Npb (neuropeptide B) - Rat Genome Database

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Gene: Npb (neuropeptide B) Mus musculus
Analyze
Symbol: Npb
Name: neuropeptide B
RGD ID: 731868
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and feeding behavior. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in extracellular space. Orthologous to human NPB (neuropeptide B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mPPL7; PPL7; preproneuropeptide B; preproprotein L7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,499,303 - 120,499,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,499,303 - 120,499,919 (+)EnsemblGRCm39 Ensembl
GRCm3811120,608,477 - 120,609,100 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,608,477 - 120,609,093 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,469,791 - 120,470,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,424,599 - 120,425,033 (+)NCBIMGSCv36mm8
Celera11132,343,769 - 132,344,392 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12118011   PMID:12466851   PMID:12477932   PMID:12719537   PMID:12925742   PMID:15983370   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:21873635  


Genomics

Comparative Map Data
Npb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,499,303 - 120,499,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,499,303 - 120,499,919 (+)EnsemblGRCm39 Ensembl
GRCm3811120,608,477 - 120,609,100 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,608,477 - 120,609,093 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,469,791 - 120,470,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,424,599 - 120,425,033 (+)NCBIMGSCv36mm8
Celera11132,343,769 - 132,344,392 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.33NCBI
NPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,902,238 - 81,902,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,900,745 - 81,902,905 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,860,114 - 79,860,781 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,453,446 - 77,453,916 (+)NCBINCBI36Build 36hg18NCBI36
Celera1776,464,079 - 76,464,788 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,261,752 - 75,262,461 (+)NCBIHuRef
CHM1_11779,946,276 - 79,946,985 (+)NCBICHM1_1
T2T-CHM13v2.01782,769,398 - 82,770,065 (+)NCBIT2T-CHM13v2.0
Npb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,382,307 - 106,385,566 (+)NCBIGRCr8
mRatBN7.210105,883,992 - 105,887,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,874,708 - 105,887,254 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,990,498 - 110,990,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,453,526 - 110,453,960 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,807,106 - 105,807,540 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,786,222 - 109,786,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,786,222 - 109,786,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,377,548 - 109,380,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,999,845 - 110,000,279 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,014,348 - 110,014,783 (+)NCBI
Celera10104,430,057 - 104,430,491 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
Npb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,268,371 - 1,268,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,268,216 - 1,268,964 (-)NCBIChiLan1.0ChiLan1.0
NPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,436,500 - 98,438,984 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,337,273 - 103,340,957 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,306,883 - 76,308,470 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19390,493 - 392,339 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9391,781 - 392,314 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9993,780 - 994,469 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09984,997 - 985,686 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9985,098 - 985,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,010,145 - 1,010,834 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,136,741 - 1,137,430 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,215,405 - 1,216,094 (-)NCBIUU_Cfam_GSD_1.0
Npb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,001,978 - 1,002,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,409,354 - 5,409,815 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,408,560 - 5,410,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,092,653 - 1,093,202 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,092,643 - 1,093,361 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,774,767 - 73,776,311 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,775,695 - 73,776,149 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,227,843 - 45,228,334 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,744,413 - 10,744,811 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,742,517 - 10,744,972 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npb
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:652
Count of miRNA genes:277
Interacting mature miRNAs:300
Transcripts:ENSMUST00000061309, ENSMUST00000106194, ENSMUST00000106195
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse

Markers in Region
UniSTS:491795  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,608,478 - 120,608,992UniSTSGRCm38
MGSCv3711120,469,792 - 120,470,306UniSTSGRCm37
Celera11132,343,770 - 132,344,284UniSTS
Cytogenetic Map11E2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061309   ⟹   ENSMUSP00000050092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,499,331 - 120,499,859 (+)Ensembl
GRCm38.p6 Ensembl11120,608,505 - 120,609,033 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106194   ⟹   ENSMUSP00000101800
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,499,303 - 120,499,919 (+)Ensembl
GRCm38.p6 Ensembl11120,608,477 - 120,609,093 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106195   ⟹   ENSMUSP00000101801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,499,303 - 120,499,919 (+)Ensembl
GRCm38.p6 Ensembl11120,608,477 - 120,609,093 (+)Ensembl
RefSeq Acc Id: NM_001347616   ⟹   NP_001334545
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,499,303 - 120,499,919 (+)NCBI
GRCm3811120,608,477 - 120,609,093 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001347617   ⟹   NP_001334546
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,499,303 - 120,499,919 (+)NCBI
GRCm3811120,608,477 - 120,609,093 (+)NCBI
Sequence:
RefSeq Acc Id: NM_153288   ⟹   NP_695020
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,499,303 - 120,499,926 (+)NCBI
GRCm3811120,608,477 - 120,609,100 (+)NCBI
MGSCv3711120,469,791 - 120,470,414 (+)RGD
Celera11132,343,769 - 132,344,392 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_695020   ⟸   NM_153288
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8K4P1 (UniProtKB/Swiss-Prot),   Q3UR83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001334545   ⟸   NM_001347616
- Peptide Label: isoform 2 precursor
- UniProtKB: A2ABY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001334546   ⟸   NM_001347617
- Peptide Label: isoform 3 precursor
- UniProtKB: A2ABY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000101801   ⟸   ENSMUST00000106195
RefSeq Acc Id: ENSMUSP00000101800   ⟸   ENSMUST00000106194
RefSeq Acc Id: ENSMUSP00000050092   ⟸   ENSMUST00000061309

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4P1-F1-model_v2 AlphaFold Q8K4P1 1-119 view protein structure

Promoters
RGD ID:6821444
Promoter ID:MM_KWN:10940
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Liver,   MEF_B6
Transcripts:ENSMUST00000061309,   ENSMUST00000106194,   NM_153288
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611120,468,911 - 120,470,262 (+)MPROMDB
RGD ID:8677704
Promoter ID:EPDNEW_M16883
Type:multiple initiation site
Name:Npb_1
Description:Mus musculus neuropeptide B , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811120,608,481 - 120,608,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2387153 AgrOrtholog
Ensembl Genes ENSMUSG00000044034 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000061309 ENTREZGENE
  ENSMUST00000061309.5 UniProtKB/TrEMBL
  ENSMUST00000106194 ENTREZGENE
  ENSMUST00000106194.8 UniProtKB/TrEMBL
  ENSMUST00000106195 ENTREZGENE
  ENSMUST00000106195.3 UniProtKB/Swiss-Prot
InterPro Neuropept_B_pre UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuropept_BW_pre UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:208990 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2387153 ENTREZGENE
NCBI Gene 208990 ENTREZGENE
PANTHER NEUROPEPTIDE B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28553 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NPBW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npb PhenoGen
PRINTS NROPEPTIDEBW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPNRPEPTIDEB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ABY0 ENTREZGENE, UniProtKB/TrEMBL
  A2ABY2 ENTREZGENE, UniProtKB/TrEMBL
  A3KPC2_MOUSE UniProtKB/TrEMBL
  NPB_MOUSE UniProtKB/Swiss-Prot
  Q3UR83 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4P1 ENTREZGENE