AZIN1 (antizyme inhibitor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: AZIN1 (antizyme inhibitor 1) Homo sapiens
Analyze
Symbol: AZIN1
Name: antizyme inhibitor 1
RGD ID: 731863
HGNC Page HGNC
Description: Exhibits ornithine decarboxylase activator activity. Involved in negative regulation of protein catabolic process and positive regulation of polyamine transmembrane transport. Predicted to localize to cytoplasm and nucleus. Implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AZI; AZI1; AZIA1; MGC3832; MGC691; OAZI; OAZIN; ODC1L; ornithine decarboxylase 1-like; ornithine decarboxylase antizyme inhibitor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8102,826,308 - 102,893,864 (-)EnsemblGRCh38hg38GRCh38
GRCh388102,826,302 - 102,864,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378103,838,530 - 103,876,428 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,907,712 - 103,945,573 (-)NCBINCBI36hg18NCBI36
Build 348103,909,226 - 103,945,551NCBI
Celera8100,025,705 - 100,063,568 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef899,039,532 - 99,077,262 (-)NCBIHuRef
CHM1_18103,878,797 - 103,916,687 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
graphite  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
nefazodone  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sulfasalazine  (ISO)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
cytoplasm  (IBA)
cytosol  (TAS)
nucleus  (ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8619474   PMID:8889548   PMID:9110174   PMID:12477932   PMID:12878157   PMID:14499622   PMID:14702039   PMID:15146197   PMID:15489334   PMID:15670771   PMID:16344560   PMID:17353931  
PMID:18062773   PMID:18508777   PMID:19322201   PMID:19920120   PMID:20215859   PMID:20217058   PMID:21837750   PMID:21873635   PMID:21931692   PMID:21988832   PMID:23844940   PMID:24952745  
PMID:25416956   PMID:25621764   PMID:25813938   PMID:26186194   PMID:26305948   PMID:26496610   PMID:26760575   PMID:27229929   PMID:28514442   PMID:28849733   PMID:30063205   PMID:30583079  
PMID:31515488   PMID:32296183   PMID:32694731  


Genomics

Comparative Map Data
AZIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8102,826,308 - 102,893,864 (-)EnsemblGRCh38hg38GRCh38
GRCh388102,826,302 - 102,864,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378103,838,530 - 103,876,428 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,907,712 - 103,945,573 (-)NCBINCBI36hg18NCBI36
Build 348103,909,226 - 103,945,551NCBI
Celera8100,025,705 - 100,063,568 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef899,039,532 - 99,077,262 (-)NCBIHuRef
CHM1_18103,878,797 - 103,916,687 (-)NCBICHM1_1
Azin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,487,674 - 38,523,506 (-)NCBIGRCm39mm39
GRCm39 Ensembl1538,487,671 - 38,519,510 (-)Ensembl
GRCm381538,487,430 - 38,519,294 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,487,427 - 38,519,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv371538,417,185 - 38,449,021 (-)NCBIGRCm37mm9NCBIm37
MGSCv361538,432,019 - 38,463,855 (-)NCBImm8
Celera1539,113,891 - 39,145,734 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Azin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBICelera
Cytogenetic Map7q22NCBI
Azin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,231,696 - 27,259,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541727,231,695 - 27,259,564 (-)NCBIChiLan1.0ChiLan1.0
AZIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18101,639,950 - 101,678,604 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,639,950 - 101,678,604 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0899,483,027 - 99,521,151 (-)NCBIMhudiblu_PPA_v0panPan3
AZIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,363,996 - 4,396,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,364,236 - 4,396,246 (-)NCBI
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBI
UMICH_Zoey_3.1134,365,307 - 4,397,317 (-)NCBI
UNSW_CanFamBas_1.0134,482,535 - 4,514,517 (-)NCBI
UU_Cfam_GSD_1.0134,495,739 - 4,527,724 (-)NCBI
Azin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,375,842 - 33,406,444 (+)NCBI
SpeTri2.0NW_00493647040,801,943 - 40,832,543 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,209,008 - 34,257,136 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,221,368 - 34,257,261 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,079,181 - 37,109,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AZIN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,679,775 - 97,717,486 (-)NCBI
ChlSab1.1 Ensembl897,679,468 - 97,696,928 (-)Ensembl
Vero_WHO_p1.0NW_02366603942,881,918 - 42,921,274 (+)NCBI
Azin1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476319,643,980 - 19,667,125 (-)NCBI

Position Markers
HSC12A042  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,840,244 - 103,840,393UniSTSGRCh37
Build 368103,909,420 - 103,909,569RGDNCBI36
Celera8100,027,413 - 100,027,562RGD
Cytogenetic Map8q22.3UniSTS
HuRef899,041,240 - 99,041,389UniSTS
GeneMap99-GB4 RH Map8438.18UniSTS
Whitehead-RH Map8572.3UniSTS
RH18526  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,839,616 - 103,839,796UniSTSGRCh37
Build 368103,908,792 - 103,908,972RGDNCBI36
Celera8100,026,785 - 100,026,965RGD
Cytogenetic Map8q22.3UniSTS
HuRef899,040,612 - 99,040,792UniSTS
GeneMap99-GB4 RH Map8438.21UniSTS
WI-19200  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,839,276 - 103,839,526UniSTSGRCh37
Build 368103,908,452 - 103,908,702RGDNCBI36
Celera8100,026,445 - 100,026,695RGD
Cytogenetic Map8q22.3UniSTS
HuRef899,040,272 - 99,040,522UniSTS
GeneMap99-GB4 RH Map8438.63UniSTS
Whitehead-RH Map8574.4UniSTS
WI-9274  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,839,273 - 103,839,388UniSTSGRCh37
GRCh3711120,511,012 - 120,511,124UniSTSGRCh37
Build 368103,908,449 - 103,908,564RGDNCBI36
Celera8100,026,442 - 100,026,557RGD
Celera11117,670,439 - 117,670,551UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map11q22.3UniSTS
HuRef11116,451,456 - 116,451,568UniSTS
HuRef899,040,269 - 99,040,384UniSTS
GeneMap99-GB4 RH Map8436.52UniSTS
Whitehead-RH Map8584.4UniSTS
G19701  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,839,909 - 103,840,015UniSTSGRCh37
Build 368103,909,085 - 103,909,191RGDNCBI36
Celera8100,027,078 - 100,027,184RGD
Cytogenetic Map8q22.3UniSTS
HuRef899,040,905 - 99,041,011UniSTS
A001V45  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,839,909 - 103,840,015UniSTSGRCh37
Build 368103,909,085 - 103,909,191RGDNCBI36
Celera8100,027,078 - 100,027,184RGD
Cytogenetic Map8q22.3UniSTS
HuRef899,040,905 - 99,041,011UniSTS
GeneMap99-GB4 RH Map8439.53UniSTS
NCBI RH Map8985.3UniSTS
WIAF-1666  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378103,868,457 - 103,868,569UniSTSGRCh37
Build 368103,937,633 - 103,937,745RGDNCBI36
Celera8100,055,628 - 100,055,740RGD
Cytogenetic Map8q22.3UniSTS
HuRef899,069,320 - 99,069,432UniSTS
GeneMap99-GB4 RH Map8440.32UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1724
Count of miRNA genes:858
Interacting mature miRNAs:1006
Transcripts:ENST00000337198, ENST00000347770, ENST00000517581, ENST00000518353, ENST00000518697, ENST00000518940, ENST00000520402, ENST00000521536, ENST00000522311, ENST00000523071
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2430 2573 1690 594 1768 436 4285 1917 3624 390 1446 1606 171 1203 2720 4
Low 2 411 33 28 180 28 70 276 86 28 2 3 1 68 1
Below cutoff 2 1 1 1 11 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_148174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF070634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI671875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU280209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM716557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU507334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX956991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN392292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN392320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV569168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX781377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA333832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA414234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA830883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB092816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB139218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB236925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000337198   ⟹   ENSP00000337180
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,826,308 - 102,864,163 (-)Ensembl
RefSeq Acc Id: ENST00000347770   ⟹   ENSP00000321507
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,827,823 - 102,864,193 (-)Ensembl
RefSeq Acc Id: ENST00000517581
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,849,999 - 102,893,864 (-)Ensembl
RefSeq Acc Id: ENST00000518353   ⟹   ENSP00000429215
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,843,554 - 102,864,128 (-)Ensembl
RefSeq Acc Id: ENST00000518697
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,828,547 - 102,830,227 (-)Ensembl
RefSeq Acc Id: ENST00000518940
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,843,708 - 102,864,035 (-)Ensembl
RefSeq Acc Id: ENST00000520402   ⟹   ENSP00000429449
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,838,902 - 102,872,412 (-)Ensembl
RefSeq Acc Id: ENST00000521536   ⟹   ENSP00000475919
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,834,261 - 102,858,102 (-)Ensembl
RefSeq Acc Id: ENST00000522311
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,836,246 - 102,858,044 (-)Ensembl
RefSeq Acc Id: ENST00000523071
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8102,834,235 - 102,835,475 (-)Ensembl
RefSeq Acc Id: NM_001301668   ⟹   NP_001288597
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,357 - 102,864,163 (-)NCBI
CHM1_18103,878,797 - 103,916,687 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363010   ⟹   NP_001349939
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
RefSeq Acc Id: NM_001363011   ⟹   NP_001349940
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
RefSeq Acc Id: NM_001363012   ⟹   NP_001349941
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
RefSeq Acc Id: NM_001363013   ⟹   NP_001349942
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
RefSeq Acc Id: NM_001363014   ⟹   NP_001349943
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
RefSeq Acc Id: NM_001363024   ⟹   NP_001349953
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
RefSeq Acc Id: NM_001363083   ⟹   NP_001350012
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
RefSeq Acc Id: NM_015878   ⟹   NP_056962
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,302 - 102,864,200 (-)NCBI
GRCh378103,838,536 - 103,876,905 (-)NCBI
Build 368103,907,712 - 103,945,573 (-)NCBI Archive
Celera8100,025,705 - 100,063,568 (-)RGD
HuRef899,039,532 - 99,077,262 (-)RGD
CHM1_18103,878,797 - 103,916,687 (-)NCBI
Sequence:
RefSeq Acc Id: NM_148174   ⟹   NP_680479
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,308 - 102,864,163 (-)NCBI
GRCh378103,838,536 - 103,876,905 (-)NCBI
Build 368103,907,712 - 103,945,573 (-)NCBI Archive
Celera8100,025,705 - 100,063,568 (-)RGD
HuRef899,039,532 - 99,077,262 (-)RGD
CHM1_18103,878,797 - 103,916,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013566   ⟹   XP_016869055
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,826,357 - 102,864,164 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_056962   ⟸   NM_015878
- Peptide Label: isoform 1
- UniProtKB: O14977 (UniProtKB/Swiss-Prot),   A0A024R9C7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_680479   ⟸   NM_148174
- Peptide Label: isoform 1
- UniProtKB: O14977 (UniProtKB/Swiss-Prot),   A0A024R9C7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288597   ⟸   NM_001301668
- Peptide Label: isoform 2
- UniProtKB: B3KTF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016869055   ⟸   XM_017013566
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001349939   ⟸   NM_001363010
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001349942   ⟸   NM_001363013
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001349940   ⟸   NM_001363011
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001349943   ⟸   NM_001363014
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001349941   ⟸   NM_001363012
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001349953   ⟸   NM_001363024
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001350012   ⟸   NM_001363083
- Peptide Label: isoform 1
RefSeq Acc Id: ENSP00000429215   ⟸   ENST00000518353
RefSeq Acc Id: ENSP00000321507   ⟸   ENST00000347770
RefSeq Acc Id: ENSP00000337180   ⟸   ENST00000337198
RefSeq Acc Id: ENSP00000429449   ⟸   ENST00000520402
RefSeq Acc Id: ENSP00000475919   ⟸   ENST00000521536
Protein Domains
Orn_Arg_deC_N   Orn_DAP_Arg_deC

Promoters
RGD ID:7213933
Promoter ID:EPDNEW_H12712
Type:single initiation site
Name:AZIN1_2
Description:antizyme inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12713  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,854,797 - 102,854,857EPDNEW
RGD ID:7213935
Promoter ID:EPDNEW_H12713
Type:initiation region
Name:AZIN1_1
Description:antizyme inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12712  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388102,864,163 - 102,864,223EPDNEW
RGD ID:6806511
Promoter ID:HG_KWN:61847
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_015878,   NM_148174
Position:
Human AssemblyChrPosition (strand)Source
Build 368103,945,476 - 103,945,976 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q22.3(chr8:101962098-103357772)x3 copy number gain See cases [RCV000050760] Chr8:101962098..103357772 [GRCh38]
Chr8:102974326..104370000 [GRCh37]
Chr8:103043502..104439176 [NCBI36]
Chr8:8q22.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NM_015878.5(AZIN1):c.730C>T (p.Gln244Ter) single nucleotide variant Malignant melanoma [RCV000068061] Chr8:102834200 [GRCh38]
Chr8:103846428 [GRCh37]
Chr8:103915604 [NCBI36]
Chr8:8q22.3
not provided
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q22.3-23.1(chr8:101884819-107356143)x1 copy number loss See cases [RCV000134099] Chr8:101884819..107356143 [GRCh38]
Chr8:102897047..108368371 [GRCh37]
Chr8:102966223..108437547 [NCBI36]
Chr8:8q22.3-23.1
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.3-23.1(chr8:101199826-105802098)x1 copy number loss See cases [RCV000136812] Chr8:101199826..105802098 [GRCh38]
Chr8:102212054..106814326 [GRCh37]
Chr8:102281230..106883502 [NCBI36]
Chr8:8q22.3-23.1
pathogenic
GRCh38/hg38 8q22.3-23.1(chr8:101171263-109127664)x1 copy number loss See cases [RCV000138134] Chr8:101171263..109127664 [GRCh38]
Chr8:102183491..110139893 [GRCh37]
Chr8:102252667..110209069 [NCBI36]
Chr8:8q22.3-23.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8q22.2-23.1(chr8:100179408-106524667)x1 copy number loss See cases [RCV000141697] Chr8:100179408..106524667 [GRCh38]
Chr8:101191636..107536895 [GRCh37]
Chr8:101260812..107606071 [NCBI36]
Chr8:8q22.2-23.1
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.3(chr8:102590127-104034598)x1 copy number loss See cases [RCV000511503] Chr8:102590127..104034598 [GRCh37]
Chr8:8q22.3
likely pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q22.3(chr8:102584167-104236192)x1 copy number loss not provided [RCV000683013] Chr8:102584167..104236192 [GRCh37]
Chr8:8q22.3
likely pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_148174.4(AZIN1):c.177G>A (p.Val59=) single nucleotide variant not provided [RCV000898394] Chr8:102839749 [GRCh38]
Chr8:103851977 [GRCh37]
Chr8:8q22.3
benign
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16432 AgrOrtholog
COSMIC AZIN1 COSMIC
Ensembl Genes ENSG00000155096 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000321507 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000337180 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429215 UniProtKB/TrEMBL
  ENSP00000429449 UniProtKB/TrEMBL
  ENSP00000475919 UniProtKB/TrEMBL
Ensembl Transcript ENST00000337198 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000347770 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000518353 UniProtKB/TrEMBL
  ENST00000520402 UniProtKB/TrEMBL
  ENST00000521536 UniProtKB/TrEMBL
Gene3D-CATH 2.40.37.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000155096 GTEx
HGNC ID HGNC:16432 ENTREZGENE
Human Proteome Map AZIN1 Human Proteome Map
InterPro Ala_racemase/Decarboxylase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Azin1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  De-COase2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  De-COase2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  De-COase2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orn/DAP/Arg_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orn_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLP-binding_barrel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51582 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 51582 ENTREZGENE
OMIM 607909 OMIM
PANTHER PTHR11482 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11482:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Orn_Arg_deC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orn_DAP_Arg_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31887 PharmGKB
PRINTS ODADCRBXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORNDCRBXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ODR_DC_2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50621 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51419 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R9C7 ENTREZGENE, UniProtKB/TrEMBL
  AZIN1_HUMAN UniProtKB/Swiss-Prot
  B3KTF6 ENTREZGENE, UniProtKB/TrEMBL
  E5RIB7_HUMAN UniProtKB/TrEMBL
  E5RJ16_HUMAN UniProtKB/TrEMBL
  O14977 ENTREZGENE
  U3KQI8_HUMAN UniProtKB/TrEMBL
UniProt Secondary A6NCD5 UniProtKB/Swiss-Prot
  Q6IBQ7 UniProtKB/Swiss-Prot
  Q96D20 UniProtKB/Swiss-Prot