse)Not determined786850979120851122Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787394725121394859Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787394725121394859Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787394725121394859Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787493929119886157Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)788200000108500000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798565687132565775Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798795739132795739Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined7100238481134238481Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7101151499135151620Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7101394038135394119Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7102094158136094307Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7102094158136094307Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7102094158136094307Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102885996136886157Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:135
Interacting mature miRNAs:140
Transcripts:ENSMUST00000047040
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047040   ⟹   ENSMUSP00000044979
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl7105,480,083 - 105,482,300 (-)Ensembl
RefSeq Acc Id: NM_028444   ⟹   NP_082720
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397105,129,823 - 105,131,404 (-)NCBI
GRCm387105,480,616 - 105,482,197 (-)ENTREZGENE
MGSCv377112,629,130 - 112,630,711 (-)RGD
Celera7105,752,686 - 105,754,267 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_082720 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH09660 (Get FASTA)   NCBI Sequence Viewer  
  BAB29133 (Get FASTA)   NCBI Sequence Viewer  
  BAC27728 (Get FASTA)   NCBI Sequence Viewer  
  EDL16772 (Get FASTA)   NCBI Sequence Viewer  
  Q91VJ2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_082720   ⟸   NM_028444
- UniProtKB: Q91VJ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000044979   ⟸   ENSMUST00000047040

Promoters
RGD ID:8665105
Promoter ID:EPDNEW_M10584
Type:initiation region
Name:Cavin3_1
Description:Mus musculus caveolae associated 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387105,482,208 - 105,482,268EPDNEW
RGD ID:6841826
Promoter ID:MM_KWN:52082
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000047040
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367112,630,256 - 112,631,127 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923422 AgrOrtholog
Ensembl Genes ENSMUSG00000037060 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000044979 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047040 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro CAVIN3 UniProtKB/Swiss-Prot
  Cavin_fam UniProtKB/Swiss-Prot
KEGG Report mmu:109042 UniProtKB/Swiss-Prot
MGD MGI:1923422 ENTREZGENE
NCBI Gene 109042 ENTREZGENE
PANTHER PTHR15240 UniProtKB/Swiss-Prot
  PTHR15240:SF2 UniProtKB/Swiss-Prot
Pfam PTRF_SDPR UniProtKB/Swiss-Prot
PhenoGen Cavin3 PhenoGen
UniProt CAVN3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8C064 UniProtKB/Swiss-Prot
  Q9CRW1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-23 Cavin3  caveolae associated 3  Prkcdbp  protein kinase C, delta binding protein  Symbol and/or name change 5135510 APPROVED